{"id":"https://openalex.org/W2983019152","doi":"https://doi.org/10.1080/14786419.2019.1686372","title":"An acetylated derivative of vitexin halts MDA-MB-231 cellular progression and improves its immunogenic profile through tuning miR- 20a-MICA/B axis","display_name":"An acetylated derivative of vitexin halts MDA-MB-231 cellular progression and improves its immunogenic profile through tuning miR- 20a-MICA/B axis","publication_year":2019,"publication_date":"2019-11-06","ids":{"openalex":"https://openalex.org/W2983019152","doi":"https://doi.org/10.1080/14786419.2019.1686372","mag":"2983019152","pmid":"https://pubmed.ncbi.nlm.nih.gov/31691589"},"language":"en","primary_location":{"id":"doi:10.1080/14786419.2019.1686372","doi":"https://doi.org/10.1080/14786419.2019.1686372","is_oa":false,"landing_page_url":"https://doi.org/10.1080/14786419.2019.1686372","pdf_url":null,"source":{"id":"https://openalex.org/S205999849","display_name":"Natural Product Research","issn_l":"1478-6419","issn":["1478-6419","1478-6427"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Natural Product Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://figshare.com/articles/An_acetylated_derivative_of_vitexin_halts_MDA-MB-231_cellular_progression_and_improves_its_immunogenic_profile_through_tuning_miR-_20a-MICA_B_axis/10259897","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049835595","display_name":"Aya R. Awad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96823368","display_name":"German University in Cairo","ror":"https://ror.org/03rjt0z37","country_code":"EG","type":"education","lineage":["https://openalex.org/I96823368"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Aya R. Awad","raw_affiliation_strings":["Biochemistry Department, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry Department, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, Egypt","institution_ids":["https://openalex.org/I96823368"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009963718","display_name":"Rana Ahmed Youness","orcid":"https://orcid.org/0000-0001-6268-7942","observed_orcids":["https://orcid.org/0000-0001-6268-7942"]},"institutions":[{"id":"https://openalex.org/I96823368","display_name":"German University in Cairo","ror":"https://ror.org/03rjt0z37","country_code":"EG","type":"education","lineage":["https://openalex.org/I96823368"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Rana A. Youness","raw_affiliation_strings":["Pharmaceutical Biology Department, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Biology Department, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, Egypt","institution_ids":["https://openalex.org/I96823368"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101599195","display_name":"Mohamed M. Ibrahim","orcid":"https://orcid.org/0000-0002-2080-1492","observed_orcids":["https://orcid.org/0000-0002-2080-1492"]},"institutions":[{"id":"https://openalex.org/I84058292","display_name":"Helwan University","ror":"https://ror.org/00h55v928","country_code":"EG","type":"education","lineage":["https://openalex.org/I84058292"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"M. Ibrahim","raw_affiliation_strings":["Pharmacognosy Department, Faculty of Pharmacy, Helwan University, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacognosy Department, Faculty of Pharmacy, Helwan University, Cairo, Egypt","institution_ids":["https://openalex.org/I84058292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049455533","display_name":"Amira A. Abdel Motaal","orcid":"https://orcid.org/0000-0002-1020-9954","observed_orcids":["https://orcid.org/0000-0002-1020-9954"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]},{"id":"https://openalex.org/I82952536","display_name":"King Khalid University","ror":"https://ror.org/052kwzs30","country_code":"SA","type":"education","lineage":["https://openalex.org/I82952536"]}],"countries":["EG","SA"],"is_corresponding":false,"raw_author_name":"Amira Abdel Motaal","raw_affiliation_strings":["Pharmacognosy Department, College of Pharmacy, King Khalid University, Abha, Saudi Arabia","Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacognosy Department, College of Pharmacy, King Khalid University, Abha, Saudi Arabia","institution_ids":["https://openalex.org/I82952536"]},{"raw_affiliation_string":"Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt","institution_ids":["https://openalex.org/I145487455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051888358","display_name":"Hesham I. El\u2010Askary","orcid":"https://orcid.org/0000-0001-7764-6588","observed_orcids":["https://orcid.org/0000-0001-7764-6588"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Hesham I. El-Askary","raw_affiliation_strings":["Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt","institution_ids":["https://openalex.org/I145487455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082721751","display_name":"R.A. Assal","orcid":"https://orcid.org/0000-0002-6207-836X","observed_orcids":["https://orcid.org/0000-0002-6207-836X"]},"institutions":[{"id":"https://openalex.org/I96823368","display_name":"German