{"id":"https://openalex.org/W2983172503","doi":"https://doi.org/10.1186/s12974-019-1618-x","title":"TRPV1 translocated to astrocytic membrane to promote migration and inflammatory infiltration thus promotes epilepsy after hypoxic ischemia in immature brain","display_name":"TRPV1 translocated to astrocytic membrane to promote migration and inflammatory infiltration thus promotes epilepsy after hypoxic ischemia in immature brain","publication_year":2019,"publication_date":"2019-11-13","ids":{"openalex":"https://openalex.org/W2983172503","doi":"https://doi.org/10.1186/s12974-019-1618-x","mag":"2983172503","pmid":"https://pubmed.ncbi.nlm.nih.gov/31722723"},"language":"en","primary_location":{"id":"doi:10.1186/s12974-019-1618-x","doi":"https://doi.org/10.1186/s12974-019-1618-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12974-019-1618-x","pdf_url":"https://jneuroinflammation.biomedcentral.com/counter/pdf/10.1186/s12974-019-1618-x","source":{"id":"https://openalex.org/S199572710","display_name":"Journal of Neuroinflammation","issn_l":"1742-2094","issn":["1742-2094"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-2","medline","norway-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroinflammation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jneuroinflammation.biomedcentral.com/counter/pdf/10.1186/s12974-019-1618-x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100328085","display_name":"Xin Wang","orcid":"https://orcid.org/0000-0003-1721-0234","observed_orcids":["https://orcid.org/0000-0003-1721-0234"]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Wang","raw_affiliation_strings":["Department of Physiology, Hubei Provincial Key Laboratory of Developmentally Originated Disease, School of Basic Medical Sciences, Wuhan University, Wuhan, 430071, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Hubei Provincial Key Laboratory of Developmentally Originated Disease, School of Basic Medical Sciences, Wuhan University, Wuhan, 430071, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111229321","display_name":"Xingliang Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xing-Liang Yang","raw_affiliation_strings":["Department of Physiology, Hubei Provincial Key Laboratory of Developmentally Originated Disease, School of Basic Medical Sciences, Wuhan University, Wuhan, 430071, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Hubei Provincial Key Laboratory of Developmentally Originated Disease, School of Basic Medical Sciences, Wuhan University, Wuhan, 430071, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044982039","display_name":"Weilin Kong","orcid":"https://orcid.org/0000-0001-5478-5083","observed_orcids":["https://orcid.org/0000-0001-5478-5083"]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei-Lin Kong","raw_affiliation_strings":["Department of Physiology, Hubei Provincial Key Laboratory of Developmentally Originated Disease, School of Basic Medical Sciences, Wuhan University, Wuhan, 430071, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Hubei Provincial Key Laboratory of Developmentally Originated Disease, School of Basic Medical Sciences, Wuhan University, Wuhan, 430071, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025870889","display_name":"Mengliu Zeng","orcid":"https://orcid.org/0009-0009-6232-9075","observed_orcids":["https://orcid.org/0009-0009-6232-9075"]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meng-Liu Zeng","raw_affiliation_strings":["Department of Physiology, Hubei Provincial Key Laboratory of Developmentally Originated Disease, School of Basic Medical Sciences, Wuhan University, Wuhan, 430071, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Hubei Provincial Key Laboratory of Developmentally Originated Disease, School of Basic Medical Sciences, Wuhan University, Wuhan, 430071, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Lin Shao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lin Shao","raw_affiliation_strings":["Department of Physiology, Hubei Provincial Key Laboratory of Developmentally Originated Disease, School of Basic Medical Sciences, Wuhan University, Wuhan, 430071, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Hubei Provincial Key Laboratory of Developmentally Originated Disease, School of Basic Medical Sciences, Wuhan University, Wuhan, 430071, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020601738","display_name":"Guang-Tong Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guang-Tong