{"id":"https://openalex.org/W2985453047","doi":"https://doi.org/10.1182/blood-2019-129018","title":"Sequential Combination of Inotuzumab Ozogamicin (InO) with Low-Intensity Chemotherapy (Mini-hyper-CVD) with or without Blinatumomab Is Highly Effective in Patients (pts) with Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia (ALL) in First Relapse","display_name":"Sequential Combination of Inotuzumab Ozogamicin (InO) with Low-Intensity Chemotherapy (Mini-hyper-CVD) with or without Blinatumomab Is Highly Effective in Patients (pts) with Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia (ALL) in First Relapse","publication_year":2019,"publication_date":"2019-11-13","ids":{"openalex":"https://openalex.org/W2985453047","doi":"https://doi.org/10.1182/blood-2019-129018","mag":"2985453047"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2019-129018","doi":"https://doi.org/10.1182/blood-2019-129018","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2019-129018","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029750735","display_name":"Koji Sasaki","orcid":"https://orcid.org/0000-0002-9140-0610","observed_orcids":["https://orcid.org/0000-0002-9140-0610"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Koji Sasaki","raw_affiliation_strings":["Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090435894","display_name":"Hagop M. Kantarjian","orcid":"https://orcid.org/0000-0002-1908-3307","observed_orcids":["https://orcid.org/0000-0002-1908-3307"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hagop M. Kantarjian","raw_affiliation_strings":["Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000750846","display_name":"Farhad Ravandi","orcid":"https://orcid.org/0000-0002-7621-377X","observed_orcids":["https://orcid.org/0000-0002-7621-377X"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Farhad Ravandi","raw_affiliation_strings":["Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091492845","display_name":"Nicholas James Short","orcid":"https://orcid.org/0000-0002-2983-2738","observed_orcids":["https://orcid.org/0000-0002-2983-2738"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas J. Short","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069460930","display_name":"Partow Kebriaei","orcid":"https://orcid.org/0000-0002-8607-9404","observed_orcids":["https://orcid.org/0000-0002-8607-9404"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Partow Kebriaei","raw_affiliation_strings":["Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057822243","display_name":"Xuelin Huang","orcid":"https://orcid.org/0000-0003-1192-9336","observed_orcids":["https://orcid.org/0000-0003-1192-9336"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xuelin Huang","raw_affiliation_strings":["Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111411510","display_name":"Michael Rytting","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael E. Rytting","raw_affiliation_strings":["Department of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021380291","display_name":"Nitin Jain","orcid":"https://orcid.org/0000-0003-0114-8384","observed_orcids":["https://orcid.org/0000-0003-0114-8384"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nitin Jain","raw_affiliation_strings":["University of Texas MD Anderson Cancer Center, Department of Leukemia, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas MD Anderson Cancer Center, Department of Leukemia, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022647201","display_name":"Marina Y Konopleva","orcid":"https://orcid.org/0000-0002-9347-2212","observed_orcids":["https://orcid.org/0000-0002-9347-2212"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marina Y Konopleva","raw_affiliation_strings":["Department of Leukemia, MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Leukemia, MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061026876","display_name":"Guillermo