{"id":"https://openalex.org/W298340976","doi":null,"title":"Differential effects of embryonic immobilization on the development of fibrocartilaginous skeletal elements.","display_name":"Differential effects of embryonic immobilization on the development of fibrocartilaginous skeletal elements.","publication_year":2000,"publication_date":"2000-03-01","ids":{"openalex":"https://openalex.org/W298340976","mag":"298340976","pmid":"https://pubmed.ncbi.nlm.nih.gov/10850818"},"language":"en","primary_location":{"id":"pmid:10850818","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10850818","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of rehabilitation research and development","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040092010","display_name":"Borjana Mikic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B Mikic","raw_affiliation_strings":["Department of Orthopaedic Surgery, University of Virginia, Charlottesville 22908, USA. bm6j@virginia.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, University of Virginia, Charlottesville 22908, USA. bm6j@virginia.edu","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113677423","display_name":"Tiffany L. Johnson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T L Johnson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101705159","display_name":"A. Bobby Chhabra","orcid":"https://orcid.org/0000-0002-7878-0962","observed_orcids":["https://orcid.org/0000-0002-7878-0962"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A B Chhabra","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078839431","display_name":"Benjamin J. Schalet","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B J Schalet","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"M Wong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Wong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5026111008","display_name":"Ernst B. Hunziker","orcid":"https://orcid.org/0000-0002-4912-3568","observed_orcids":["https://orcid.org/0000-0002-4912-3568"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E B Hunziker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.876,"has_fulltext":false,"cited_by_count":131,"citation_normalized_percentile":{"value":0.72267259,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"37","issue":"2","first_page":"127","last_page":"33"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.8651999831199646,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.8651999831199646,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13107","display_name":"Congenital limb and hand anomalies","score":0.01899999938905239,"subfield":{"id":"https://openalex.org/subfields/1309","display_name":"Developmental Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.009100000374019146,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/meniscus-formation","display_name":"meniscus formation","score":0.7080000042915344},{"id":"https://openalex.org/keywords/sesamoid-bones","display_name":"sesamoid bones","score":0.7170000076293945},{"id":"https://openalex.org/keywords/tibiofemoral-joint","display_name":"tibiofemoral joint","score":0.9259999990463257},{"id":"https://openalex.org/keywords/tibiotarsal-joint","display_name":"tibiotarsal joint","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mechanical-loading","display_name":"mechanical loading","score":0.5049999952316284},{"id":"https://openalex.org/keywords/chick-embryo","display_name":"chick embryo","score":0.8320000171661377},{"id":"https://openalex.org/keywords/skeletal-muscle-contraction","display_name":"skeletal muscle contraction","score":0.6200000047683716},{"id":"https://openalex.org/keywords/meniscal-degeneration","display_name":"meniscal degeneration","score":0.8410000205039978}],"concepts":[{"id":"https://openalex.org/C189178095","wikidata":"https://www.wikidata.org/wiki/Q15834833","display_name":"Meniscus","level":3,"score":0.7317728996276855},{"id":"https://openalex.org/C2779663596","wikidata":"https://www.wikidata.org/wiki/Q2741512","display_name":"Synovial joint","level":5,"score":0.704840898513794},{"id":"https://openalex.org/C18555067","wikidata":"https://www.wikidata.org/wiki/Q8375051","display_name":"Joint (building)","level":2,"score":0.675610363483429},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.6523322463035583},{"id":"https://openalex.org/C2910849840","wikidata":"https://www.wikidata.org/wiki/Q1365684","display_name":"Sesamoid bone","level":3,"score":0.6252562403678894},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.5299552083015442},{"id":"https://openalex.org/C2908736133","wikidata":"https://www.wikidata.org/wiki/Q37425","display_name":"Knee Joint","level":2,"score":0.46382465958595276},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44797295331954956},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.4108070731163025},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37427955865859985},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3347398042678833},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18433278799057007},{"id":"https://openalex.org/C3020332539","wikidata":"https://www.wikidata.org/wiki/Q2014564","display_name":"Articular