{"id":"https://openalex.org/W2983529465","doi":"https://doi.org/10.1021/acs.jpcb.9b08470","title":"Dynamical Recrossing in the Intercalation Process of the Anticancer Agent Proflavine into DNA","display_name":"Dynamical Recrossing in the Intercalation Process of the Anticancer Agent Proflavine into DNA","publication_year":2019,"publication_date":"2019-10-31","ids":{"openalex":"https://openalex.org/W2983529465","doi":"https://doi.org/10.1021/acs.jpcb.9b08470","mag":"2983529465","pmid":"https://pubmed.ncbi.nlm.nih.gov/31671261"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jpcb.9b08470","doi":"https://doi.org/10.1021/acs.jpcb.9b08470","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jpcb.9b08470","pdf_url":null,"source":{"id":"https://openalex.org/S185621672","display_name":"The Journal of Physical Chemistry B","issn_l":"1520-5207","issn":["1520-5207","1520-6106"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physical Chemistry B","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hal.sorbonne-universite.fr/hal-02985731v1/document","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053792365","display_name":"V. M. Hridya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181996519","display_name":"Indian Institute of Science Education and Research Pune","ror":"https://ror.org/028qa3n13","country_code":"IN","type":"education","lineage":["https://openalex.org/I181996519"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"V. M. Hridya","raw_affiliation_strings":["Department of Chemistry, Indian Institute of Science Education and Research, Pune 411008, India","IISER Pune - Indian Institute of Science Education and Research Pune (Pashan, Pune, Maharashtra 411021 - India)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Indian Institute of Science Education and Research, Pune 411008, India","institution_ids":["https://openalex.org/I181996519"]},{"raw_affiliation_string":"IISER Pune - Indian Institute of Science Education and Research Pune (Pashan, Pune, Maharashtra 411021 - India)","institution_ids":["https://openalex.org/I181996519"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000113075","display_name":"James T. Hynes","orcid":"https://orcid.org/0000-0003-2683-0304","observed_orcids":["https://orcid.org/0000-0003-2683-0304"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]},{"id":"https://openalex.org/I29607241","display_name":"\u00c9cole Normale Sup\u00e9rieure - PSL","ror":"https://ror.org/05a0dhs15","country_code":"FR","type":"other","lineage":["https://openalex.org/I2746051580","https://openalex.org/I29607241"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]}],"countries":["FR","US"],"is_corresponding":true,"raw_author_name":"James T. Hynes","raw_affiliation_strings":["Department of Chemistry, University of Colorado, Boulder, Colorado 80309-0215, United States","PASTEUR, Department of Chemistry, \u00c9cole normale sup\u00e9rieure, PSL University, Sorbonne Universit\u00e9, CNRS, 75005 Paris, France"],"raw_orcid":"https://orcid.org/0000-0003-2683-0304","affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Colorado, Boulder, Colorado 80309-0215, United States","institution_ids":["https://openalex.org/I188538660"]},{"raw_affiliation_string":"PASTEUR, Department of Chemistry, \u00c9cole normale sup\u00e9rieure, PSL University, Sorbonne Universit\u00e9, CNRS, 75005 Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I29607241","https://openalex.org/I39804081"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026772468","display_name":"Arnab Mukherjee","orcid":"https://orcid.org/0000-0001-5691-6120","observed_orcids":["https://orcid.org/0000-0001-5691-6120","https://orcid.org/0000-0002-6783-8225"]},"institutions":[{"id":"https://openalex.org/I181996519","display_name":"Indian Institute of Science Education and Research Pune","ror":"https://ror.org/028qa3n13","country_code":"IN","type":"education","lineage":["https://openalex.org/I181996519"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Arnab Mukherjee","raw_affiliation_strings":["Department of Chemistry, Indian Institute of Science Education and Research, Pune 411008, India","IISER Pune - Indian Institute of Science Education and Research Pune (Pashan, Pune, Maharashtra 411021 - India)"],"raw_orcid":"https://orcid.org/0000-0001-5691-6120","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Indian Institute of Science Education and Research, Pune 411008, India","institution_ids":["https://openalex.org/I181996519"]},{"raw_affiliation_string":"IISER Pune - Indian Institute of Science Education and Research Pune (Pashan, Pune, Maharashtra 411021 - India)","institution_ids":["https://openalex.org/I181996519"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5000113075","https://openalex.org/A5026772468"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I181996519","https://openalex.org/I188538660","https://openalex.org/I29607241","https://openalex.org/I39804081"],"apc_list":null,"apc_paid":null,"fwci":0.6598,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.65088303,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"123","issue":"51","first_page":"10904","last_page":"10914"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12044","display_name":"Advanced Physical and Chemical Molecular Interactions","score":0.5503000020980835,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12044","display_name":"Advanced