{"id":"https://openalex.org/W2983754697","doi":"https://doi.org/10.1021/acsomega.9b02201","title":"Design of a Helical-Stabilized, Cyclic, and Nontoxic Analogue of the Peptide Cm-p5 with Improved Antifungal Activity","display_name":"Design of a Helical-Stabilized, Cyclic, and Nontoxic Analogue of the Peptide Cm-p5 with Improved Antifungal Activity","publication_year":2019,"publication_date":"2019-11-05","ids":{"openalex":"https://openalex.org/W2983754697","doi":"https://doi.org/10.1021/acsomega.9b02201","mag":"2983754697","pmid":"https://pubmed.ncbi.nlm.nih.gov/31763531","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6868880"},"language":"en","primary_location":{"id":"doi:10.1021/acsomega.9b02201","doi":"https://doi.org/10.1021/acsomega.9b02201","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsomega.9b02201","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acsomega.9b02201","source":{"id":"https://openalex.org/S4210239500","display_name":"ACS Omega","issn_l":"2470-1343","issn":["2470-1343"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://pubs.acs.org/doi/pdf/10.1021/acsomega.9b02201","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047179012","display_name":"Fidel Morales-Vicente","orcid":"https://orcid.org/0000-0003-2037-239X","observed_orcids":["https://orcid.org/0000-0003-2037-239X"]},"institutions":[{"id":"https://openalex.org/I177909021","display_name":"Universidade Federal de S\u00e3o Carlos","ror":"https://ror.org/00qdc6m37","country_code":"BR","type":"education","lineage":["https://openalex.org/I177909021"]},{"id":"https://openalex.org/I2656126","display_name":"University of Havana","ror":"https://ror.org/04204gr61","country_code":"CU","type":"education","lineage":["https://openalex.org/I2656126"]},{"id":"https://openalex.org/I4210130720","display_name":"Centro de Ingenier\u00eda Gen\u00e9tica y Biotecnolog\u00eda","ror":"https://ror.org/03qxwgf98","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210130720"]}],"countries":["BR","CU"],"is_corresponding":false,"raw_author_name":"Fidel E. Morales Vicente","raw_affiliation_strings":["Federal University of Sa\u0303o Carlos-UFSCar , , ,","Synthetic Peptides Group, Center for Genetic Engineering and Biotechnology , P.O. Box 6162, ,","University of Havana , , Zapata y G, ,","Center of Excellence for Research in Sustainable Chemistry (CERSusChem), Department of Chemistry, Federal University of S\u00e3o Carlos-UFSCar, S\u00e3o Paulo 13565-905, Brazil","Synthetic Peptides Group, Center for Genetic Engineering and Biotechnology, P.O. Box 6162, 10600 La Habana, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal University of Sa\u0303o Carlos-UFSCar , , ,","institution_ids":["https://openalex.org/I177909021"]},{"raw_affiliation_string":"Synthetic Peptides Group, Center for Genetic Engineering and Biotechnology , P.O. Box 6162, ,","institution_ids":["https://openalex.org/I4210130720"]},{"raw_affiliation_string":"University of Havana , , Zapata y G, ,","institution_ids":["https://openalex.org/I2656126"]},{"raw_affiliation_string":"Center of Excellence for Research in Sustainable Chemistry (CERSusChem), Department of Chemistry, Federal University of S\u00e3o Carlos-UFSCar, S\u00e3o Paulo 13565-905, Brazil","institution_ids":["https://openalex.org/I177909021"]},{"raw_affiliation_string":"Synthetic Peptides Group, Center for Genetic Engineering and Biotechnology, P.O. Box 6162, 10600 La Habana, Cuba","institution_ids":["https://openalex.org/I4210130720"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060672399","display_name":"Melaine Gonz\u00e1lez-Garc\u00eda","orcid":"https://orcid.org/0000-0002-9762-6389","observed_orcids":["https://orcid.org/0000-0002-9762-6389"]},"institutions":[{"id":"https://openalex.org/I2656126","display_name":"University of Havana","ror":"https://ror.org/04204gr61","country_code":"CU","type":"education","lineage":["https://openalex.org/I2656126"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Melaine Gonza\u0301lez-Garcia","raw_affiliation_strings":["University of Havana , , 25 and I, ,","Center for Protein Studies, Faculty of Biology, University of Havana, 25 and I, 10400 La