{"id":"https://openalex.org/W2985366299","doi":"https://doi.org/10.7554/elife.50777","title":"Single-cell proteomics reveals changes in expression during hair-cell development","display_name":"Single-cell proteomics reveals changes in expression during hair-cell development","publication_year":2019,"publication_date":"2019-11-04","ids":{"openalex":"https://openalex.org/W2985366299","doi":"https://doi.org/10.7554/elife.50777","mag":"2985366299","pmid":"https://pubmed.ncbi.nlm.nih.gov/31682227"},"language":"en","primary_location":{"id":"doi:10.7554/elife.50777","doi":"https://doi.org/10.7554/elife.50777","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.50777","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.7554/elife.50777","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006092446","display_name":"Ying Zhu","orcid":"https://orcid.org/0000-0002-5416-0566","observed_orcids":["https://orcid.org/0000-0002-5416-0566","https://orcid.org/0009-0003-7717-7090"]},"institutions":[{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]},{"id":"https://openalex.org/I2801280572","display_name":"Environmental Molecular Sciences Laboratory","ror":"https://ror.org/04rc0xn13","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I2801280572","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ying Zhu","raw_affiliation_strings":["Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, United States","institution_ids":["https://openalex.org/I142606810","https://openalex.org/I2801280572"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028448184","display_name":"Mirko Scheibinger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mirko Scheibinger","raw_affiliation_strings":["Department of Otolaryngology Head and Neck Surgery, Stanford University, Stanford, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology Head and Neck Surgery, Stanford University, Stanford, United States","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058893751","display_name":"Daniel Christian Ellwanger","orcid":"https://orcid.org/0000-0002-3481-8455","observed_orcids":["https://orcid.org/0000-0002-3481-8455"]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Christian Ellwanger","raw_affiliation_strings":["Department of Otolaryngology Head and Neck Surgery, Stanford University, Stanford, United States","Genome Analysis Unit, Amgen Research, Amgen Inc, South San Francisco, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology Head and Neck Surgery, Stanford University, Stanford, United States","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Genome Analysis Unit, Amgen Research, Amgen Inc, South San Francisco, United States","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070314255","display_name":"Jocelyn F. Krey","orcid":"https://orcid.org/0000-0002-3015-4081","observed_orcids":["https://orcid.org/0000-0002-3015-4081"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I2802707198","display_name":"Vollum Institute","ror":"https://ror.org/054hm6j14","country_code":"US","type":"facility","lineage":["https://openalex.org/I2802707198"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jocelyn F Krey","raw_affiliation_strings":["Oregon Hearing Research Center, Oregon Health & Science University, Portland, United States","Vollum Institute, Oregon Health & Science University, Portland, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Hearing Research Center, Oregon Health & Science University, Portland, United States","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Vollum Institute, Oregon Health & Science University, Portland, United States","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I2802707198"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025905999","display_name":"Dongseok Choi","orcid":"https://orcid.org/0000-0002-1552-4072","observed_orcids":["https://orcid.org/0000-0002-1552-4072"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR","US"],"is_corresponding":false,"raw_author_name":"Dongseok Choi","raw_affiliation_strings":["Graduate School of Dentistry, Kyung Hee University, Seoul, Republic of Korea","OHSU-PSU School of Public Health, Oregon Health & Science University, Portland, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Dentistry, Kyung Hee University, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I35928602"]},{"raw_affiliation_string":"OHSU-PSU School of Public Health, Oregon Health & Science University, Portland, United States","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039065189","display_name":"Ryan Kelly","orcid":"https://orcid.org/0000-0002-3339-4443","observed_orcids":["https://orcid.org/0000-0002-3339-4443"]},"institutions":[{"id":"https://openalex.org/I100005738","display_name":"Brigham Young University","ror":"https://ror.org/047rhhm47","country_code":"US","type":"education","lineage":["https://openalex.org/I100005738"]},{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]},{"id":"https://openalex.org/I2801280572","display_name":"Environmental