{"id":"https://openalex.org/W2984785409","doi":null,"title":"HPV16 viral load and physical state measurement as a potential immediate triage strategy for HR-HPV-infected women: a study in 644 women with single HPV16 infections.","display_name":"HPV16 viral load and physical state measurement as a potential immediate triage strategy for HR-HPV-infected women: a study in 644 women with single HPV16 infections.","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2984785409","mag":"2984785409","pmid":"https://pubmed.ncbi.nlm.nih.gov/29736316","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5934561"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:4858584","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5934561","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5934561","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017482684","display_name":"Anna Manawapat-Klopfer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094118","display_name":"Universit\u00e4tsklinikum T\u00fcbingen","ror":"https://ror.org/00pjgxh97","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094118"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anna Manawapat-Klopfer","raw_affiliation_strings":["Division of Experimental Virology, Institute for Medical Virology, University Hospital T\u00fcbingen, Elfriede-Aulhorn Str. 6, 72076, T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Experimental Virology, Institute for Medical Virology, University Hospital T\u00fcbingen, Elfriede-Aulhorn Str. 6, 72076, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I4210094118"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028677586","display_name":"Lisa E. Wang","orcid":"https://orcid.org/0000-0001-9726-0383","observed_orcids":["https://orcid.org/0000-0001-9726-0383"]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lisa Wang","raw_affiliation_strings":["Institute for Clinical Epidemiology and Applied Biometry Silcherstra\u00dfe 5, 72076, T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Clinical Epidemiology and Applied Biometry Silcherstra\u00dfe 5, 72076, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018723638","display_name":"Juliane Haedicke","orcid":"https://orcid.org/0000-0001-8637-0931","observed_orcids":["https://orcid.org/0000-0001-8637-0931"]},"institutions":[{"id":"https://openalex.org/I4210094118","display_name":"Universit\u00e4tsklinikum T\u00fcbingen","ror":"https://ror.org/00pjgxh97","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094118"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Juliane Haedicke-Jarboui","raw_affiliation_strings":["Division of Experimental Virology, Institute for Medical Virology, University Hospital T\u00fcbingen, Elfriede-Aulhorn Str. 6, 72076, T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Experimental Virology, Institute for Medical Virology, University Hospital T\u00fcbingen, Elfriede-Aulhorn Str. 6, 72076, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I4210094118"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066778878","display_name":"Frank Stubenrauch","orcid":"https://orcid.org/0000-0002-6685-299X","observed_orcids":["https://orcid.org/0000-0002-6685-299X"]},"institutions":[{"id":"https://openalex.org/I4210094118","display_name":"Universit\u00e4tsklinikum T\u00fcbingen","ror":"https://ror.org/00pjgxh97","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094118"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Frank Stubenrauch","raw_affiliation_strings":["Division of Experimental Virology, Institute for Medical Virology, University Hospital T\u00fcbingen, Elfriede-Aulhorn Str. 6, 72076, T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Experimental Virology, Institute for Medical Virology, University Hospital T\u00fcbingen, Elfriede-Aulhorn Str. 6, 72076, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I4210094118"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008457916","display_name":"Christian Munk","orcid":"https://orcid.org/0000-0001-5248-5431","observed_orcids":["https://orcid.org/0000-0001-5248-5431","https://orcid.org/0000-0002-8743-2150"]},"institutions":[{"id":"https://openalex.org/I4210148920","display_name":"Danish Cancer Society","ror":"https://ror.org/03ytt7k16","country_code":"DK","type":"nonprofit","lineage":["https://openalex.org/I4210148920"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Christian Munk","raw_affiliation_strings":["Unit of Virus, Lifestyle and Genes, Danish Cancer Society Research Center Strandboulevarden 49, DK-2100 Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Virus, Lifestyle and Genes, Danish Cancer Society Research Center Strandboulevarden 49, DK-2100 Copenhagen, Denmark","institution_ids":["https://openalex.org/I4210148920"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056923848","display_name":"Louise Thirstrup Thomsen","orcid":"https://orcid.org/0000-0002-0738-8410","observed_orcids":["https://orcid.org/0000-0002-0738-8410"]},"institutions":[{"id":"https://openalex.org/I4210148920","display_name":"Danish Cancer Society","ror":"https://ror.org/03ytt7k16","country_code":"DK","type":"nonprofit","lineage":["https://openalex.org/I4210148920"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Louise T Thomsen","raw_affiliation_strings":["Unit of Virus, Lifestyle and Genes, Danish Cancer Society Research Center Strandboulevarden 49, DK-2100 Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Virus, Lifestyle