Habana, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Havana , , 25 and I, ,","institution_ids":["https://openalex.org/I2656126"]},{"raw_affiliation_string":"Center for Protein Studies, Faculty of Biology, University of Havana, 25 and I, 10400 La Habana, Cuba","institution_ids":["https://openalex.org/I2656126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025857280","display_name":"Erbio D\u00edaz Pico","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130720","display_name":"Centro de Ingenier\u00eda Gen\u00e9tica y Biotecnolog\u00eda","ror":"https://ror.org/03qxwgf98","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210130720"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Erbio Diaz Pico","raw_affiliation_strings":["Synthetic Peptides Group, Center for Genetic Engineering and Biotechnology , P.O. Box 6162, ,","Synthetic Peptides Group, Center for Genetic Engineering and Biotechnology, P.O. Box 6162, 10600 La Habana, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Synthetic Peptides Group, Center for Genetic Engineering and Biotechnology , P.O. Box 6162, ,","institution_ids":["https://openalex.org/I4210130720"]},{"raw_affiliation_string":"Synthetic Peptides Group, Center for Genetic Engineering and Biotechnology, P.O. Box 6162, 10600 La Habana, Cuba","institution_ids":["https://openalex.org/I4210130720"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061043367","display_name":"Elena Moreno Castillo","orcid":"https://orcid.org/0000-0002-8614-5846","observed_orcids":["https://orcid.org/0000-0002-8614-5846"]},"institutions":[{"id":"https://openalex.org/I2656126","display_name":"University of Havana","ror":"https://ror.org/04204gr61","country_code":"CU","type":"education","lineage":["https://openalex.org/I2656126"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Elena Moreno-Castillo","raw_affiliation_strings":["University of Havana , , Zapata y G, ,","Center for Natural Products Research, Faculty of Chemistry, University of Havana, Zapata y G, 10400 La Habana, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Havana , , Zapata y G, ,","institution_ids":["https://openalex.org/I2656126"]},{"raw_affiliation_string":"Center for Natural Products Research, Faculty of Chemistry, University of Havana, Zapata y G, 10400 La Habana, Cuba","institution_ids":["https://openalex.org/I2656126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074444464","display_name":"Hilda Garay","orcid":"https://orcid.org/0000-0003-3101-255X","observed_orcids":["https://orcid.org/0000-0003-3101-255X"]},"institutions":[{"id":"https://openalex.org/I4210130720","display_name":"Centro de Ingenier\u00eda Gen\u00e9tica y Biotecnolog\u00eda","ror":"https://ror.org/03qxwgf98","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210130720"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Hilda E. Garay","raw_affiliation_strings":["Synthetic Peptides Group, Center for Genetic Engineering and Biotechnology , P.O. Box 6162, ,","Synthetic Peptides Group, Center for Genetic Engineering and Biotechnology, P.O. Box 6162, 10600 La Habana, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Synthetic Peptides Group, Center for Genetic Engineering and Biotechnology , P.O. Box 6162, ,","institution_ids":["https://openalex.org/I4210130720"]},{"raw_affiliation_string":"Synthetic Peptides Group, Center for Genetic Engineering and Biotechnology, P.O. Box 6162, 10600 La Habana, Cuba","institution_ids":["https://openalex.org/I4210130720"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068900809","display_name":"Pablo E. Rosi","orcid":"https://orcid.org/0000-0002-9901-4474","observed_orcids":["https://orcid.org/0000-0002-9901-4474"]},"institutions":[{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Pablo E. Rosi","raw_affiliation_strings":["Universidad de Buenos Aires , , ,","Department of Inorganic Chemistry, Analytical and Physical Chemistry, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires C1428EGA, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidad de Buenos Aires , , ,","institution_ids":["https://openalex.org/I24354313"]},{"raw_affiliation_string":"Department of Inorganic Chemistry, Analytical and Physical