{"id":"https://openalex.org/W2984202091","doi":"https://doi.org/10.1097/mnh.0000000000000568","title":"Novel dietary and pharmacologic approaches for acid\u2013base modulation to preserve kidney function and manage uremia","display_name":"Novel dietary and pharmacologic approaches for acid\u2013base modulation to preserve kidney function and manage uremia","publication_year":2019,"publication_date":"2019-11-13","ids":{"openalex":"https://openalex.org/W2984202091","doi":"https://doi.org/10.1097/mnh.0000000000000568","mag":"2984202091","pmid":"https://pubmed.ncbi.nlm.nih.gov/31725012"},"language":"en","primary_location":{"id":"doi:10.1097/mnh.0000000000000568","doi":"https://doi.org/10.1097/mnh.0000000000000568","is_oa":false,"landing_page_url":"https://doi.org/10.1097/mnh.0000000000000568","pdf_url":null,"source":{"id":"https://openalex.org/S185853653","display_name":"Current Opinion in Nephrology & Hypertension","issn_l":"1062-4821","issn":["1062-4821","1080-8221","1473-6543"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Nephrology and Hypertension","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112327253","display_name":"Nimrit Goraya","orcid":"https://orcid.org/0000-0003-1429-5711","observed_orcids":["https://orcid.org/0000-0003-1429-5711"]},"institutions":[{"id":"https://openalex.org/I4210102330","display_name":"Baylor Scott & White Medical Center - Temple","ror":"https://ror.org/017cm6884","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210102330","https://openalex.org/I4210160418"]},{"id":"https://openalex.org/I4210160418","display_name":"Baylor Scott & White Health","ror":"https://ror.org/05wevan27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160418"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nimrit Goraya","raw_affiliation_strings":["Texas A&M College of Medicine Baylor Scott and White Health, Temple Department of Internal Medicine, Temple, and Texas A&M Health Sciences Center College of Medicine The Baylor Scott and White Health and Wellness Center, Dallas, Texas, USA","Baylor Scott and White Health, Temple","Texas A&M College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas A&M College of Medicine Baylor Scott and White Health, Temple Department of Internal Medicine, Temple, and Texas A&M Health Sciences Center College of Medicine The Baylor Scott and White Health and Wellness Center, Dallas, Texas, USA","institution_ids":["https://openalex.org/I4210102330","https://openalex.org/I4210160418"]},{"raw_affiliation_string":"Baylor Scott and White Health, Temple","institution_ids":["https://openalex.org/I4210102330"]},{"raw_affiliation_string":"Texas A&M College of Medicine","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019935894","display_name":"Donald E. Wesson","orcid":"https://orcid.org/0009-0007-7952-7401","observed_orcids":["https://orcid.org/0009-0007-7952-7401"]},"institutions":[{"id":"https://openalex.org/I125029298","display_name":"Texas A&M Health Science Center","ror":"https://ror.org/01tx6pn92","country_code":"US","type":"education","lineage":["https://openalex.org/I125029298","https://openalex.org/I91045830"]},{"id":"https://openalex.org/I4210160418","display_name":"Baylor Scott & White Health","ror":"https://ror.org/05wevan27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160418"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Donald E. Wesson","raw_affiliation_strings":["Department of Internal Medicine, Temple, and Texas A&M Health Sciences Center College of Medicine","The Baylor Scott and White Health and Wellness Center, Dallas, Texas, USA","to Donald E. Wesson, MD, Baylor Scott and White Health and Wellness Center, Texas A&M Health Sciences Center College of Medicine, 4500 Spring Avenue, Dallas, TX 75216, USA. Tel: +1 214 865 3064; fax: +1 214 865 3070; e-mail: [email\u00a0protected]","e-mail: [email\u00a0protected]","fax: +1 214 865 3070","to Donald E. Wesson, MD, Baylor Scott and White Health and Wellness Center, Texas A&M Health Sciences Center College of Medicine, 4500 Spring Avenue, Dallas, TX 75216, USA. Tel: +1 214 865 3064"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Temple, and Texas A&M Health Sciences Center College of Medicine","institution_ids":["https://openalex.org/I125029298","https://openalex.org/I91045830"]},{"raw_affiliation_string":"The Baylor Scott and White Health and Wellness Center, Dallas, Texas, USA","institution_ids":["https://openalex.org/I4210160418"]},{"raw_affiliation_string":"to Donald E. Wesson, MD, Baylor Scott and White Health and Wellness Center, Texas A&M Health Sciences Center College of Medicine, 4500 Spring Avenue, Dallas, TX 75216, USA. Tel: +1 214 865 3064; fax: +1 214 865 3070; e-mail: [email\u00a0protected]","institution_ids":["https://openalex.org/I125029298","https://openalex.org/I4210160418"]},{"raw_affiliation_string":"e-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"fax: +1 214 865 3070","institution_ids":[]},{"raw_affiliation_string":"to Donald E. Wesson, MD, Baylor Scott and White Health and Wellness Center, Texas A&M Health Sciences Center College of Medicine, 4500 Spring Avenue, Dallas, TX 75216, USA. Tel: +1 214 865 