{"id":"https://openalex.org/W2983400463","doi":"https://doi.org/10.3389/fmicb.2019.02596","title":"Multiomic Fermentation Using Chemically Defined Synthetic Hydrolyzates Revealed Multiple Effects of Lignocellulose-Derived Inhibitors on Cell Physiology and Xylose Utilization in Zymomonas mobilis","display_name":"Multiomic Fermentation Using Chemically Defined Synthetic Hydrolyzates Revealed Multiple Effects of Lignocellulose-Derived Inhibitors on Cell Physiology and Xylose Utilization in Zymomonas mobilis","publication_year":2019,"publication_date":"2019-11-06","ids":{"openalex":"https://openalex.org/W2983400463","doi":"https://doi.org/10.3389/fmicb.2019.02596","mag":"2983400463","pmid":"https://pubmed.ncbi.nlm.nih.gov/31787963","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6853872"},"language":"en","primary_location":{"id":"doi:10.3389/fmicb.2019.02596","doi":"https://doi.org/10.3389/fmicb.2019.02596","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmicb.2019.02596","pdf_url":"https://www.frontiersin.org/articles/10.3389/fmicb.2019.02596/pdf","source":{"id":"https://openalex.org/S2484704948","display_name":"Frontiers in Microbiology","issn_l":"1664-302X","issn":["1664-302X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fmicb.2019.02596/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101943252","display_name":"Yaoping Zhang","orcid":"https://orcid.org/0000-0002-6887-8982","observed_orcids":["https://orcid.org/0000-0002-6887-8982"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I2801044051","display_name":"Great Lakes Bioenergy Research Center","ror":"https://ror.org/01ca2by25","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I2801044051"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yaoping Zhang","raw_affiliation_strings":["DOE-Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, WI, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DOE-Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, WI, United States","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I2801044051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018554997","display_name":"Jessica M. Vera","orcid":"https://orcid.org/0000-0001-7411-8501","observed_orcids":["https://orcid.org/0000-0001-7411-8501"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I2801044051","display_name":"Great Lakes Bioenergy Research Center","ror":"https://ror.org/01ca2by25","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I2801044051"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica M. Vera","raw_affiliation_strings":["DOE-Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, WI, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DOE-Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, WI, United States","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I2801044051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101526756","display_name":"Dan Xie","orcid":"https://orcid.org/0000-0002-7335-3726","observed_orcids":["https://orcid.org/0000-0002-7335-3726"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I2801044051","display_name":"Great Lakes Bioenergy Research Center","ror":"https://ror.org/01ca2by25","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I2801044051"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dan Xie","raw_affiliation_strings":["DOE-Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, WI, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DOE-Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, WI, United States","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I2801044051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058872943","display_name":"Jos\u00e9 Serate","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I2801044051","display_name":"Great Lakes Bioenergy Research Center","ror":"https://ror.org/01ca2by25","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I2801044051"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jose Serate","raw_affiliation_strings":["DOE-Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, WI, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DOE-Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, WI, United States","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I2801044051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049472174","display_name":"Edward L. Pohlmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I2801044051","display_name":"Great Lakes Bioenergy Research Center","ror":"https://ror.org/01ca2by25","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I2801044051"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward Pohlmann","raw_affiliation_strings":["DOE-Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, WI, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DOE-Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, WI, United