Chemistry, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires C1428EGA, Argentina","institution_ids":["https://openalex.org/I24354313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087089006","display_name":"Asiel Mena Jimenez","orcid":"https://orcid.org/0000-0003-1429-0320","observed_orcids":["https://orcid.org/0000-0003-1429-0320"]},"institutions":[{"id":"https://openalex.org/I2656126","display_name":"University of Havana","ror":"https://ror.org/04204gr61","country_code":"CU","type":"education","lineage":["https://openalex.org/I2656126"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Asiel Mena Jimenez","raw_affiliation_strings":["University of Havana , , Zapata y G, ,","Center for Natural Products Research, Faculty of Chemistry, University of Havana, Zapata y G, 10400 La Habana, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Havana , , Zapata y G, ,","institution_ids":["https://openalex.org/I2656126"]},{"raw_affiliation_string":"Center for Natural Products Research, Faculty of Chemistry, University of Havana, Zapata y G, 10400 La Habana, Cuba","institution_ids":["https://openalex.org/I2656126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073599844","display_name":"Jos\u00e9 A. C. Delgado","orcid":"https://orcid.org/0000-0002-5994-7384","observed_orcids":["https://orcid.org/0000-0002-5994-7384"]},"institutions":[{"id":"https://openalex.org/I177909021","display_name":"Universidade Federal de S\u00e3o Carlos","ror":"https://ror.org/00qdc6m37","country_code":"BR","type":"education","lineage":["https://openalex.org/I177909021"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jose A. Campos-Delgado","raw_affiliation_strings":["Federal University of Sa\u0303o Carlos-UFSCar , , ,","Center of Excellence for Research in Sustainable Chemistry (CERSusChem), Department of Chemistry, Federal University of S\u00e3o Carlos-UFSCar, S\u00e3o Paulo 13565-905, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal University of Sa\u0303o Carlos-UFSCar , , ,","institution_ids":["https://openalex.org/I177909021"]},{"raw_affiliation_string":"Center of Excellence for Research in Sustainable Chemistry (CERSusChem), Department of Chemistry, Federal University of S\u00e3o Carlos-UFSCar, S\u00e3o Paulo 13565-905, Brazil","institution_ids":["https://openalex.org/I177909021"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053911504","display_name":"Daniel G. Rivera","orcid":"https://orcid.org/0000-0002-5538-1555","observed_orcids":["https://orcid.org/0000-0002-5538-1555"]},"institutions":[{"id":"https://openalex.org/I2656126","display_name":"University of Havana","ror":"https://ror.org/04204gr61","country_code":"CU","type":"education","lineage":["https://openalex.org/I2656126"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Daniel G. Rivera","raw_affiliation_strings":["University of Havana , , Zapata y G, ,","Center for Natural Products Research, Faculty of Chemistry, University of Havana, Zapata y G, 10400 La Habana, Cuba"],"raw_orcid":"https://orcid.org/0000-0002-5538-1555","affiliations":[{"raw_affiliation_string":"University of Havana , , Zapata y G, ,","institution_ids":["https://openalex.org/I2656126"]},{"raw_affiliation_string":"Center for Natural Products Research, Faculty of Chemistry, University of Havana, Zapata y G, 10400 La Habana, Cuba","institution_ids":["https://openalex.org/I2656126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071334575","display_name":"Glay Chinea","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130720","display_name":"Centro de Ingenier\u00eda Gen\u00e9tica y Biotecnolog\u00eda","ror":"https://ror.org/03qxwgf98","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210130720"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Glay Chinea","raw_affiliation_strings":["Synthetic Peptides Group, Center for Genetic Engineering and Biotechnology , P.O. Box 6162, ,","Synthetic Peptides Group, Center for Genetic Engineering and Biotechnology, P.O. Box 6162, 10600 La Habana, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Synthetic Peptides Group, Center for Genetic Engineering and Biotechnology , P.O. Box 6162, ,","institution_ids":["https://openalex.org/I4210130720"]},{"raw_affiliation_string":"Synthetic