University in Cairo","ror":"https://ror.org/03rjt0z37","country_code":"EG","type":"education","lineage":["https://openalex.org/I96823368"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Reem.A. Assal","raw_affiliation_strings":["Pharmacology and Toxicology Department, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology and Toxicology Department, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, Egypt","institution_ids":["https://openalex.org/I96823368"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003347732","display_name":"Mohamed Zakaria Gad","orcid":"https://orcid.org/0000-0003-1173-8628","observed_orcids":["https://orcid.org/0000-0003-1173-8628"]},"institutions":[{"id":"https://openalex.org/I96823368","display_name":"German University in Cairo","ror":"https://ror.org/03rjt0z37","country_code":"EG","type":"education","lineage":["https://openalex.org/I96823368"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Mohamed Z. Gad","raw_affiliation_strings":["Biochemistry Department, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry Department, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, Egypt","institution_ids":["https://openalex.org/I96823368"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5003347732"],"corresponding_institution_ids":["https://openalex.org/I96823368"],"apc_list":null,"apc_paid":null,"fwci":1.9927,"has_fulltext":true,"cited_by_count":42,"citation_normalized_percentile":{"value":0.83548971,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"35","issue":"18","first_page":"3126","last_page":"3130"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.760699987411499,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.760699987411499,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.08529999852180481,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.03099999949336052,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitexin","display_name":"vitexin","score":0.9639999866485596},{"id":"https://openalex.org/keywords/mir-20a","display_name":"miR-20a","score":0.890999972820282},{"id":"https://openalex.org/keywords/mica-b","display_name":"MICA/B","score":0.9940000176429749},{"id":"https://openalex.org/keywords/nkg2d","display_name":"NKG2D","score":0.8259999752044678},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.9269999861717224},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.9589999914169312},{"id":"https://openalex.org/keywords/mda-mb-231-cells","display_name":"MDA-MB-231 cells","score":0.8690000176429749},{"id":"https://openalex.org/keywords/immunogenicity","display_name":"immunogenicity","score":0.5619999766349792},{"id":"https://openalex.org/keywords/tumor-cell-migration","display_name":"tumor cell migration","score":0.5019999742507935},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.47099998593330383},{"id":"https://openalex.org/keywords/natural-product-derivatives","display_name":"natural product derivatives","score":0.3310000002384186}],"concepts":[{"id":"https://openalex.org/C2779301978","wikidata":"https://www.wikidata.org/wiki/Q259075","display_name":"Vitexin","level":4,"score":0.6886244416236877},{"id":"https://openalex.org/C119157956","wikidata":"https://www.wikidata.org/wiki/Q796604","display_name":"Acetylation","level":3,"score":0.6533876657485962},{"id":"https://openalex.org/C111771559","wikidata":"https://www.wikidata.org/wiki/Q66295","display_name":"Derivative (finance)","level":2,"score":0.6158721446990967},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49404266476631165},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20338469743728638},{"id":"https://openalex.org/C2779054382","wikidata":"https://www.wikidata.org/wiki/Q72185287","display_name":"Flavonoid","level":3,"score":0.12630555033683777},{"id":"https://openalex.org/C106159729","wikidata":"https://www.wikidata.org/wiki/Q2294553","display_name":"Financial economics","level":1,"score":0.0},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015395","descriptor_name":"Histocompatibility Antigens Class I","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047310","descriptor_name":"Apigenin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D047310","descriptor_name":"Apigenin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D055655","descriptor_name":"NK Cell Lectin-Like Receptor Subfamily K","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1080/14786419.2019.1686372","doi":"https://doi.org/10.1080/14786419.2019.1686372","is_oa":false,"landing_page_url":"https://doi.org/10.1080/14786419.2019.1686372","pdf_url":null,"source":{"id":"https://openalex.org/S205999849","display_name":"Natural Product Research","issn_l":"1478-6419","issn":["1478-6419","1478-6427"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Natural