{"id":"https://openalex.org/W2985635904","doi":"https://doi.org/10.1093/infdis/jiz359","title":"Cell-Free Hemoglobin Is Associated With Increased Vascular Resistance and Reduced Peripheral Perfusion in Severe Malaria","display_name":"Cell-Free Hemoglobin Is Associated With Increased Vascular Resistance and Reduced Peripheral Perfusion in Severe Malaria","publication_year":2019,"publication_date":"2019-09-26","ids":{"openalex":"https://openalex.org/W2985635904","doi":"https://doi.org/10.1093/infdis/jiz359","mag":"2985635904","pmid":"https://pubmed.ncbi.nlm.nih.gov/31693729"},"language":"en","primary_location":{"id":"doi:10.1093/infdis/jiz359","doi":"https://doi.org/10.1093/infdis/jiz359","is_oa":true,"landing_page_url":"https://doi.org/10.1093/infdis/jiz359","pdf_url":"https://academic.oup.com/jid/article-pdf/221/1/127/31516556/jiz359.pdf","source":{"id":"https://openalex.org/S54542293","display_name":"The Journal of Infectious Diseases","issn_l":"0022-1899","issn":["0022-1899","1537-6613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/jid/article-pdf/221/1/127/31516556/jiz359.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013296722","display_name":"Hugh W. F. Kingston","orcid":"https://orcid.org/0000-0003-1869-8307","observed_orcids":["https://orcid.org/0000-0003-1869-8307"]},"institutions":[{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]},{"id":"https://openalex.org/I2801179840","display_name":"Churchill Hospital","ror":"https://ror.org/009vheq40","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801179840","https://openalex.org/I4210147381"]},{"id":"https://openalex.org/I29894533","display_name":"Charles Darwin University","ror":"https://ror.org/048zcaj52","country_code":"AU","type":"education","lineage":["https://openalex.org/I29894533"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210085939","display_name":"Menzies School of Health Research","ror":"https://ror.org/006mbby82","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I29894533","https://openalex.org/I4210085939"]},{"id":"https://openalex.org/I4210126604","display_name":"Mahidol Oxford Tropical Medicine Research Unit","ror":"https://ror.org/03fs9z545","country_code":"TH","type":"facility","lineage":["https://openalex.org/I25399158","https://openalex.org/I40120149","https://openalex.org/I4210126604","https://openalex.org/I87048295"]}],"countries":["AU","GB","TH"],"is_corresponding":true,"raw_author_name":"Hugh W F Kingston","raw_affiliation_strings":["Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, Churchill Hospital, Oxford, United Kingdom","Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia","Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, Churchill Hospital, Oxford, United Kingdom","institution_ids":["https://openalex.org/I2801179840","https://openalex.org/I40120149"]},{"raw_affiliation_string":"Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia","institution_ids":["https://openalex.org/I29894533","https://openalex.org/I4210085939"]},{"raw_affiliation_string":"Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University","institution_ids":["https://openalex.org/I25399158","https://openalex.org/I4210126604"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080286071","display_name":"Aniruddha Ghose","orcid":"https://orcid.org/0000-0002-5551-6691","observed_orcids":["https://orcid.org/0000-0002-5551-6691"]},"institutions":[{"id":"https://openalex.org/I2653708","display_name":"Chittagong Medical College","ror":"https://ror.org/01y8zn427","country_code":"BD","type":"healthcare","lineage":["https://openalex.org/I2653708"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Aniruddha Ghose","raw_affiliation_strings":["Chittagong Medical College, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chittagong Medical College, Bangladesh","institution_ids":["https://openalex.org/I2653708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037845151","display_name":"Voravut Rungpradubvong","orcid":"https://orcid.org/0000-0002-3661-1490","observed_orcids":["https://orcid.org/0000-0002-3661-1490"]},"institutions":[{"id":"https://openalex.org/I158708052","display_name":"Chulalongkorn University","ror":"https://ror.org/028wp3y58","country_code":"TH","type":"education","lineage":["https://openalex.org/I158708052"]},{"id":"https://openalex.org/I2802209374","display_name":"King Chulalongkorn Memorial Hospital","ror":"https://ror.org/05jd2pj53","country_code":"TH","type":"healthcare","lineage":["https://openalex.org/I2802209374"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Voravut Rungpradubvong","raw_affiliation_strings":["Cardiac