{"id":"https://openalex.org/W2984504366","doi":"https://doi.org/10.3390/ijms20225800","title":"The Regulation of NFE2L2 (NRF2) Signalling and Epithelial-to-Mesenchymal Transition in Age-Related Macular Degeneration Pathology","display_name":"The Regulation of NFE2L2 (NRF2) Signalling and Epithelial-to-Mesenchymal Transition in Age-Related Macular Degeneration Pathology","publication_year":2019,"publication_date":"2019-11-18","ids":{"openalex":"https://openalex.org/W2984504366","doi":"https://doi.org/10.3390/ijms20225800","mag":"2984504366","pmid":"https://pubmed.ncbi.nlm.nih.gov/31752195","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6888570"},"language":"en","primary_location":{"id":"doi:10.3390/ijms20225800","doi":"https://doi.org/10.3390/ijms20225800","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/ijms20225800","pdf_url":"https://www.mdpi.com/1422-0067/20/22/5800/pdf?version=1574298155","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/20/22/5800/pdf?version=1574298155","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063873950","display_name":"Juha M. T. Hyttinen","orcid":"https://orcid.org/0000-0002-3414-4032","observed_orcids":["https://orcid.org/0000-0002-3414-4032"]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"Juha M. T. Hyttinen","raw_affiliation_strings":["Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059784129","display_name":"Ram Kannan","orcid":"https://orcid.org/0000-0002-1583-3414","observed_orcids":["https://orcid.org/0000-0002-1583-3414"]},"institutions":[{"id":"https://openalex.org/I4210095445","display_name":"Doheny Eye Institute","ror":"https://ror.org/00qvx5329","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210095445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ram Kannan","raw_affiliation_strings":["The Stephen J. Ryan Initiative for Macular Research (RIMR), Doheny Eye Institute, DVRC 203, 1355 San Pablo Street, Los Angeles, CA 90033, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Stephen J. Ryan Initiative for Macular Research (RIMR), Doheny Eye Institute, DVRC 203, 1355 San Pablo Street, Los Angeles, CA 90033, USA","institution_ids":["https://openalex.org/I4210095445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078927638","display_name":"Szabolcs Felszeghy","orcid":"https://orcid.org/0000-0003-2656-3939","observed_orcids":["https://orcid.org/0000-0003-2656-3939"]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Szabolcs Felszeghy","raw_affiliation_strings":["Institute of Biomedicine, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland","Institute of Dentistry, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedicine, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]},{"raw_affiliation_string":"Institute of Dentistry, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021206221","display_name":"Minna Niittykoski","orcid":"https://orcid.org/0000-0002-2816-9874","observed_orcids":["https://orcid.org/0000-0002-2816-9874"]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Minna Niittykoski","raw_affiliation_strings":["A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080618425","display_name":"Antero Salminen","orcid":"https://orcid.org/0000-0001-6691-6909","observed_orcids":["https://orcid.org/0000-0001-6691-6909"]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Antero Salminen","raw_affiliation_strings":["Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021448617","display_name":"Kai Kaarniranta","orcid":"https://orcid.org/0000-0003-2600-8679","observed_orcids":["https://orcid.org/0000-0003-2600-8679"]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]},{"id":"https://openalex.org/I4210092991","display_name":"Kuopio University Hospital","ror":"https://ror.org/00fqdfs68","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210092991","https://openalex.org/I4405278559"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Kai Kaarniranta","raw_affiliation_strings":["Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland","Department of Ophthalmology, Kuopio University Hospital, P.O. Box 100, 70029 KYS Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]},{"raw_affiliation_string":"Department of Ophthalmology, Kuopio University Hospital, P.O. Box 100, 70029 KYS