{"id":"https://openalex.org/W2985311368","doi":"https://doi.org/10.2174/1573399815666191111152248","title":"Chronic Stress and Diabetes Mellitus: Interwoven Pathologies","display_name":"Chronic Stress and Diabetes Mellitus: Interwoven Pathologies","publication_year":2019,"publication_date":"2019-11-12","ids":{"openalex":"https://openalex.org/W2985311368","doi":"https://doi.org/10.2174/1573399815666191111152248","mag":"2985311368","pmid":"https://pubmed.ncbi.nlm.nih.gov/31713487"},"language":"en","primary_location":{"id":"doi:10.2174/1573399815666191111152248","doi":"https://doi.org/10.2174/1573399815666191111152248","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1573399815666191111152248","pdf_url":null,"source":{"id":"https://openalex.org/S204739293","display_name":"Current Diabetes Reviews","issn_l":"1573-3998","issn":["1573-3998","1875-6417"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Diabetes Reviews","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027544487","display_name":"Vivek Sharma","orcid":"https://orcid.org/0000-0003-1678-4180","observed_orcids":["https://orcid.org/0000-0003-1678-4180"]},"institutions":[{"id":"https://openalex.org/I74319210","display_name":"Chitkara University","ror":"https://ror.org/057d6z539","country_code":"IN","type":"education","lineage":["https://openalex.org/I74319210"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Vivek Kumar Sharma","raw_affiliation_strings":["Chitkara College of Pharmacy, Chitkara University, Punjab, India"],"raw_orcid":"https://orcid.org/0000-0003-1678-4180","affiliations":[{"raw_affiliation_string":"Chitkara College of Pharmacy, Chitkara University, Punjab, India","institution_ids":["https://openalex.org/I74319210"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016919399","display_name":"Thakur Gurjeet Singh","orcid":"https://orcid.org/0000-0003-2979-1590","observed_orcids":["https://orcid.org/0000-0003-2979-1590"]},"institutions":[{"id":"https://openalex.org/I74319210","display_name":"Chitkara University","ror":"https://ror.org/057d6z539","country_code":"IN","type":"education","lineage":["https://openalex.org/I74319210"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Thakur Gurjeet Singh","raw_affiliation_strings":["Chitkara College of Pharmacy, Chitkara University, Punjab, India"],"raw_orcid":"https://orcid.org/0000-0003-2979-1590","affiliations":[{"raw_affiliation_string":"Chitkara College of Pharmacy, Chitkara University, Punjab, India","institution_ids":["https://openalex.org/I74319210"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5016919399"],"corresponding_institution_ids":["https://openalex.org/I74319210"],"apc_list":null,"apc_paid":null,"fwci":0.8154,"has_fulltext":false,"cited_by_count":120,"citation_normalized_percentile":{"value":0.58064516,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"16","issue":"6","first_page":"546","last_page":"556"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.9223999977111816,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.9223999977111816,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.030300000682473183,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.01979999989271164,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-stress","display_name":"chronic stress","score":0.996999979019165},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9559999704360962},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-adrenal-axis","display_name":"hypothalamic-pituitary-adrenal axis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/glucocorticoids","display_name":"glucocorticoids","score":0.9200000166893005},{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":0.699999988079071},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.765999972820282},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.7860000133514404},{"id":"https://openalex.org/keywords/gluconeogenesis","display_name":"gluconeogenesis","score":0.7960000038146973},{"id":"https://openalex.org/keywords/sympathetic-nervous-system","display_name":"sympathetic nervous system","score":0.7459999918937683},{"id":"https://openalex.org/keywords/catecholamines","display_name":"catecholamines","score":0.9739999771118164},{"id":"https://openalex.org/keywords/neuroendocrine-feedback","display_name":"neuroendocrine feedback","score":0.5740000009536743},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6669999957084656},{"id":"https://openalex.org/keywords/glucose-homeostasis","display_name":"glucose homeostasis","score":0.8659999966621399}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7262189388275146},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6768508553504944},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.6200872659683228},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.6048797369003296},{"id":"https://openalex.org/C2780694816","wikidata":"https://www.wikidata.org/wiki/Q712294","display_name":"Adrenal