cartilage","level":4,"score":0.1608288586139679},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.15651807188987732},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.1327475905418396},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.10860368609428406},{"id":"https://openalex.org/C36454342","wikidata":"https://www.wikidata.org/wiki/Q245341","display_name":"Radiography","level":2,"score":0.07976412773132324},{"id":"https://openalex.org/C66938386","wikidata":"https://www.wikidata.org/wiki/Q633538","display_name":"Structural engineering","level":1,"score":0.06514254212379456},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D002356","descriptor_name":"Cartilage","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D002356","descriptor_name":"Cartilage","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005314","descriptor_name":"Embryonic and Fetal Development","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007719","descriptor_name":"Knee Joint","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D007719","descriptor_name":"Knee Joint","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D008592","descriptor_name":"Menisci, Tibial","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D008592","descriptor_name":"Menisci, Tibial","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:10850818","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10850818","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of rehabilitation research and development","raw_type":"Comparative Study"},{"id":"mag:298340976","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10850818","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4000000059604645}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W608448141","https://openalex.org/W1526154605","https://openalex.org/W1604024841","https://openalex.org/W1786831643","https://openalex.org/W1971454187","https://openalex.org/W1979789847","https://openalex.org/W1988324978","https://openalex.org/W1999639777","https://openalex.org/W2008581918","https://openalex.org/W2018634292","https://openalex.org/W2025356145","https://openalex.org/W2027751122","https://openalex.org/W2046312093","https://openalex.org/W2070040120","https://openalex.org/W2084531260","https://openalex.org/W2084907525","https://openalex.org/W2143593686","https://openalex.org/W2463939158"],"related_works":["https://openalex.org/W139486898","https://openalex.org/W7097706852","https://openalex.org/W3199285482","https://openalex.org/W4383302630","https://openalex.org/W3010470973","https://openalex.org/W2058256770","https://openalex.org/W2084907525","https://openalex.org/W2110050523","https://openalex.org/W1974932176","https://openalex.org/W1786831643"],"abstract_inverted_index":{"The":[0,153],"importance":[1],"of":[2,21,32,47,57,83,92,97,121,148,155,173,181,191],"mechanical":[3,105,127,189],"influences":[4],"during":[5],"skeletal":[6,192],"development":[7],"has":[8,25],"been":[9,26],"well":[10],"established":[11],"in":[12,55,68,77,107,118,137,160,169],"both":[13],"experimental":[14],"studies":[15],"and":[16,39,50,87,201],"computer":[17],"models.":[18],"Under":[19],"conditions":[20],"embryonic":[22,141],"immobilization,":[23],"it":[24],"observed":[27],"that":[28,140],"the":[29,44,58,62,81,84,88,93,115,119,133,145,156,170,178,187,196],"early":[30,179],"stages":[31,46,180],"joint":[33,48,64,86,116],"formation":[34,172,183],"proceed":[35,184],"normally":[36],"(up":[37],"to":[38,103,111,124,129,166,199],"including":[40],"interzone":[41],"formation),":[42],"but":[43],"later":[45],"cavitation":[49],"maintenance":[51],"are":[52,70,101],"impaired,":[53],"resulting":[54],"fusion":[56],"cartilaginous":[59],"elements":[60],"across":[61,132],"presumptive":[63],"line.":[65],"Two":[66],"structures":[67,100],"particular":[69],"noticeably":[71],"absent":[72],"from":[73],"late-stage":[74,161],"synovial":[75],"joints":[76],"immobilized":[78,162],"chick":[79],"embryos:":[80],"menisci":[82],"tibiofemoral":[85],"plantar":[89,157],"tarsal":[90,158],"sesamoid":[91,122,159],"tibiotarsal":[94],"joint.":[95,134],"Both":[96],"these":[98,149],"fibrocartilaginous":[99],"known":[102],"serve":[104],"functions":[106],"postnatal":[108],"animals,":[109],"helping":[110],"distribute":[112],"loads":[113],"within":[114],"and,":[117],"case":[120],"structures,":[123],"provide":[125],"a":[126,167],"advantage":[128],"muscles":[130],"acting":[131],"We":[135],"demonstrate":[136],"this":[138,174],"study":[139],"immobilization":[142],"differentially":[143],"affects":[144],"developmental":[146],"fate":[147],"two":[150],"distinct":[151],"fibrocartilages.":[152],"absence":[154],"embryos":[163],"is":[164],"due":[165],"failure":[168],"initial":[171],"structure.":[175],"In":[176],"contrast,":[177],"meniscus":[182,197],"normally.":[185],"Without":[186],"normal":[188],"stimuli":[190],"muscle":[193],"contractions,":[194],"however,":[195],"fails":[198],"mature":[200],"ultimately":[202],"degenerates.":[203]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":10},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