Kuopio, Finland","institution_ids":["https://openalex.org/I4210092991"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5063873950"],"corresponding_institution_ids":["https://openalex.org/I175532246"],"apc_list":{"value":1800,"currency":"CHF","value_usd":1824},"apc_paid":{"value":1800,"currency":"CHF","value_usd":1824},"fwci":1.7063,"has_fulltext":true,"cited_by_count":72,"citation_normalized_percentile":{"value":0.83891753,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"20","issue":"22","first_page":"5800","last_page":"5800"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.8755000233650208,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.8755000233650208,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.1128000020980835,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/age-related-macular-degeneration","display_name":"age-related macular degeneration","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.9589999914169312},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.949999988079071},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9940000176429749},{"id":"https://openalex.org/keywords/retinal-pigment-epithelium","display_name":"retinal pigment epithelium","score":0.9980000257492065},{"id":"https://openalex.org/keywords/retinal-fibrosis","display_name":"retinal fibrosis","score":0.8429999947547913}],"concepts":[{"id":"https://openalex.org/C2776403814","wikidata":"https://www.wikidata.org/wiki/Q27429789","display_name":"Macular degeneration","level":2,"score":0.9304050207138062},{"id":"https://openalex.org/C2778024200","wikidata":"https://www.wikidata.org/wiki/Q2346242","display_name":"Retinal pigment epithelium","level":3,"score":0.6586788892745972},{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.6247734427452087},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5670979022979736},{"id":"https://openalex.org/C2779093074","wikidata":"https://www.wikidata.org/wiki/Q1140528","display_name":"Drusen","level":3,"score":0.4537336230278015},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4232773780822754},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4202057123184204},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3985975384712219},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34914907813072205},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3355821967124939},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3338392972946167},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.2205689549446106},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.21100419759750366},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2047760784626007},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16577160358428955},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11492007970809937},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.09617915749549866},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008268","descriptor_name":"Macular Degeneration","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008268","descriptor_name":"Macular Degeneration","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055213","descriptor_name":"Retinal Pigment Epithelium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055213","descriptor_name":"Retinal Pigment Epithelium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D058750","descriptor_name":"Epithelial-Mesenchymal Transition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3390/ijms20225800","doi":"https://doi.org/10.3390/ijms20225800","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/ijms20225800","pdf_url":"https://www.mdpi.com/1422-0067/20/22/5800/pdf?version=1574298155","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6888570","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6888570","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:31752195","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31752195","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:9db6b6af959e447ebcaf4bc51825ea45","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/9db6b6af959e447ebcaf4bc51825ea45","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Sciences, Vol 20, Iss 22, p 5800 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/ijms20225800","doi":"https://doi.org/10.3390/ijms20225800","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/ijms20225800","pdf_url":"https://www.mdpi.com/1422-0067/20/22/5800/pdf?version=1574298155","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Partnerships for the goals","score":0.49000000953674316,"id":"https://metadata.un.org/sdg/17"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1179284138","display_name":null,"funder_award_id":"296840","funder_id":"https://openalex.org/F4320322356","funder_display_name":"Kuopion Yliopistollinen