Jiang","raw_affiliation_strings":["Department of Physiology, Hubei Provincial Key Laboratory of Developmentally Originated Disease, School of Basic Medical Sciences, Wuhan University, Wuhan, 430071, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Hubei Provincial Key Laboratory of Developmentally Originated Disease, School of Basic Medical Sciences, Wuhan University, Wuhan, 430071, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087375932","display_name":"Jingjing Cheng","orcid":"https://orcid.org/0000-0002-8202-2486","observed_orcids":["https://orcid.org/0000-0002-8202-2486","https://orcid.org/0000-0001-8366-4117"]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing-Jing Cheng","raw_affiliation_strings":["Department of Physiology, Hubei Provincial Key Laboratory of Developmentally Originated Disease, School of Basic Medical Sciences, Wuhan University, Wuhan, 430071, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Hubei Provincial Key Laboratory of Developmentally Originated Disease, School of Basic Medical Sciences, Wuhan University, Wuhan, 430071, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007004250","display_name":"Shuo Kong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuo Kong","raw_affiliation_strings":["Department of Physiology, Hubei Provincial Key Laboratory of Developmentally Originated Disease, School of Basic Medical Sciences, Wuhan University, Wuhan, 430071, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Hubei Provincial Key Laboratory of Developmentally Originated Disease, School of Basic Medical Sciences, Wuhan University, Wuhan, 430071, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102001581","display_name":"Xiaohua He","orcid":"https://orcid.org/0000-0001-5719-8669","observed_orcids":["https://orcid.org/0000-0001-5719-8669"]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao-Hua He","raw_affiliation_strings":["Department of Pathophysiology, School of Basic Medical Sciences, Wuhan University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathophysiology, School of Basic Medical Sciences, Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102937494","display_name":"Wanhong Liu","orcid":"https://orcid.org/0000-0003-3271-4342","observed_orcids":["https://orcid.org/0000-0003-3271-4342"]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wan-Hong Liu","raw_affiliation_strings":["Department of Immunology, School of Basic Medical Sciences, Wuhan University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, School of Basic Medical Sciences, Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090046952","display_name":"Tao-Xiang Chen","orcid":"https://orcid.org/0000-0001-9723-3115","observed_orcids":["https://orcid.org/0000-0001-9723-3115"]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tao-Xiang Chen","raw_affiliation_strings":["Department of Physiology, Hubei Provincial Key Laboratory of Developmentally Originated Disease, School of Basic Medical Sciences, Wuhan University, Wuhan, 430071, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Hubei Provincial Key Laboratory of Developmentally Originated Disease, School of Basic Medical Sciences, Wuhan University, Wuhan, 430071, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110373460","display_name":"Biwen Peng","orcid":"https://orcid.org/0000-0002-5599-6779","observed_orcids":["https://orcid.org/0000-0002-5599-6779"]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Bi-Wen Peng","raw_affiliation_strings":["Department of Physiology, Hubei Provincial Key Laboratory of Developmentally Originated Disease, School of Basic Medical Sciences, Wuhan University, Wuhan, 430071, China. pengbiwen@whu.edu.cn","Department of Physiology, Hubei Provincial Key Laboratory of Developmentally Originated Disease, School of Basic Medical Sciences, Wuhan University, Wuhan, 430071, China"],"raw_orcid":"https://orcid.org/0000-0002-5599-6779","affiliations":[{"raw_affiliation_string":"Department of Physiology, Hubei Provincial Key Laboratory of Developmentally Originated Disease, School of Basic Medical Sciences, Wuhan University, Wuhan, 430071, China. pengbiwen@whu.edu.cn","institution_ids":["https://openalex.org/I37461747"]},{"raw_affiliation_string":"Department of Physiology, Hubei Provincial Key Laboratory of Developmentally Originated Disease, School of Basic Medical