{"id":"https://openalex.org/W2983201959","doi":"https://doi.org/10.1158/1055-9965.epi-19-0653","title":"Urinary Cotinine Is as Good a Biomarker as Serum Cotinine for Cigarette Smoking Exposure and Lung Cancer Risk Prediction","display_name":"Urinary Cotinine Is as Good a Biomarker as Serum Cotinine for Cigarette Smoking Exposure and Lung Cancer Risk Prediction","publication_year":2019,"publication_date":"2019-11-04","ids":{"openalex":"https://openalex.org/W2983201959","doi":"https://doi.org/10.1158/1055-9965.epi-19-0653","mag":"2983201959","pmid":"https://pubmed.ncbi.nlm.nih.gov/31685561","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7695222"},"language":"en","primary_location":{"id":"doi:10.1158/1055-9965.epi-19-0653","doi":"https://doi.org/10.1158/1055-9965.epi-19-0653","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1055-9965.epi-19-0653","pdf_url":null,"source":{"id":"https://openalex.org/S8391440","display_name":"Cancer Epidemiology Biomarkers & Prevention","issn_l":"1055-9965","issn":["1055-9965","1538-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Epidemiology, Biomarkers & Prevention","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7695222","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040276257","display_name":"Claire Elizabeth Thomas","orcid":"https://orcid.org/0000-0001-9515-3277","observed_orcids":["https://orcid.org/0000-0001-9515-3277"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Claire E. Thomas","raw_affiliation_strings":["1Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania","2Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210128526","https://openalex.org/I4210134769"]},{"raw_affiliation_string":"2Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063230233","display_name":"Renwei Wang","orcid":"https://orcid.org/0000-0001-8871-7054","observed_orcids":["https://orcid.org/0000-0001-8871-7054"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Renwei Wang","raw_affiliation_strings":["1Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210128526","https://openalex.org/I4210134769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068308715","display_name":"Jennifer\u00a0M. Adams\u2010Haduch","orcid":"https://orcid.org/0000-0002-0640-3076","observed_orcids":["https://orcid.org/0000-0002-0640-3076"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Adams-Haduch","raw_affiliation_strings":["1Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210128526","https://openalex.org/I4210134769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022126431","display_name":"Sharon E. Murphy","orcid":"https://orcid.org/0000-0001-5391-8104","observed_orcids":["https://orcid.org/0000-0001-5391-8104"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4390039358","display_name":"Masonic Cancer Center","ror":"https://ror.org/05x083d20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sharon E. Murphy","raw_affiliation_strings":["3Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota","4Department of Biochemistry, Molecular Biology and BioPhysics, University of Minnesota, Minneapolis, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]},{"raw_affiliation_string":"4Department of Biochemistry, Molecular Biology and BioPhysics, University of Minnesota, Minneapolis, Minnesota","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026276538","display_name":"Per Magne Ueland","orcid":"https://orcid.org/0000-0002-1903-0571","observed_orcids":["https://orcid.org/0000-0002-1903-0571"]},"institutions":[{"id":"https://openalex.org/I2800740805","display_name":"Haukeland University Hospital","ror":"https://ror.org/03np4e098","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I2800740805"]},{"id":"https://openalex.org/I4432739","display_name":"University of Bergen","ror":"https://ror.org/03zga2b32","country_code":"NO","type":"education","lineage":["https://openalex.org/I4432739"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Per Magne Ueland","raw_affiliation_strings":["5Department of Clinical Sciences, Laboratory of Clinical Biochemistry, University of Bergen, Bergen, Norway","6Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway"],"raw_orcid":"https://orcid.org/0000-0002-1903-0571","affiliations":[{"raw_affiliation_string":"5Department of Clinical Sciences, Laboratory of Clinical Biochemistry, University of Bergen, Bergen, Norway","institution_ids":["https://openalex.org/I4432739"]},{"raw_affiliation_string":"6Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway","institution_ids":["https://openalex.org/I2800740805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055368205","display_name":"\u00d8ivind Midttun","orcid":"https://orcid.org/0000-0003-2937-5351","observed_orcids":["https://orcid.org/0000-0003-2937-5351"]},"institutions":[{"id":"https://openalex.org/I4210142572","display_name":"Bevital (Norway)","ror":"https://ror.org/03whyax55","country_code":"NO","type":"company","lineage":["https://openalex.org/I4210142572"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"\u00d8ivind Midttun","raw_affiliation_strings":["7Bevital AS, Bergen, Norway"],"raw_orcid":"https://orcid.org/0000-0003-2937-5351","affiliations":[{"raw_affiliation_string":"7Bevital AS, Bergen, Norway","institution_ids":["https://openalex.org/I4210142572"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001258652","display_name":"Paul Brennan","orcid":"https://orcid.org/0000-0002-0518-8714","observed_orcids":["https://orcid.org/0000-0002-0518-8714","https://orcid.org/0000-0001-8368-1478","https://orcid.org/0000-0002-7977-6818"]},"institutions":[{"id":"https://openalex.org/I42237331","display_name":"Centre