Peptides Group, Center for Genetic Engineering and Biotechnology, P.O. Box 6162, 10600 La Habana, Cuba","institution_ids":["https://openalex.org/I4210130720"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003129505","display_name":"Rosemeire Cristina Linhari Rodrigues Pietro","orcid":"https://orcid.org/0000-0001-7859-8127","observed_orcids":["https://orcid.org/0000-0001-7859-8127"]},"institutions":[{"id":"https://openalex.org/I879563668","display_name":"Universidade Estadual Paulista (Unesp)","ror":"https://ror.org/00987cb86","country_code":"BR","type":"education","lineage":["https://openalex.org/I879563668"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Rosemeire C. L. R. Pietro","raw_affiliation_strings":["UNESP , , ,","Laboratory of Pharmaceutical Biotechnology, Department of Drugs and Medicines, School of Pharmaceutical Sciences, UNESP, Araraquara 14800-900, Brazil"],"raw_orcid":"https://orcid.org/0000-0001-7859-8127","affiliations":[{"raw_affiliation_string":"UNESP , , ,","institution_ids":["https://openalex.org/I879563668"]},{"raw_affiliation_string":"Laboratory of Pharmaceutical Biotechnology, Department of Drugs and Medicines, School of Pharmaceutical Sciences, UNESP, Araraquara 14800-900, Brazil","institution_ids":["https://openalex.org/I879563668"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051544508","display_name":"Steffen Stenger","orcid":"https://orcid.org/0000-0001-5471-0807","observed_orcids":["https://orcid.org/0000-0001-5471-0807"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]},{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Steffen Stenger","raw_affiliation_strings":["University Clinic of Ulm , , Robert Koch Str. 8 , ,","Institute of Medical Microbiology and Hygiene, University Clinic of Ulm, Robert Koch Str. 8, Ulm D-89081, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Clinic of Ulm , , Robert Koch Str. 8 , ,","institution_ids":["https://openalex.org/I4210155144"]},{"raw_affiliation_string":"Institute of Medical Microbiology and Hygiene, University Clinic of Ulm, Robert Koch Str. 8, Ulm D-89081, Germany","institution_ids":["https://openalex.org/I196349391","https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035126492","display_name":"Barbara Spellerberg","orcid":"https://orcid.org/0000-0001-7552-8764","observed_orcids":["https://orcid.org/0000-0001-7552-8764"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]},{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Barbara Spellerberg","raw_affiliation_strings":["University Clinic of Ulm , , Robert Koch Str. 8 , ,","Institute of Medical Microbiology and Hygiene, University Clinic of Ulm, Robert Koch Str. 8, Ulm D-89081, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Clinic of Ulm , , Robert Koch Str. 8 , ,","institution_ids":["https://openalex.org/I4210155144"]},{"raw_affiliation_string":"Institute of Medical Microbiology and Hygiene, University Clinic of Ulm, Robert Koch Str. 8, Ulm D-89081, Germany","institution_ids":["https://openalex.org/I196349391","https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024946611","display_name":"Dennis Horst Kubiczek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dennis Kubiczek","raw_affiliation_strings":["Ulm University , , James-Frank-Ring N27 , ,","Institute of Pharmaceutical Biotechnology, Ulm University, James-Frank-Ring N27, 89081 Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ulm University , , James-Frank-Ring N27 , ,","institution_ids":["https://openalex.org/I196349391"]},{"raw_affiliation_string":"Institute of Pharmaceutical Biotechnology, Ulm University, James-Frank-Ring N27, 89081 Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016356256","display_name":"Nicholas Emil Bodenberger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nicholas Bodenberger","raw_affiliation_strings":["Ulm University , , James-Frank-Ring N27 , ,","Institute of Pharmaceutical Biotechnology, Ulm University, James-Frank-Ring N27, 89081 Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ulm University , , James-Frank-Ring N27 , ,","institution_ids":["https://openalex.org/I196349391"]},{"raw_affiliation_string":"Institute