Sciences, Wuhan University, Wuhan, 430071, China","institution_ids":["https://openalex.org/I37461747"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5110373460"],"corresponding_institution_ids":["https://openalex.org/I37461747"],"apc_list":{"value":2680,"currency":"USD","value_usd":2680},"apc_paid":{"value":2680,"currency":"USD","value_usd":2680},"fwci":4.7366,"has_fulltext":true,"cited_by_count":56,"citation_normalized_percentile":{"value":0.95239132,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"16","issue":"1","first_page":"214","last_page":"214"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.8452000021934509,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.8452000021934509,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.1460999995470047,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trpv1","display_name":"TRPV1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/astrocyte-migration","display_name":"astrocyte migration","score":0.9430000185966492},{"id":"https://openalex.org/keywords/actin-cytoskeleton-reorganization","display_name":"actin cytoskeleton remodeling","score":0.7789999842643738},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.859000027179718},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8420000076293945},{"id":"https://openalex.org/keywords/neuronal-excitability","display_name":"neuronal excitability","score":0.9330000281333923},{"id":"https://openalex.org/keywords/seizure-susceptibility","display_name":"seizure susceptibility","score":0.5600000023841858},{"id":"https://openalex.org/keywords/ion-channel-dysfunction","display_name":"ion channel dysfunction","score":0.8019999861717224}],"concepts":[{"id":"https://openalex.org/C160145004","wikidata":"https://www.wikidata.org/wiki/Q413209","display_name":"TRPV1","level":4,"score":0.6861521601676941},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.6629965305328369},{"id":"https://openalex.org/C2781458332","wikidata":"https://www.wikidata.org/wiki/Q720026","display_name":"Brain damage","level":2,"score":0.6304305195808411},{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.5945165157318115},{"id":"https://openalex.org/C2780495277","wikidata":"https://www.wikidata.org/wiki/Q905442","display_name":"Glial fibrillary acidic protein","level":3,"score":0.4572732746601105},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.4317362904548645},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41864213347435},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3547072112560272},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.34918656945228577},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.3482606112957001},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33501487970352173},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3226006031036377},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3151153326034546},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.29273054003715515},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25036826729774475},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.11692383885383606},{"id":"https://openalex.org/C155164980","wikidata":"https://www.wikidata.org/wiki/Q304043","display_name":"Transient receptor potential channel","level":3,"score":0.07940974831581116},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.06477820873260498}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020925","descriptor_name":"Hypoxia-Ischemia, Brain","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D020925","descriptor_name":"Hypoxia-Ischemia, Brain","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D020925","descriptor_name":"Hypoxia-Ischemia, Brain","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D020925","descriptor_name":"Hypoxia-Ischemia, Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020925","descriptor_name":"Hypoxia-Ischemia, Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020925","descriptor_name":"Hypoxia-Ischemia, Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050916","descriptor_name":"TRPV Cation Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050916","descriptor_name":"TRPV Cation Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050916","descriptor_name":"TRPV