{"id":"https://openalex.org/W2985696482","doi":"https://doi.org/10.1093/neuonc/noz175.123","title":"CBMT-01. ALANINE FUELS ENERGY METABOLISM OF GLIOBLASTOMA CELLS","display_name":"CBMT-01. ALANINE FUELS ENERGY METABOLISM OF GLIOBLASTOMA CELLS","publication_year":2019,"publication_date":"2019-11-01","ids":{"openalex":"https://openalex.org/W2985696482","doi":"https://doi.org/10.1093/neuonc/noz175.123","mag":"2985696482"},"language":"en","primary_location":{"id":"doi:10.1093/neuonc/noz175.123","doi":"https://doi.org/10.1093/neuonc/noz175.123","is_oa":false,"landing_page_url":"https://doi.org/10.1093/neuonc/noz175.123","pdf_url":null,"source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6846899","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037817807","display_name":"Omkar B. Ijare","orcid":"https://orcid.org/0000-0003-1855-8232","observed_orcids":["https://orcid.org/0000-0003-1855-8232"]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]},{"id":"https://openalex.org/I4405286254","display_name":"Houston Methodist Research Institute","ror":"https://ror.org/01mcrxx35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Omkar Ijare","raw_affiliation_strings":["Houston Methodist Hospital and Research Institute, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Houston Methodist Hospital and Research Institute, Houston, TX, USA","institution_ids":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113572501","display_name":"David S. Baskin","orcid":"https://orcid.org/0000-0002-8076-382X","observed_orcids":["https://orcid.org/0000-0002-8076-382X"]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]},{"id":"https://openalex.org/I4405286254","display_name":"Houston Methodist Research Institute","ror":"https://ror.org/01mcrxx35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Baskin","raw_affiliation_strings":["The Peak Center for Brain and Pituitary Tumor, Dept of Neurosurgery, Houston Methodist Research Institute, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Peak Center for Brain and Pituitary Tumor, Dept of Neurosurgery, Houston Methodist Research Institute, Houston, TX, USA","institution_ids":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036568543","display_name":"Kumar Pichumani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]},{"id":"https://openalex.org/I4405286254","display_name":"Houston Methodist Research Institute","ror":"https://ror.org/01mcrxx35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kumar Pichumani","raw_affiliation_strings":["Houston Methodist Hospital and Research Institute, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Houston Methodist Hospital and Research Institute, Houston, TX, USA","institution_ids":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5132,"currency":"USD","value_usd":5132},"apc_paid":null,"fwci":0.0759,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.3607997,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"21","issue":"Supplement_6","first_page":"vi32","last_page":"vi33"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9526000022888184,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9526000022888184,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.01640000008046627,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.011800000444054604,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9710000157356262},{"id":"https://openalex.org/keywords/alanine-metabolism","display_name":"alanine metabolism","score":0.9559999704360962},{"id":"https://openalex.org/keywords/cancer-energy-metabolism","display_name":"cancer energy metabolism","score":0.7009999752044678},{"id":"https://openalex.org/keywords/pyruvate","display_name":"pyruvate","score":0.7250000238418579},{"id":"https://openalex.org/keywords/lactate","display_name":"lactate","score":0.7139999866485596},{"id":"https://openalex.org/keywords/acetyl-coa","display_name":"acetyl-CoA","score":0.972000002861023},{"id":"https://openalex.org/keywords/tca-cycle-intermediates","display_name":"TCA cycle intermediates","score":0.9110000133514404},{"id":"https://openalex.org/keywords/citrate","display_name":"citrate","score":0.6399999856948853},{"id":"https://openalex.org/keywords/glutamate","display_name":"glutamate","score":0.7689999938011169},{"id":"https://openalex.org/keywords/malate","display_name":"malate","score":0.8209999799728394},{"id":"https://openalex.org/keywords/aspartate","display_name":"aspartic acid","score":0.9850000143051147},{"id":"https://openalex.org/keywords/non-essential-amino-acids","display_name":"non-essential amino acids","score":0.734000027179718},{"id":"https://openalex.org/keywords/patient-derived-tumor-cells","display_name":"patient-derived tumor cells","score":0.5580000281333923}],"concepts":[{"id":"https://openalex.org/C2779856020","wikidata":"https://www.wikidata.org/wiki/Q218642","display_name":"Alanine","level":3,"score":0.7884179353713989},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.6889394521713257},{"id":"https://openalex.org/C165135838","wikidata":"https://www.wikidata.org/wiki/Q133895","display_name":"Citric acid cycle","level":3,"score":0.5731238722801208},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.548210084438324},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.5118169188499451},{"id":"https://openalex.org/C55885012","wikidata":"https://www.wikidata.org/wiki/Q4750801","display_name":"Anaerobic