of Pharmaceutical Biotechnology, Ulm University, James-Frank-Ring N27, 89081 Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Steffen Dietz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Steffen Dietz","raw_affiliation_strings":["Ulm University , , James-Frank-Ring N27 , ,","Institute of Pharmaceutical Biotechnology, Ulm University, James-Frank-Ring N27, 89081 Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ulm University , , James-Frank-Ring N27 , ,","institution_ids":["https://openalex.org/I196349391"]},{"raw_affiliation_string":"Institute of Pharmaceutical Biotechnology, Ulm University, James-Frank-Ring N27, 89081 Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018302047","display_name":"Frank Rosenau","orcid":"https://orcid.org/0000-0002-9297-6419","observed_orcids":["https://orcid.org/0000-0002-9297-6419"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Frank Rosenau","raw_affiliation_strings":["Ulm University , , James-Frank-Ring N27 , ,","Institute of Pharmaceutical Biotechnology, Ulm University, James-Frank-Ring N27, 89081 Ulm, Germany"],"raw_orcid":"https://orcid.org/0000-0002-9297-6419","affiliations":[{"raw_affiliation_string":"Ulm University , , James-Frank-Ring N27 , ,","institution_ids":["https://openalex.org/I196349391"]},{"raw_affiliation_string":"Institute of Pharmaceutical Biotechnology, Ulm University, James-Frank-Ring N27, 89081 Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020914880","display_name":"M\u00e1rcio W. Paix\u00e3o","orcid":"https://orcid.org/0000-0002-0421-2831","observed_orcids":["https://orcid.org/0000-0002-0421-2831"]},"institutions":[{"id":"https://openalex.org/I177909021","display_name":"Universidade Federal de S\u00e3o Carlos","ror":"https://ror.org/00qdc6m37","country_code":"BR","type":"education","lineage":["https://openalex.org/I177909021"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ma\u0301rcio Weber Paixa\u0303o","raw_affiliation_strings":["Federal University of Sa\u0303o Carlos-UFSCar , , ,","Center of Excellence for Research in Sustainable Chemistry (CERSusChem), Department of Chemistry, Federal University of S\u00e3o Carlos-UFSCar, S\u00e3o Paulo 13565-905, Brazil"],"raw_orcid":"https://orcid.org/0000-0002-0421-2831","affiliations":[{"raw_affiliation_string":"Federal University of Sa\u0303o Carlos-UFSCar , , ,","institution_ids":["https://openalex.org/I177909021"]},{"raw_affiliation_string":"Center of Excellence for Research in Sustainable Chemistry (CERSusChem), Department of Chemistry, Federal University of S\u00e3o Carlos-UFSCar, S\u00e3o Paulo 13565-905, Brazil","institution_ids":["https://openalex.org/I177909021"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004160752","display_name":"Ludger St\u00e4ndker","orcid":"https://orcid.org/0000-0002-8436-4260","observed_orcids":["https://orcid.org/0000-0002-8436-4260"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ludger Sta\u0308ndker","raw_affiliation_strings":["Ulm University , , ,","Core Facility for Functional Peptidomics, Ulm Peptide Pharmaceuticals (U-PEP), University Ulm, Faculty of Medicine, Ulm University, 89081 Ulm, Germany"],"raw_orcid":"https://orcid.org/0000-0002-8436-4260","affiliations":[{"raw_affiliation_string":"Ulm University , , ,","institution_ids":["https://openalex.org/I196349391"]},{"raw_affiliation_string":"Core Facility for Functional Peptidomics, Ulm Peptide Pharmaceuticals (U-PEP), University Ulm, Faculty of Medicine, Ulm University, 89081 Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062281474","display_name":"Anselmo J. Otero\u2010Gonz\u00e1lez","orcid":"https://orcid.org/0000-0002-1719-0117","observed_orcids":["https://orcid.org/0000-0002-1719-0117"]},"institutions":[{"id":"https://openalex.org/I2656126","display_name":"University of Havana","ror":"https://ror.org/04204gr61","country_code":"CU","type":"education","lineage":["https://openalex.org/I2656126"]}],"countries":["CU"],"is_corresponding":true,"raw_author_name":"Anselmo J. Otero-Gonza\u0301lez","raw_affiliation_strings":["University of Havana , , 25 and I, ,","Center for Protein Studies, Faculty of Biology, University of Havana, 25 and I, 10400 La