{"id":"https://openalex.org/W2983109199","doi":null,"title":"Chemoresistance and targeting of growth factors/cytokines signalling pathways: towards the development of effective therapeutic strategy for endometrial cancer.","display_name":"Chemoresistance and targeting of growth factors/cytokines signalling pathways: towards the development of effective therapeutic strategy for endometrial cancer.","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2983109199","mag":"2983109199","pmid":"https://pubmed.ncbi.nlm.nih.gov/30094104","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6079151"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:5033010","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6079151","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6079151","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030633656","display_name":"Fengjun Guo","orcid":"https://orcid.org/0000-0003-0130-9694","observed_orcids":["https://orcid.org/0000-0003-0130-9694"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4210142484","display_name":"Second Affiliated Hospital of Jilin University","ror":"https://ror.org/03x6hbh34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142484"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fengjun Guo","raw_affiliation_strings":["Department of Gynaecology and Obstetrics, The Second Hospital of Jilin University 218 Ziqiang Rd, Changchun 130041, Jilin, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynaecology and Obstetrics, The Second Hospital of Jilin University 218 Ziqiang Rd, Changchun 130041, Jilin, People's Republic of China","institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210142484"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091575402","display_name":"Haina Zhang","orcid":"https://orcid.org/0000-0003-4548-3766","observed_orcids":["https://orcid.org/0000-0003-4548-3766"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4210142484","display_name":"Second Affiliated Hospital of Jilin University","ror":"https://ror.org/03x6hbh34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142484"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haina Zhang","raw_affiliation_strings":["Department of Rehabilitation, The Second Hospital of Jilin University 218 Ziqiang Rd, Changchun 130041, Jilin, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rehabilitation, The Second Hospital of Jilin University 218 Ziqiang Rd, Changchun 130041, Jilin, People's Republic of China","institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210142484"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089511297","display_name":"Zanhui Jia","orcid":"https://orcid.org/0000-0002-7079-6599","observed_orcids":["https://orcid.org/0000-0002-7079-6599","https://orcid.org/0000-0002-6032-1047"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4210142484","display_name":"Second Affiliated Hospital of Jilin University","ror":"https://ror.org/03x6hbh34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142484"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zanhui Jia","raw_affiliation_strings":["Department of Gynaecology and Obstetrics, The Second Hospital of Jilin University 218 Ziqiang Rd, Changchun 130041, Jilin, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynaecology and Obstetrics, The Second Hospital of Jilin University 218 Ziqiang Rd, Changchun 130041, Jilin, People's Republic of China","institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210142484"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062442867","display_name":"Manhua Cui","orcid":"https://orcid.org/0000-0001-7694-6917","observed_orcids":["https://orcid.org/0000-0001-7694-6917"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4210142484","display_name":"Second Affiliated Hospital of Jilin University","ror":"https://ror.org/03x6hbh34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142484"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Manhua Cui","raw_affiliation_strings":["Department of Gynaecology and Obstetrics, The Second Hospital of Jilin University 218 Ziqiang Rd, Changchun 130041, Jilin, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynaecology and Obstetrics, The Second Hospital of Jilin University 218 Ziqiang Rd, Changchun 130041, Jilin, People's Republic of China","institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210142484"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103068471","display_name":"Jingyan Tian","orcid":"https://orcid.org/0000-0001-8463-5262","observed_orcids":["https://orcid.org/0000-0001-8463-5262"]},"institutions":[{"id":"https://openalex.org/I4210125137","display_name":"First Hospital of Jilin University","ror":"https://ror.org/034haf133","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210125137"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingyan Tian","raw_affiliation_strings":["Department of Urology, Second Division of The First Hospital of Jilin University 3302 Jilin Rd, Changchun 130031, Jilin, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Second Division of The First Hospital of Jilin University 3302 Jilin Rd, Changchun 130031, Jilin, People's Republic of China","institution_ids":["https://openalex.org/I4210125137"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8585,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.69001703,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"8","issue":"7","first_page":"1317","last_page":"1331"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.6528000235557556,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.6528000235557556,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.34200000762939453,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endometrial-cancer","display_name":"endometrial