Center, King Chulalongkorn Memorial Hospital, Bangkok, Thailand","Division of Cardiology, Department of Medicine, Faculty of Medicine, Chulalongkorn University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiac Center, King Chulalongkorn Memorial Hospital, Bangkok, Thailand","institution_ids":["https://openalex.org/I2802209374"]},{"raw_affiliation_string":"Division of Cardiology, Department of Medicine, Faculty of Medicine, Chulalongkorn University","institution_ids":["https://openalex.org/I158708052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001826458","display_name":"Sudarat Satitthummanid","orcid":"https://orcid.org/0000-0001-5580-4709","observed_orcids":["https://orcid.org/0000-0001-5580-4709"]},"institutions":[{"id":"https://openalex.org/I158708052","display_name":"Chulalongkorn University","ror":"https://ror.org/028wp3y58","country_code":"TH","type":"education","lineage":["https://openalex.org/I158708052"]},{"id":"https://openalex.org/I2802209374","display_name":"King Chulalongkorn Memorial Hospital","ror":"https://ror.org/05jd2pj53","country_code":"TH","type":"healthcare","lineage":["https://openalex.org/I2802209374"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Sudarat Satitthummanid","raw_affiliation_strings":["Cardiac Center, King Chulalongkorn Memorial Hospital, Bangkok, Thailand","Division of Cardiology, Department of Medicine, Faculty of Medicine, Chulalongkorn University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiac Center, King Chulalongkorn Memorial Hospital, Bangkok, Thailand","institution_ids":["https://openalex.org/I2802209374"]},{"raw_affiliation_string":"Division of Cardiology, Department of Medicine, Faculty of Medicine, Chulalongkorn University","institution_ids":["https://openalex.org/I158708052"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M Trent Herdman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]},{"id":"https://openalex.org/I4210126604","display_name":"Mahidol Oxford Tropical Medicine Research Unit","ror":"https://ror.org/03fs9z545","country_code":"TH","type":"facility","lineage":["https://openalex.org/I25399158","https://openalex.org/I40120149","https://openalex.org/I4210126604","https://openalex.org/I87048295"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"M Trent Herdman","raw_affiliation_strings":["Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University","institution_ids":["https://openalex.org/I25399158","https://openalex.org/I4210126604"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037063881","display_name":"Katherine Plewes","orcid":"https://orcid.org/0000-0002-3596-3267","observed_orcids":["https://orcid.org/0000-0002-3596-3267"]},"institutions":[{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]},{"id":"https://openalex.org/I2801179840","display_name":"Churchill Hospital","ror":"https://ror.org/009vheq40","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801179840","https://openalex.org/I4210147381"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210126604","display_name":"Mahidol Oxford Tropical Medicine Research Unit","ror":"https://ror.org/03fs9z545","country_code":"TH","type":"facility","lineage":["https://openalex.org/I25399158","https://openalex.org/I40120149","https://openalex.org/I4210126604","https://openalex.org/I87048295"]}],"countries":["GB","TH"],"is_corresponding":false,"raw_author_name":"Katherine Plewes","raw_affiliation_strings":["Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, Churchill Hospital, Oxford, United Kingdom","Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, Churchill Hospital, Oxford, United Kingdom","institution_ids":["https://openalex.org/I2801179840","https://openalex.org/I40120149"]},{"raw_affiliation_string":"Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University","institution_ids":["https://openalex.org/I25399158","https://openalex.org/I4210126604"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037538047","display_name":"Haruhiko Ishioka","orcid":"https://orcid.org/0000-0002-1033-6056","observed_orcids":["https://orcid.org/0000-0002-1033-6056"]},"institutions":[{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]},{"id":"https://openalex.org/I4210126604","display_name":"Mahidol Oxford Tropical Medicine Research Unit","ror":"https://ror.org/03fs9z545","country_code":"TH","type":"facility","lineage":["https://openalex.org/I25399158","https://openalex.org/I40120149","https://openalex.org/I4210126604","https://openalex.org/I87048295"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Haruhiko