Habana, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Havana , , 25 and I, ,","institution_ids":["https://openalex.org/I2656126"]},{"raw_affiliation_string":"Center for Protein Studies, Faculty of Biology, University of Havana, 25 and I, 10400 La Habana, Cuba","institution_ids":["https://openalex.org/I2656126"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5062281474"],"corresponding_institution_ids":["https://openalex.org/I2656126"],"apc_list":{"value":750,"currency":"USD","value_usd":750},"apc_paid":{"value":750,"currency":"USD","value_usd":750},"fwci":3.1174,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.91991658,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"4","issue":"21","first_page":"19081","last_page":"19095"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclic-peptides","display_name":"cyclic peptides","score":0.5759999752044678},{"id":"https://openalex.org/keywords/antifungal-activity","display_name":"antifungal activity","score":0.824999988079071},{"id":"https://openalex.org/keywords/candida-albicans","display_name":"Candida albicans","score":0.9160000085830688},{"id":"https://openalex.org/keywords/candida-parapsilosis","display_name":"Candida parapsilosis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/disulfide-bonds","display_name":"disulfide bonds","score":0.906000018119812},{"id":"https://openalex.org/keywords/peptide-dimers","display_name":"peptide dimers","score":0.7099999785423279},{"id":"https://openalex.org/keywords/antiparallel-dimer","display_name":"antiparallel dimer","score":0.7440000176429749},{"id":"https://openalex.org/keywords/parallel-dimer","display_name":"parallel dimer","score":0.6349999904632568},{"id":"https://openalex.org/keywords/listeria-monocytogenes","display_name":"Listeria monocytogenes","score":0.7440000176429749},{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":0.9980000257492065},{"id":"https://openalex.org/keywords/macrophage-mediated-cytotoxicity","display_name":"macrophage cytotoxicity","score":0.8759999871253967},{"id":"https://openalex.org/keywords/rational-design","display_name":"rational design","score":0.45500001311302185},{"id":"https://openalex.org/keywords/antimicrobial-peptides","display_name":"antimicrobial peptides","score":0.5580000281333923}],"concepts":[{"id":"https://openalex.org/C142089489","wikidata":"https://www.wikidata.org/wiki/Q1053976","display_name":"Antiparallel (mathematics)","level":3,"score":0.8502442836761475},{"id":"https://openalex.org/C2779546866","wikidata":"https://www.wikidata.org/wiki/Q531306","display_name":"Dimer","level":2,"score":0.7450674176216125},{"id":"https://openalex.org/C2780917455","wikidata":"https://www.wikidata.org/wiki/Q310443","display_name":"Candida albicans","level":2,"score":0.7159801125526428},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.713849663734436},{"id":"https://openalex.org/C166940927","wikidata":"https://www.wikidata.org/wiki/Q178827","display_name":"Monomer","level":3,"score":0.6970964670181274},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.5963679552078247},{"id":"https://openalex.org/C133571119","wikidata":"https://www.wikidata.org/wiki/Q899102","display_name":"Circular dichroism","level":2,"score":0.5260137319564819},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5045350790023804},{"id":"https://openalex.org/C30765947","wikidata":"https://www.wikidata.org/wiki/Q899119","display_name":"Salt bridge","level":4,"score":0.5006036758422852},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4907344579696655},{"id":"https://openalex.org/C53105671","wikidata":"https://www.wikidata.org/wiki/Q14777816","display_name":"Rational design","level":2,"score":0.46547409892082214},{"id":"https://openalex.org/C60984968","wikidata":"https://www.wikidata.org/wiki/Q389172","display_name":"Cyclic