States","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I2801044051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105836187","display_name":"Jason D. Russell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I2801044051","display_name":"Great Lakes Bioenergy Research Center","ror":"https://ror.org/01ca2by25","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I2801044051"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason D. Russell","raw_affiliation_strings":["DOE-Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, WI, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DOE-Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, WI, United States","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I2801044051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051218655","display_name":"Alexander S. Hebert","orcid":"https://orcid.org/0000-0003-4882-2241","observed_orcids":["https://orcid.org/0000-0003-4882-2241"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I2801044051","display_name":"Great Lakes Bioenergy Research Center","ror":"https://ror.org/01ca2by25","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I2801044051"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander S. Hebert","raw_affiliation_strings":["DOE-Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, WI, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DOE-Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, WI, United States","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I2801044051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086840789","display_name":"Joshua J. Coon","orcid":"https://orcid.org/0000-0002-0004-8253","observed_orcids":["https://orcid.org/0000-0002-0004-8253"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I2801044051","display_name":"Great Lakes Bioenergy Research Center","ror":"https://ror.org/01ca2by25","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I2801044051"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua J. Coon","raw_affiliation_strings":["DOE-Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, WI, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DOE-Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, WI, United States","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I2801044051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076563127","display_name":"Trey K. Sato","orcid":"https://orcid.org/0000-0001-6592-9337","observed_orcids":["https://orcid.org/0000-0001-6592-9337"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I2801044051","display_name":"Great Lakes Bioenergy Research Center","ror":"https://ror.org/01ca2by25","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I2801044051"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Trey K. Sato","raw_affiliation_strings":["DOE-Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, WI, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DOE-Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, WI, United States","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I2801044051"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010325555","display_name":"Robert C. Landick","orcid":"https://orcid.org/0000-0002-5042-0383","observed_orcids":["https://orcid.org/0000-0002-5042-0383"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I2801044051","display_name":"Great Lakes Bioenergy Research Center","ror":"https://ror.org/01ca2by25","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I2801044051"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert Landick","raw_affiliation_strings":["DOE-Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, WI, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DOE-Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, WI, United States","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I2801044051"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5010325555","https://openalex.org/A5101943252"],"corresponding_institution_ids":["https://openalex.org/I135310074","https://openalex.org/I2801044051"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":1.0559,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.73069815,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"10","issue":null,"first_page":"2596","last_page":"2596"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10171","display_name":"Biofuel production and bioconversion","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10171","display_name":"Biofuel production and bioconversion","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11009","display_name":"Catalysis for Biomass Conversion","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zymomonas-mobilis","display_name":"Zymomonas