Sairaala"},{"id":"https://openalex.org/G1440975073","display_name":null,"funder_award_id":"296840","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G3437687327","display_name":null,"funder_award_id":"296840","funder_id":"https://openalex.org/F4320328032","funder_display_name":"Silm\u00e4s\u00e4\u00e4ti\u00f6"},{"id":"https://openalex.org/G433546193","display_name":null,"funder_award_id":"5503743","funder_id":"https://openalex.org/F4320322356","funder_display_name":"Kuopion Yliopistollinen Sairaala"},{"id":"https://openalex.org/G6865327707","display_name":null,"funder_award_id":"296840","funder_id":"https://openalex.org/F4320322456","funder_display_name":"P\u00e4ivikki ja Sakari Sohlbergin S\u00e4\u00e4ti\u00f6"}],"funders":[{"id":"https://openalex.org/F4320310055","display_name":"It\u00e4-Suomen Yliopisto","ror":"https://ror.org/00cyydd11"},{"id":"https://openalex.org/F4320312354","display_name":"\u00d6gonfonden","ror":"https://ror.org/00n58s174"},{"id":"https://openalex.org/F4320321108","display_name":"Academy of Finland","ror":"https://ror.org/05k73zm37"},{"id":"https://openalex.org/F4320322356","display_name":"Kuopion Yliopistollinen Sairaala","ror":"https://ror.org/00fqdfs68"},{"id":"https://openalex.org/F4320322456","display_name":"P\u00e4ivikki ja Sakari Sohlbergin S\u00e4\u00e4ti\u00f6","ror":"https://ror.org/03bj5da63"},{"id":"https://openalex.org/F4320328032","display_name":"Silm\u00e4s\u00e4\u00e4ti\u00f6","ror":"https://ror.org/033r0hh63"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2984504366.pdf","grobid_xml":"https://content.openalex.org/works/W2984504366.grobid-xml"},"referenced_works_count":278,"referenced_works":["https://openalex.org/W171311212","https://openalex.org/W199058501","https://openalex.org/W320198380","https://openalex.org/W373873944","https://openalex.org/W775311174","https://openalex.org/W952491933","https://openalex.org/W1084058705","https://openalex.org/W1523693806","https://openalex.org/W1530827369","https://openalex.org/W1531477522","https://openalex.org/W1561096292","https://openalex.org/W1604547442","https://openalex.org/W1715823723","https://openalex.org/W1784434253","https://openalex.org/W1814756288","https://openalex.org/W1826137220","https://openalex.org/W1896020998","https://openalex.org/W1898729433","https://openalex.org/W1899746275","https://openalex.org/W1938542587","https://openalex.org/W1955438350","https://openalex.org/W1963501822","https://openalex.org/W1964190328","https://openalex.org/W1964847767","https://openalex.org/W1965827991","https://openalex.org/W1965957522","https://openalex.org/W1967828638","https://openalex.org/W1968425609","https://openalex.org/W1968883331","https://openalex.org/W1969392895","https://openalex.org/W1973103230","https://openalex.org/W1974437991","https://openalex.org/W1975940353","https://openalex.org/W1976448006","https://openalex.org/W1978882265","https://openalex.org/W1980811308","https://openalex.org/W1981887843","https://openalex.org/W1982723437","https://openalex.org/W1983390331","https://openalex.org/W1983929660","https://openalex.org/W1984107344","https://openalex.org/W1985026615","https://openalex.org/W1988024592","https://openalex.org/W1988227670","https://openalex.org/W1990271214","https://openalex.org/W1990949451","https://openalex.org/W1991631628","https://openalex.org/W1992101294","https://openalex.org/W1992681889","https://openalex.org/W1995513142","https://openalex.org/W1999148207","https://openalex.org/W1999273706","https://openalex.org/W1999872962","https://openalex.org/W2001591494","https://openalex.org/W2002061608","https://openalex.org/W2003503672","https://openalex.org/W2004112218","https://openalex.org/W2006242015","https://openalex.org/W2007014682","https://openalex.org/W2007973129","https://openalex.org/W2009247499","https://openalex.org/W2013654121","https://openalex.org/W2014475655","https://openalex.org/W2014687077","https://openalex.org/W2016435749","https://openalex.org/W2017136158","https://openalex.org/W2018427433","https://openalex.org/W2020608357","https://openalex.org/W2021270662","https://openalex.org/W2021814263","https://openalex.org/W2021910662","https://openalex.org/W2021945948","https://openalex.org/W2023598683","https://openalex.org/W2027881600","https://openalex.org/W2030856137","https://openalex.org/W2030867249","https://openalex.org/W2032627423","https://openalex.org/W2032749652","https://openalex.org/W2034421571","https://openalex.org/W2035396934","https://openalex.org/W2036704550","https://openalex.org/W2037657244","https://openalex.org/W2038612772","https://openalex.org/W2039002855","https://openalex.org/W2039874643","https://openalex.org/W2040064522","https://openalex.org/W2040114786","https://openalex.org/W2045247817","https://openalex.org/W2047052890