glycolysis","level":4,"score":0.49129408597946167},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4910697937011719},{"id":"https://openalex.org/C109156525","wikidata":"https://www.wikidata.org/wiki/Q56770304","display_name":"Warburg effect","level":4,"score":0.4613805413246155},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4539172947406769},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44739192724227905},{"id":"https://openalex.org/C100206155","wikidata":"https://www.wikidata.org/wiki/Q570714","display_name":"Bioenergetics","level":3,"score":0.4224078357219696},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3649389147758484},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.31669360399246216},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2955300211906433},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2848963141441345},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.26177889108657837},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17892798781394958},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.13017961382865906}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/neuonc/noz175.123","doi":"https://doi.org/10.1093/neuonc/noz175.123","is_oa":false,"landing_page_url":"https://doi.org/10.1093/neuonc/noz175.123","pdf_url":null,"source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6846899","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6846899","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro Oncol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6846899","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6846899","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro Oncol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2988926360","https://openalex.org/W2537345927","https://openalex.org/W4308976903","https://openalex.org/W3145385701","https://openalex.org/W7034771159","https://openalex.org/W3112208293","https://openalex.org/W4388588684","https://openalex.org/W2535613053","https://openalex.org/W4385555394","https://openalex.org/W3155418988"],"abstract_inverted_index":{"Abstract":[0],"Despite":[1],"available":[2],"aggressive":[3],"treatment":[4],"options,":[5],"glioblastoma":[6],"multiforme":[7],"(GBM)":[8],"has":[9,99],"a":[10,145],"median":[11],"survival":[12],"of":[13,43,63,71,204,232,243,282],"16":[14],"months":[15],"indicating":[16],"an":[17,129],"urgent":[18],"unmet":[19],"need":[20],"to":[21,41,60,110,141,147,197,229,285],"develop":[22],"new":[23],"therapeutic":[24],"strategies.":[25],"Earlier,":[26],"we":[27,133],"have":[28,138],"demonstrated":[29],"that":[30,57,77,102,214,277],"both":[31],"glucose":[32],"and":[33,87,179,207,220,238,247,288],"acetate":[34],"are":[35,280],"the":[36,48,72,111,139,163,189,217,230,251],"two":[37],"major":[38],"nutrients":[39,56],"leading":[40],"synthesis":[42],"approximately":[44],"~60%":[45],"acetyl-CoA":[46],"in":[47,81,90,114,168,172],"brain":[49],"tumors.":[50],"Therefore,":[51],"there":[52],"must":[53],"be":[54],"other":[55],"may":[58],"contribute":[59],"bioenergetic":[61],"needs":[62],"highly":[64],"proliferative":[65],"GBM":[66,124,136,154,218,278],"cells.":[67,117],"Alanine":[68],"is":[69,78,93,120],"one":[70],"non-essential":[73],"amino":[74],"acids":[75],"(NEAA)":[76],"constantly":[79],"produced":[80,104,221,239],"cancer":[82,91,116],"cells":[83,108,137,155,219,279],"through":[84],"Warburg":[85],"glycolysis":[86],"its":[88,149],"role":[89],"metabolism":[92,113],"not":[94,121],"well":[95],"understood.":[96],"Recently,":[97],"it":[98,119],"been":[100],"shown":[101],"alanine":[103,127,143,284],"by":[105],"pancreatic":[106,115],"stellar":[107],"contributed":[109],"energy":[112,130,151,287],"However,":[118],"known":[122],"whether":[123,135],"can":[125],"use":[126],"as":[128,144],"source.":[131],"Here,":[132],"test":[134],"ability":[140],"metabolize":[142],"fuel":[146],"meet":[148],"increased":[150],"requirements.":[152],"Patient-derived":[153],"were":[156,181,192],"cultured":[157],"with":[158],"2.0":[159],"mM":[160],"[3-13C]alanine":[161,215],"for":[162,194,291],"final":[164],"24":[165],"hours,":[166],"harvested":[167],"50%":[169],"methanol,":[170],"snap-frozen":[171],"liquid":[173],"N2,":[174],"freeze-thaw":[175],"cycle":[176,209,237],"3":[177],"times":[178],"lysates":[180,191],"stored":[182],"at":[183],"-80":[184],"\u00b0C.":[185],"Derivatized":[186],"material":[187],"from":[188],"frozen":[190],"used":[193],"GC-MS":[195],"analysis":[196],"determine":[198],"carbon":[199],"mass":[200],"isotopomer":[201],"distribution":[202],"(MID)":[203],"various":[205],"glycolytic":[206],"TCA":[208,236],"intermediates.":[210],"Our":[211],"results":[212],"indicated":[213],"entered":[216,235],"[3-13C]lactate":[222],"via":[223],"pyruvate.":[224],"Also,":[225],"alanine-derived":[226],"[3-13C]pyruvate":[227],"led":[228],"generation":[231],"[2-13C]acetyl-CoA,":[233],"which":[234],"M+1":[240],"13C":[241,253],"isotopomers":[242],"citrate,":[244,257],"glutamate,":[245,262],"malate":[246],"aspartate.":[248],"MID":[249],"showed":[250],"following":[252],"enrichment":[254],"(M+1)":[255],"values:":[256],"6.9":[258],"%":[259],"\u00b1":[260,264,268,271],"0.3%;":[261,265],"4.4%":[263],"malate,":[266],"2.1%":[267,270],"0.6%;":[269],"0.5%.":[272],"This":[273],"preliminary":[274],"data":[275],"shows":[276],"capable":[281],"utilizing":[283],"generate":[286],"produce":[289],"precursors":[290],"biomolecular":[292],"synthesis.":[293]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-11-22T00:00:00"}