mobilis","score":0.9190000295639038},{"id":"https://openalex.org/keywords/lignocellulose-derived-inhibitors","display_name":"lignocellulose-derived inhibitors","score":0.9319999814033508},{"id":"https://openalex.org/keywords/xylose-utilization","display_name":"xylose utilization","score":0.9449999928474426},{"id":"https://openalex.org/keywords/lignocellulosic-hydrolysates","display_name":"lignocellulosic hydrolysates","score":0.8529999852180481},{"id":"https://openalex.org/keywords/alcoholic-fermentation","display_name":"alcoholic fermentation","score":0.5920000076293945},{"id":"https://openalex.org/keywords/xylonic-acid","display_name":"xylonic acid","score":0.9290000200271606},{"id":"https://openalex.org/keywords/rnd-efflux-pumps","display_name":"RND efflux pumps","score":0.7770000100135803},{"id":"https://openalex.org/keywords/type-i-secretion-system","display_name":"type I secretion system","score":0.7710000276565552},{"id":"https://openalex.org/keywords/sulfur-assimilation","display_name":"sulfur assimilation","score":0.8330000042915344},{"id":"https://openalex.org/keywords/cysteine-synthesis","display_name":"cysteine biosynthesis","score":0.9369999766349792},{"id":"https://openalex.org/keywords/glutathione-depletion","display_name":"glutathione depletion","score":0.8980000019073486},{"id":"https://openalex.org/keywords/multi-omics-profiling","display_name":"multi-omics profiling","score":0.4429999887943268},{"id":"https://openalex.org/keywords/lignocellulosic-biorefinery","display_name":"lignocellulosic biorefinery","score":0.8349999785423279}],"concepts":[{"id":"https://openalex.org/C2780604136","wikidata":"https://www.wikidata.org/wiki/Q245744","display_name":"Zymomonas mobilis","level":4,"score":0.9595074653625488},{"id":"https://openalex.org/C2780294150","wikidata":"https://www.wikidata.org/wiki/Q66589603","display_name":"Xylose","level":3,"score":0.9076457023620605},{"id":"https://openalex.org/C2781135521","wikidata":"https://www.wikidata.org/wiki/Q8045523","display_name":"Xylose metabolism","level":4,"score":0.6995042562484741},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6847681999206543},{"id":"https://openalex.org/C28800991","wikidata":"https://www.wikidata.org/wiki/Q15634405","display_name":"Hydrolysate","level":3,"score":0.6842054724693298},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6528100967407227},{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.5992620587348938},{"id":"https://openalex.org/C6350086","wikidata":"https://www.wikidata.org/wiki/Q6822347","display_name":"Metabolic engineering","level":3,"score":0.4321726858615875},{"id":"https://openalex.org/C65183824","wikidata":"https://www.wikidata.org/wiki/Q194361","display_name":"Ethanol fuel","level":3,"score":0.42774614691734314},{"id":"https://openalex.org/C2776726243","wikidata":"https://www.wikidata.org/wiki/Q12208391","display_name":"Corn stover","level":3,"score":0.416110634803772},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.14633020758628845},{"id":"https://openalex.org/C94412978","wikidata":"https://www.wikidata.org/wiki/Q103135","display_name":"Hydrolysis","level":2,"score":0.10004305839538574}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.3389/fmicb.2019.02596","doi":"https://doi.org/10.3389/fmicb.2019.02596","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmicb.2019.02596","pdf_url":"https://www.frontiersin.org/articles/10.3389/fmicb.2019.02596/pdf","source":{"id":"https://openalex.org/S2484704948","display_name":"Frontiers in Microbiology","issn_l":"1664-302X","issn":["1664-302X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Microbiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6853872","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6853872","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Microbiol","raw_type":"Text"},{"id":"pmid:31787963","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31787963","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in microbiology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:4bcab52504294d2598ed3666c9618f18","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/4bcab52504294d2598ed3666c9618f18","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Microbiology, Vol 10 (2019)","raw_type":"article"},{"id":"pmh:oai:osti.gov:1573411","doi":null,"is_oa":false,"landing_page_url":"https://www.osti.gov/biblio/1573411","pdf_url":null,"source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:osti.gov:1799693","doi":null,"is_oa":false,"landing_page_url":"https://www.osti.gov/biblio/1799693","pdf_url":null,"source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.3389/fmicb.2019.02596","doi":"https://doi.org/10.3389/fmicb.2019.02596","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmicb.2019.02596","pdf_url":"https://www.frontiersin.org/articles/10.3389/fmicb.2019.02596/pdf","source":{"id":"https://openalex.org/S2484704948","display_name":"Frontiers