{"id":"https://openalex.org/W2985583965","doi":"https://doi.org/10.7554/elife.17756.016","title":"Author response: Nonenzymatic copying of RNA templates containing all four letters is catalyzed by activated oligonucleotides","display_name":"Author response: Nonenzymatic copying of RNA templates containing all four letters is catalyzed by activated oligonucleotides","publication_year":2016,"publication_date":"2016-06-27","ids":{"openalex":"https://openalex.org/W2985583965","doi":"https://doi.org/10.7554/elife.17756.016","mag":"2985583965"},"language":"en","primary_location":{"id":"doi:10.7554/elife.17756.016","doi":"https://doi.org/10.7554/elife.17756.016","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.17756.016","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"peer-review"},"volume":null,"type":"peer-review","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.7554/elife.17756.016","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063126231","display_name":"Noam Prywes","orcid":"https://orcid.org/0000-0003-2526-2392","observed_orcids":["https://orcid.org/0000-0003-2526-2392"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4405271026","display_name":"Center for Computational and Integrative Biology, Massachusetts General Hospital","ror":"https://ror.org/01qt3xv71","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405271026"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Noam Prywes","raw_affiliation_strings":["Department of Chemistry and Chemical Biology, Harvard University","Department of Molecular Biology and Center for Computational and Integrative Biology, Howard Hughes Medical Institute, Massachusetts General Hospital"],"raw_orcid":"https://orcid.org/0000-0003-2526-2392","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Chemical Biology, Harvard University","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Molecular Biology and Center for Computational and Integrative Biology, Howard Hughes Medical Institute, Massachusetts General Hospital","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I4210087915","https://openalex.org/I4405271026"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039506372","display_name":"J. Craig Blain","orcid":"https://orcid.org/0000-0001-5664-4065","observed_orcids":["https://orcid.org/0000-0001-5664-4065"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4405271026","display_name":"Center for Computational and Integrative Biology, Massachusetts General Hospital","ror":"https://ror.org/01qt3xv71","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405271026"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Craig Blain","raw_affiliation_strings":["Department of Molecular Biology and Center for Computational and Integrative Biology, Howard Hughes Medical Institute, Massachusetts General Hospital"],"raw_orcid":"https://orcid.org/0000-0001-5664-4065","affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Center for Computational and Integrative Biology, Howard Hughes Medical Institute, Massachusetts General Hospital","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I4210087915","https://openalex.org/I4405271026"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018335983","display_name":"Francesca Del Frate","orcid":"https://orcid.org/0000-0003-2782-1290","observed_orcids":["https://orcid.org/0000-0003-2782-1290"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4405271026","display_name":"Center for Computational and Integrative Biology, Massachusetts General Hospital","ror":"https://ror.org/01qt3xv71","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405271026"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francesca Del Frate","raw_affiliation_strings":["Department of Molecular Biology and Center for Computational and Integrative Biology, Howard Hughes Medical Institute, Massachusetts General Hospital"],"raw_orcid":"https://orcid.org/0000-0003-2782-1290","affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Center for Computational and Integrative Biology, Howard Hughes Medical Institute, Massachusetts General Hospital","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I4210087915","https://openalex.org/I4405271026"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023274897","display_name":"Jack W. Szostak","orcid":"https://orcid.org/0000-0003-4131-1203","observed_orcids":["https://orcid.org/0000-0003-4131-1203"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4405271026","display_name":"Center for Computational and Integrative Biology, Massachusetts General Hospital","ror":"https://ror.org/01qt3xv71","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405271026"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jack W Szostak","raw_affiliation_strings":["Department of Chemistry and Chemical Biology, Harvard University","Department of Molecular Biology and Center for Computational and Integrative Biology, Howard Hughes Medical Institute, Massachusetts General Hospital"],"raw_orcid":"https://orcid.org/0000-0003-4131-1203","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Chemical Biology, Harvard University","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Molecular Biology and Center for Computational and Integrative Biology, Howard Hughes Medical Institute, Massachusetts General Hospital","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I4210087915","https://openalex.org/I4405271026"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":2500},"apc_paid":{"value":3000,"currency":"USD","value_usd":2500},"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11445","display_name":"Origins and Evolution of Life","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/3103","display_name":"Astronomy and Astrophysics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11445","display_name":"Origins and Evolution of Life","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/3103","display_name":"Astronomy and Astrophysics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rna-template","display_name":"RNA template","score":0.47999998927116394},{"id":"https://openalex.org/keywords/rna-self-replication","display_name":"RNA self-replication","score":0.5630000233650208},{"id":"https://openalex.org/keywords/origin-of-life","display_name":"origin of life","score":0.8799999952316284},{"id":"https://openalex.org/keywords/prebiotic-chemistry","display_name":"prebiotic chemistry","score":0.7319999933242798},{"id":"https://openalex.org/keywords/rna-catalysis","display_name":"RNA catalysis","score":0.45399999618530273}],"concepts":[{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.7203090786933899},{"id":"https://openalex.org/C129312508","wikidata":"https://www.wikidata.org/wiki/Q133686","display_name":"Oligonucleotide","level":3,"score":0.6420737504959106},{"id":"https://openalex.org/C76346623","wikidata":"https://www.wikidata.org/wiki/Q205858","display_name":"Ribozyme","level":4,"score":0.6015725135803223},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.574838399887085},{"id":"https://openalex.org/C1342335","wikidata":"https://www.wikidata.org/wiki/Q6545871","display_name":"Ligase ribozyme","level":5,"score":0.5407528877258301},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.4757646918296814},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4286673069000244},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42038440704345703},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4200460910797119},{"id":"https://openalex.org/C190161988","wikidata":"https://www.wikidata.org/wiki/Q231218","display_name":"Abiogenesis","level":2,"score":0.41697633266448975},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3667405843734741},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23301571607589722}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.7554/elife.17756.016","doi":"https://doi.org/10.7554/elife.17756.016","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.17756.016","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"peer-review"}],"best_oa_location":{"id":"doi:10.7554/elife.17756.016","doi":"https://doi.org/10.7554/elife.17756.016","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.17756.016","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"peer-review"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2467190354","https://openalex.org/W2135676218","https://openalex.org/W3025679535","https://openalex.org/W4378746493","https://openalex.org/W2035868417","https://openalex.org/W4224217187","https://openalex.org/W3083243880","https://openalex.org/W2755147830","https://openalex.org/W4281560085","https://openalex.org/W4232210604"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2019-11-22T00:00:00"}