","https://openalex.org/W2048030072","https://openalex.org/W2050703639","https://openalex.org/W2051019986","https://openalex.org/W2051494994","https://openalex.org/W2052408989","https://openalex.org/W2053063855","https://openalex.org/W2053405442","https://openalex.org/W2057539833","https://openalex.org/W2060241324","https://openalex.org/W2060362359","https://openalex.org/W2063028754","https://openalex.org/W2065371404","https://openalex.org/W2065942680","https://openalex.org/W2068671512","https://openalex.org/W2071313689","https://openalex.org/W2074817792","https://openalex.org/W2077895679","https://openalex.org/W2080119127","https://openalex.org/W2080155284","https://openalex.org/W2080261745","https://openalex.org/W2081802434","https://openalex.org/W2082835477","https://openalex.org/W2083371936","https://openalex.org/W2086378628","https://openalex.org/W2087386497","https://openalex.org/W2089525975","https://openalex.org/W2091055530","https://openalex.org/W2092482659","https://openalex.org/W2092758553","https://openalex.org/W2093295909","https://openalex.org/W2094117056","https://openalex.org/W2095158646","https://openalex.org/W2095714788","https://openalex.org/W2096065258","https://openalex.org/W2097634036","https://openalex.org/W2101084484","https://openalex.org/W2101540252","https://openalex.org/W2102354517","https://openalex.org/W2109034822","https://openalex.org/W2111274886","https://openalex.org/W2112052713","https://openalex.org/W2115338196","https://openalex.org/W2116223499","https://openalex.org/W2117871001","https://openalex.org/W2117917811","https://openalex.org/W2120480388","https://openalex.org/W2122044177","https://openalex.org/W2122065834","https://openalex.org/W2126934086","https://openalex.org/W2129264099","https://openalex.org/W2129325060","https://openalex.org/W2130029858","https://openalex.org/W2132892999","https://openalex.org/W2133954905","https://openalex.org/W2135995469","https://openalex.org/W2137373909","https://openalex.org/W2137761999","https://openalex.org/W2142670987","https://openalex.org/W2148607448","https://openalex.org/W2154589460","https://openalex.org/W2158535498","https://openalex.org/W2158716366","https://openalex.org/W2160226180","https://openalex.org/W2163798990","https://openalex.org/W2164663225","https://openalex.org/W2165468754","https://openalex.org/W2165901622","https://openalex.org/W2166649117","https://openalex.org/W2168212241","https://openalex.org/W2168395641","https://openalex.org/W2169052484","https://openalex.org/W2169680924","https://openalex.org/W2171218310","https://openalex.org/W2173462178","https://openalex.org/W2174675031","https://openalex.org/W2202703189","https://openalex.org/W2207044403","https://openalex.org/W2214193457","https://openalex.org/W2218490930","https://openalex.org/W2221163883","https://openalex.org/W2234001892","https://openalex.org/W2236886709","https://openalex.org/W2258772674","https://openalex.org/W2264982258","https://openalex.org/W2269360289","https://openalex.org/W2273142706","https://openalex.org/W2292591940","https://openalex.org/W2293092002","https://openalex.org/W2305005443","https://openalex.org/W2309675626","https://openalex.org/W2313536763","https://openalex.org/W2315925646","https://openalex.org/W2339680553","https://openalex.org/W2340338776","https://openalex.org/W2344051932","https://openalex.org/W2346475789","https://openalex.org/W2463082079","https://openalex.org/W2463176095","https://openalex.org/W2487655429","https://openalex.org/W2495582206","https://openalex.org/W2496399177","https://openalex.org/W2498125942","https://openalex.org/W2509051476","https://openalex.org/W2513174667","https://openalex.org/W2521343068","https://openalex.org/W2525039541","https://openalex.org/W2527716629","https://openalex.org/W2529992956","https://openalex.org/W2537898560","https://openalex.org/W2552484355","https://openalex.org/W2559175446","https://openalex.org/W2559284385","https://openalex.org/W2563497525","https://openalex.org/W2566643825","https://openalex.org/W2566910587","https://openalex.org/W2568774976","https://openalex.org/W2573963236","https://openalex.org/W2579804224","https://openalex.org/W2580838661","https://openalex.org/W2594015133","https://openalex.org/W2598351654","https://openalex.org/W2605631009","https://openalex.org/W2614711052","https://openalex.org/W2620784367","https://openalex.org/W2625941776","https://openalex.org/W2694095774","https://openalex.org/W2727096719","https://openalex.org/W2734165961","https://openalex.org/W2738996050","https://openalex.org/W2743830008","https://openalex.org/W2745428357","https://openalex.org/W2746