3064","institution_ids":["https://openalex.org/I4210160418"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5019935894"],"corresponding_institution_ids":["https://openalex.org/I125029298","https://openalex.org/I4210160418","https://openalex.org/I91045830"],"apc_list":null,"apc_paid":null,"fwci":0.3114,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.32734153,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"29","issue":"1","first_page":"39","last_page":"48"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.5160999894142151,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.5160999894142151,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12840","display_name":"Renal function and acid-base balance","score":0.45260000228881836,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.008999999612569809,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-kidney-disease-progression","display_name":"chronic kidney disease progression","score":0.9940000176429749},{"id":"https://openalex.org/keywords/acid-stress","display_name":"acid stress","score":0.843999981880188},{"id":"https://openalex.org/keywords/metabolic-acidosis","display_name":"metabolic acidosis","score":0.7929999828338623},{"id":"https://openalex.org/keywords/renal-protection","display_name":"renal protection","score":0.5040000081062317},{"id":"https://openalex.org/keywords/uremia","display_name":"uremia","score":0.7459999918937683},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9860000014305115},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.6240000128746033},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cigarette-smoking","display_name":"cigarette smoking","score":0.7099999785423279},{"id":"https://openalex.org/keywords/dietary-intervention","display_name":"dietary intervention","score":0.9120000004768372},{"id":"https://openalex.org/keywords/pharmacological-interventions","display_name":"pharmacological interventions","score":0.7319999933242798},{"id":"https://openalex.org/keywords/smoking-cessation","display_name":"smoking cessation","score":0.5389999747276306}],"concepts":[{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.8132747411727905},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6882331371307373},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6882126927375793},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4861876368522644},{"id":"https://openalex.org/C2776635150","wikidata":"https://www.wikidata.org/wiki/Q13365776","display_name":"Uremia","level":2,"score":0.4688739776611328},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.45357832312583923},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.433488667011261},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4010627269744873},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3887465298175812},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3504815101623535},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.134613037109375}],"mesh":[{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000136","descriptor_name":"Acid-Base Equilibrium","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014511","descriptor_name":"Uremia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014511","descriptor_name":"Uremia","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D057911","descriptor_name":"Angiotensin Receptor Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/mnh.0000000000000568","doi":"https://doi.org/10.1097/mnh.0000000000000568","is_oa":false,"landing_page_url":"https://doi.org/10.1097/mnh.0000000000000568","pdf_url":null,"source":{"id":"https://openalex.org/S185853653","display_name":"Current Opinion in Nephrology & Hypertension","issn_l":"1062-4821","issn":["1062-4821","1080-8221","1473-6543"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Nephrology and Hypertension","raw_type":"journal-article"},{"id":"pmid:31725012","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31725012","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in nephrology and hypertension","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2236202782","display_name":"Reducing chronic kidney disease burden in an underserved population","funder_award_id":"R21DK113440","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":99,"referenced_works":["https://openalex.org/W102131595","https://openalex.org/W1502733965","https://openalex.org/W1966368391","https://openalex.org/W1968794790","https://openalex.org/W1970498119","https://openalex.org/W1972949428","https://openalex.org/W1973666679","https://openalex.org/W1976341970","https://openalex.org/W1977362933","https://openalex.org/W1983636771","https://openalex.org/W1990460736","https://openalex.org/W1991210746","https://openalex.org/W1991734701","https://openalex.org/W1994174181","https://openalex.org/W2000060059","https://openalex.org/W2002497681","https://openalex.org/W2004230365","https://openalex.org/W2006335407","https://openalex.org/W2009572885","https://openalex.org/W2010550213","https://openalex.org/W2014046186","https://openalex.org/W2017689959","https://openalex.org/W2020772760","https://openalex.org/W2023113567","https://openalex.org/W2023824179","https://openalex.org/W2030530251","https://openalex.org/W2035799712","https://openalex.org/W2039312335","https://openalex.org/W2043666955","https://openalex.org/W2044075985