Product Research","raw_type":"journal-article"},{"id":"pmid:31691589","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31691589","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Natural product research","raw_type":"Journal Article"},{"id":"pmh:oai:figshare.com:article/10259897","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/An_acetylated_derivative_of_vitexin_halts_MDA-MB-231_cellular_progression_and_improves_its_immunogenic_profile_through_tuning_miR-_20a-MICA_B_axis/10259897","pdf_url":"https://figshare.com/articles/An_acetylated_derivative_of_vitexin_halts_MDA-MB-231_cellular_progression_and_improves_its_immunogenic_profile_through_tuning_miR-_20a-MICA_B_axis/10259897","source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"doi:10.6084/m9.figshare.10259897.v1","doi":"https://doi.org/10.6084/m9.figshare.10259897.v1","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.10259897.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"pmh:oai:figshare.com:article/10259897","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/An_acetylated_derivative_of_vitexin_halts_MDA-MB-231_cellular_progression_and_improves_its_immunogenic_profile_through_tuning_miR-_20a-MICA_B_axis/10259897","pdf_url":"https://figshare.com/articles/An_acetylated_derivative_of_vitexin_halts_MDA-MB-231_cellular_progression_and_improves_its_immunogenic_profile_through_tuning_miR-_20a-MICA_B_axis/10259897","source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9789000153541565}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2983019152.pdf","grobid_xml":"https://content.openalex.org/works/W2983019152.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1533691218","https://openalex.org/W1547523787","https://openalex.org/W1597895778","https://openalex.org/W1757407923","https://openalex.org/W1973855239","https://openalex.org/W1980021547","https://openalex.org/W1996972040","https://openalex.org/W2007400263","https://openalex.org/W2037671671","https://openalex.org/W2046698026","https://openalex.org/W2048250100","https://openalex.org/W2052313621","https://openalex.org/W2059357290","https://openalex.org/W2061569346","https://openalex.org/W2073300038","https://openalex.org/W2079870561","https://openalex.org/W2080302526","https://openalex.org/W2086023449","https://openalex.org/W2166970460","https://openalex.org/W2266564746","https://openalex.org/W2493410411","https://openalex.org/W2600723487","https://openalex.org/W2605182832","https://openalex.org/W2755196285","https://openalex.org/W2782319349","https://openalex.org/W2799479746","https://openalex.org/W2901619788","https://openalex.org/W2905364781","https://openalex.org/W2906113826"],"related_works":["https://openalex.org/W2892143134","https://openalex.org/W3091799076","https://openalex.org/W2079870561","https://openalex.org/W1506624080","https://openalex.org/W2375222221","https://openalex.org/W222592989","https://openalex.org/W7203547332","https://openalex.org/W2109398166","https://openalex.org/W4214896600","https://openalex.org/W7161409125"],"abstract_inverted_index":{"The":[0],"activating":[1],"immune":[2,29],"ligands,":[3],"MICA/B,":[4],"act":[5,135],"as":[6,136],"a":[7,98,117,124,137],"\"kill":[8],"me\"":[9],"signal":[10],"through":[11,31],"the":[12,22,76],"NKG2D":[13],"receptor":[14],"expressed":[15],"on":[16,80],"natural":[17,44],"killer":[18],"(NK)":[19],"cells.":[20,39],"Recently,":[21],"oncogenic":[23],"miR-20a":[24,122],"was":[25],"found":[26],"to":[27,74,85],"mediate":[28],"escape":[30],"repressing":[32],"MICA/B":[33,129],"levels":[34],"in":[35,69,116,128],"breast":[36],"cancer":[37,62],"(BC)":[38],"However,":[40],"targeting":[41],"miR-20a-MICA/B":[42],"using":[43],"compounds":[45],"has":[46,52,65],"rarely":[47],"been":[48,67],"investigated.":[49],"Our":[50,71],"group":[51],"successfully":[53],"isolated":[54],"3'-O-acetylvitexin":[55,79,113,133],"that":[56,95],"showed":[57,94],"cytotoxic":[58],"effects":[59,77],"against":[60],"colon":[61],"cells":[63],"but":[64],"never":[66],"evaluated":[68],"BC.":[70],"aim":[72],"is":[73],"investigate":[75],"of":[78,91,103,121],"BC":[81],"cell":[82],"lines":[83],"and":[84,108],"further":[86],"elucidate":[87],"its":[88],"molecular":[89],"mechanism":[90],"action.The":[92],"results":[93],"3'-O-acetylvitex":[96],"depicted":[97],"more":[99],"pronounced":[100],"dose-dependent":[101,119,126],"repression":[102,120],"TNBC":[104,142],"cellular":[105],"viability,":[106],"colonogenicity":[107],"migration":[109],"capacity":[110],"than":[111],"Vitexin.":[112],"treatment":[114],"resulted":[115],"marked":[118],"with":[123],"concomitant":[125],"increase":[127],"expression.":[130],"In":[131],"conclusion,":[132],"might":[134],"promising":[138],"therapeutic":[139],"agent":[140],"for":[141],"patients.":[143]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":5}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2019-11-22T00:00:00"}