Garcia\u2010Manero","orcid":"https://orcid.org/0000-0002-3631-2482","observed_orcids":["https://orcid.org/0000-0002-3631-2482"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guillermo Garcia-Manero","raw_affiliation_strings":["University of Texas MD Anderson Cancer Center, Department of Leukemia, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas MD Anderson Cancer Center, Department of Leukemia, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048913229","display_name":"Richard E. Champlin","orcid":"https://orcid.org/0000-0002-4314-5037","observed_orcids":["https://orcid.org/0000-0002-4314-5037"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard E. Champlin","raw_affiliation_strings":["University of Texas MD Anderson Cancer Center, Department of Stem Cell Transplantation and Cellular Therapy, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas MD Anderson Cancer Center, Department of Stem Cell Transplantation and Cellular Therapy, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020340537","display_name":"Tapan Mahendra Kadia","orcid":"https://orcid.org/0000-0002-9892-9832","observed_orcids":["https://orcid.org/0000-0002-9892-9832"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tapan M. Kadia","raw_affiliation_strings":["Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015101485","display_name":"J\u00f6rge E. Cortes","orcid":"https://orcid.org/0000-0002-8636-1071","observed_orcids":["https://orcid.org/0000-0002-8636-1071"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jorge E. Cortes","raw_affiliation_strings":["Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084290698","display_name":"Zeev E. Estrov","orcid":"https://orcid.org/0000-0002-1623-3613","observed_orcids":["https://orcid.org/0000-0002-1623-3613"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zeev E. Estrov","raw_affiliation_strings":["Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051949215","display_name":"Koichi Takahashi","orcid":"https://orcid.org/0000-0002-8027-9659","observed_orcids":["https://orcid.org/0000-0002-8027-9659"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Koichi Takahashi","raw_affiliation_strings":["Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087551533","display_name":"Christopher R. Loiselle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Loiselle","raw_affiliation_strings":["Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051456514","display_name":"Corabelle Encarnacion","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Corabelle Encarnacion","raw_affiliation_strings":["Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002849366","display_name":"Meagan Rostykus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meagan Rostykus","raw_affiliation_strings":["Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045705543","display_name":"Rita B. Khouri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rita Khouri","raw_affiliation_strings":["University of Texas MD Anderson Cancer Center, Department of Leukemia, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas MD Anderson Cancer Center, Department of Leukemia, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091723676","display_name":"Patrice Eric Nasnas","orcid":"https://orcid.org/0009-0008-5149-8618","observed_orcids":["https://orcid.org/0009-0008-5149-8618"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrice Nasnas","raw_affiliation_strings":["Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112411374","display_name":"Jovitta Jacob","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jovitta Jacob","raw_affiliation_strings":["Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077963154","display_name":"Monica I. Kwari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Monica Kwari","raw_affiliation_strings":["Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043585566","display_name":"Rebecca E. Garris","orcid":"https://orcid.org/0000-0001-8009-5529","observed_orcids":["https://orcid.org/0000-0001-8009-5529"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca Garris","raw_affiliation_strings":["Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":null,"display_name":"Elias Jabbour","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elias Jabbour","raw_affiliation_strings":["Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"134","issue":"Supplement_1","first_page":"3806","last_page":"3806"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inotuzumab-ozogamicin","display_name":"inotuzumab ozogamicin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/blinatumomab","display_name":"blinatumomab","score":0.9559999704360962},{"id":"https://openalex.org/keywords/philadelphia-chromosome-negative-acute-lymphoblastic-leukemia","display_name":"Philadelphia chromosome-negative acute lymphoblastic leukemia","score":0.9639999866485596},{"id":"https://openalex.org/keywords/first-relapse","display_name":"first relapse","score":0.9449999928474426},{"id":"https://openalex.org/keywords/low-intensity-chemotherapy","display_name":"low-intensity chemotherapy","score":0.7649999856948853},{"id":"https://openalex.org/keywords/sequential-therapy","display_name":"sequential therapy","score":0.7770000100135803},{"id":"https://openalex.org/keywords/allogeneic-stem-cell-transplantation","display_name":"allogeneic stem cell transplantation","score":0.8679999709129333},{"id":"https://openalex.org/keywords/measurable-residual-disease","display_name":"minimal residual disease","score":0.7829999923706055},{"id":"https://openalex.org/keywords/hepatic-veno-occlusive-disease","display_name":"veno-occlusive disease","score":0.9620000123977661},{"id":"https://openalex.org/keywords/salvage-therapy","display_name":"salvage therapy","score":0.4000000059604645},{"id":"https://openalex.org/keywords/methotrexate","display_name":"methotrexate","score":0.6169999837875366},{"id":"https://openalex.org/keywords/cytarabine","display_name":"cytarabine","score":0.9610000252723694},{"id":"https://openalex.org/keywords/cyclophosphamide","display_name":"cyclophosphamide","score":0.8270000219345093}],"concepts":[{"id":"https://openalex.org/C2778020697","wikidata":"https://www.wikidata.org/wiki/Q410189","display_name":"Blinatumomab","level":4,"score":0.9793984293937683},{"id":"https://openalex.org/C2909962599","wikidata":"https://www.wikidata.org/wiki/Q180664","display_name":"Lymphoblastic Leukemia","level":3,"score":0.6894024014472961},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6577035188674927},{"id":"https://openalex.org/C2778623314","wikidata":"https://www.wikidata.org/wiki/Q412685","display_name":"Gemtuzumab ozogamicin","level":5,"score":0.6403253078460693},{"id":"https://openalex.org/C2778904597","wikidata":"https://www.wikidata.org/wiki/Q1129111","display_name":"Philadelphia chromosome","level":4,"score":0.48558372259140015},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.41561371088027954},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3850781321525574},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3840906322002411},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.30470460653305054},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.11947274208068848},{"id":"https://openalex.org/C138626823","wikidata":"https://www.wikidata.org/wiki/Q916504","display_name":"Chromosomal translocation","level":3,"score":0.10863518714904785},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09682410955429077},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08159264922142029},{"id":"https://openalex.org/C176290653","wikidata":"https://www.wikidata.org/wiki/Q21114013","display_name":"CD33","level":4,"score":0.0},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood-2019-129018","doi":"https://doi.org/10.1182/blood-2019-129018","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2019-129018","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.6000000238418579,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