in Microbiology","issn_l":"1664-302X","issn":["1664-302X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1052503337","display_name":"GREAT LAKES BIOENERGY RESEARCH CENTER","funder_award_id":"FC02-07ER64494","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G1592975470","display_name":null,"funder_award_id":"DE\u2010FC02\u201007ER64494","funder_id":"https://openalex.org/F4320333880","funder_display_name":"Great Lakes Bioenergy Research Center"},{"id":"https://openalex.org/G1648283888","display_name":null,"funder_award_id":"DE\u2010SC0018409","funder_id":"https://openalex.org/F4320337509","funder_display_name":"Biological and Environmental Research"},{"id":"https://openalex.org/G222180108","display_name":null,"funder_award_id":"07ER64494","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G3193070969","display_name":null,"funder_award_id":"DE-FC02-07ER64494","funder_id":"https://openalex.org/F4320337509","funder_display_name":"Biological and Environmental Research"},{"id":"https://openalex.org/G4020120983","display_name":"GREAT LAKES BIOENERGY RESEARCH CENTER","funder_award_id":"DESC0018409","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"},{"id":"https://openalex.org/G4385836085","display_name":"GREAT LAKES BIOENERGY RESEARCH CENTER","funder_award_id":"FC02-07ER64494","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"},{"id":"https://openalex.org/G455569901","display_name":null,"funder_award_id":"DE-SC0018409","funder_id":"https://openalex.org/F4320333880","funder_display_name":"Great Lakes Bioenergy Research Center"},{"id":"https://openalex.org/G5983990188","display_name":null,"funder_award_id":"SC0018409","funder_id":"https://openalex.org/F4320333880","funder_display_name":"Great Lakes Bioenergy Research Center"},{"id":"https://openalex.org/G7350903426","display_name":null,"funder_award_id":"SC0018409","funder_id":"https://openalex.org/F4320337509","funder_display_name":"Biological and Environmental Research"},{"id":"https://openalex.org/G7714489378","display_name":"TAS::89 0227:: TAS RECOVERY ACT - BIOENERGY RESEARCH CENTER CAPITAL EQUIPMENT - GLBRC","funder_award_id":"DEFC0207ER64494","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G8173602837","display_name":"TAS::89 0227:: TAS RECOVERY ACT - BIOENERGY RESEARCH CENTER CAPITAL EQUIPMENT - GLBRC","funder_award_id":"DEFC0207ER64494","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"},{"id":"https://openalex.org/G8743181101","display_name":"GREAT LAKES BIOENERGY RESEARCH CENTER","funder_award_id":"DESC0018409","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"}],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320332359","display_name":"Office of Science","ror":"https://ror.org/00mmn6b08"},{"id":"https://openalex.org/F4320333880","display_name":"Great Lakes Bioenergy Research Center","ror":"https://ror.org/01ca2by25"},{"id":"https://openalex.org/F4320337509","display_name":"Biological and Environmental Research","ror":"https://ror.org/0114b2m14"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2983400463.pdf","grobid_xml":"https://content.openalex.org/works/W2983400463.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W3373608","https://openalex.org/W1943554511","https://openalex.org/W1964509770","https://openalex.org/W1979283544","https://openalex.org/W1986140055","https://openalex.org/W1989249481","https://openalex.org/W1991482073","https://openalex.org/W1999574084","https://openalex.org/W2012043656","https://openalex.org/W2016854891","https://openalex.org/W2024424485","https://openalex.org/W2028277456","https://openalex.org/W2033707984","https://openalex.org/W2042669181","https://openalex.org/W2050451954","https://openalex.org/W2054129051","https://openalex.org/W2056128904","https://openalex.org/W2064671512","https://openalex.org/W2076233570","https://openalex.org/W2084015464","https://openalex.org/W2095136914","https://openalex.org/W2096056489","https://openalex.org/W2097358561","https://openalex.org/W2099095400","https://openalex.org/W2099149842","https://openalex.org/W2107764928","https://openalex.org/W2108192693","https://openalex.org/W2119674204","https://openalex.org/W2122293981","https://openalex.org/W2124985265","https://openalex.org/W2126764428","https://openalex.org/W2130381741","https://openalex.org/W2131271579","https://openalex.org/W2142432270","https://openalex.org/W2146031120","https://openalex.org/W2153024398","https://openalex.org/W2161161201","https://openalex.org/W2165646311","https://openalex.org/W2169377423","https://openalex.org/W2172228379","