172096","https://openalex.org/W2751709667","https://openalex.org/W2755686579","https://openalex.org/W2756208820","https://openalex.org/W2762844085","https://openalex.org/W2766072135","https://openalex.org/W2768709890","https://openalex.org/W2769077130","https://openalex.org/W2771506923","https://openalex.org/W2774895818","https://openalex.org/W2777352963","https://openalex.org/W2777753472","https://openalex.org/W2782521952","https://openalex.org/W2787642299","https://openalex.org/W2787724467","https://openalex.org/W2792235400","https://openalex.org/W2794139372","https://openalex.org/W2794898956","https://openalex.org/W2795555262","https://openalex.org/W2800211923","https://openalex.org/W2803368104","https://openalex.org/W2803977908","https://openalex.org/W2809261456","https://openalex.org/W2809270825","https://openalex.org/W2809479151","https://openalex.org/W2826708737","https://openalex.org/W2884082777","https://openalex.org/W2885494745","https://openalex.org/W2887215970","https://openalex.org/W2887977772","https://openalex.org/W2889611453","https://openalex.org/W2889672514","https://openalex.org/W2890361890","https://openalex.org/W2890851015","https://openalex.org/W2891031609","https://openalex.org/W2893953017","https://openalex.org/W2894685444","https://openalex.org/W2894888786","https://openalex.org/W2898292602","https://openalex.org/W2899167901","https://openalex.org/W2899531007","https://openalex.org/W2899864830","https://openalex.org/W2903716049","https://openalex.org/W2910269822","https://openalex.org/W2910409074","https://openalex.org/W2912136735","https://openalex.org/W2913211229","https://openalex.org/W2917254076","https://openalex.org/W2920994691","https://openalex.org/W2946298228","https://openalex.org/W4248078302","https://openalex.org/W6635869713","https://openalex.org/W6681867550","https://openalex.org/W6731858637","https://openalex.org/W6738370941","https://openalex.org/W6747171933","https://openalex.org/W6756089835","https://openalex.org/W7075616282"],"related_works":["https://openalex.org/W4400010264","https://openalex.org/W3034099144","https://openalex.org/W2034421571","https://openalex.org/W2036704550","https://openalex.org/W2258002496","https://openalex.org/W6968837101","https://openalex.org/W4410442706","https://openalex.org/W3127494486","https://openalex.org/W7079914155","https://openalex.org/W2995649437"],"abstract_inverted_index":{"Age-related":[0],"macular":[1],"degeneration":[2],"(AMD)":[3],"is":[4,30,40,49,97],"a":[5,19,31,106,124,139,165],"mounting":[6],"cause":[7],"of":[8,10,26,66,74,102,108,117,141,144,170,176,188],"loss":[9],"sight":[11],"in":[12,15,79,99,114,126,137,185],"the":[13,16,23,27,56,64,71,84,100,115,127,134,145,168,186],"elderly":[14],"developed":[17],"countries,":[18],"trend":[20],"enhanced":[21],"by":[22,151],"continual":[24],"ageing":[25],"population.":[28],"AMD":[29,46],"multifactorial":[32],"and":[33,61,105,172],"only":[34],"partly":[35],"understood,":[36],"malady.":[37],"Unfortunately,":[38],"there":[39],"no":[41],"effective":[42],"treatment":[43],"for":[44],"most":[45],"patients.":[47],"It":[48],"known":[50],"that":[51],"oxidative":[52,103],"stress":[53],"(OS)":[54],"damages":[55],"retinal":[57],"pigment":[58],"epithelium":[59],"(RPE)":[60],"contributes":[62],"to":[63,81,133],"progression":[65],"AMD.":[67,82,118,142,189],"We":[68],"review":[69],"here":[70],"potential":[72],"importance":[73],"two":[75,158],"OS-related":[76],"cellular":[77,128,179],"systems":[78],"relation":[80],"First,":[83],"nuclear":[85],"factor":[86,89],"erythroid":[87],"2-related":[88],"2":[90],"(NFE2L2;":[91],"NRF2)-mediated":[92],"OS":[93],"response":[94],"signalling":[95,159],"pathway":[96],"important":[98],"prevention":[101],"damage":[104,180],"failure":[107],"this":[109],"system":[110],"could":[111,181],"be":[112,182],"critical":[113],"development":[116],"Second,":[119],"epithelial-to-mesenchymal":[120],"transition":[121],"(EMT)":[122],"represents":[123],"change":[125],"phenotype,":[129],"which":[130],"ultimately":[131],"leads":[132],"fibrosis":[135],"encountered":[136],"RPE,":[138],"characteristic":[140],"Many":[143],"pathways":[146],"triggering":[147],"EMT":[148,173],"are":[149,161],"promoted":[150],"OS.":[152],"The":[153],"possible":[154],"interconnections":[155],"between":[156],"these":[157],"routes":[160],"discussed":[162],"here.":[163],"From":[164],"broader":[166],"perspective,":[167],"control":[169],"NFE2L2":[171],"as":[174],"ways":[175],"preventing":[177],"OS-derived":[178],"potentially":[183],"valuable":[184],"therapy":[187]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-11-22T00:00:00"}