and Genes, Danish Cancer Society Research Center Strandboulevarden 49, DK-2100 Copenhagen, Denmark","institution_ids":["https://openalex.org/I4210148920"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048007851","display_name":"Peter Martus","orcid":"https://orcid.org/0000-0002-5386-5732","observed_orcids":["https://orcid.org/0000-0002-5386-5732"]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Peter Martus","raw_affiliation_strings":["Institute for Clinical Epidemiology and Applied Biometry Silcherstra\u00dfe 5, 72076, T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Clinical Epidemiology and Applied Biometry Silcherstra\u00dfe 5, 72076, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037046832","display_name":"Susanne K. Kj\u00e6r","orcid":"https://orcid.org/0000-0002-8347-1398","observed_orcids":["https://orcid.org/0000-0002-8347-1398"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]},{"id":"https://openalex.org/I4210148920","display_name":"Danish Cancer Society","ror":"https://ror.org/03ytt7k16","country_code":"DK","type":"nonprofit","lineage":["https://openalex.org/I4210148920"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Susanne K Kjaer","raw_affiliation_strings":["Unit of Virus, Lifestyle and Genes, Danish Cancer Society Research Center Strandboulevarden 49, DK-2100 Copenhagen, Denmark","Department of Obstetrics and Gynecology, Rigshospitalet, University of Copenhagen Blegdamsvej 9, DK-2100 Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Virus, Lifestyle and Genes, Danish Cancer Society Research Center Strandboulevarden 49, DK-2100 Copenhagen, Denmark","institution_ids":["https://openalex.org/I4210148920"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Rigshospitalet, University of Copenhagen Blegdamsvej 9, DK-2100 Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2802709434"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031102468","display_name":"Thomas Iftner","orcid":"https://orcid.org/0000-0002-5929-7078","observed_orcids":["https://orcid.org/0000-0002-5929-7078"]},"institutions":[{"id":"https://openalex.org/I4210094118","display_name":"Universit\u00e4tsklinikum T\u00fcbingen","ror":"https://ror.org/00pjgxh97","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094118"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Iftner","raw_affiliation_strings":["Division of Experimental Virology, Institute for Medical Virology, University Hospital T\u00fcbingen, Elfriede-Aulhorn Str. 6, 72076, T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Experimental Virology, Institute for Medical Virology, University Hospital T\u00fcbingen, Elfriede-Aulhorn Str. 6, 72076, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I4210094118"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"8","issue":"4","first_page":"715","last_page":"722"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10428","display_name":"Reproductive tract infections research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hpv-16","display_name":"HPV16","score":0.9430000185966492},{"id":"https://openalex.org/keywords/viral-load","display_name":"viral load","score":0.9919999837875366},{"id":"https://openalex.org/keywords/high-grade-squamous-intraepithelial-lesion","display_name":"high-grade squamous intraepithelial lesion","score":0.9100000262260437},{"id":"https://openalex.org/keywords/high-risk-hpv-infection","display_name":"high-risk HPV infection","score":0.6850000023841858},{"id":"https://openalex.org/keywords/cervical-cytology","display_name":"cervical cytology","score":0.6230000257492065},{"id":"https://openalex.org/keywords/quantitative-real-time-pcr","display_name":"quantitative real-time PCR","score":0.5709999799728394}],"concepts":[{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.8371255397796631},{"id":"https://openalex.org/C2776511402","wikidata":"https://www.wikidata.org/wiki/Q4804081","display_name":"Ascus (bryozoa)","level":4,"score":0.6693867444992065},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.567514181137085},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45387473702430725},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.4511057138442993},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37305688858032227},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.37018829584121704},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35740914940834045},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3452518582344055},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.3282099664211273},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.25510257482528687},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.08409774303436279},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.07231307029724121},{"id":"https://openalex.org/C174618031","wikidata":"https://www.wikidata.org/wiki/Q177332","display_name":"Spore","level":2,"score":0.0},{"id":"https://openalex.org/C2777083264","wikidata":"https://www.wikidata.org/wiki/Q2445285","display_name":"Ascospore","level":3,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"pmh:oai:europepmc.org:4858584","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5934561","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:29736316","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29736316","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5934561","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5934561/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/e891bedc-2ee1-4652-bfee-235ba7cb4532","doi":null,"is_oa":false,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/e891bedc-2ee1-4652-bfee-235ba7cb4532","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Manawapat-Klopfer , A , Wang , L , Haedicke-Jarboui , J , Stubenrauch , F , Munk , C , Thomsen , L T , Martus , P , Kj\u00e6r , S K & Iftner , T 2018 , ' HPV16 viral load and physical state measurement as a potential immediate triage strategy for HR-HPV-infected women : a study in 644 women with single HPV16 infections ' , American Journal of Cancer Research , vol. 8 , no. 4 , pp. 715-722 .","raw_type":"article"},{"id":"mag:2984785409","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29736316","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:4858584","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5934561","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1583197669","https://openalex.org/W1640570245","https://openalex.org/W1885045607","https://openalex.org/W1963829251","https://openalex.org/W1970570432","https://openalex.org/W1979055772","https://openalex.org/W1984766536","https://openalex.org/W2032517857","https://openalex.org/W2040572148","https://openalex.org/W2044988899","https://openalex.org/W2047663650","https://openalex.org/W2053954567","https://openalex.org/W2054407949","https://openalex.org/W2061958016","https://openalex.org/W2062176771","https://openalex.org/W2064296266","https://openalex.org/W2075791308","https://openalex.org/W2078202741","https://openalex.org/W2086480947","https://openalex.org/W2093901599","https://openalex.org/W2095976339","https://openalex.org/W2103089376","https://openalex.org/W2106213615","https://openalex.org/W2109840766","https://openalex.org/W2112458179","https://openalex.org/W2117931146","https://openalex.org/W2121732950","https://openalex.org/W2123905003","https://openalex.org/W2126351557","https://openalex.org/W2134564320","https://openalex.org/W2152820745","https://openalex.org/W2160110525","https://openalex.org/W2170918168","https://openalex.org/W3147283743","https://openalex.org/W3175504568"],"related_works":["https://openalex.org/W1640570245","https://openalex.org/W2047663650","https://openalex.org/W4303671925","https://openalex.org/W1583197669","https://openalex.org/W3135113837","https://openalex.org/W3195529854","https://openalex.org/W7099314728","https://openalex.org/W2126351557","https://openalex.org/W2970910541","https://openalex.org/W2037333640"],"abstract_inverted_index":{"High":[0],"genome":[1,76],"copy":[2,132],"number":[3,133],"(viral":[4],"load)":[5],"of":[6,31,74,96,124,138,168,208],"human":[7],"papillomavirus":[8],"(HPV)":[9],"is":[10],"being":[11],"discussed":[12],"as":[13,34],"a":[14,90,105,156,203],"risk":[15,35,207],"factor":[16],"for":[17,37,59,114,187,259],"high-grade":[18,39],"cervical":[19,145,263],"lesions.":[20],"However,":[21],"conflicting":[22],"data":[23],"about":[24],"the":[25,32,47,66,71,75,125,130,166],"integration":[26,55],"status":[27,56],"or":[28,62],"viral":[29,52,68,131,139,160,199,224,233,237,248],"load":[30,53,69,140,161,234,249],"virus":[33],"factors":[36],"prevalent":[38,60,243],"squamous":[40],"intraepithelial":[41],"lesions":[42],"(HSIL)":[43],"are":[44,57],"found":[45,154],"in":[46,77,159,223],"literature.":[48],"To":[49],"investigate":[50],"whether":[51],"and/or":[54],"indicative":[58],"ASCUS/LSIL":[61,169,209],"HSIL,":[63,244],"we":[64,201],"determined":[65],"HPV16":[67,82,115],"and":[70,118,129,141,174,214,235,250],"physical":[72,127,142,251],"state":[73,128,143,252],"644":[78],"women":[79,196,261],"with":[80,111,144,165,183,197,242],"single":[81],"infections":[83],"stratified":[84],"by":[85],"their":[86],"cytology":[87],"results":[88],"from":[89],"large":[91],"Danish":[92],"population-based":[93],"cohort":[94],"consisting":[95],"40,399":[97],"women.":[98],"Cervical":[99],"smear":[100],"samples":[101],"were":[102,147,239],"tested":[103],"using":[104,149],"multiplex":[106],"quantitative":[107],"real-time":[108],"PCR":[109],"(qPCR)":[110],"primers":[112],"specific":[113],"E2,":[116],"E6":[117],"beta":[119],"actin,":[120],"allowing":[121],"simultaneous":[122],"determination":[123],"genome's":[126],"per":[134,220],"cell.":[135],"The":[136],"associations":[137],"abnormalities":[146],"assessed":[148],"multinomial":[150],"logistic":[151],"regression.":[152],"We":[153],"that":[155,247],"10-fold":[157,221],"increase":[158,222],"was":[162,185],"significantly":[163,240],"associated":[164,241],"presence":[167],"(OR=3.91;":[170],"95%":[171,177,192,211,217],"CI,":[172,178,193],"2.49-6.13)":[173],"HSIL":[175,184,215],"(OR=4.1;":[176],"2.45-6.68).":[179],"A":[180],"significant":[181],"association":[182],"observed":[186,202],"primarily":[188],"integrated":[189,198,236],"genomes":[190,238],"(OR=6.68;":[191],"1.45-30.8).":[194],"Among":[195],"genomes,":[200],"trend":[204],"towards":[205],"increased":[206],"(OR=1.32;":[210],"CI":[212,218],"-2.90-3.44)":[213],"(OR=5.10;":[216],"-0.67-38.9)":[219],"load,":[225],"although":[226],"not":[227],"statistically":[228],"significant.":[229],"In":[230],"conclusion,":[231],"increasing":[232],"thus":[245],"indicating":[246],"may":[253],"potentially":[254],"be":[255],"useful":[256],"triage":[257],"markers":[258],"HPV16-positive":[260],"during":[262],"screening.":[264]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":7}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-11-22T00:00:00"}