Ishioka","raw_affiliation_strings":["Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University","institution_ids":["https://openalex.org/I25399158","https://openalex.org/I4210126604"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051698032","display_name":"Stije J. Leopold","orcid":"https://orcid.org/0000-0002-0482-5689","observed_orcids":["https://orcid.org/0000-0002-0482-5689"]},"institutions":[{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]},{"id":"https://openalex.org/I2801179840","display_name":"Churchill Hospital","ror":"https://ror.org/009vheq40","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801179840","https://openalex.org/I4210147381"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210126604","display_name":"Mahidol Oxford Tropical Medicine Research Unit","ror":"https://ror.org/03fs9z545","country_code":"TH","type":"facility","lineage":["https://openalex.org/I25399158","https://openalex.org/I40120149","https://openalex.org/I4210126604","https://openalex.org/I87048295"]}],"countries":["GB","TH"],"is_corresponding":false,"raw_author_name":"Stije J Leopold","raw_affiliation_strings":["Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, Churchill Hospital, Oxford, United Kingdom","Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, Churchill Hospital, Oxford, United Kingdom","institution_ids":["https://openalex.org/I2801179840","https://openalex.org/I40120149"]},{"raw_affiliation_string":"Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University","institution_ids":["https://openalex.org/I25399158","https://openalex.org/I4210126604"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008232863","display_name":"Ipsita Sinha","orcid":"https://orcid.org/0000-0002-6574-310X","observed_orcids":["https://orcid.org/0000-0002-6574-310X"]},"institutions":[{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]},{"id":"https://openalex.org/I2801179840","display_name":"Churchill Hospital","ror":"https://ror.org/009vheq40","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801179840","https://openalex.org/I4210147381"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210126604","display_name":"Mahidol Oxford Tropical Medicine Research Unit","ror":"https://ror.org/03fs9z545","country_code":"TH","type":"facility","lineage":["https://openalex.org/I25399158","https://openalex.org/I40120149","https://openalex.org/I4210126604","https://openalex.org/I87048295"]}],"countries":["GB","TH"],"is_corresponding":false,"raw_author_name":"Ipsita Sinha","raw_affiliation_strings":["Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, Churchill Hospital, Oxford, United Kingdom","Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, Churchill Hospital, Oxford, United Kingdom","institution_ids":["https://openalex.org/I2801179840","https://openalex.org/I40120149"]},{"raw_affiliation_string":"Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University","institution_ids":["https://openalex.org/I25399158","https://openalex.org/I4210126604"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035463491","display_name":"Benjamas Intharabut","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]},{"id":"https://openalex.org/I4210126604","display_name":"Mahidol Oxford Tropical Medicine Research Unit","ror":"https://ror.org/03fs9z545","country_code":"TH","type":"facility","lineage":["https://openalex.org/I25399158","https://openalex.org/I40120149","https://openalex.org/I4210126604","https://openalex.org/I87048295"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Benjamas Intharabut","raw_affiliation_strings":["Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University","institution_ids":["https://openalex.org/I25399158","https://openalex.org/I4210126604"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070653684","display_name":"Kim A. Piera","orcid":"https://orcid.org/0000-0002-7414-9604","observed_orcids":["https://orcid.org/0000-0002-7414-9604"]},"institutions":[{"id":"https://openalex.org/I29894533","display_name":"Charles Darwin University","ror":"https://ror.org/048zcaj52","country_code":"AU","type":"education","lineage":["https://openalex.org/I29894533"]},{"id":"https://openalex.org/I4210085939","display_name":"Menzies School of Health Research","ror":"https://ror.org/006mbby82","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I29894533","https://openalex.org/I4210085939"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Kim Piera","raw_affiliation_strings":["Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia","institution_ids":["https://openalex.org/I29894533","https://openalex.org/I4210085939"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083109502","display_name":"Yvette