Cation Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12974-019-1618-x","doi":"https://doi.org/10.1186/s12974-019-1618-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12974-019-1618-x","pdf_url":"https://jneuroinflammation.biomedcentral.com/counter/pdf/10.1186/s12974-019-1618-x","source":{"id":"https://openalex.org/S199572710","display_name":"Journal of Neuroinflammation","issn_l":"1742-2094","issn":["1742-2094"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-2","medline","norway-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroinflammation","raw_type":"journal-article"},{"id":"pmid:31722723","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31722723","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neuroinflammation","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6852893","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6852893","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Neuroinflammation","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:73aac5be2c014d0bb30be65d14fd3856","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/73aac5be2c014d0bb30be65d14fd3856","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-14 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12974-019-1618-x","doi":"https://doi.org/10.1186/s12974-019-1618-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12974-019-1618-x","pdf_url":"https://jneuroinflammation.biomedcentral.com/counter/pdf/10.1186/s12974-019-1618-x","source":{"id":"https://openalex.org/S199572710","display_name":"Journal of Neuroinflammation","issn_l":"1742-2094","issn":["1742-2094"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-2","medline","norway-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroinflammation","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1784294815","display_name":null,"funder_award_id":"TFJC2018001","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2687126260","display_name":null,"funder_award_id":"2017CFA017","funder_id":"https://openalex.org/F4320322186","funder_display_name":"Natural Science Foundation of Hubei Province"},{"id":"https://openalex.org/G3427458924","display_name":null,"funder_award_id":"TFJC2018001","funder_id":"https://openalex.org/F4320324116","funder_display_name":"Wuhan University"},{"id":"https://openalex.org/G602682464","display_name":null,"funder_award_id":"2017CFA017","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7211439501","display_name":null,"funder_award_id":"81571481","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8280219185","display_name":"NKCC1\u4ecb\u5bfc\u7684\u65b0\u751f\u5927\u9f20\u7f3a\u6c27\u7f3a\u8840\u6027\u8111\u635f\u4f24\u81f4\u60ca\u53a5\u7684\u673a\u5236\u7814\u7a76","funder_award_id":"81370737","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322186","display_name":"Natural Science Foundation of Hubei Province","ror":null},{"id":"https://openalex.org/F4320324116","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2983172503.pdf","grobid_xml":"https://content.openalex.org/works/W2983172503.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W1511198581","https://openalex.org/W1572350532","https://openalex.org/W1706942228","https://openalex.org/W1771769775","https://openalex.org/W1947382567","https://openalex.org/W1972346280","https://openalex.org/W1979575851","https://openalex.org/W1986557899","https://openalex.org/W1986696922","https://openalex.org/W1990519416","https://openalex.org/W1991380003","https://openalex.org/W1992560928","https://openalex.org/W2006495215","https://openalex.org/W2015679500","https://openalex.org/W2022116223","https://openalex.org/W2028053972","https://openalex.org/W2035471044","https://openalex.org/W2039263844","https://openalex.org/W2047025991","https://openalex.org/W2074570596","https://openalex.org/W2075682801","https://openalex.org/W2076644208","https://openalex.org/W2083146047","https://openalex.org/W2085157974","https://openalex.org/W2089648703","https://openalex.org/W2089895199","https://openalex.org/W2101979195","https://openalex.org/W2102748186","https://openalex.org/W2106105150","https://openalex.org/W2106201634","https://openalex.org/W2108435419","https://openalex.org/W2121860798","https://openalex.org/W2148642633","https://openalex.org/W2150641624","https://openalex.org/W2152482858","https://openalex.org/W2153026104","https://openalex.org/W2190725993","https://openalex.org/W2192584681","https://openalex.org/W2198623424","https://openalex.org/W2208088507","https://openalex.org/W2229449005","https://openalex.org/W2280811146","https://openalex.org/W2398197037","