Physical and Chemical Molecular Interactions","score":0.5503000020980835,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.21289999783039093,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13187","display_name":"Diffusion and Search Dynamics","score":0.06260000169277191,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/proflavine","display_name":"proflavine","score":0.9890000224113464},{"id":"https://openalex.org/keywords/dna-intercalation","display_name":"DNA intercalation","score":0.9909999966621399},{"id":"https://openalex.org/keywords/recrossing","display_name":"recrossing","score":0.5509999990463257},{"id":"https://openalex.org/keywords/transmission-coefficient","display_name":"transmission coefficient","score":0.9340000152587891},{"id":"https://openalex.org/keywords/transition-state-theory","display_name":"transition state theory","score":0.9369999766349792},{"id":"https://openalex.org/keywords/committor-analysis","display_name":"committor analysis","score":0.9319999814033508},{"id":"https://openalex.org/keywords/grote-hynes-theory","display_name":"Grote-Hynes theory","score":0.8349999785423279},{"id":"https://openalex.org/keywords/kramers-theory","display_name":"Kramers theory","score":0.9959999918937683},{"id":"https://openalex.org/keywords/anthracyclines","display_name":"anthracyclines","score":0.7860000133514404},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.9070000052452087},{"id":"https://openalex.org/keywords/rate-constants","display_name":"rate constants","score":0.4659999907016754},{"id":"https://openalex.org/keywords/molecular-mechanisms","display_name":"molecular mechanisms","score":0.35600000619888306}],"concepts":[{"id":"https://openalex.org/C2776594999","wikidata":"https://www.wikidata.org/wiki/Q420454","display_name":"Proflavine","level":3,"score":0.9444425106048584},{"id":"https://openalex.org/C137824038","wikidata":"https://www.wikidata.org/wiki/Q175562","display_name":"Intercalation (chemistry)","level":2,"score":0.8656496405601501},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5366314053535461},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.478464812040329},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4777992367744446},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.41207724809646606},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3205040693283081},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.25774046778678894},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2105647623538971},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1874944567680359},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.08620992302894592},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007364","descriptor_name":"Intercalating Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011370","descriptor_name":"Proflavine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019277","descriptor_name":"Entropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/acs.jpcb.9b08470","doi":"https://doi.org/10.1021/acs.jpcb.9b08470","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jpcb.9b08470","pdf_url":null,"source":{"id":"https://openalex.org/S185621672","display_name":"The Journal of Physical Chemistry B","issn_l":"1520-5207","issn":["1520-5207","1520-6106"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physical Chemistry B","raw_type":"journal-article"},{"id":"pmid:31671261","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31671261","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journal of physical chemistry. B","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-02985731v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.sorbonne-universite.fr/hal-02985731","pdf_url":"https://hal.sorbonne-universite.fr/hal-02985731v1/document","source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Physical Chemistry B, 2019, 123 (51), pp.10904-10914. ⟨10.1021/acs.jpcb.9b08470⟩","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:HAL:hal-02985731v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.sorbonne-universite.fr/hal-02985731","pdf_url":"https://hal.sorbonne-universite.fr/hal-02985731v1/document","source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Physical Chemistry B, 2019, 123 (51), pp.10904-10914. ⟨10.1021/acs.jpcb.9b08470⟩","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1509238881","display_name":"Theory of Reactions in Solution and at Surfaces","funder_award_id":"1112564","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5763062231","display_name":null,"funder_award_id":"EMR/2016/001069","funder_id":"https://openalex.org/F4320334771","funder_display_name":"Science and Engineering Research Board"},{"id":"https://openalex.org/G6118678196","display_name":null,"funder_award_id":"EMR/2016/001069","funder_id":"https://openalex.org/F4320320719","funder_display_name":"Department of Science and Technology, Ministry of Science and Technology, India"},{"id":"https://openalex.org/G6119075960","display_name":null,"funder_award_id":"1112564","funder_id":"https://openalex.org/F4320337393","funder_display_name":"Division of Chemistry"},{"id":"https://openalex.org/G6832662191","display_name":null,"funder_award_id":"CHE-1112564","funder_id":"https://openalex.org/F4320337393","funder_display_name":"Division of Chemistry"},{"id":"https://openalex.org/G8572416517","display_name":null,"funder_award_id":"EMR/2016","funder_id":"https://openalex.org/F4320334771","funder_display_name":"Science and Engineering Research Board"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320320719","display_name":"Department of Science and Technology, Ministry of Science and Technology, India","ror":"https://ror.org/0101xrq71"},{"id":"https://openalex.org/F4320324168","display_name":"Indian Institute of Science Education and Research Pune","ror":"https://ror.org/028qa3n13"},{"id":"https://openalex.org/F4320334771","display_name":"Science and Engineering Research Board","ror":"https://ror.org/03ffdsr55"},{"id":"https://openalex.org/F4320337393","display_name":"Division of Chemistry","ror":"https://ror.org/01ar8dr59"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2983529465.pdf","grobid_xml":"https://content.openalex.org/works/W2983529465.