2564594542","https://openalex.org/W4313147396","https://openalex.org/W4234188263","https://openalex.org/W3129188320","https://openalex.org/W2593690819","https://openalex.org/W2970148422","https://openalex.org/W3002538939","https://openalex.org/W4296532741","https://openalex.org/W4389436949","https://openalex.org/W4388902950"],"abstract_inverted_index":{"Background:":[0],"The":[1,28,76,96,272,352,454,513,614,627,721,759],"combination":[2,722,773],"of":[3,31,38,42,55,78,86,179,187,213,218,233,251,283,303,386,487,515,558,573,578,592,604,648,695,723,757,761,774,818,858,899,914,929,944,959,977,993,1015,1032,1048,1063,1177,1200,1213,1226,1237,1248],"low":[4,768],"intensity":[5],"therapy":[6],"with":[7,92,276,289,326,330,443,664,698,725,747,753,766],"InO":[8,19,43,172,222,329,574,709,724,770],"improved":[9,716,734],"survival":[10,717],"compared":[11,689,736],"to":[12,16,67,82,209,274,320,646,690,737],"intensive":[13,743],"chemotherapy":[14,165,701,744],"and":[15,44,72,121,123,130,149,160,163,228,235,246,253,333,345,416,436,456,462,480,500,538,547,575,610,617,622,630,634,659,665,678,732,742,771,1168],"single":[17,739],"agent":[18,740],"in":[20,88,197,349,394,402,413,418,429,478,484,491,520,536,540,545,551,586,608,662,714,745,750],"Salvage":[21],"1":[22,120,434,531,535,539,542,556,777],"(Jabbour":[23],"et":[24],"al.":[25],"Cancer.":[26],"2018).":[27],"sequential":[29,576,772],"addition":[30,577],"blinatumomab":[32],"(blina)":[33],"may":[34],"allow":[35],"the":[36,52,59,84,180,185,231,249,281,284,290,339,563,569,639,643,653,672,686],"administration":[37],"weekly":[39,570],"lower":[40,571],"dose":[41,54,117,186,232,250,572,769],"distancing":[45],"allogeneic":[46,476],"stem":[47],"cell":[48],"transplant":[49],"(ASCT)":[50],"from":[51],"last":[53],"InO,":[56],"while":[57],"deepening":[58],"minimal":[60],"residual":[61],"disease":[62,70],"response.":[63],"This":[64],"will":[65],"lead":[66],"less":[68,376],"veno-occlusive":[69],"(VOD)":[71],"better":[73],"long-term":[74],"efficacy.":[75],"aim":[77],"this":[79,93,580],"study":[80],"is":[81,729],"evaluate":[83],"outcome":[85,346,735],"pts":[87,202,295,323,367,382,408,431,438,442,490,505,521,565,599,663,696,746],"first":[89,169,181,340,751],"relapse":[90],"treated":[91,325,697],"combination.":[94],"Methods:":[95],"mini-hyper-CVD":[97,219,327,707,726],"(cycles":[98,137],"1,":[99,192,240],"3,":[100],"5,":[101],"7)":[102],"comprised":[103,142],"cyclophosphamide":[104],"(150":[105],"mg/m2":[106,145,189,196,237,255],"every":[107,154,266],"12":[108,155,378],"h":[109,156],"on":[110,118,127,146,157,176,225,280,298,814,854,895,910,925,940,955,973,989,1011,1028,1044,1059,1173,1196,1209,1222,1233,1244],"days":[111,119,128,131,158,226,244,265],"1-3),":[112],"vincristine":[113],"(2":[114],"mg":[115,126],"flat":[116],"8),":[122],"dexamethasone":[124],"(20":[125],"1-4":[129],"11-14)":[132],"without":[133,334,666],"anthracycline.":[134],"Even":[135],"cycles":[136,183,212,217],"2,":[138],"4,":[139],"6,":[140],"8)":[141],"methotrexate":[143],"(250":[144],"day":[147,177],"1)":[148],"cytarabine":[150],"(0.5":[151],"g/m2":[152],"given":[153,167,175,224],"2":[159,227,245,533],"3).":[161],"Rituximab":[162],"intrathecal":[164],"were":[166,203,296,324,460,601,607,620,632],"for":[168,269,489],"4":[170,211,216,270,481,649],"courses.":[171],"was":[173,207,223,260,278,307,357,392,400,427,517,560,656,675],"originally":[174],"3":[178,548],"four":[182],"at":[184,190,230,238,248,256,315,355,642],"1.3-1.8":[188],"cycle":[191,239,268,435],"followed":[193,242],"by":[194,243,390,423],"1.0-1.3":[195],"subsequent":[198,257,511],"cycles.":[199,271],"After":[200,292],"38":[201,676],"treated,":[204],"an":[205,815,855,896,911,926,941,956,967,974,990,1012,1029,1045,1060,1174,1197,1210,1223,1234,1245],"amendment":[206],"made":[208],"incorporate":[210],"blina":[214,259,335,447,452,711,728],"after":[215,287,309,433,451,510],"+":[220,328,708],"InO.":[221],"8":[229,247,365],"0.6":[234],"0.3":[236,252,254