{"id":"https://openalex.org/W2985642416","doi":"https://doi.org/10.1136/bmj.l5887","title":"Benefits and harms of intensive glycemic control in patients with type 2 diabetes","display_name":"Benefits and harms of intensive glycemic control in patients with type 2 diabetes","publication_year":2019,"publication_date":"2019-11-05","ids":{"openalex":"https://openalex.org/W2985642416","doi":"https://doi.org/10.1136/bmj.l5887","mag":"2985642416","pmid":"https://pubmed.ncbi.nlm.nih.gov/31690574"},"language":"en","primary_location":{"id":"doi:10.1136/bmj.l5887","doi":"https://doi.org/10.1136/bmj.l5887","is_oa":false,"landing_page_url":"https://doi.org/10.1136/bmj.l5887","pdf_url":null,"source":{"id":"https://openalex.org/S4393917726","display_name":"BMJ","issn_l":"1756-1833","issn":["1756-1833"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035283542","display_name":"Ren\u00e9 Rodr\u00edguez\u2010Guti\u00e9rrez","orcid":"https://orcid.org/0000-0002-3022-5302","observed_orcids":["https://orcid.org/0000-0002-3022-5302"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I169046204","display_name":"Universidad Aut\u00f3noma de Nuevo Le\u00f3n","ror":"https://ror.org/01fh86n78","country_code":"MX","type":"education","lineage":["https://openalex.org/I169046204"]},{"id":"https://openalex.org/I4210132044","display_name":"Hospital Universitario Dr Jos\u00e9 Eleuterio Gonzalez","ror":"https://ror.org/030ms0x66","country_code":"MX","type":"healthcare","lineage":["https://openalex.org/I4210132044"]}],"countries":["MX","US"],"is_corresponding":false,"raw_author_name":"Ren\u00e9 Rodriguez-Gutierrez","raw_affiliation_strings":["Endocrinology Division, Department of Internal Medicine, University Hospital \"Dr Jos\u00e9 E Gonz\u00e1lez,\" Universidad Autonoma de Nuevo Leon, Monterrey, 64460, Mexico","Knowledge and Evaluation Research Unit in Endocrinology, Mayo Clinic, Rochester, MN 55905, USA","Plataforma INVEST Medicina UANL - KER Unit (KER Unit M\u00e9xico), Subdireccion de Investigacion, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Monterrey, 64460, Mexico","Endocrinology Division, Department of Internal Medicine, University Hospital \u201cDr Jos\u00e9 E Gonz\u00e1lez,\u201d Universidad Autonoma de Nuevo Leon, Monterrey, 64460, Mexico","Plataforma INVEST Medicina UANL \u2013 KER Unit (KER Unit M\u00e9xico), Subdireccion de Investigacion, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Monterrey, 64460, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrinology Division, Department of Internal Medicine, University Hospital \"Dr Jos\u00e9 E Gonz\u00e1lez,\" Universidad Autonoma de Nuevo Leon, Monterrey, 64460, Mexico","institution_ids":["https://openalex.org/I169046204","https://openalex.org/I4210132044"]},{"raw_affiliation_string":"Knowledge and Evaluation Research Unit in Endocrinology, Mayo Clinic, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Plataforma INVEST Medicina UANL - KER Unit (KER Unit M\u00e9xico), Subdireccion de Investigacion, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Monterrey, 64460, Mexico","institution_ids":["https://openalex.org/I169046204"]},{"raw_affiliation_string":"Endocrinology Division, Department of Internal Medicine, University Hospital \u201cDr Jos\u00e9 E Gonz\u00e1lez,\u201d Universidad Autonoma de Nuevo Leon, Monterrey, 64460, Mexico","institution_ids":["https://openalex.org/I169046204"]},{"raw_affiliation_string":"Plataforma INVEST Medicina UANL \u2013 KER Unit (KER Unit M\u00e9xico), Subdireccion de Investigacion, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Monterrey, 64460, Mexico","institution_ids":["https://openalex.org/I169046204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031965655","display_name":"Jos\u00e9 Gerardo Gonz\u00e1lez\u2010Gonz\u00e1lez","orcid":"https://orcid.org/0000-0002-6609-9483","observed_orcids":["https://orcid.org/0000-0002-6609-9483"]},"institutions":[{"id":"https://openalex.org/I169046204","display_name":"Universidad Aut\u00f3noma de Nuevo Le\u00f3n","ror":"https://ror.org/01fh86n78","country_code":"MX","type":"education","lineage":["https://openalex.org/I169046204"]},{"id":"https://openalex.org/I4210132044","display_name":"Hospital Universitario Dr Jos\u00e9 Eleuterio