McNeil","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I29894533","display_name":"Charles Darwin University","ror":"https://ror.org/048zcaj52","country_code":"AU","type":"education","lineage":["https://openalex.org/I29894533"]},{"id":"https://openalex.org/I4210085939","display_name":"Menzies School of Health Research","ror":"https://ror.org/006mbby82","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I29894533","https://openalex.org/I4210085939"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Yvette McNeil","raw_affiliation_strings":["Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia","institution_ids":["https://openalex.org/I29894533","https://openalex.org/I4210085939"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007697425","display_name":"Sanjib Mohanty","orcid":"https://orcid.org/0009-0000-2068-5228","observed_orcids":["https://orcid.org/0009-0000-2068-5228"]},"institutions":[{"id":"https://openalex.org/I4210106902","display_name":"Ispat General Hospital","ror":"https://ror.org/01ned1220","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210106902"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sanjib Mohanty","raw_affiliation_strings":["ISPAT General Hospital, Rourkela, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ISPAT General Hospital, Rourkela, India","institution_ids":["https://openalex.org/I4210106902"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006115428","display_name":"Richard J. Maude","orcid":"https://orcid.org/0000-0002-5355-0562","observed_orcids":["https://orcid.org/0000-0002-5355-0562"]},"institutions":[{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]},{"id":"https://openalex.org/I2801179840","display_name":"Churchill Hospital","ror":"https://ror.org/009vheq40","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801179840","https://openalex.org/I4210147381"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210126604","display_name":"Mahidol Oxford Tropical Medicine Research Unit","ror":"https://ror.org/03fs9z545","country_code":"TH","type":"facility","lineage":["https://openalex.org/I25399158","https://openalex.org/I40120149","https://openalex.org/I4210126604","https://openalex.org/I87048295"]}],"countries":["GB","TH"],"is_corresponding":false,"raw_author_name":"Richard J Maude","raw_affiliation_strings":["Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, Churchill Hospital, Oxford, United Kingdom","Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, Churchill Hospital, Oxford, United Kingdom","institution_ids":["https://openalex.org/I2801179840","https://openalex.org/I40120149"]},{"raw_affiliation_string":"Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University","institution_ids":["https://openalex.org/I25399158","https://openalex.org/I4210126604"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084217335","display_name":"Nicholas John White","orcid":"https://orcid.org/0000-0002-1897-1978","observed_orcids":["https://orcid.org/0000-0002-1897-1978","https://orcid.org/0000-0002-3396-1700","https://orcid.org/0000-0001-5038-8865"]},"institutions":[{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]},{"id":"https://openalex.org/I2801179840","display_name":"Churchill Hospital","ror":"https://ror.org/009vheq40","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801179840","https://openalex.org/I4210147381"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210126604","display_name":"Mahidol Oxford Tropical Medicine Research Unit","ror":"https://ror.org/03fs9z545","country_code":"TH","type":"facility","lineage":["https://openalex.org/I25399158","https://openalex.org/I40120149","https://openalex.org/I4210126604","https://openalex.org/I87048295"]}],"countries":["GB","TH"],"is_corresponding":false,"raw_author_name":"Nicholas J White","raw_affiliation_strings":["Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, Churchill Hospital, Oxford, United Kingdom","Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, Churchill Hospital, Oxford, United Kingdom","institution_ids":["https://openalex.org/I2801179840","https://openalex.org/I40120149"]},{"raw_affiliation_string":"Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University","institution_ids":["https://openalex.org/I25399158","https://openalex.org/I4210126604"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034097318","display_name":"Nicholas Day","orcid":"https://orcid.org/0000-0003-2309-1171","observed_orcids":["https://orcid.org/0000-0003-2309-1171"]},"institutions":[{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]},{"id":"https://openalex.org/I2801179840","display_name":"Churchill