gland","level":2,"score":0.5899895429611206},{"id":"https://openalex.org/C3018667095","wikidata":"https://www.wikidata.org/wiki/Q3455903","display_name":"Glucose homeostasis","level":4,"score":0.5697271227836609},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.569251537322998},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.5597328543663025},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5329267382621765},{"id":"https://openalex.org/C2779146795","wikidata":"https://www.wikidata.org/wiki/Q1369123","display_name":"Hypothalamic\u2013pituitary\u2013adrenal axis","level":3,"score":0.5272017121315002},{"id":"https://openalex.org/C157541749","wikidata":"https://www.wikidata.org/wiki/Q3612637","display_name":"Allostasis","level":2,"score":0.4952634871006012},{"id":"https://openalex.org/C2780841215","wikidata":"https://www.wikidata.org/wiki/Q422549","display_name":"Glucocorticoid","level":2,"score":0.4762544631958008},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.45574522018432617},{"id":"https://openalex.org/C140985366","wikidata":"https://www.wikidata.org/wiki/Q898489","display_name":"Lipolysis","level":3,"score":0.4148731529712677},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.2681756019592285},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.16097578406333923},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0781833827495575}],"mesh":[{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007030","descriptor_name":"Hypothalamo-Hypophyseal System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007030","descriptor_name":"Hypothalamo-Hypophyseal System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D013564","descriptor_name":"Sympathetic Nervous System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013564","descriptor_name":"Sympathetic Nervous System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2174/1573399815666191111152248","doi":"https://doi.org/10.2174/1573399815666191111152248","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1573399815666191111152248","pdf_url":null,"source":{"id":"https://openalex.org/S204739293","display_name":"Current Diabetes Reviews","issn_l":"1573-3998","issn":["1573-3998","1875-6417"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Diabetes Reviews","raw_type":"journal-article"},{"id":"pmid:31713487","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31713487","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current diabetes reviews","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":118,"referenced_works":["https://openalex.org/W139355624","https://openalex.org/W153393150","https://openalex.org/W1494780959","https://openalex.org/W1523733505","https://openalex.org/W1525971453","https://openalex.org/W1539455338","https://openalex.org/W1836764230","https://openalex.org/W1918442376","https://openalex.org/W1918784986","https://openalex.org/W1934437006","https://openalex.org/W1965316819","https://openalex.org/W1966210896","https://openalex.org/W1967646152","https://openalex.org/W1968430077","https://openalex.org/W1971639265","https://openalex.org/W1974323299","https://openalex.org/W1976844022","https://openalex.org/W1978180139","https://openalex.org/W1978919889","https://openalex.org/W1979498709","https://openalex.org/W1981958256","https://openalex.org/W1990714106","https://openalex.org/W1993719296","https://openalex.org/W1997976062","https://openalex.org/W1998099581","https://openalex.org/W2013930478","https://openalex.org/W2018283808","https://openalex.org/W2021943148","https://openalex.org/W2023367357","https://openalex.org/W2028502151","https://openalex.org/W2031152730","https://openalex.org/W2035966509","https://openalex.org/W2036467841","https://openalex.org/W2039531356","https://openalex.org/W2039556928","https://openalex.org/W2046960533","https://openalex.org/W2047680032","https://openalex.org/W2053524551","https://openalex.org/W2054096821","https://openalex.org/W2056973638","https://openalex.org/W2062298786","https://openalex.org/W2063100393","https://openalex.org/W2064910482","https://openalex.org/W2065861810","https://openalex.org/W2067184340","https://openalex.org/W2074706971","https://openalex.org/W2076507733","https://openalex.org/W2081264545","https://openalex.org/W2083100406","https://openalex.org/W2086547011","https://openalex.org/W2089363822","https://openalex.org/W2095036452","https://openalex.org/W2097943077","https://openalex.org/W2100232797","https://openalex.org/W2104572166","https://openalex.org/W2109552319","https://openalex.org/W2109781781","https://openalex.org/W2113544353","https://openalex.org/W2114301383","https://openalex.org/W2116000137","https://openalex.org/W2116084470","https://openalex.org/W2118548611","https://openalex.org/W2119911216","https