https://openalex.org/W2401782172","https://openalex.org/W2414352146","https://openalex.org/W2485564204","https://openalex.org/W2531859534","https://openalex.org/W2572710398","https://openalex.org/W2598521796","https://openalex.org/W2604440807","https://openalex.org/W2610976827","https://openalex.org/W2611610652","https://openalex.org/W2614071465","https://openalex.org/W2670179021","https://openalex.org/W2737261996","https://openalex.org/W2751701458","https://openalex.org/W2758048250","https://openalex.org/W2759514908","https://openalex.org/W2769140026","https://openalex.org/W2775745707","https://openalex.org/W2794230688","https://openalex.org/W2801744150","https://openalex.org/W2808614434","https://openalex.org/W2884236029","https://openalex.org/W2889719632","https://openalex.org/W2946016906","https://openalex.org/W2947235002"],"related_works":["https://openalex.org/W2136454944","https://openalex.org/W3193914952","https://openalex.org/W2886765439","https://openalex.org/W2076206894","https://openalex.org/W2349220395","https://openalex.org/W1964650815","https://openalex.org/W2021735051","https://openalex.org/W2011704181","https://openalex.org/W2058391066","https://openalex.org/W4244209049"],"abstract_inverted_index":{"BACKGROUND:":[0],"Neonatal":[1,67],"hypoxic-ischemic":[2],"brain":[3,113,179],"damage":[4],"(HIBD),":[5],"a":[6,61,242,250],"leading":[7],"cause":[8],"of":[9,24,47,58,93,159,221,234],"neonatal":[10],"mortality,":[11],"has":[12],"intractable":[13],"sequela":[14],"such":[15],"as":[16,60],"epilepsy":[17],"that":[18,31,192],"seriously":[19],"affected":[20],"the":[21,36,45,55,91,155,219,232],"life":[22],"quality":[23],"HIBD":[25,78,183,190],"survivors.":[26],"We":[27],"have":[28],"previously":[29],"shown":[30],"ion":[32],"channel":[33],"dysfunction":[34],"in":[35,44,79,82,116,182],"central":[37],"nervous":[38],"system":[39],"played":[40],"an":[41],"important":[42],"role":[43],"process":[46],"HIBD-induced":[48],"epilepsy.":[49,65,238],"Therefore,":[50],"we":[51],"continued":[52],"to":[53,76,89,142,236,248],"validate":[54],"underlying":[56],"mechanisms":[57],"TRPV1":[59,125,152,193,213,247],"potential":[62],"target":[63,252],"for":[64,187,245,253],"METHODS:":[66],"hypoxic":[68],"ischemia":[69],"and":[70,81,102,110,127,157,165,178,202,227],"oxygen-glucose":[71],"deprivation":[72],"(OGD)":[73],"were":[74,87,130],"used":[75,88],"simulate":[77],"vivo":[80],"vitro.":[83],"Primarily":[84],"cultured":[85],"astrocytes":[86,230],"assess":[90],"expression":[92],"TRPV1,":[94],"glial":[95],"fibrillary":[96],"acidic":[97],"protein":[98],"(GFAP),":[99],"cytoskeletal":[100],"rearrangement,":[101],"inflammatory":[103],"cytokines":[104,161,223],"by":[105,122,132],"using":[106],"Western":[107],"blot,":[108],"q-PCR,":[109],"immunofluorescence.":[111],"Furthermore,":[112],"electrical":[114,180],"activity":[115,181],"freely":[117],"moving":[118],"mice":[119,195],"was":[120],"recorded":[121],"electroencephalography":[123],"(EEG).":[124],"current":[126],"neuronal":[128,174],"excitability":[129,175],"detected":[131],"whole-cell":[133],"patch":[134],"clamp.":[135],"RESULTS:":[136],",":[137],"which":[138],"promoted":[139,145,214],"G-actin":[140],"polymerized":[141],"F-actin,":[143],"thus":[144,217],"astrocyte":[146,215],"migration":[147,216],"after":[148,167,176,189,255],"OGD.":[149,168],"Moreover,":[150],"astrocytic":[151,246],"deficiency":[153],"decreased":[154,203],"production":[156],"release":[158],"pro-inflammatory":[160,222],"(TNF,":[162,224],"IL-6,":[163,226],"IL-1\u03b2,":[164,225],"iNOS)":[166,228],"It":[169],"could":[170],"also":[171],"dramatically":[172],"attenuate":[173],"OGD":[177],"mice.":[184,210],"Behavioral":[185],"testing":[186],"seizures":[188],"revealed":[191],"knockout":[194],"demonstrated":[196],"prolonged":[197],"onset":[198],"latency,":[199],"shortened":[200],"duration,":[201],"seizure":[204],"severity":[205],"when":[206],"compared":[207],"with":[208],"wild-type":[209],"CONCLUSIONS:":[211],"Collectively,":[212],"helped":[218],"infiltration":[220],"from":[229],"into":[231],"vicinity":[233],"neurons":[235],"promote":[237],"Our":[239],"study":[240],"provides":[241],"strong":[243],"rationale":[244],"be":[249],"therapeutic":[251],"anti-epileptogenesis":[254],"HIBD.":[256]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":15},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":5}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}