Gonzalez","ror":"https://ror.org/030ms0x66","country_code":"MX","type":"healthcare","lineage":["https://openalex.org/I4210132044"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Gerardo Gonzalez-Gonzalez","raw_affiliation_strings":["Endocrinology Division, Department of Internal Medicine, University Hospital \"Dr Jos\u00e9 E Gonz\u00e1lez,\" Universidad Autonoma de Nuevo Leon, Monterrey, 64460, Mexico","Plataforma INVEST Medicina UANL - KER Unit (KER Unit M\u00e9xico), Subdireccion de Investigacion, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Monterrey, 64460, Mexico","Endocrinology Division, Department of Internal Medicine, University Hospital \u201cDr Jos\u00e9 E Gonz\u00e1lez,\u201d Universidad Autonoma de Nuevo Leon, Monterrey, 64460, Mexico","Plataforma INVEST Medicina UANL \u2013 KER Unit (KER Unit M\u00e9xico), Subdireccion de Investigacion, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Monterrey, 64460, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrinology Division, Department of Internal Medicine, University Hospital \"Dr Jos\u00e9 E Gonz\u00e1lez,\" Universidad Autonoma de Nuevo Leon, Monterrey, 64460, Mexico","institution_ids":["https://openalex.org/I169046204","https://openalex.org/I4210132044"]},{"raw_affiliation_string":"Plataforma INVEST Medicina UANL - KER Unit (KER Unit M\u00e9xico), Subdireccion de Investigacion, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Monterrey, 64460, Mexico","institution_ids":["https://openalex.org/I169046204"]},{"raw_affiliation_string":"Endocrinology Division, Department of Internal Medicine, University Hospital \u201cDr Jos\u00e9 E Gonz\u00e1lez,\u201d Universidad Autonoma de Nuevo Leon, Monterrey, 64460, Mexico","institution_ids":["https://openalex.org/I169046204"]},{"raw_affiliation_string":"Plataforma INVEST Medicina UANL \u2013 KER Unit (KER Unit M\u00e9xico), Subdireccion de Investigacion, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Monterrey, 64460, Mexico","institution_ids":["https://openalex.org/I169046204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080234471","display_name":"Jorge Alberto Z\u00fa\u00f1iga Hern\u00e1ndez","orcid":"https://orcid.org/0000-0002-2038-609X","observed_orcids":["https://orcid.org/0000-0002-2038-609X"]},"institutions":[{"id":"https://openalex.org/I169046204","display_name":"Universidad Aut\u00f3noma de Nuevo Le\u00f3n","ror":"https://ror.org/01fh86n78","country_code":"MX","type":"education","lineage":["https://openalex.org/I169046204"]},{"id":"https://openalex.org/I4210132044","display_name":"Hospital Universitario Dr Jos\u00e9 Eleuterio Gonzalez","ror":"https://ror.org/030ms0x66","country_code":"MX","type":"healthcare","lineage":["https://openalex.org/I4210132044"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Jorge A Zu\u00f1iga-Hernandez","raw_affiliation_strings":["Endocrinology Division, Department of Internal Medicine, University Hospital \"Dr Jos\u00e9 E Gonz\u00e1lez,\" Universidad Autonoma de Nuevo Leon, Monterrey, 64460, Mexico","Plataforma INVEST Medicina UANL - KER Unit (KER Unit M\u00e9xico), Subdireccion de Investigacion, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Monterrey, 64460, Mexico","Endocrinology Division, Department of Internal Medicine, University Hospital \u201cDr Jos\u00e9 E Gonz\u00e1lez,\u201d Universidad Autonoma de Nuevo Leon, Monterrey, 64460, Mexico","Plataforma INVEST Medicina UANL \u2013 KER Unit (KER Unit M\u00e9xico), Subdireccion de Investigacion, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Monterrey, 64460, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrinology Division, Department of Internal Medicine, University Hospital \"Dr Jos\u00e9 E Gonz\u00e1lez,\" Universidad Autonoma de Nuevo Leon, Monterrey, 64460, Mexico","institution_ids":["https://openalex.org/I169046204","https://openalex.org/I4210132044"]},{"raw_affiliation_string":"Plataforma INVEST Medicina UANL - KER Unit (KER Unit M\u00e9xico), Subdireccion de Investigacion, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Monterrey, 64460, Mexico","institution_ids":["https://openalex.org/I169046204"]},{"raw_affiliation_string":"Endocrinology Division, Department of Internal Medicine, University Hospital \u201cDr Jos\u00e9 E Gonz\u00e1lez,\u201d Universidad Autonoma de Nuevo Leon, Monterrey, 