://openalex.org/W2122380998","https://openalex.org/W2125978064","https://openalex.org/W2127658779","https://openalex.org/W2131147572","https://openalex.org/W2131714425","https://openalex.org/W2132667679","https://openalex.org/W2134870202","https://openalex.org/W2137219871","https://openalex.org/W2140567030","https://openalex.org/W2141335918","https://openalex.org/W2142328753","https://openalex.org/W2142394429","https://openalex.org/W2142481399","https://openalex.org/W2144473676","https://openalex.org/W2148510598","https://openalex.org/W2148713009","https://openalex.org/W2150367899","https://openalex.org/W2152656461","https://openalex.org/W2155881904","https://openalex.org/W2156877200","https://openalex.org/W2170288220","https://openalex.org/W2170926352","https://openalex.org/W2171303876","https://openalex.org/W2173507839","https://openalex.org/W2181244039","https://openalex.org/W2259912978","https://openalex.org/W2317998661","https://openalex.org/W2331459600","https://openalex.org/W2461546171","https://openalex.org/W2470404765","https://openalex.org/W2511574967","https://openalex.org/W2525671160","https://openalex.org/W2537885802","https://openalex.org/W2547919763","https://openalex.org/W2554391049","https://openalex.org/W2556385749","https://openalex.org/W2582950243","https://openalex.org/W2656568860","https://openalex.org/W2741329974","https://openalex.org/W2750024737","https://openalex.org/W2766941386","https://openalex.org/W2773900121","https://openalex.org/W2807484787","https://openalex.org/W2900722595","https://openalex.org/W2908781865","https://openalex.org/W2913807423","https://openalex.org/W2915042421","https://openalex.org/W2915519520","https://openalex.org/W2915571323","https://openalex.org/W2933738638","https://openalex.org/W2936309685","https://openalex.org/W2945505270","https://openalex.org/W3139007527","https://openalex.org/W4236074123","https://openalex.org/W4255304519"],"related_works":["https://openalex.org/W4214552559","https://openalex.org/W4389467596","https://openalex.org/W2537885802","https://openalex.org/W4205919916","https://openalex.org/W3207276136","https://openalex.org/W26123145","https://openalex.org/W7166499671","https://openalex.org/W3029575707","https://openalex.org/W79013676","https://openalex.org/W4214669565"],"abstract_inverted_index":{"Stress":[0],"threatens":[1],"the":[2,15,20,28,57,83,118,154,182],"homeostasis":[3],"and":[4,11,19,32,41,79,105,124,137,145,186],"mobilizes":[5],"a":[6,36,50,68,75,178],"plethora":[7],"of":[8,39,95,103,109,150,157,159,174,184],"adaptive":[9],"physiological":[10,85],"behavioral":[12],"changes":[13,141],"via":[14,35],"hypothalamic-pituitary-adrenal":[16],"(HPA)":[17],"axis":[18,26,63,97],"sympathetic":[21],"nervous":[22],"system.":[23,44],"The":[24,45,61,164],"HPA":[25,62,96],"influences":[27,111],"pituitary":[29],"gland,":[30],"hypothalamus":[31],"adrenal":[33],"gland":[34],"complex":[37],"set":[38],"positive":[40],"negative":[42],"feedback":[43,46],"system":[47],"operates":[48],"in":[49,117,129],"well":[51],"regulated":[52],"neuroendocrine":[53,143],"manner":[54],"to":[55,81,147,187],"reestablish":[56],"threatened":[58],"body":[59],"equilibrium.":[60],"secreted":[64],"major":[65],"product":[66],"is":[67,72,98],"glucocorticoid":[69],"(cortisol)":[70],"which":[71],"kept":[73],"within":[74],"physiologically":[76],"optimal":[77],"range":[78],"serves":[80],"accomplish":[82],"various":[84],"functions":[86],"crucial":[87],"for":[88,181],"survival.":[89],"In":[90],"chronically":[91],"stressed":[92],"individuals":[93],"dishabituation":[94],"followed":[99],"by":[100,114],"increased":[101],"release":[102],"glucocorticoids":[104,110,175],"catecholamines.":[106],"Higher":[107],"secretion":[108],"glucose":[112,121,189],"metabolism":[113],"promoting":[115,127],"gluconeogenesis":[116],"liver,":[119],"suppressing":[120,131],"uptake":[122],"(adipocytes":[123],"skeletal":[125],"muscles),":[126],"lipolysis":[128],"adipocytes,":[130],"insulin":[132,135],"secretion,":[133],"inflicting":[134],"resistance":[136],"inflammation.":[138],"These":[139],"biological":[140],"alter":[142],"mechanisms":[144],"lead":[146],"maladaptive":[148],"congregation":[149],"events":[151],"that":[152,169],"form":[153],"underlying":[155],"cause":[156],"development":[158],"Type":[160],"2":[161],"diabetes":[162],"(T2D).":[163],"currently":[165],"reviewed":[166],"evidences":[167],"advocate":[168],"targeting":[170],"stress":[171],"mediated":[172],"hypersecretion":[173],"may":[176],"be":[177],"viable":[179],"approach":[180],"treatment":[183],"T2D":[185],"reinstate":[188],"homeostasis.":[190]},"counts_by_year":[{"year":2026,"cited_by_count":14},{"year":2025,"cited_by_count":29},{"year":2024,"cited_by_count":23},{"year":2023,"cited_by_count":23},{"year":2022,"cited_by_count":20},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-11-22T00:00:00"}