Hospital","ror":"https://ror.org/009vheq40","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801179840","https://openalex.org/I4210147381"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210126604","display_name":"Mahidol Oxford Tropical Medicine Research Unit","ror":"https://ror.org/03fs9z545","country_code":"TH","type":"facility","lineage":["https://openalex.org/I25399158","https://openalex.org/I40120149","https://openalex.org/I4210126604","https://openalex.org/I87048295"]}],"countries":["GB","TH"],"is_corresponding":false,"raw_author_name":"Nicholas P J Day","raw_affiliation_strings":["Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, Churchill Hospital, Oxford, United Kingdom","Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, Churchill Hospital, Oxford, United Kingdom","institution_ids":["https://openalex.org/I2801179840","https://openalex.org/I40120149"]},{"raw_affiliation_string":"Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University","institution_ids":["https://openalex.org/I25399158","https://openalex.org/I4210126604"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089350667","display_name":"Tsin Wen Yeo","orcid":"https://orcid.org/0000-0002-4060-7902","observed_orcids":["https://orcid.org/0000-0002-4060-7902"]},"institutions":[{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]},{"id":"https://openalex.org/I2802408685","display_name":"Tan Tock Seng Hospital","ror":"https://ror.org/032d59j24","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I2802408685"]},{"id":"https://openalex.org/I29894533","display_name":"Charles Darwin University","ror":"https://ror.org/048zcaj52","country_code":"AU","type":"education","lineage":["https://openalex.org/I29894533"]},{"id":"https://openalex.org/I4210085939","display_name":"Menzies School of Health Research","ror":"https://ror.org/006mbby82","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I29894533","https://openalex.org/I4210085939"]},{"id":"https://openalex.org/I4210150597","display_name":"National Centre for Infectious Diseases","ror":"https://ror.org/03rtrce80","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I4210150597"]}],"countries":["AU","SG"],"is_corresponding":false,"raw_author_name":"Tsin W Yeo","raw_affiliation_strings":["Communicable Disease Centre, Institute of Infectious Diseases and Epidemiology, Tan Tock Seng Hospital, Singapore","Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia","Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Communicable Disease Centre, Institute of Infectious Diseases and Epidemiology, Tan Tock Seng Hospital, Singapore","institution_ids":["https://openalex.org/I2802408685","https://openalex.org/I4210150597"]},{"raw_affiliation_string":"Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia","institution_ids":["https://openalex.org/I29894533","https://openalex.org/I4210085939"]},{"raw_affiliation_string":"Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore","institution_ids":["https://openalex.org/I172675005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101743366","display_name":"Md Amir Hossain","orcid":"https://orcid.org/0000-0003-3236-6165","observed_orcids":["https://orcid.org/0000-0003-3236-6165"]},"institutions":[{"id":"https://openalex.org/I2653708","display_name":"Chittagong Medical College","ror":"https://ror.org/01y8zn427","country_code":"BD","type":"healthcare","lineage":["https://openalex.org/I2653708"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Md Amir Hossain","raw_affiliation_strings":["Chittagong Medical College, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chittagong Medical College, Bangladesh","institution_ids":["https://openalex.org/I2653708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032095213","display_name":"Nicholas M. Anstey","orcid":"https://orcid.org/0000-0002-2192-0506","observed_orcids":["https://orcid.org/0000-0002-2192-0506"]},"institutions":[{"id":"https://openalex.org/I29894533","display_name":"Charles Darwin University","ror":"https://ror.org/048zcaj52","country_code":"AU","type":"education","lineage":["https://openalex.org/I29894533"]},{"id":"https://openalex.org/I4210085939","display_name":"Menzies School of Health Research","ror":"https://ror.org/006mbby82","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I29894533","https://openalex.org/I4210085939"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Nicholas M