https://openalex.org/W2179438025","https://openalex.org/W2181257242","https://openalex.org/W2507431734","https://openalex.org/W2550102892","https://openalex.org/W2582828046","https://openalex.org/W2769535391","https://openalex.org/W2807249764","https://openalex.org/W2883134646","https://openalex.org/W2883928066","https://openalex.org/W2899760200","https://openalex.org/W4307611699","https://openalex.org/W6640744973","https://openalex.org/W6654375667","https://openalex.org/W6684193601","https://openalex.org/W6685684588"],"related_works":["https://openalex.org/W4414284527","https://openalex.org/W2755971990","https://openalex.org/W2794580877","https://openalex.org/W2896075869","https://openalex.org/W2165646311","https://openalex.org/W4409583364","https://openalex.org/W2068343664","https://openalex.org/W281519138","https://openalex.org/W2288368003","https://openalex.org/W2745272842"],"abstract_inverted_index":{"Utilization":[0],"of":[1,19,80,86,91,116,152,159,169,177,183,200,226,234,239,265,305,312,320,334,344],"both":[2,274],"C5":[3],"and":[4,10,106,128,137,155,166,180,185,245,260,268,277,308,331],"C6":[5],"sugars":[6],"to":[7,34,37,203,300,329],"produce":[8],"biofuels":[9],"bioproducts":[11],"is":[12,229],"a":[13,170],"key":[14],"goal":[15],"for":[16,132],"the":[17,78,83,210,223,232,237,302],"development":[18],"integrated":[20],"lignocellulosic":[21,315],"biorefineries.":[22],"Previously":[23],"we":[24,98,255],"found":[25,110],"that":[26,64,103,222,289,338],"although":[27],"engineered":[28],"Zymomonas":[29],"mobilis":[30,88,118,195,294],"2032":[31,119,196,295],"was":[32,59,68,248,271],"able":[33,299],"ferment":[35],"glucose":[36,57,244,259],"ethanol":[38],"when":[39,188],"fermenting":[40],"highly":[41,313],"concentrated":[42,314],"hydrolysates":[43,101,316],"such":[44],"as":[45],"9%":[46,112,216],"glucan-loading":[47],"AFEX-pretreated":[48],"corn":[49],"stover":[50],"hydrolysate":[51],"(9%":[52],"ACSH),":[53],"xylose":[54,66,96,212,227,246,261,290,336],"conversion":[55,67,284,337],"after":[56],"depletion":[58,176],"greatly":[60],"impaired.":[61],"We":[62],"hypothesized":[63],"impaired":[65,335],"caused":[69],"by":[70,251],"lignocellulose-derived":[71],"inhibitors":[72],"(LDIs)":[73],"in":[74,111,190,205,215,231,243,258,273,292],"hydrolysates.":[75],"To":[76],"investigate":[77],"effects":[79,142],"LDIs":[81,107,125,330],"on":[82,95],"cellular":[84,303,327],"physiology":[85],"Z.":[87,117,194,293,345],"during":[89,148,310],"fermentation":[90,149,311],"hydrolysates,":[92],"including":[93,150],"impacts":[94],"utilization,":[97],"generated":[99],"synthetic":[100],"(SynHs)":[102],"contained":[104],"nutrients":[105],"at":[108,145],"concentrations":[109],"ACSH.":[113,217],"Comparative":[114],"fermentations":[115],"using":[120],"SynH":[121,191,206,275],"with":[122,276,317],"or":[123],"without":[124,207,278],"were":[126,130,143],"performed,":[127],"samples":[129],"collected":[131],"end":[133],"product,":[134],"transcriptomic,":[135],"metabolomic,":[136],"proteomic":[138],"analyses.":[139],"Several":[140],"LDI-specific":[141],"observed":[144,214,272],"various":[146],"timepoints":[147],"upregulation":[151,158],"sulfur":[153],"assimilation":[154,247],"cysteine":[156],"biosynthesis,":[157],"RND":[160],"family":[161],"efflux":[162],"pump":[163],"systems":[164],"(ZMO0282-0285)":[165],"ZMO1429-1432,":[167],"downregulation":[168],"Type":[171],"I":[172],"secretion":[173],"system":[174],"(ZMO0252-0255),":[175],"reduced":[178,230],"glutathione,":[179],"intracellular":[181,266],"accumulation":[182],"mannose-1P":[184],"mannose-6P.":[186],"Furthermore,":[187],"grown":[189],"containing":[192],"LDIs,":[193,208,252,279],"only":[197],"metabolized":[198],"~50%":[199],"xylose,":[201],"compared":[202],"~80%":[204],"recapitulating":[209],"poor":[211],"utilization":[213],"Our":[218,286],"metabolomic":[219],"data":[220],"suggest":[221,288],"overall":[224,282],"flux":[225],"metabolism":[228,291],"presence":[233],"LDIs.":[235,321],"However,":[236],"expression":[238],"most":[240],"genes":[241],"involved":[242],"not":[249,297],"affected":[250],"nor":[253],"did":[254],"observe":[256],"blocks":[257],"metabolic":[262],"pathways.":[263],"Accumulations":[264],"xylitol":[267],"xylonic":[269],"acid":[270],"which":[280],"decreased":[281],"xylose-to-ethanol":[283],"efficiency.":[285],"results":[287],"may":[296],"be":[298],"support":[301],"demands":[304],"LDI":[306],"mitigation":[307],"detoxification":[309],"elevated":[318],"levels":[319],"Together,":[322],"our":[323],"findings":[324],"identify":[325],"several":[326],"responses":[328],"possible":[332],"causes":[333],"will":[339],"enable":[340],"future":[341],"strain":[342],"engineering":[343],"mobilis.":[346]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2019-11-22T00:00:00"}