peptide","level":3,"score":0.4529605507850647},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.43411359190940857},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4311670958995819},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.4246065318584442},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.41141384840011597},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3504296541213989},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.16236522793769836},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.12152817845344543},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09993907809257507},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.07488054037094116},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.06966081261634827},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C115260700","wikidata":"https://www.wikidata.org/wiki/Q11408","display_name":"Magnetic field","level":2,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1021/acsomega.9b02201","doi":"https://doi.org/10.1021/acsomega.9b02201","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsomega.9b02201","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acsomega.9b02201","source":{"id":"https://openalex.org/S4210239500","display_name":"ACS Omega","issn_l":"2470-1343","issn":["2470-1343"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"journal-article"},{"id":"pmid:31763531","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31763531","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS omega","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6868880","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6868880/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:b6b61c13663645a58e25f2f09186234b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b6b61c13663645a58e25f2f09186234b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ACS Omega, Vol 4, Iss 21, Pp 19081-19095 (2019)","raw_type":"article"},{"id":"pmh:oai:repositorio.unesp.br:11449/199624","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11449/199624","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:UNESP","raw_type":"info:eu-repo/semantics/publishedVersion"}],"best_oa_location":{"id":"doi:10.1021/acsomega.9b02201","doi":"https://doi.org/10.1021/acsomega.9b02201","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsomega.9b02201","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acsomega.9b02201","source":{"id":"https://openalex.org/S4210239500","display_name":"ACS Omega","issn_l":"2470-1343","issn":["2470-1343"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1861563813","display_name":null,"funder_award_id":"CRC 1279","funder_id":"https://openalex.org/F4320325530","funder_display_name":"Universit\u00e4t Ulm"},{"id":"https://openalex.org/G3595503415","display_name":null,"funder_award_id":"DLR CUB 17WTZ-014/01DN18009","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"}],"funders":[{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"},{"id":"https://openalex.org/F4320325530","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2983754697.pdf"},"referenced_works_count":69,"referenced_works":["https://openalex.org/W46619318","https://openalex.org/W658459357","https://openalex.org/W1511398922","https://openalex.org/W1547998655","https://openalex.org/W1588979652","https://openalex.org/W1604020339","https://openalex.org/W1964937304","https://openalex.org/W1965846042","https://openalex.org/W1971024387","https://openalex.org/W1973815577","https://openalex.org/W1985842673","https://openalex.org/W1987095367","https://openalex.org/W1992148964","https://openalex.org/W1995816895","https://openalex.org/W1996520702","https://openalex.org/W1999887286","https://openalex.org/W2003897459","https://openalex.org/W2006570293","https://openalex.org/W2006975013","https://openalex.org/W2008708467","https://openalex.org/W2011788706","https://openalex.org/W2017862190","https://openalex.org/W2018471420","https://openalex.org/W2023697479","https://openalex.org/W2031984989","https://openalex.org/W2038845644","https://openalex.org/W2048136224","https://openalex.org/W2050871371","https://openalex.org/W2063051937","https://openalex.org/W2070150871","https://openalex.org/W2075892592","https://openalex.org/W2076444761","https://openalex.org/W2082102819","https://openalex.org/W2083183071","https://openalex.org/W2084588991","https://openalex.org/W2090289564","https://openalex.org/W2091874747","https://openalex.org/W2098786490","https://openalex.org/W2100266303","https://openalex.org/W2114496961","https://