Anstey","raw_affiliation_strings":["Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia","institution_ids":["https://openalex.org/I29894533","https://openalex.org/I4210085939"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051408897","display_name":"Arjen M. Dondorp","orcid":"https://orcid.org/0000-0001-5190-2395","observed_orcids":["https://orcid.org/0000-0001-5190-2395"]},"institutions":[{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]},{"id":"https://openalex.org/I2801179840","display_name":"Churchill Hospital","ror":"https://ror.org/009vheq40","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801179840","https://openalex.org/I4210147381"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210126604","display_name":"Mahidol Oxford Tropical Medicine Research Unit","ror":"https://ror.org/03fs9z545","country_code":"TH","type":"facility","lineage":["https://openalex.org/I25399158","https://openalex.org/I40120149","https://openalex.org/I4210126604","https://openalex.org/I87048295"]}],"countries":["GB","TH"],"is_corresponding":false,"raw_author_name":"Arjen M Dondorp","raw_affiliation_strings":["Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, Churchill Hospital, Oxford, United Kingdom","Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, Churchill Hospital, Oxford, United Kingdom","institution_ids":["https://openalex.org/I2801179840","https://openalex.org/I40120149"]},{"raw_affiliation_string":"Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University","institution_ids":["https://openalex.org/I25399158","https://openalex.org/I4210126604"]}]}],"institutions":[],"countries_distinct_count":6,"institutions_distinct_count":13,"corresponding_author_ids":["https://openalex.org/A5013296722"],"corresponding_institution_ids":["https://openalex.org/I25399158","https://openalex.org/I2801179840","https://openalex.org/I29894533","https://openalex.org/I40120149","https://openalex.org/I4210085939","https://openalex.org/I4210126604"],"apc_list":{"value":4763,"currency":"USD","value_usd":4763},"apc_paid":{"value":2807,"currency":"EUR","value_usd":3027},"fwci":0.9209,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.76044239,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"221","issue":"1","first_page":"127","last_page":"137"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/free-hemoglobin","display_name":"free hemoglobin","score":0.9739999771118164},{"id":"https://openalex.org/keywords/severe-malaria","display_name":"severe malaria","score":0.8790000081062317},{"id":"https://openalex.org/keywords/falciparum-malaria","display_name":"falciparum malaria","score":0.9079999923706055},{"id":"https://openalex.org/keywords/systemic-vascular-resistance","display_name":"systemic vascular resistance","score":0.7879999876022339},{"id":"https://openalex.org/keywords/peripheral-perfusion","display_name":"peripheral perfusion","score":0.921999990940094},{"id":"https://openalex.org/keywords/nitric-oxide-bioavailability","display_name":"nitric oxide bioavailability","score":0.847000002861023},{"id":"https://openalex.org/keywords/asymmetric-dimethylarginine","display_name":"asymmetric dimethylarginine","score":0.9210000038146973},{"id":"https://openalex.org/keywords/bacterial-sepsis","display_name":"bacterial sepsis","score":0.7919999957084656},{"id":"https://openalex.org/keywords/mean-arterial-pressure","display_name":"mean arterial pressure","score":0.7630000114440918},{"id":"https://openalex.org/keywords/perfusion-index","display_name":"perfusion index","score":0.8500000238418579},{"id":"https://openalex.org/keywords/lactate","display_name":"lactate","score":0.8759999871253967},{"id":"https://openalex.org/keywords/mortality-prediction","display_name":"mortality prediction","score":0.48399999737739563},{"id":"https://openalex.org/keywords/hematocrit","display_name":"hematocrit","score":0.7350000143051147}],"concepts":[{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.7249942421913147},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.6148455142974854},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.603349506855011},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.5889803171157837},{"id":"https://openalex.org/C58245268","wikidata":"https://www.wikidata.org/wiki/Q456026","display_name":"Vascular resistance","level":3,"score":0.558326780796051},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5108956694602966},{"id":"https://openalex.org/C2994230362","wikidata":"https://www.wikidata.org/wiki/Q456026","display_name":"Peripheral resistance","level":4,"score":0.46406230330467224},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3923795819282532},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34545841813087463},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.342621386051178},{"id":"https://openalex.org/C139940330","wikidata":"https://www.wikidata.org/wiki/Q596579","display_name":"Cardiac