international de recherche sur le cancer","ror":"https://ror.org/00v452281","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210105654","https://openalex.org/I42237331"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Paul Brennan","raw_affiliation_strings":["8Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"8Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France","institution_ids":["https://openalex.org/I42237331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033972061","display_name":"Mattias Johansson","orcid":"https://orcid.org/0000-0002-3116-5081","observed_orcids":["https://orcid.org/0000-0002-3116-5081"]},"institutions":[{"id":"https://openalex.org/I42237331","display_name":"Centre international de recherche sur le cancer","ror":"https://ror.org/00v452281","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210105654","https://openalex.org/I42237331"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Mattias Johansson","raw_affiliation_strings":["8Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"8Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France","institution_ids":["https://openalex.org/I42237331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107841198","display_name":"Yu-Tang Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210110011","display_name":"Shanghai Cancer Institute","ror":"https://ror.org/01ty4bg86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210110011"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu-Tang Gao","raw_affiliation_strings":["9Department of Epidemiology, Shanghai Cancer Institute, Shanghai Jiaotong University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"9Department of Epidemiology, Shanghai Cancer Institute, Shanghai Jiaotong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210110011"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081606775","display_name":"Jian\u2010Min Yuan","orcid":"https://orcid.org/0000-0002-4620-3108","observed_orcids":["https://orcid.org/0000-0002-4620-3108"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jian-Min Yuan","raw_affiliation_strings":["1Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania","2Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210128526","https://openalex.org/I4210134769"]},{"raw_affiliation_string":"2Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5081606775"],"corresponding_institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210128526","https://openalex.org/I4210134769"],"apc_list":null,"apc_paid":null,"fwci":3.015,"has_fulltext":false,"cited_by_count":48,"citation_normalized_percentile":{"value":0.91706684,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"29","issue":"1","first_page":"127","last_page":"132"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/urinary-cotinine","display_name":"urinary cotinine","score":0.9750000238418579},{"id":"https://openalex.org/keywords/serum-cotinine","display_name":"serum cotinine","score":1.0},{"id":"https://openalex.org/keywords/lung-cancer-risk-prediction","display_name":"lung cancer risk prediction","score":0.8650000095367432},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.878000020980835},{"id":"https://openalex.org/keywords/current-smokers","display_name":"current smokers","score":0.828000009059906},{"id":"https://openalex.org/keywords/risk-prediction-model","display_name":"risk prediction model","score":0.8090000152587891},{"id":"https://openalex.org/keywords/noninvasive-biomarkers","display_name":"non-invasive biomarkers","score":0.7770000100135803}],"concepts":[{"id":"https://openalex.org/C2776319443","wikidata":"https://www.wikidata.org/wiki/Q421177","display_name":"Cotinine","level":3,"score":0.9552046060562134},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7946149110794067},{"id":"https://openalex.org/C68443243","wikidata":"https://www.wikidata.org/wiki/Q2786686","display_name":"Quartile","level":3,"score":0.720853865146637},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.689387321472168},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.6830723285675049},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.558173656463623},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.528660774230957},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.5154191255569458},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.4654124081134796},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.463384747505188},{"id":"https://openalex.org/C2779547902","wikidata":"https://www.wikidata.org/wiki/Q28086552","display_name":"Nicotine","level":2,"score":0.42462122440338135},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3523895740509033},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.3422977328300476},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.07983791828155518},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000073865","descriptor_name":"Cigarette Smoking","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000073865","descriptor_name":"Cigarette Smoking","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000073865","descriptor_name":"Cigarette Smoking","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D003367","descriptor_name":"Cotinine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003367","descriptor_name":"Cotinine","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1158/1055-9965.epi-19-0653","doi":"https://doi.org/10.1158/1055-9965.epi-19-0653","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1055-9965.epi-19-0653","pdf_url":null,"source":{"id":"https://openalex.org/S8391440","display_name":"Cancer Epidemiology Biomarkers & Prevention","issn_l":"1055-9965","issn":["1055-9965","1538-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Epidemiology, Biomarkers & Prevention","raw_type":"journal-article"},{"id":"pmid:31685561","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31685561","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7695222","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7695222","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cancer Epidemiol Biomarkers Prev","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7695222","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7695222","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cancer Epidemiol Biomarkers Prev","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G2566001298","display_name":"Prospective studies of cancer etiology and prevention in Shanghai and Singapore","funder_award_id":"R01CA144034","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3579970556","display_name":"One-carbon metabolism biomarkers and lung cancer risk","funder_award_id":"U01CA155340","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3835957205","display_name":"Integrative Analysis of Lung Cancer Etiology and Risk","funder_award_id":"U19CA203654","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4662333112","display_name":null,"funder_award_id":"R01CA1144034","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7390542150","display_name":"Cancer epidemiology cohorts in Shanghai and Singapore ","funder_award_id":"UM1CA182876","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8469227669","display_name":"The Singapore Chinese Health Study","funder_award_id":"U01CA182876","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000889303","display_name":"Translational Research Training in Cancer Prevention and Control","funder_award_id":"T32CA186873","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320307856","display_name":"World Health Organization","ror":"https://ror.org/01f80g185"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W130099911","https://openalex.org/W1963878232","https://openalex.org/W1970748036","https://openalex.org/W1985099573","https://openalex.org/W1999084888","https://openalex.org/W2004256112","https://openalex.org/W2020466267","https://openalex.org/W2044318646","https://openalex.org/W2047810781","https://openalex.org/W2057228359","https://openalex.org/W2057749448","https://openalex.org/W2079670701","https://openalex.org/W2115105291","https://openalex.org/W2126645982","https://openalex.org/W2130829295","https://openalex.org/W2155963578","https://openalex.org/W2191110339","https://openalex.org/W2280957887","https://openalex.org/W2739699909","https://openalex.org/W2807953401","https://openalex.org/W2889646458","https://openalex.org/W4247748440"],"related_works":["https://openalex.org/W1966632018","https://openalex.org/W2007690438","https://openalex.org/W2155963578","https://openalex.org/W2030749524","https://openalex.org/W2807953401","https://openalex.org/W2083701204","https://openalex.org/W4246726997","https://openalex.org/W4308620600","https://openalex.org/W1978361750","https://openalex.org/W2057749448"],"abstract_inverted_index":{"BACKGROUND:":[0],"Cotinine":[1],"is":[2,221],"a":[3,222],"metabolite":[4],"of":[5,80,103,131,165,179,211,233],"nicotine.":[6],"Serum":[7,106],"and":[8,43,64,93,107,187,202],"urinary":[9,108,166,193],"cotinine":[10,61,109,126,168,186,195,204,220,229],"are":[11],"validated":[12],"biomarkers":[13],"for":[14,19,96,134,155,184,192,215,238],"cigarette":[15],"exposure.":[16],"Their":[17],"performance":[18,208],"lung":[20,40,97,115,132,212,235],"cancer":[21,41,78,98,116,133,213,236],"risk":[22,173,214,231,237],"prediction":[23,174,210,232],"has":[24],"not":[25],"been":[26],"simultaneously":[27],"examined":[28],"in":[29,47,62,114,136,209,230],"epidemiologic":[30],"studies.":[31],"METHODS:":[32],"A":[33,172],"nested":[34],"case-control":[35],"study,":[36,51],"including":[37],"452":[38,44],"incident":[39],"cases":[42,117],"smoking-matched":[45],"controls":[46],"the":[48,122,129,137,148,162,206],"Shanghai":[49],"cohort":[50],"was":[52,84,142,150],"conducted.":[53],"Mass":[54],"spectrometry-based":[55],"methods":[56],"were":[57,111],"used":[58,85],"to":[59,86,161],"quantify":[60],"serum":[63,125,185,203,228],"urine":[65],"samples":[66],"collected":[67],"from":[68],"current":[69,216,239],"smokers":[70,135],"at":[71],"baseline,":[72],"on":[73],"average":[74],"10":[75],"years":[76],"before":[77],"diagnosis":[79],"cases.":[81],"Logistic":[82],"regression":[83],"estimate":[87],"ORs,":[88],"95%":[89],"confidence":[90],"intervals":[91],"(CI),":[92],"AUC":[94,178],"ROC":[95],"associated":[99],"with":[100,121,197],"higher":[101,113],"levels":[102,110],"cotinine.":[104],"RESULTS:":[105],"significantly":[112],"than":[118],"controls.":[119],"Compared":[120],"lowest":[123,163],"quartile":[124,164],"(\u22640.40":[127],"nmol/mL),":[128],"OR":[130,149],"highest":[138,156],"quartiles":[139],"(>1.39":[140],"nmol/mL)":[141],"5.46":[143],"(95%":[144,152,181,189],"CI,":[145,153,182,190],"3.38-8.81).":[146],"Similarly,":[147],"5.49":[151],"3.39-8.87)":[154],"(>16.38":[157],"nmol/mg":[158,170],"creatinine)":[159],"relative":[160],"total":[167,194],"(\u22644.11":[169],"creatinine).":[171],"model":[175],"yielded":[176],"an":[177],"0.72":[180,188],"0.69-0.75)":[183,191],"combined":[196],"smoking":[198],"history.":[199],"CONCLUSIONS:":[200],"Urinary":[201,219],"have":[205],"same":[207],"smokers.":[217,240],"IMPACT:":[218],"noninvasive":[223],"biomarker":[224],"that":[225],"can":[226],"replace":[227],"future":[234]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2019-11-22T00:00:00"}