64460, Mexico","institution_ids":["https://openalex.org/I169046204"]},{"raw_affiliation_string":"Plataforma INVEST Medicina UANL \u2013 KER Unit (KER Unit M\u00e9xico), Subdireccion de Investigacion, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Monterrey, 64460, Mexico","institution_ids":["https://openalex.org/I169046204"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001881870","display_name":"Rozalina G. McCoy","orcid":"https://orcid.org/0000-0002-2289-3183","observed_orcids":["https://orcid.org/0000-0002-2289-3183"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rozalina G McCoy","raw_affiliation_strings":["Division of Community Internal Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA","Division of Health Care Policy and Research, Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Community Internal Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Division of Health Care Policy and Research, Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":12.9136,"has_fulltext":false,"cited_by_count":152,"citation_normalized_percentile":{"value":0.99235861,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"367","issue":null,"first_page":"l5887","last_page":"l5887"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.01769999973475933,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9670000076293945},{"id":"https://openalex.org/keywords/intensive-glycemic-control","display_name":"tight glycemic control","score":0.996999979019165},{"id":"https://openalex.org/keywords/glycemic-targets","display_name":"glycemic targets","score":0.9340000152587891},{"id":"https://openalex.org/keywords/hypoglycemia","display_name":"hypoglycemia","score":0.9399999976158142},{"id":"https://openalex.org/keywords/microvascular-complications","display_name":"microvascular complications","score":0.6669999957084656},{"id":"https://openalex.org/keywords/macrovascular-outcomes","display_name":"macrovascular outcomes","score":0.8960000276565552},{"id":"https://openalex.org/keywords/cardiovascular-outcomes","display_name":"cardiovascular outcomes","score":0.718999981880188},{"id":"https://openalex.org/keywords/renal-outcomes","display_name":"renal outcomes","score":0.6460000276565552},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.9629999995231628},{"id":"https://openalex.org/keywords/antidiabetic-drugs","display_name":"antidiabetic drugs","score":0.8820000290870667},{"id":"https://openalex.org/keywords/polypharmacy","display_name":"polypharmacy","score":0.9139999747276306},{"id":"https://openalex.org/keywords/treatment-burden","display_name":"treatment burden","score":0.7979999780654907},{"id":"https://openalex.org/keywords/patient-centered-care","display_name":"patient-centered care","score":0.8529999852180481},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.8989999890327454}],"concepts":[{"id":"https://openalex.org/C2780473172","wikidata":"https://www.wikidata.org/wiki/Q5572518","display_name":"Glycemic","level":3,"score":0.9101998805999756},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8822721242904663},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.7546947002410889},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.7171637415885925},{"id":"https://openalex.org/C2780668416","wikidata":"https://www.wikidata.org/wiki/Q202758","display_name":"Hypoglycemia","level":3,"score":0.6446933746337891},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6012974977493286},{"id":"https://openalex.org/C36434225","wikidata":"https://www.wikidata.org/wiki/Q1895998","display_name":"Polypharmacy","level":2,"score":0.5239108800888062},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.06889718770980835}],"mesh":[{"descriptor_ui":"D000078202","descriptor_name":"Systematic Reviews as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000078202","descriptor_name":"Systematic Reviews as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000078202","descriptor_name":"Systematic Reviews