output","level":3,"score":0.11376935243606567},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.10087922215461731}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004452","descriptor_name":"Echocardiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006400","descriptor_name":"Hematocrit","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006454","descriptor_name":"Hemoglobins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012039","descriptor_name":"Regional Blood Flow","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014655","descriptor_name":"Vascular Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016470","descriptor_name":"Bacteremia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D016778","descriptor_name":"Malaria, Falciparum","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062072","descriptor_name":"Patient Acuity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062186","descriptor_name":"Arterial Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1093/infdis/jiz359","doi":"https://doi.org/10.1093/infdis/jiz359","is_oa":true,"landing_page_url":"https://doi.org/10.1093/infdis/jiz359","pdf_url":"https://academic.oup.com/jid/article-pdf/221/1/127/31516556/jiz359.pdf","source":{"id":"https://openalex.org/S54542293","display_name":"The Journal of Infectious Diseases","issn_l":"0022-1899","issn":["0022-1899","1537-6613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Infectious Diseases","raw_type":"journal-article"},{"id":"pmid:31693729","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31693729","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of infectious diseases","raw_type":"Journal Article"},{"id":"pmh:oai:dr.ntu.edu.sg:10356/152850","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10356/152850","pdf_url":null,"source":{"id":"https://openalex.org/S4306402609","display_name":"DR-NTU (Nanyang Technological University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I172675005","host_organization_name":"Nanyang Technological University","host_organization_lineage":["https://openalex.org/I172675005"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"},{"id":"doi:10.60692/2bmsh-jzp10","doi":"https://doi.org/10.60692/2bmsh-jzp10","is_oa":true,"landing_page_url":"https://doi.org/10.60692/2bmsh-jzp10","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.60692/4qxpg-pwa73","doi":"https://doi.org/10.60692/4qxpg-pwa73","is_oa":true,"landing_page_url":"https://doi.org/10.60692/4qxpg-pwa73","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1093/infdis/jiz359","doi":"https://doi.org/10.1093/infdis/jiz359","is_oa":true,"landing_page_url":"https://doi.org/10.1093/infdis/jiz359","pdf_url":"https://academic.oup.com/jid/article-pdf/221/1/127/31516556/jiz359.pdf","source":{"id":"https://openalex.org/S54542293","display_name":"The Journal of Infectious Diseases","issn_l":"0022-1899","issn":["0022-1899","1537-6613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Infectious Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8600000143051147,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1746560681","display_name":"Improving blood vessel function in severe malaria","funder_award_id":"605807","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G2396195497","display_name":"Decreased nitric oxide, severe malaria","funder_award_id":"605831","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G675268645","display_name":null,"funder_award_id":"1037304","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G801224714","display_name":"Tropical Disease - immunity, pathogenesis and vaccine development: global translation","funder_award_id":"1037304","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G8508389274","display_name":"Understanding how to develop new vaccines and drugs for tropical diseases.","funder_award_id":"496600","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G8970450113","display_name":"Pathophysiology and treatment of malaria and other tropical infectious diseases prevalent in our region","funder_award_id":"1042072","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320315885","display_name":"Australian Government","ror":"https://ror.org/0314h5y94"},{"id":"https://openalex.org/F4320320272","display_name":"University College, Oxford","ror":null},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2985635904.pdf","grobid_xml":"https://content.openalex.org/works/W2985635904.