{"id":"https://openalex.org/W2984926795","doi":"https://doi.org/10.1182/blood-2019-130588","title":"Creating and Testing a CD207+ Langerhans Cell Histiocytosis-like Cell Line","display_name":"Creating and Testing a CD207+ Langerhans Cell Histiocytosis-like Cell Line","publication_year":2019,"publication_date":"2019-11-13","ids":{"openalex":"https://openalex.org/W2984926795","doi":"https://doi.org/10.1182/blood-2019-130588","mag":"2984926795"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2019-130588","doi":"https://doi.org/10.1182/blood-2019-130588","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2019-130588","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108573220","display_name":"Jessica Velazquez","orcid":"https://orcid.org/0000-0002-4384-8744","observed_orcids":["https://orcid.org/0000-0002-4384-8744"]},"institutions":[{"id":"https://openalex.org/I4210147586","display_name":"Texas Children's Hospital","ror":"https://ror.org/05cz92x43","country_code":"US","type":"funder","lineage":["https://openalex.org/I4210147586"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica Velazquez","raw_affiliation_strings":["Texas Children's Cancer Center, Texas Children's Hospital, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas Children's Cancer Center, Texas Children's Hospital, Houston, TX","institution_ids":["https://openalex.org/I4210147586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078748941","display_name":"Amel G. Sengal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210147586","display_name":"Texas Children's Hospital","ror":"https://ror.org/05cz92x43","country_code":"US","type":"funder","lineage":["https://openalex.org/I4210147586"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amel Sengal","raw_affiliation_strings":["Texas Children's Cancer Center, Texas Children's Hospital, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas Children's Cancer Center, Texas Children's Hospital, Houston, TX","institution_ids":["https://openalex.org/I4210147586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006499960","display_name":"Carl E. Allen","orcid":"https://orcid.org/0000-0002-6625-739X","observed_orcids":["https://orcid.org/0000-0002-6625-739X","https://orcid.org/0000-0002-2241-5712"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210147586","display_name":"Texas Children's Hospital","ror":"https://ror.org/05cz92x43","country_code":"US","type":"funder","lineage":["https://openalex.org/I4210147586"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carl E. Allen","raw_affiliation_strings":["Department of Pediatrics, Baylor College of Medicine, Houston, TX","Texas Children's Cancer Center, Texas Children's Hospital, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Baylor College of Medicine, Houston, TX","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Texas Children's Cancer Center, Texas Children's Hospital, Houston, TX","institution_ids":["https://openalex.org/I4210147586"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006453605","display_name":"Rikhia Chakraborty","orcid":"https://orcid.org/0000-0002-6661-8079","observed_orcids":["https://orcid.org/0000-0002-6661-8079"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210147586","display_name":"Texas Children's Hospital","ror":"https://ror.org/05cz92x43","country_code":"US","type":"funder","lineage":["https://openalex.org/I4210147586"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rikhia Chakraborty","raw_affiliation_strings":["Department of Pediatrics, Baylor College of Medicine, Houston, TX","Texas Children's Cancer Center, Texas Children's Hospital, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Baylor College of Medicine, Houston, TX","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Texas Children's Cancer Center, Texas Children's Hospital, Houston, TX","institution_ids":["https://openalex.org/I4210147586"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"134","issue":"Supplement_1","first_page":"5399","last_page":"5399"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11909","display_name":"Histiocytic Disorders and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11909","display_name":"Histiocytic Disorders and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10980","display_name":"Vascular Malformations and Hemangiomas","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cell-line-establishment","display_name":"cell line establishment","score":0.6019999980926514},{"id":"https://openalex.org/keywords/mapk-pathway-mutations","display_name":"MAPK pathway mutations","score":0.7960000038146973},{"id":"https://openalex.org/keywords/braf","display_name":"BRAF","score":0.7269999980926514},{"id":"https://openalex.org/keywords/mek1","display_name":"MEK1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hoxa9","display_name":"HOXA9","score":0.7409999966621399},{"id":"https://openalex.org/keywords/tert","display_name":"telomerase reverse transcriptase","score":0.8730000257492065},{"id":"https://openalex.org/keywords/myeloid-neoplasms","display_name":"myeloid neoplasms","score":0.699999988079071}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7605791091918945},{"id":"https://openalex.org/C2777484599","wikidata":"https://www.wikidata.org/wiki/Q374036","display_name":"Langerhans cell histiocytosis","level":3,"score":0.6581016778945923},{"id":"https://openalex.org/C125593758","wikidata":"https://www.wikidata.org/wiki/Q15315135","display_name":"Telomerase reverse