as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006943","descriptor_name":"Hyperglycemia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006943","descriptor_name":"Hyperglycemia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006943","descriptor_name":"Hyperglycemia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006943","descriptor_name":"Hyperglycemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006943","descriptor_name":"Hyperglycemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006943","descriptor_name":"Hyperglycemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D007003","descriptor_name":"Hypoglycemia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D007003","descriptor_name":"Hypoglycemia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D007003","descriptor_name":"Hypoglycemia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D007003","descriptor_name":"Hypoglycemia","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D007003","descriptor_name":"Hypoglycemia","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D007003","descriptor_name":"Hypoglycemia","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015201","descriptor_name":"Meta-Analysis as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015201","descriptor_name":"Meta-Analysis as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015201","descriptor_name":"Meta-Analysis as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017410","descriptor_name":"Practice Guidelines as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017410","descriptor_name":"Practice Guidelines as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017410","descriptor_name":"Practice Guidelines as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018802","descriptor_name":"Patient-Centered Care","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018802","descriptor_name":"Patient-Centered Care","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018802","descriptor_name":"Patient-Centered Care","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018802","descriptor_name":"Patient-Centered Care","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D018802","descriptor_name":"Patient-Centered Care","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D018802","descriptor_name":"Patient-Centered Care","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D019317","descriptor_name":"Evidence-Based Medicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019317","descriptor_name":"Evidence-Based Medicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019317","descriptor_name":"Evidence-Based Medicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019317","descriptor_name":"Evidence-Based Medicine","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D019317","descriptor_name":"Evidence-Based Medicine","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D019317","descriptor_name":"Evidence-Based Medicine","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D048909","descriptor_name":"Diabetes Complications","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D048909","descriptor_name":"Diabetes Complications","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D048909","descriptor_name":"Diabetes Complications","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D048909","descriptor_name":"Diabetes Complications","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D048909","descriptor_name":"Diabetes Complications","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D048909","descriptor_name":"Diabetes Complications","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1136/bmj.l5887","doi":"https://doi.org/10.1136/bmj.l5887","is_oa":false,"landing_page_url":"https://doi.org/10.1136/bmj.l5887","pdf_url":null,"source":{"id":"https://openalex.org/S4393917726","display_name":"BMJ","issn_l":"1756-1833","issn":["1756-1833"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ","raw_type":"journal-article"},{"id":"pmid:31690574","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31690574","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ (Clinical research ed.)","raw_type":"Journal