Molecular Sciences Laboratory","ror":"https://ror.org/04rc0xn13","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I2801280572","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan T Kelly","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Brigham Young University, Provo, United States","Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Brigham Young University, Provo, United States","institution_ids":["https://openalex.org/I100005738"]},{"raw_affiliation_string":"Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, United States","institution_ids":["https://openalex.org/I142606810","https://openalex.org/I2801280572"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067865290","display_name":"Stefan Heller","orcid":"https://orcid.org/0000-0002-0490-4440","observed_orcids":["https://orcid.org/0000-0002-0490-4440"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stefan Heller","raw_affiliation_strings":["Department of Otolaryngology Head and Neck Surgery, Stanford University, Stanford, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology Head and Neck Surgery, Stanford University, Stanford, United States","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079975848","display_name":"Peter G. Gillespie","orcid":"https://orcid.org/0000-0002-9787-5860","observed_orcids":["https://orcid.org/0000-0002-9787-5860"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I2802707198","display_name":"Vollum Institute","ror":"https://ror.org/054hm6j14","country_code":"US","type":"facility","lineage":["https://openalex.org/I2802707198"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter G Barr-Gillespie","raw_affiliation_strings":["Oregon Hearing Research Center, Oregon Health & Science University, Portland, United States","Vollum Institute, Oregon Health & Science University, Portland, United States"],"raw_orcid":"https://orcid.org/0000-0002-9787-5860","affiliations":[{"raw_affiliation_string":"Oregon Hearing Research Center, Oregon Health & Science University, Portland, United States","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Vollum Institute, Oregon Health & Science University, Portland, United States","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I2802707198"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":9,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":2500},"apc_paid":{"value":3000,"currency":"USD","value_usd":2500},"fwci":7.4423,"has_fulltext":false,"cited_by_count":106,"citation_normalized_percentile":{"value":0.98581875,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"8","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.5889000296592712,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.5889000296592712,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.3698999881744385,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.010900000110268593,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hair-cell-development","display_name":"hair cell development","score":0.8379999995231628},{"id":"https://openalex.org/keywords/single-cell-proteomics","display_name":"single-cell proteomics","score":0.8220000267028809},{"id":"https://openalex.org/keywords/hair-cell-differentiation","display_name":"hair cell differentiation","score":0.7120000123977661},{"id":"https://openalex.org/keywords/utricle","display_name":"utricle","score":0.7300000190734863},{"id":"https://openalex.org/keywords/chick-embryo","display_name":"chick embryo","score":0.6140000224113464},{"id":"https://openalex.org/keywords/inner-ear","display_name":"inner ear","score":0.5529999732971191},{"id":"https://openalex.org/keywords/developmental-trajectories","display_name":"developmental trajectories","score":0.5360000133514404},{"id":"https://openalex.org/keywords/protein-expression","display_name":"protein expression","score":0.49399998784065247},{"id":"https://openalex.org/keywords/progenitor-cells","display_name":"progenitor cells","score":0.8159999847412109},{"id":"https://openalex.org/keywords/single-cell-transcriptomics","display_name":"single-cell transcriptomics","score":0.7120000123977661}],"concepts":[{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.8133700489997864},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.7518213391304016},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7110981345176697},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.6809206604957581},{"id":"https://openalex.org/C2778585322","wikidata":"https://www.wikidata.org/wiki/Q1566641","display_name":"Hair cell","level":3,"score":0.64836585521698},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6391269564628601},{"id":"https://openalex.org/C68289359","wikidata":"https://www.wikidata.org/wiki/Q7502514","display_name":"Shotgun