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W72019451","https://openalex.org/W1672667089","https://openalex.org/W1673362020","https://openalex.org/W1767153609","https://openalex.org/W1866849497","https://openalex.org/W1900275564","https://openalex.org/W1964328764","https://openalex.org/W1966641545","https://openalex.org/W1976371937","https://openalex.org/W1977048165","https://openalex.org/W1993146023","https://openalex.org/W1998682400","https://openalex.org/W1999556036","https://openalex.org/W2000803055","https://openalex.org/W2006767862","https://openalex.org/W2007778278","https://openalex.org/W2017268005","https://openalex.org/W2029120592","https://openalex.org/W2029510081","https://openalex.org/W2034177159","https://openalex.org/W2046754389","https://openalex.org/W2056778604","https://openalex.org/W2058093556","https://openalex.org/W2060432861","https://openalex.org/W2063792386","https://openalex.org/W2080347627","https://openalex.org/W2083320362","https://openalex.org/W2095421042","https://openalex.org/W2099417642","https://openalex.org/W2108555819","https://openalex.org/W2110383454","https://openalex.org/W2111886454","https://openalex.org/W2112789217","https://openalex.org/W2115265020","https://openalex.org/W2118621907","https://openalex.org/W2127963725","https://openalex.org/W2135662590","https://openalex.org/W2149795152","https://openalex.org/W2154195797","https://openalex.org/W2165056787","https://openalex.org/W2170046496","https://openalex.org/W2240726636","https://openalex.org/W2280404143","https://openalex.org/W2320022633","https://openalex.org/W2464829722","https://openalex.org/W2768146862","https://openalex.org/W4211136995","https://openalex.org/W4239528954","https://openalex.org/W4292339330"],"related_works":["https://openalex.org/W2118621907","https://openalex.org/W2608789756","https://openalex.org/W2106647080","https://openalex.org/W6958238362","https://openalex.org/W2520176501","https://openalex.org/W2108555819","https://openalex.org/W2148087131","https://openalex.org/W6945643893","https://openalex.org/W2982862076","https://openalex.org/W2156376620"],"abstract_inverted_index":{"BACKGROUND:":[0],"In":[1,105],"severe":[2,31,36,119,145,194,211],"falciparum":[3],"malaria,":[4,100,120,146],"unlike":[5],"sepsis,":[6],"hypotension":[7],"on":[8],"admission":[9],"is":[10,198],"uncommon.":[11],"We":[12],"hypothesized":[13],"that":[14],"low":[15,180],"nitric":[16,219],"oxide":[17,220],"bioavailability":[18],"due":[19],"to":[20],"the":[21,72,77,159,170,218],"presence":[22],"of":[23,223],"cell-free":[24],"hemoglobin":[25],"(CFH)":[26],"increases":[27],"vascular":[28,65,227],"tone":[29,228],"in":[30,97,116,135,142,191,208],"malaria.":[32,195,212],"METHODS:":[33],"Patients":[34],"with":[35,99,102,118,137,144,158,169,193,200,210],"malaria":[37,42],"(n":[38,43,50,58],"=":[39,44,51,59],"119),":[40],"uncomplicated":[41],"91),":[45],"or":[46,114,183],"suspected":[47,138],"bacterial":[48,139],"sepsis":[49,140],"56),":[52],"as":[53,55,176],"well":[54],"healthy":[56,103],"participants":[57],"50),":[60],"were":[61,86,95,128],"recruited.":[62],"The":[63,131],"systemic":[64],"resistance":[66],"index":[67,75,182],"(SVRI)":[68],"was":[69,133],"estimated":[70],"from":[71],"echocardiographic":[73],"cardiac":[74],"and":[76,83,88,91,122,151,163,167,205,229],"mean":[78,111,201],"arterial":[79,112,202],"pressure.":[80],"RESULTS:":[81],"SVRI":[82,115,132],"hematocrit":[84,121,150],"levels":[85,94,155,166],"lower":[87,134],"plasma":[89,164],"CFH":[90,123,154,197],"asymmetric":[92,126],"dimethylarginine":[93,127],"higher":[96],"patients":[98,117,136,192,209],"compared":[101],"participants.":[104],"multivariate":[106],"linear":[107],"regression":[108],"models":[109],"for":[110,149],"pressure":[113],"but":[124],"not":[125],"significant":[129],"predictors.":[130],"than":[141],"those":[143],"after":[147],"adjustment":[148],"age.":[152],"Plasma":[153],"correlated":[156],"positively":[157],"core-peripheral":[160,186],"temperature":[161,187],"gradient":[162],"lactate":[165],"inversely":[168],"perfusion":[171,181,207],"index.":[172],"Impaired":[173],"peripheral":[174,206],"perfusion,":[175],"reflected":[177],"by":[178],"a":[179,184],"high":[185],"gradient,":[188],"predicted":[189],"mortality":[190],"CONCLUSIONS:":[196],"associated":[199],"pressure,":[203],"SVRI,":[204],"This":[213],"may":[214],"be":[215],"mediated":[216],"through":[217],"scavenging":[221],"potency":[222],"CFH,":[224],"increasing":[225],"basal":[226],"impairing":[230],"tissue":[231],"perfusion.":[232]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-11-22T00:00:00"}