Article"},{"id":"pmh:oai:open-archive.highwire.org:bmj:367/nov05_8/l5887","doi":null,"is_oa":false,"landing_page_url":"http://www.bmj.com/cgi/content/short/367/nov05_8/l5887","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.7699999809265137,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G315250905","display_name":null,"funder_award_id":"K23DK114497","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":157,"referenced_works":["https://openalex.org/W97375214","https://openalex.org/W172609984","https://openalex.org/W1526927233","https://openalex.org/W1532938938","https://openalex.org/W1551630433","https://openalex.org/W1602152367","https://openalex.org/W1901059681","https://openalex.org/W1943745580","https://openalex.org/W1978874367","https://openalex.org/W1983251610","https://openalex.org/W1984427078","https://openalex.org/W1985772842","https://openalex.org/W1985941010","https://openalex.org/W1992243359","https://openalex.org/W1993063275","https://openalex.org/W1994691784","https://openalex.org/W2009975518","https://openalex.org/W2011753046","https://openalex.org/W2020494695","https://openalex.org/W2020591896","https://openalex.org/W2021446295","https://openalex.org/W2023547464","https://openalex.org/W2025353246","https://openalex.org/W2025544664","https://openalex.org/W2028164567","https://openalex.org/W2035882325","https://openalex.org/W2055423970","https://openalex.org/W2061325466","https://openalex.org/W2064130493","https://openalex.org/W2068821193","https://openalex.org/W2068907080","https://openalex.org/W2074151142","https://openalex.org/W2076573528","https://openalex.org/W2078089300","https://openalex.org/W2079538046","https://openalex.org/W2082057981","https://openalex.org/W2090132603","https://openalex.org/W2095409509","https://openalex.org/W2096721022","https://openalex.org/W2097341069","https://openalex.org/W2097995302","https://openalex.org/W2100862440","https://openalex.org/W2110664743","https://openalex.org/W2111824270","https://openalex.org/W2113880168","https://openalex.org/W2115653936","https://openalex.org/W2122908662","https://openalex.org/W2123946565","https://openalex.org/W2124788738","https://openalex.org/W2124909544","https://openalex.org/W2125468958","https://openalex.org/W2127125241","https://openalex.org/W2127854619","https://openalex.org/W2127960841","https://openalex.org/W2128930711","https://openalex.org/W2131347767","https://openalex.org/W2131490500","https://openalex.org/W2131735394","https://openalex.org/W2134625795","https://openalex.org/W2136044050","https://openalex.org/W2136068942","https://openalex.org/W2139634859","https://openalex.org/W2142526493","https://openalex.org/W2142830692","https://openalex.org/W2143066955","https://openalex.org/W2144125787","https://openalex.org/W2146264128","https://openalex.org/W2147663252","https://openalex.org/W2153327521","https://openalex.org/W2153552938","https://openalex.org/W2153957843","https://openalex.org/W2154604904","https://openalex.org/W2158666727","https://openalex.org/W2159969745","https://openalex.org/W2160088494","https://openalex.org/W2164127864","https://openalex.org/W2165732356","https://openalex.org/W2166180770","https://openalex.org/W2167520440","https://openalex.org/W2169362019","https://openalex.org/W2169961704","https://openalex.org/W2170271198","https://openalex.org/W2171294019","https://openalex.org/W2171466942","https://openalex.org/W2172111876","https://openalex.org/W2188846692","https://openalex.org/W2199867537","https://openalex.org/W2252603999","https://openalex.org/W2271771390","https://openalex.org/W2275139239","https://openalex.org/W2282578582","https://openalex.org/W2286933633","https://openalex.org/W2295084748","https://openalex.org/W2337004113","https://openalex.org/W2337454357","https://openalex.org/W2340250892","https://openalex.org/W2414217396","https://openalex.org/W2425644022","https://openalex.org/W2461567036","https://openalex.org/W2508307252","https://openalex.org/W2519510391","https://openalex.org/W2520432709","https://openalex.org/W2521785266","https://openalex.org/W2533540300","https://openalex.org/W2535116416","https://openalex.org/W2561206249","https://openalex.org/W2582155847","https://openalex.org/W2619136524","https://openalex.org/W2625031949","https://openalex.org/W2626446274","https://openalex.org/W2632975088","https://openalex.org/W2738970206","https://openalex.org/W2754041380","https://openalex.org/W2759092248","https://openalex.org/W2761594440","https://openalex.org/W2768583495","https://openalex.org/W2769264260","https://openalex.org/W2779223875","https://openalex.org/W2784849160","https://openalex.org/W2789529434","https://openalex.org/W2806521060","https://openalex.org/W2808915250","https://openalex.