cancer","score":1.0},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.9869999885559082},{"id":"https://openalex.org/keywords/cytokine-signaling","display_name":"cytokine signaling","score":0.9259999990463257},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.9649999737739563},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.9779999852180481},{"id":"https://openalex.org/keywords/fgf-signaling","display_name":"FGF signaling","score":0.7289999723434448},{"id":"https://openalex.org/keywords/mtor-signaling","display_name":"mTOR signaling","score":0.7850000262260437},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.984000027179718},{"id":"https://openalex.org/keywords/pten","display_name":"PTEN","score":0.6169999837875366},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9779999852180481},{"id":"https://openalex.org/keywords/ras-mapk-pathway","display_name":"RAS/MAPK pathway","score":0.8939999938011169},{"id":"https://openalex.org/keywords/fgfr2-mutations","display_name":"FGFR2 mutations","score":0.921999990940094},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.9120000004768372},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.9679999947547913},{"id":"https://openalex.org/keywords/mtor-inhibitors","display_name":"mTOR inhibitors","score":0.9879999756813049},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.37299999594688416}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7417553067207336},{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.6925530433654785},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.6678144335746765},{"id":"https://openalex.org/C2777088508","wikidata":"https://www.wikidata.org/wiki/Q944777","display_name":"Endometrial cancer","level":3,"score":0.5460025668144226},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.48650044202804565},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.4621181786060333},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4346717298030853},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.4152454733848572},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.39536145329475403},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3671422004699707},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.3575640320777893},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3254016041755676},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22422844171524048},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1584920883178711}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:5033010","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6079151","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:30094104","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30094104","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6079151","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6079151/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},{"id":"mag:2983109199","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30094104","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5033010","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6079151","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":103,"referenced_works":["https://openalex.org/W145577621","https://openalex.org/W236091721","https://openalex.org/W1498931318","https://openalex.org/W1523248080","https://openalex.org/W1536110039","https://openalex.org/W1566932673","https://openalex.org/W1581204894","https://openalex.org/W1589121026","https://openalex.org/W1683991985","https://openalex.org/W1894751757","https://openalex.org/W1963528972","https://openalex.org/W1965568527","https://openalex.org/W1966841369","https://openalex.org/W1968395938","https://openalex.org/W1971924476","https://openalex.org/W1975352300","https://openalex.org/W1980746395","https://openalex.org/W1981215026","https://openalex.org/W1987604182","https://openalex.org/W1995197723","https://openalex.org/W1998203489","https://openalex.org/W1998919876","https://openalex.org/W1999224816","https://openalex.org/W2007466764","https://openalex.org/W2008463032","https://openalex.org/W2010397777","https://openalex.org/W2010485879","https://openalex.org/W2012047645","https://openalex.org/W2013977089","https://openalex.org/W2014224486","https://openalex.org/W2015173256","https://openalex.org/W2022882480","https://openalex.org/W2022884538","https://openalex.org/W2025480694","https://openalex.org/W2026530576","https://openalex.org/W2027879081","https://openalex.org/W2033947957","https://openalex.org/W2034883987","https://openalex.org/W2037489170","https://openalex.org/W2042862016","https://openalex.org/W2045031715","https://openalex.org/W2045327531","https://openalex.org/W2047408781","https://openalex.org/W2047510068","https://openalex.org/W2049499974","https://openalex.org/W2049573968","https://openalex.org/W2054071295","https://openalex.org/W2056312339","https://openalex.org/W2059857815","https://openalex.org/W2067970783","https://openalex.org/W2069439270","https://openalex.org/W2072767112","https://openalex.org/W2073863379","https://openalex.org/W2075790601","https://openalex.org/W2079537922","https://openalex.org/W2080196131","https://openalex.org/W2083453016","https