","https://openalex.org/W2045621264","https://openalex.org/W2047221974","https://openalex.org/W2048627003","https://openalex.org/W2049099916","https://openalex.org/W2055623658","https://openalex.org/W2059726620","https://openalex.org/W2060804509","https://openalex.org/W2062197547","https://openalex.org/W2065876809","https://openalex.org/W2065895671","https://openalex.org/W2066523471","https://openalex.org/W2069148587","https://openalex.org/W2078075875","https://openalex.org/W2085323089","https://openalex.org/W2091886687","https://openalex.org/W2096606258","https://openalex.org/W2097312477","https://openalex.org/W2097805169","https://openalex.org/W2100860618","https://openalex.org/W2104170721","https://openalex.org/W2104357975","https://openalex.org/W2104975759","https://openalex.org/W2105922007","https://openalex.org/W2106947836","https://openalex.org/W2108629029","https://openalex.org/W2115358501","https://openalex.org/W2117650285","https://openalex.org/W2118265549","https://openalex.org/W2119924280","https://openalex.org/W2120235169","https://openalex.org/W2121061355","https://openalex.org/W2129559166","https://openalex.org/W2132264428","https://openalex.org/W2132389690","https://openalex.org/W2132638001","https://openalex.org/W2132820464","https://openalex.org/W2141438558","https://openalex.org/W2146488133","https://openalex.org/W2147085936","https://openalex.org/W2150908752","https://openalex.org/W2151343477","https://openalex.org/W2154905690","https://openalex.org/W2162369874","https://openalex.org/W2162483948","https://openalex.org/W2164860876","https://openalex.org/W2168987491","https://openalex.org/W2171540831","https://openalex.org/W2172140066","https://openalex.org/W2180350916","https://openalex.org/W2243040103","https://openalex.org/W2347092661","https://openalex.org/W2397513318","https://openalex.org/W2428037793","https://openalex.org/W2510521632","https://openalex.org/W2580767461","https://openalex.org/W2589957161","https://openalex.org/W2605075104","https://openalex.org/W2620100369","https://openalex.org/W2755728348","https://openalex.org/W2761903250","https://openalex.org/W2767614071","https://openalex.org/W2768439266","https://openalex.org/W2800762318","https://openalex.org/W2886853362","https://openalex.org/W2896592652","https://openalex.org/W2903428876","https://openalex.org/W2905034532","https://openalex.org/W2930835088","https://openalex.org/W2940408000"],"related_works":["https://openalex.org/W3207252461","https://openalex.org/W1974365779","https://openalex.org/W4297101520","https://openalex.org/W1222622451","https://openalex.org/W2012979540","https://openalex.org/W2770529219","https://openalex.org/W2013564590","https://openalex.org/W2604997079","https://openalex.org/W2915213565","https://openalex.org/W1992387069"],"abstract_inverted_index":{"PURPOSE":[0],"OF":[1],"REVIEW:":[2],"We":[3],"review":[4],"mechanisms":[5],"for":[6,183],"chronic":[7],"kidney":[8,161,184],"disease":[9,99],"(CKD)":[10],"progression":[11,91,118,134,158,209],"that":[12,63,73],"might":[13],"be":[14,212],"addressed":[15,214],"with":[16,104],"nonpharmacologic":[17,216],"and":[18,92,107,135,140,149,178,200,210,217],"novel":[19,108,218],"pharmacologic":[20,109,181,219],"interventions":[21,110],"as":[22,54,113],"strategies":[23,114],"by":[24,159,215],"which":[25,50],"to":[26,53,57,76,87,89,93,115,131,154,168,170,188,205,207],"slow":[27,116],"or":[28],"even":[29],"prevent":[30],"CKD":[31,58,90,117,133,157,208],"progression.":[32,59],"RECENT":[33],"FINDINGS:":[34],"Evolving":[35],"data":[36],"support":[37,62],"the":[38,41,94,171],"contribution":[39],"of":[40,44,46,65,70,122,174],"broad":[42],"spectrum":[43],"disorders":[45],"acid":[47],"(H)":[48],"accumulation,":[49],"we":[51],"refer":[52],"'H":[55],"stress',":[56],"Recent":[60],"studies":[61],"amelioration":[64],"H":[66,71],"stress,":[67,195],"including":[68],"spectra":[69],"accumulation":[72],"are":[74],"insufficient":[75],"cause":[77],"metabolic":[78],"acidosis,":[79],"is":[80],"kidney-protective.":[81],"In":[82,126],"addition,":[83,127],"gut-derived":[84,124],"toxins":[85],"appear":[86,204],"contribute":[88,206],"well":[95],"described":[96],"increased":[97],"cardiovascular":[98],"(CVD)":[100],"risk":[101],"in":[102],"patients":[103],"CKD.":[105],"Dietary":[106,147],"hold":[111,152],"promise":[112,153],"through":[119],"reducing":[120,160],"levels":[121],"these":[123],"toxins.":[125],"oxidative":[128,145,162,201],"stress":[129,202],"appears":[130],"mediate":[132],"contributing":[136],"factors":[137],"like":[138],"diet":[139],"cigarette":[141],"smoking":[142,150],"can":[143,211],"exacerbate":[144],"stress.":[146,163],"changes":[148],"cessation":[151],"favorably":[155],"affect":[156],"SUMMARY:":[164],"The":[165],"urgent":[166],"need":[167],"add":[169],"traditional":[172],"armamentarium":[173],"blood":[175],"pressure":[176],"control":[177],"antiangiotensin":[179],"II":[180],"therapy":[182],"protection":[185],"has":[186],"led":[187],"investigations":[189],"into":[190],"additional":[191],"kidney-protective":[192],"strategies.":[193],"Acid":[194],"a":[196],"disordered":[197],"gut":[198],"microbiome,":[199],"each":[203],"potentially":[213],"interventions.":[220]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-11-22T00:00:00"}