],"respectively,":[241],"cycles;":[258],"continuously":[261],"infused":[262],"over":[263],"28":[264],"42-day":[267],"decision":[273],"proceed":[275],"ASCT":[277,544,550,585,647],"based":[279],"discretion":[282],"treating":[285],"physician":[286],"discussion":[288],"pt.":[291],"amendment,":[293],"all":[294,527],"placed":[297],"prophylactic":[299],"ursodiol.":[300],"Inverse":[301],"probability":[302],"treatment":[304],"weighting":[305],"(IPTW)":[306],"performed":[308],"propensity":[310],"score":[311],"calculations":[312],"using":[313],"covariates":[314],"diagnosis.":[316],"Results:":[317],"From":[318],"2/2013":[319],"3/2019,":[321],"62":[322,363],"(n=38,":[331],"55%)":[332],"(n=24,":[336],"45%)":[337],"as":[338],"salvage":[341,700],"therapy.":[342,453],"Pt":[343],"characteristics":[344],"are":[347],"summarized":[348],"Table":[350],"1.":[351],"median":[353,590,628,644,654,673],"age":[354],"diagnosis":[356],"39":[358],"years":[359],"(range,":[360,595,651],"19-87).":[361],"Among":[362,465],"pts,":[364],"(13%)":[366],"had":[368,383,529,582],"primary":[369],"refractory":[370],"disease;":[371],"24":[372],"(38%),":[373],"CR1":[374,537],"duration":[375],"than":[377],"months.":[379],"7":[380],"(11%)":[381],"prior":[384],"history":[385],"ASCT.":[387,512],"MLL":[388],"rearrangement":[389,399],"FISH":[391],"observed":[393,401,561],"11":[395,470],"(18%)":[396],"pts;":[397],"CRLF2":[398],"6":[403,504],"(10%).":[404],"Overall,":[405,503],"57":[406,466],"(92%)":[407],"achieved":[409,428,448,468],"response":[410],"including":[411],"CR":[412,609],"43":[414],"(69%),":[415],"CRp/CRi":[417],"14":[419],"(23%).":[420],"MRD":[421,445,450,611],"negativity":[422],"6-color":[424],"flow":[425],"cytometry":[426],"31/52":[430],"(60%)":[432],"47/55":[437],"(85%)":[439],"overall.":[440],"Three":[441],"detectable":[444],"before":[446],"negative":[449,612],"30-day":[455],"60-day":[457],"mortality":[458],"rates":[459,619],"2%":[461],"3%,":[463],"respectively.":[464,637],"who":[467,522,567],"remission,":[469],"(19%)":[471],"relapsed,":[472],"31":[473,679],"(54%)":[474],"underwent":[475],"SCT":[477],"CR2,":[479],"(6%)":[482],"died":[483],"CR/CRp.":[485],"Causes":[486],"death":[488],"CR/CRp":[492],"included:":[493],"unknown":[494],"(n=1),":[495,497,499],"VOD":[496,516,559,583,762],"sepsis":[498],"pneumonia":[501],"(n=1).":[502],"(10%)":[506],"developed":[507],"VOD;":[508],"5":[509,528],"rate":[514,756],"5/42":[518],"(12%)":[519],"did":[523],"not":[524],"receive":[525],"blina;":[526,579],"ASCT-related;":[530],"received":[532,543,549,568],"ASCT,":[534,667],"CR2;":[541],"CR1;":[546],"CR2.":[552,587],"In":[553],"contrast,":[554],"only":[555],"case":[557],"among":[562],"20":[564],"(5%)":[566],"pt":[581],"post":[584],"With":[588,638],"a":[589,691],"follow-up":[591],"34":[593],"months":[594,650,658,661,677],"2-75":[596],"months),":[597],"29":[598],"(47%)":[600],"alive,":[602],"21":[603],"whom":[605],"(34%)":[606],"status.":[613],"3-year":[615,754],"EFS":[616,629,655],"OS":[618,631,674,755],"31%":[621],"42%,":[623],"respectively":[624,668,681],"(Figure":[625,669,682],"1).":[626],"10":[633],"17":[635],"months,":[636,680],"landmark":[640],"analysis":[641],"time":[645],"1.9-9.5),":[652],"13":[657],"15":[660],"2A;":[670],"P=0.92);":[671],"2B;":[683],"P=0.910).":[684],"Using":[685],"IPTW":[687],"analysis,":[688],"similar":[692],"historical":[693],"cohort":[694],"standard":[699,738],"(n=39)":[702],"or":[703,820,860,901,916,931,946,961,979,995,1017,1034,1050,1065,1179,1202,1215,1228,1239,1250],"Ino":[704,741],"monotherapy":[705],"(n=29),":[706],"\u00b1":[710],"(n=62)":[712],"resulted":[713],"significantly":[715],"(P<0.001;":[718],"P<0.001).":[719],"Conclusion:":[720],"+/-":[727],"highly":[730],"effective":[731],"shows":[733],"relapsed/refractory":[748],"ALL":[749],"relapse,":[752],"42%.":[758],"risk":[760],"can":[763],"be":[764],"minimized":[765],"fractionated":[767],"blina.":[775],"Figure":[776],"Disclosures":[778],"Sasaki:":[779],"Pfizer:":[780,787,