openalex.org/W2116541825","https://openalex.org/W2116830693","https://openalex.org/W2119993590","https://openalex.org/W2120557074","https://openalex.org/W2126103104","https://openalex.org/W2138323709","https://openalex.org/W2143610825","https://openalex.org/W2144149632","https://openalex.org/W2147537773","https://openalex.org/W2153819056","https://openalex.org/W2157824837","https://openalex.org/W2160171025","https://openalex.org/W2165655011","https://openalex.org/W2171350307","https://openalex.org/W2171466020","https://openalex.org/W2273511562","https://openalex.org/W2337957188","https://openalex.org/W2404631572","https://openalex.org/W2412920431","https://openalex.org/W2503574200","https://openalex.org/W2734725127","https://openalex.org/W2739354616","https://openalex.org/W2753674187","https://openalex.org/W2788314593","https://openalex.org/W2796712624","https://openalex.org/W2802500969","https://openalex.org/W2802898722","https://openalex.org/W2978758176","https://openalex.org/W4255594044"],"related_works":["https://openalex.org/W4407563765","https://openalex.org/W3160414492","https://openalex.org/W2143610825","https://openalex.org/W2737994744","https://openalex.org/W2094789085","https://openalex.org/W2747741021","https://openalex.org/W7197004588","https://openalex.org/W3091366618","https://openalex.org/W2075769340","https://openalex.org/W1580562627"],"abstract_inverted_index":{"Abstract":[0],"Following":[1],"the":[2,16,52,62,88,91,110,127,145,158,167,172,178,196,200,242],"information":[3],"obtained":[4,96],"by":[5,97],"a":[6,10,47,74,78,113,130,138,182,189,226,248],"rational":[7,48],"design":[8,49],"study,":[9],"cyclic":[11,22,114,146,197,244],"and":[12,33,55,101,107,132,188,229,238],"helical-stabilized":[13],"analogue":[14],"of":[15,42,68,99,112,163,171],"peptide":[17],"Cm-p5":[18,43,84,245],"was":[19,64,105],"synthetized.":[20],"The":[21,135],"monomer":[23,115,147,198,246],"showed":[24,60,137,149,181],"an":[25],"increased":[26,213],"activity":[27,54,63,184,191],"in":[28,66,142,152,239],"vitro":[29],"against":[30,185,192,204],"Candida":[31,34],"albicans":[32],"parapsilosis,":[35],"compared":[36,218],"to":[37,50,211,219],"Cm-p5.":[38],"Initially,":[39],"14":[40,70],"mutants":[41],"were":[44,124,202],"synthesized":[45,106],"following":[46],"improve":[51],"antifungal":[53,118,251],"pharmacological":[56],"properties.":[57],"Antimicrobial":[58],"testing":[59],"that":[61,77,232],"lost":[65],"each":[67],"these":[69],"analogues,":[71],"suggesting,":[72],"as":[73],"main":[75],"conclusion,":[76],"Glu\u2013His":[79,173],"salt":[80,174],"bridge":[81],"could":[82],"stabilize":[83],"helical":[85,139,159],"conformation":[86,151],"during":[87,126],"interaction":[89],"with":[90,109,116,225],"plasma":[92],"membrane.":[93],"A":[94],"derivative,":[95],"substitution":[98],"Glu":[100],"His":[102],"for":[103,161,215],"Cys,":[104],"oxidized":[108],"generation":[111],"improved":[117],"activity.":[119],"In":[120,176],"addition,":[121,177],"two":[122],"dimers":[123,136,201],"generated":[125],"oxidation":[128],"procedure,":[129],"parallel":[131],"antiparallel":[133,179],"one.":[134],"secondary":[140],"structure":[141],"water,":[143],"whereas":[144],"only":[148],"this":[150],"SDS.":[153],"Molecular":[154],"dynamic":[155],"simulations":[156],"confirmed":[157],"stabilizations":[160],"all":[162],"them,":[164],"therefore":[165],"indicating":[166],"possible":[168],"essential":[169],"role":[170],"bridge.":[175],"dimer":[180],"moderate":[183],"Pseudomonas":[186],"aeruginosa":[187],"significant":[190],"Listeria":[193],"monocytogenes.":[194],"Neither":[195],"nor":[199],"toxic":[203],"macrophages":[205],"or":[206],"THP-1":[207],"human":[208],"cells.":[209],"Due":[210],"its":[212,221,235],"capacity":[214],"fungal":[216],"control":[217],"fluconazole,":[220],"low":[222],"cytotoxicity,":[223],"together":[224],"stabilized":[227],"\u03b1-helix":[228],"disulfide":[230],"bridges,":[231],"may":[233],"advance":[234],"metabolic":[236],"stability,":[237],"vivo":[240],"activity,":[241],"new":[243],"represents":[247],"potential":[249],"systemic":[250],"therapeutic":[252],"candidate.":[253]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-11-22T00:00:00"}