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W52184334","https://openalex.org/W1966078827","https://openalex.org/W1966616271","https://openalex.org/W1968408643","https://openalex.org/W1969993471","https://openalex.org/W1970440715","https://openalex.org/W1972830475","https://openalex.org/W1975308009","https://openalex.org/W1976499671","https://openalex.org/W1991794210","https://openalex.org/W1993177346","https://openalex.org/W1994567486","https://openalex.org/W1998904893","https://openalex.org/W2001955511","https://openalex.org/W2005763236","https://openalex.org/W2007239151","https://openalex.org/W2013733971","https://openalex.org/W2014295466","https://openalex.org/W2026310190","https://openalex.org/W2026485889","https://openalex.org/W2032820551","https://openalex.org/W2034588787","https://openalex.org/W2034777905","https://openalex.org/W2037080134","https://openalex.org/W2040190546","https://openalex.org/W2041638382","https://openalex.org/W2041902442","https://openalex.org/W2043551434","https://openalex.org/W2044174858","https://openalex.org/W2046286471","https://openalex.org/W2046749552","https://openalex.org/W2052945733","https://openalex.org/W2057980421","https://openalex.org/W2063281586","https://openalex.org/W2067174909","https://openalex.org/W2067568349","https://openalex.org/W2067878166","https://openalex.org/W2076524576","https://openalex.org/W2076960131","https://openalex.org/W2084513255","https://openalex.org/W2084618988","https://openalex.org/W2085266415","https://openalex.org/W2086950053","https://openalex.org/W2087551836","https://openalex.org/W2093687460","https://openalex.org/W2094389811","https://openalex.org/W2110272809","https://openalex.org/W2131288855","https://openalex.org/W2136729627","https://openalex.org/W2139138867","https://openalex.org/W2145013380","https://openalex.org/W2147993766","https://openalex.org/W2312559691","https://openalex.org/W2317670110","https://openalex.org/W2326170450","https://openalex.org/W2330622353","https://openalex.org/W2610786768","https://openalex.org/W2796282471"],"related_works":["https://openalex.org/W2297996883","https://openalex.org/W2005763236","https://openalex.org/W4238477313","https://openalex.org/W2330622353","https://openalex.org/W2049029170","https://openalex.org/W178249657","https://openalex.org/W1972830475","https://openalex.org/W2094566960","https://openalex.org/W2047440985","https://openalex.org/W2061584790"],"abstract_inverted_index":{"Intercalation":[0],"into":[1,37],"DNA":[2,38],"is":[3,139,154],"the":[4,12,21,29,33,41,48,55,61,65,74,102,112,148,161,177],"interaction":[5],"mode":[6],"of":[7,15,35,47,60,78,89,92,101,110,127,150,160],"some":[8],"anthracycline":[9],"antibiotics.":[10],"Recently,":[11],"molecular":[13],"mechanism":[14],"this":[16,79,128,143,151],"process":[17,178],"was":[18,118],"explored":[19],"using":[20],"static":[22],"free":[23],"energy":[24],"landscape.":[25],"Here":[26],"we":[27,71],"explore":[28],"dynamical":[30,173],"effects":[31,174],"in":[32,106,181],"intercalation":[34],"proflavine":[36],"by":[39,83],"calculating":[40],"transmission":[42,103],"coefficient":[43,104],"\u03ba-providing":[44],"a":[45,84,87,98,121],"measure":[46],"departure":[49,123],"from":[50,124],"transition":[51,66,76],"state":[52,77],"theory":[53,138],"for":[54,167,176,187],"reaction":[56],"rate":[57],"constant-by":[58],"examination":[59],"recrossing":[62,146],"events":[63],"at":[64],"state.":[67],"For":[68],"that":[69,136],"purpose,":[70],"first":[72],"found":[73],"accurate":[75],"complex":[80,144,180],"system-as":[81],"judged":[82],"committor":[85],"analysis-using":[86],"set":[88,109],"all-atom":[90],"simulations":[91,111],"total":[93],"length":[94],"6.3":[95],"ms.":[96],"In":[97],"subsequent":[99],"calculation":[100],"\u03ba":[105,115],"another":[107],"extensive":[108],"small":[113],"value":[114],"=":[116],"0.1":[117],"found,":[119],"indicating":[120],"significant":[122],"TST.":[125],"Comparison":[126],"result":[129],"with":[130],"Grote-Hynes":[131],"and":[132,183],"Kramers":[133],"theories":[134],"shows":[135],"neither":[137],"able":[140],"to":[141,171],"capture":[142],"system's":[145],"events;":[147],"source":[149],"striking":[152],"failure":[153],"discussed,":[155],"as":[156],"are":[157,179],"related":[158],"aspects":[159],"mechanism.":[162],"This":[163],"study":[164],"suggests":[165],"that,":[166],"biomolecular":[168],"processes":[169],"similar":[170],"this,":[172],"essential":[175],"nature":[182],"require":[184],"novel":[185],"approaches":[186],"their":[188],"elucidation.":[189]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-11-22T00:00:00"}