888,936,1207,1273,1342],"Consultancy;":[781,887,1166,1279],"Otsuka:":[782],"Honoraria.":[783,889],"Kantarjian:Astex:":[784],"Research":[785,789,792,796,800,803,806,809,826,830,834,837,841,845,849,863,866,870,877,884,904,919,934,949,964,982,998,1001,1004,1020,1038,1053,1068,1071,1075,1088,1095,1099,1102,1108,1113,1117,1123,1129,1132,1136,1139,1142,1145,1149,1153,1156,1160,1163,1182,1185,1189,1192,1205,1218,1255,1260,1266,1271,1276,1288,1293,1298,1302,1308,1313,1317,1324,1328,1332,1336,1340,1344],"Funding;":[786,790,793,797,801,804,807,810,827,831,835,842,846,850,864,867,878,885,905,920,935,950,965,983,999,1002,1005,1021,1039,1054,1072,1076,1089,1096,1100,1103,1109,1114,1118,1124,1133,1137,1140,1143,1146,1150,1154,1157,1164,1183,1186,1190,1193,1206,1219,1261,1267,1272,1277,1289,1294,1299,1303,1309,1314,1325,1329,1333,1337,1341,1345],"Honoraria,":[788,795,812,829,833,852,893,908,923,938,953,971,987,1009,1026,1042,1057,1087,1094,1098,1112,1265,1270,1275,1287,1292,1297,1307],"Novartis:":[791,1141,1268],"Amgen:":[794,851,883,1125,1194],"Jazz":[798],"Pharma:":[799,1263,1301],"Cyclacel:":[802],"BMS:":[805,1037,1184,1334],"Immunogen:":[808,1295],"Actinium:":[811,1165],"Membership":[813,853,894,909,924,939,954,972,988,1010,1027,1043,1058,1172,1195,1208,1221,1232,1243],"entity's":[816,856,897,912,927,942,957,975,991,1013,1030,1046,1061,1175,1198,1211,1224,1235,1246],"Board":[817,857,898,913,928,943,958,976,992,1014,1031,1047,1062,1176,1199,1212,1225,1236,1247],"Directors":[819,859,900,915,930,945,960,978,994,1016,1033,1049,1064,1178,1201,1214,1227,1238,1249],"advisory":[821,861,902,917,932,947,962,980,996,1018,1035,1051,1066,1180,1203,1216,1229,1240,1251],"committees;":[822,1036,1230,1241,1252],"Takeda:":[823,1242,1315,1330],"Honoraria;":[824,873,882,1106,1121,1127,1283],"Daiichi-Sankyo:":[825],"Agios:":[828],"AbbVie:":[832,951,1110,1144,1253,1338],"Ariad:":[836],"Funding.":[838,871,1069,1130,1161,1256,1318],"Ravandi:Xencor:":[839],"Consultancy,":[840,869,876,892,907,922,937,952,970,986,1008,1025,1041,1056,1086,1093,1105,1111,1120,1126,1135,1148,1152,1254,1259,1264,1269,1274,1282,1286,1291,1296,1306,1312,1316,1323,1331,1335,1339,1343],"Cyclacel":[843,1326],"LTD:":[844,1327],"Menarini":[847],"Ricerche:":[848],"committees,":[862,903,918,933,948,963,981,997,1019,1052,1067,1181,1204,1217],"Selvita:":[865],"Macrogenix:":[868],"Short:Amgen:":[872],"Takeda":[874],"Oncology:":[875],"AstraZeneca:":[879,921],"Consultancy.":[880,1170,1321],"Kebriaei:Kite:":[881],"Jazz:":[886],"Jain:Precision":[890],"Biosciences:":[891],"Servier:":[906],"Pharmacyclics,":[966],"AbbVie":[968],"company:":[969],"ADC":[984],"Therapeutics:":[985,1085,1285],"Cellectis:":[1000,1128],"Incyte:":[1003],"Adaptive":[1006],"Biotechnologies:":[1007],"Janssen":[1022],"Pharmaceuticals,":[1023],"Inc.:":[1024],"Genentech:":[1040,1097,1220],"Verastem:":[1055],"Konopleva:Agios:":[1070],"Astra":[1073],"Zeneca:":[1074],"Reata":[1077],"Pharmaceuticals:":[1078,1258,1320],"Equity":[1079],"Ownership,":[1080],"Patents":[1081],"&":[1082],"Royalties;":[1083],"Stemline":[1084],"F.":[1090],"Hoffman":[1091],"La-Roche:":[1092],"Ascentage:":[1101],"Kisoji:":[1104],"Ablynx:":[1107],"Eli":[1115],"Lilly:":[1116],"Forty-Seven:":[1119],"Calithera:":[1122],"Garcia-Manero:Merck:":[1131],"Amphivena:":[1134],"Helsinn:":[1138],"Celgene:":[1147,1191],"Astex:":[1151],"Onconova:":[1155],"H3":[1158],"Biomedicine:":[1159],"Champlin:Sanofi-Genzyme:":[1162],"Johnson":[1167],"Johnson:":[1169],"Kadia:Jazz:":[1171],"Bioline":[1187],"RX:":[1188],"Pharmacyclics:":[1231],"Cortes:Jazz":[1257],"Astellas":[1262],"BiolineRx:":[1278],"Biopath":[1280],"Holdings:":[1281],"Forma":[1284],"Merus:":[1290],"Sun":[1300],"Daiichi":[1304],"Sankyo:":[1305],"Bristol-Myers":[1310],"Squibb:":[1311],"Takahashi:Symbio":[1319],"Jabbour:Amgen:":[1322],"Adaptive:":[1346],"Consult":[1347]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":5}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2025-10-10T00:00:00"}