proteomics","level":4,"score":0.633758544921875},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.5189507007598877},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.5134676098823547},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.504607081413269},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.4930419623851776},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.48082244396209717},{"id":"https://openalex.org/C163952510","wikidata":"https://www.wikidata.org/wiki/Q5058196","display_name":"Cell fate determination","level":4,"score":0.43937593698501587},{"id":"https://openalex.org/C2781434637","wikidata":"https://www.wikidata.org/wiki/Q486396","display_name":"Shotgun","level":3,"score":0.43051719665527344},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4245792627334595},{"id":"https://openalex.org/C2780130748","wikidata":"https://www.wikidata.org/wiki/Q317857","display_name":"Cochlea","level":2,"score":0.4055788815021515},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.29618170857429504},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18616583943367004},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.18512949347496033},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16271299123764038},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.13112562894821167},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.10780563950538635}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006198","descriptor_name":"Hair Cells, Auditory","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006198","descriptor_name":"Hair Cells, Auditory","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006198","descriptor_name":"Hair Cells, Auditory","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006198","descriptor_name":"Hair Cells, Auditory","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006198","descriptor_name":"Hair Cells, Auditory","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006198","descriptor_name":"Hair Cells, Auditory","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018069","descriptor_name":"Hair Cells, Vestibular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018069","descriptor_name":"Hair Cells, Vestibular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018069","descriptor_name":"Hair Cells, Vestibular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018069","descriptor_name":"Hair Cells, Vestibular","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018069","descriptor_name":"Hair Cells, Vestibular","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018069","descriptor_name":"Hair Cells, Vestibular","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.7554/elife.50777","doi":"https://doi.org/10.7554/elife.50777","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.50777","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},{"id":"pmid:31682227","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31682227","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5822176","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6855842","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6855842","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6855842","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eLife","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:19e6a3669263492e9fe408c93b8d336a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/19e6a3669263492e9fe408c93b8d336a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eLife, Vol 8 (2019)","raw_type":"article"},{"id":"pmh:oai:osti.gov:1575404","doi":null,"is_oa":false,"landing_page_url":"https://www.osti.gov/biblio/1575404","pdf_url":null,"source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:osti.gov:1592800","doi":null,"is_oa":false,"landing_page_url":"https://www.osti.gov/biblio/1592800","pdf_url":null,"source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:osti.gov:1592801","doi":null,"is_oa":false,"landing_page_url":"https://www.osti.gov/biblio/1592801","pdf_url":null,"source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.7554/elife.50777","doi":"https://doi.org/10.7554/elife.50777","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.50777","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.44999998807907104,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1581679921","display_name":null,"funder_award_id":"P30 CA-069533","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2498733953","display_name":"Area A: In-Depth Proteome Mapping of the Tumor Microenvironment with Single-  Cell Resolution","funder_award_id":"R33CA225248","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2561928420","display_name":null,"funder_award_id":"R01 DC015201","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"},{"id":"https://openalex.org/G327967867","display_name":null,"funder_award_id":"R01 DC011034","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"},{"id":"https://openalex.org/G3517203791","display_name":null,"funder_award_id":"P30 NS061800","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G9000002783","display_name":null,"funder_award_id":"R01DC015201","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000350024","display_name":null,"funder_award_id":"R01 