org/W2809031508","https://openalex.org/W2890465901","https://openalex.org/W2894250176","https://openalex.org/W2894746763","https://openalex.org/W2894993577","https://openalex.org/W2900149048","https://openalex.org/W2900413769","https://openalex.org/W2902701051","https://openalex.org/W2911825173","https://openalex.org/W2915807915","https://openalex.org/W2916996193","https://openalex.org/W2921012991","https://openalex.org/W2931122946","https://openalex.org/W2937585590","https://openalex.org/W2939222610","https://openalex.org/W2948519518","https://openalex.org/W2948612418","https://openalex.org/W2952833925","https://openalex.org/W2955148946","https://openalex.org/W2967571408","https://openalex.org/W2968633786","https://openalex.org/W2971589574","https://openalex.org/W3134431802","https://openalex.org/W4210347219","https://openalex.org/W4213140092","https://openalex.org/W4230518743","https://openalex.org/W4233007762","https://openalex.org/W4241883936","https://openalex.org/W4247402140","https://openalex.org/W4250208868","https://openalex.org/W4254778823","https://openalex.org/W4256426132","https://openalex.org/W4300987042","https://openalex.org/W4366064179","https://openalex.org/W6682862971"],"related_works":["https://openalex.org/W4310739378","https://openalex.org/W2594890405","https://openalex.org/W2103640491","https://openalex.org/W2398672653","https://openalex.org/W3028382539","https://openalex.org/W2171692026","https://openalex.org/W2269921241","https://openalex.org/W2983667031","https://openalex.org/W1997275959","https://openalex.org/W2998462387"],"abstract_inverted_index":{"Diabetes":[0],"is":[1],"a":[2,149],"major":[3],"and":[4,14,65,92,102,114,152,186,191,200],"costly":[5],"health":[6],"concern":[7],"worldwide,":[8],"with":[9,25,59,71,120,144],"high":[10],"morbidity,":[11],"disability,":[12],"mortality,":[13],"impaired":[15],"quality":[16,202],"of":[17,22,38,50,56,74,77,89,98,122,125,131,159,163,198,203],"life.":[18,204],"The":[19],"vast":[20],"majority":[21],"people":[23,143],"living":[24],"diabetes":[26,41,147,160,178],"have":[27],"type":[28,39,145],"2":[29,40,146],"diabetes.":[30],"Historically,":[31],"the":[32,48,72,87,155,168,196],"main":[33],"strategy":[34],"to":[35,69,142,171,176,183],"reduce":[36],"complications":[37],"has":[42],"been":[43],"intensive":[44,57,165],"glycemic":[45,61,82,133,166,181],"control.":[46],"However,":[47],"body":[49],"evidence":[51,137],"shows":[52],"no":[53],"meaningful":[54],"benefit":[55],"(compared":[58],"moderate)":[60],"control":[62,83],"for":[63],"microvascular":[64],"macrovascular":[66],"outcomes":[67,108,116],"important":[68],"patients,":[70],"exception":[73],"reduced":[75],"rates":[76],"non-fatal":[78],"myocardial":[79],"infarction.":[80],"Intensive":[81],"does,":[84],"however,":[85],"increase":[86],"risk":[88],"severe":[90],"hypoglycemia":[91],"incurs":[93],"additional":[94],"burden":[95,197],"by":[96],"way":[97],"polypharmacy,":[99],"side":[100],"effects,":[101],"cost.":[103],"Additionally,":[104],"data":[105],"from":[106,154],"cardiovascular":[107],"trials":[109],"showed":[110],"that":[111],"cardiovascular,":[112],"kidney,":[113],"mortality":[115],"may":[117],"be":[118,172],"improved":[119],"use":[121],"specific":[123],"classes":[124],"glucose":[126],"lowering":[127],"drugs":[128],"largely":[129],"independently":[130],"their":[132],"effects.":[134],"Therefore,":[135],"delivering":[136],"based,":[138],"patient":[139],"centered":[140],"care":[141],"requires":[148],"paradigm":[150],"shift":[151],"departure":[153],"predominantly":[156],"glucocentric":[157],"view":[158],"management.":[161],"Instead":[162],"prioritizing":[164],"control,":[167],"focus":[169],"needs":[170],"on":[173],"ensuring":[174],"access":[175],"adequate":[177],"care,":[179],"aligning":[180],"targets":[182],"patients'":[184],"goals":[185],"situations,":[187],"minimizing":[188],"short":[189],"term":[190,193],"long":[192],"complications,":[194],"reducing":[195],"treatment,":[199],"improving":[201]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":19},{"year":2024,"cited_by_count":28},{"year":2023,"cited_by_count":21},{"year":2022,"cited_by_count":31},{"year":2021,"cited_by_count":26},{"year":2020,"cited_by_count":18}],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2025-10-10T00:00:00"}