://openalex.org/W2088561077","https://openalex.org/W2088769048","https://openalex.org/W2091030555","https://openalex.org/W2093024396","https://openalex.org/W2093351885","https://openalex.org/W2096055270","https://openalex.org/W2096950509","https://openalex.org/W2101657485","https://openalex.org/W2101844536","https://openalex.org/W2102981736","https://openalex.org/W2105616976","https://openalex.org/W2106465830","https://openalex.org/W2106771830","https://openalex.org/W2110104390","https://openalex.org/W2110443482","https://openalex.org/W2115954319","https://openalex.org/W2119607431","https://openalex.org/W2136555106","https://openalex.org/W2141416577","https://openalex.org/W2142134791","https://openalex.org/W2145978712","https://openalex.org/W2146274229","https://openalex.org/W2147114673","https://openalex.org/W2152550058","https://openalex.org/W2154307309","https://openalex.org/W2154885792","https://openalex.org/W2155191323","https://openalex.org/W2163155435","https://openalex.org/W2164185692","https://openalex.org/W2164452916","https://openalex.org/W2164778107","https://openalex.org/W2167068682","https://openalex.org/W2168215385","https://openalex.org/W2170454539","https://openalex.org/W2182443159","https://openalex.org/W2284799106","https://openalex.org/W2327130041","https://openalex.org/W2416800009","https://openalex.org/W2555468434","https://openalex.org/W2560080300","https://openalex.org/W2563277046","https://openalex.org/W2566586795","https://openalex.org/W2588723373","https://openalex.org/W2739392386","https://openalex.org/W2783423818","https://openalex.org/W4234164256"],"related_works":["https://openalex.org/W3195309792","https://openalex.org/W2110104390","https://openalex.org/W1996842414","https://openalex.org/W2157079036","https://openalex.org/W2257154986","https://openalex.org/W82591098","https://openalex.org/W4237667588","https://openalex.org/W2904745157","https://openalex.org/W7099049227","https://openalex.org/W2335585954"],"abstract_inverted_index":{"Endometrial":[0],"cancer":[1],"tends":[2],"to":[3,132],"be":[4,13],"an":[5],"aggressive":[6],"malignancy.":[7],"Although":[8],"the":[9,16,21,40,49,54,103,110,123,162,239,244,248,260],"disease":[10,57],"prognosis":[11],"can":[12],"good":[14],"at":[15],"early":[17],"stages":[18],"of":[19,42,56,60,66,81,105,112,151],"disease,":[20],"advanced":[22],"condition":[23],"is":[24],"not":[25],"curable.":[26],"Chemotherapy":[27],"regimens":[28],"and":[29,52,74,77,108,125,164,173,192,196,224,231,255,257],"hormone-based":[30],"therapy":[31],"in":[32,85,115,205,238],"combination":[33],"with":[34,155,207],"surgery":[35],"are":[36,153,201],"major":[37],"approaches":[38],"for":[39,212,262],"management":[41],"endometrial":[43,87,156,179,208,213,251],"cancers.":[44],"However,":[45],"intrinsic":[46],"chemoresistance":[47],"reduces":[48],"success":[50],"rate":[51],"increases":[53,102],"possibility":[55],"relapse.":[58],"Investigation":[59],"underlying":[61,250],"mechanisms":[62],"revealed":[63],"altered":[64],"activation":[65],"PI3K/AKT,":[67],"MAPK,":[68],"fibroblast":[69],"growth":[70],"factor":[71],"(FGF),":[72],"mTOR":[73,159,229],"WNT":[75,182],"pathways":[76,200],"reduced":[78],"gene":[79,146],"expression":[80],"tumor":[82,214],"suppressor":[83],"p53":[84],"recurrent":[86],"cancer.":[88,157,209],"A":[89],"PTEN":[90],"mutation,":[91],"deletion":[92],"or":[93,148],"degradation":[94],"induces":[95],"positive":[96],"p-AKT":[97],"expression,":[98],"while":[99],"PI3K":[100],"knock-down":[101],"level":[104,111],"pro-apoptotic":[106],"proteins":[107,120],"decreases":[109],"anti-apoptotic":[113],"ones":[114],"cancerous":[116],"cells.":[117],"Additionally,":[118],"RAS":[119],"trigger":[121,234],"both":[122],"RAF-MEK-ERK":[124],"PI3K-PTEN-AKT":[126],"signalling":[127,183],"mechanisms,":[128],"thus":[129],"conferring":[130],"resistance":[131],"anti-tumor":[133],"agents.":[134],"FGF":[135],"up-regulates":[136],"angiogenesis":[137],"via":[138,167],"receptor-mediated":[139],"tyrosine":[140,225],"kinase":[141,170,226],"activation.":[142],"Single":[143],"nucleotide":[144],"polymorphism,":[145],"amplification":[147],"missense":[149],"mutations":[150],"FGFR2":[152],"associated":[154],"The":[158],"complex":[160],"integrates":[161],"nutrient":[163],"mitogen":[165],"signals":[166],"AMPKs,":[168],"S6":[169],"1":[171],"(S6K1)":[172],"eukaryotic":[174],"initiation":[175],"factors,":[176],"causing":[177],"unrestricted":[178],"cellular":[180],"proliferation.":[181],"molecules,":[184],"such":[185],"as":[186],"frizzled":[187],"receptors,":[188],"\u03b2-catenin,":[189],"PORCN,":[190],"RSPO3":[191],"DKK1":[193],"undergo":[194],"dysregulation,":[195],"drugs":[197,232],"targeting":[198],"these":[199],"under":[202],"clinical":[203],"trials":[204],"patients":[206],"Common":[210],"therapies":[211,254],"include":[215],"platinum-based":[216],"anti-neoplastics,":[217],"taxanes,":[218],"nucleoside":[219],"analogues,":[220],"immune":[221],"modulators,":[222],"FGFR":[223],"inhibitors,":[227],"small-molecule":[228],"inhibitors":[230],"that":[233,265],"cell":[235],"cycle":[236],"arrest":[237],"G1":[240],"phase.":[241],"Taken":[242],"together,":[243],"current":[245],"review":[246],"elucidates":[247],"mechanism":[249],"cancer,":[252],"existing":[253],"chemoresistance,":[256],"points":[258],"towards":[259],"need":[261],"novel":[263],"therapeutics":[264],"may":[266],"promote":[267],"disease-free":[268],"survival.":[269]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-11-22T00:00:00"}