DC011034","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000919045","display_name":"OHSU Knight Cancer Institute","funder_award_id":"5p30ca069533-27","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320306926","display_name":"Hearing Health Foundation","ror":"https://ror.org/04ntvzq34"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337352","display_name":"National Institute on Deafness and Other Communication Disorders","ror":"https://ror.org/04mhx6838"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W156844130","https://openalex.org/W1971566627","https://openalex.org/W1972105564","https://openalex.org/W1998148816","https://openalex.org/W2016370879","https://openalex.org/W2023410605","https://openalex.org/W2024736481","https://openalex.org/W2036321220","https://openalex.org/W2039314838","https://openalex.org/W2042707088","https://openalex.org/W2046422273","https://openalex.org/W2049092511","https://openalex.org/W2068767807","https://openalex.org/W2073834370","https://openalex.org/W2074322379","https://openalex.org/W2079228567","https://openalex.org/W2080752012","https://openalex.org/W2083869228","https://openalex.org/W2086194510","https://openalex.org/W2088646459","https://openalex.org/W2107665951","https://openalex.org/W2108213241","https://openalex.org/W2110065044","https://openalex.org/W2128551987","https://openalex.org/W2136285830","https://openalex.org/W2146512944","https://openalex.org/W2148445634","https://openalex.org/W2151619201","https://openalex.org/W2160782434","https://openalex.org/W2161239003","https://openalex.org/W2161809910","https://openalex.org/W2178701884","https://openalex.org/W2184791342","https://openalex.org/W2249084272","https://openalex.org/W2335061421","https://openalex.org/W2340761255","https://openalex.org/W2509957998","https://openalex.org/W2516647334","https://openalex.org/W2544360569","https://openalex.org/W2548903426","https://openalex.org/W2582282677","https://openalex.org/W2605611918","https://openalex.org/W2622807556","https://openalex.org/W2737367164","https://openalex.org/W2744808095","https://openalex.org/W2750641710","https://openalex.org/W2767910296","https://openalex.org/W2769650903","https://openalex.org/W2774486220","https://openalex.org/W2804399702","https://openalex.org/W2806046393","https://openalex.org/W2807662170","https://openalex.org/W2810783472","https://openalex.org/W2883554591","https://openalex.org/W2893216910","https://openalex.org/W2899760200","https://openalex.org/W2902578311","https://openalex.org/W2905317377","https://openalex.org/W2949237386","https://openalex.org/W2951821937","https://openalex.org/W2972334216","https://openalex.org/W4299625508"],"related_works":["https://openalex.org/W2066073064","https://openalex.org/W2036789867","https://openalex.org/W4299663967","https://openalex.org/W2971480178","https://openalex.org/W2371475667","https://openalex.org/W2516115481","https://openalex.org/W2046727518","https://openalex.org/W1973062043","https://openalex.org/W1998648829","https://openalex.org/W2121165269"],"abstract_inverted_index":{"Hearing":[0],"and":[1,60,98],"balance":[2],"rely":[3],"on":[4],"small":[5],"sensory":[6],"hair":[7,26,58,90,119],"cells":[8,59,91],"that":[9,82,100,134],"reside":[10],"in":[11,19,24,85,114],"the":[12,20,68],"inner":[13],"ear.":[14],"To":[15],"explore":[16],"dynamic":[17],"changes":[18,113],"abundant":[21],"proteins":[22,52,81],"present":[23],"differentiating":[25],"cells,":[27,36],"we":[28],"used":[29],"nanoliter-scale":[30],"shotgun":[31],"mass":[32],"spectrometry":[33],"of":[34,42,51,72,89,118,131],"single":[35],"each":[37],"~1":[38],"picoliter,":[39],"from":[40,56,61],"utricles":[41],"embryonic":[43],"day":[44],"15":[45],"chickens.":[46],"We":[47],"identified":[48],"unique":[49],"constellations":[50],"or":[53],"protein":[54,77],"groups":[55],"presumptive":[57],"progenitor":[62],"cells.":[63,120],"The":[64],"single-cell":[65,108],"proteomes":[66],"enabled":[67],"de":[69],"novo":[70],"reconstruction":[71],"a":[73],"developmental":[74],"trajectory":[75],"using":[76],"expression":[78,86],"levels,":[79],"revealing":[80],"greatly":[83],"increased":[84],"during":[87,102,116],"differentiation":[88,103],"(e.g.,":[92,104],"OCM,":[93],"CRABP1,":[94],"GPX2,":[95],"AK1,":[96],"GSTO1)":[97],"those":[99],"decreased":[101],"TMSB4X,":[105],"AGR3).":[106],"Complementary":[107],"transcriptome":[109],"profiling":[110],"showed":[111],"corresponding":[112],"mRNA":[115],"maturation":[117],"Single-cell":[121],"proteomics":[122],"data":[123],"thus":[124],"can":[125],"be":[126,136],"mined":[127],"to":[128],"reveal":[129],"features":[130],"cellular":[132],"development":[133],"may":[135],"missed":[137],"with":[138],"transcriptomics.":[139]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":19},{"year":2021,"cited_by_count":24},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-21T09:56:26.102985","created_date":"2025-10-10T00:00:00"}