transcriptase","level":4,"score":0.5525769591331482},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5300013422966003},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.49936985969543457},{"id":"https://openalex.org/C94581717","wikidata":"https://www.wikidata.org/wiki/Q331839","display_name":"Telomerase","level":3,"score":0.479838103055954},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.43417567014694214},{"id":"https://openalex.org/C119765067","wikidata":"https://www.wikidata.org/wiki/Q6485957","display_name":"Langerin","level":4,"score":0.4203992784023285},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.4190632402896881},{"id":"https://openalex.org/C2778170410","wikidata":"https://www.wikidata.org/wiki/Q506253","display_name":"Dendritic cell","level":3,"score":0.41245460510253906},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4080083966255188},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.40172654390335083},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37380731105804443},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.22338765859603882},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.20647123456001282},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15451660752296448},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.14222514629364014},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12489452958106995},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood-2019-130588","doi":"https://doi.org/10.1182/blood-2019-130588","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2019-130588","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3168739199","https://openalex.org/W2787437846","https://openalex.org/W2595071543","https://openalex.org/W2997476486","https://openalex.org/W4389221971","https://openalex.org/W3123735196","https://openalex.org/W2071062089","https://openalex.org/W2168827093","https://openalex.org/W2584488569","https://openalex.org/W1981026122"],"abstract_inverted_index":{"Langerhans":[0],"cell":[1,39,58,100,105,322],"histiocytosis":[2],"(LCH)":[3],"is":[4],"an":[5,74],"inflammatory":[6],"myeloid":[7],"neoplasia":[8],"characterized":[9],"by":[10,30,248,293],"pathological":[11],"CD207+":[12,36,48,66,118,144],"dendritic":[13],"cells":[14,67,84,121,145,153,164,197,210,223,233,283,312],"(DCs)":[15],"with":[16,41,167],"persistent":[17],"mitogen-activated":[18],"protein":[19],"kinase":[20],"(MAPK)":[21],"activation.":[22],"Investigations":[23],"into":[24],"LCH":[25,46,62,75,138,315,333],"have":[26,260],"historically":[27],"been":[28,191,257],"challenged":[29],"the":[31,71,120,129,155,281,285,320,332],"small":[32],"percentage":[33],"of":[34,73,158,267,280,331,340],"pathologic":[35],"DCs.":[37],"No":[38,337],"lines":[40],"morphology":[42,101],"or":[43],"function":[44],"representing":[45],"lesion":[47,72,139,334],"DCs":[49,140],"currently":[50],"exist.":[51],"We":[52],"utilized":[53],"four":[54],"strategies":[55],"to":[56,104,113,141,259,263,311,317,342],"generate":[57],"line(s)":[59],"mimicking":[60],"differentiated":[61],"pathogenic":[63],"cells.":[64],"First,":[65],"were":[68,96,122,146,165,198,224],"isolated":[69,148,313],"from":[70,149,154,314],"patient":[76],"and":[77,87,102,115,214,243,277,304,306],"cultured":[78,199],"in":[79,99,137,194,200,216,298,328],"a":[80,108,168,201,228,326],"cytokine":[81,202],"cocktail.":[82],"The":[83,162,209,222,275],"maintained":[85,234],"CD1a":[86],"CD207":[88,212,235],"expression":[89,213,302],"for":[90,124,132,218],"two":[91,184,220],"weeks,":[92],"after":[93],"which":[94,195,204],"there":[95],"significant":[97],"changes":[98],"progression":[103],"death.":[106],"When":[107],"similar":[109],"approach":[110,189],"was":[111],"implemented":[112],"isolate":[114],"culture":[116,217],"skin":[117],"cells,":[119,177],"viable":[123,327],"only":[125,268],"three":[126],"days,":[127],"supporting":[128],"potential":[130],"role":[131],"somatic":[133],"activating":[134,181],"MAPK":[135,180,206,239,287],"mutations":[136,241,289],"prolong":[142],"viability.":[143],"then":[147,225],"HLA-DR+":[150],"(lineage":[151],"negative)":[152],"lymphoid":[156],"stroma":[157],"healthy":[159],"tonsils":[160],"(tCD207+).":[161],"tCD207+":[163,196],"transduced":[166],"lentivirus":[169,229],"encoding":[170,230],"human":[171],"telomerase":[172],"reverse":[173],"transcriptase":[174],"(hTERT).":[175],"These":[176],"also":[178],"lacking":[179],"mutations,":[182],"died":[183],"weeks":[185],"post-transduction.":[186],"A":[187],"fourth":[188],"has":[190,256],"more":[192],"successful":[193],"cocktail":[203],"provided":[205],"pathway":[207,240,288],"stimulation.":[208],"retained":[211],"survived":[215],"over":[219],"weeks.":[221],"immortalized":[226,282],"using":[227],"HOXA9.":[231],"Immortalized":[232],"expression.":[236],"Allele":[237],"specific":[238,265],"(BRAF":[242],"MAP2K1)":[244],"are":[245],"being":[246],"generated":[247],"class":[249],"II":[250],"CRISPR/Cpf1":[251],"genome":[252],"editing":[253],"as":[254],"Cpf1":[255],"shown":[258],"robust":[261],"activity":[262],"induce":[264],"disruption":[266],"mutant,":[269],"but":[270],"not":[271],"wild-type,":[272],"BRAF":[273],"allele.":[274],"phenotypic":[276],"genomic":[278],"characteristics":[279],"expressing":[284],"different":[286],"will":[290,308],"be":[291,309,325],"assessed":[292],"RHG-banding":[294],"cytogenetic":[295],"analysis,":[296,303],"fluorescence":[297],"situ":[299],"hybridization,":[300],"gene":[301],"immuno\u2010cytochemistry":[305],"results":[307],"compared":[310],"lesions":[316],"confirm":[318],"whether":[319],"established":[321],"line":[323],"may":[324],"vitro":[329],"mimic":[330],"DC.":[335],"Disclosures":[336],"relevant":[338],"conflicts":[339],"interest":[341],"declare.":[343]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-11-22T00:00:00"}