{"id":"https://openalex.org/W2982929035","doi":"https://doi.org/10.1182/blood.v128.22.1159.1159","title":"Multiplexed Engineering of CD19CAR T Cells for Post-Transplant Consolidative Immunotherapy","display_name":"Multiplexed Engineering of CD19CAR T Cells for Post-Transplant Consolidative Immunotherapy","publication_year":2016,"publication_date":"2016-12-02","ids":{"openalex":"https://openalex.org/W2982929035","doi":"https://doi.org/10.1182/blood.v128.22.1159.1159","mag":"2982929035"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v128.22.1159.1159","doi":"https://doi.org/10.1182/blood.v128.22.1159.1159","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v128.22.1159.1159","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068513988","display_name":"Corinne N. Summers","orcid":"https://orcid.org/0000-0003-1769-7388","observed_orcids":["https://orcid.org/0000-0003-1769-7388"]},"institutions":[{"id":"https://openalex.org/I4405262941","display_name":"Seattle Children's Research Institute","ror":"https://ror.org/00cz0md82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534","https://openalex.org/I4405262941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Corinne Summers","raw_affiliation_strings":["Seattle Children's Research Institute, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seattle Children's Research Institute, Seattle, WA","institution_ids":["https://openalex.org/I4405262941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082827208","display_name":"Alexandra E. Grier","orcid":"https://orcid.org/0000-0001-5382-989X","observed_orcids":["https://orcid.org/0000-0001-5382-989X"]},"institutions":[{"id":"https://openalex.org/I4405262941","display_name":"Seattle Children's Research Institute","ror":"https://ror.org/00cz0md82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534","https://openalex.org/I4405262941"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alexandra Grier","raw_affiliation_strings":["Seattle Children's Research Institute, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seattle Children's Research Institute, Seattle, WA","institution_ids":["https://openalex.org/I4405262941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082052104","display_name":"Rebecca Alice Gardner","orcid":"https://orcid.org/0000-0003-1532-3200","observed_orcids":["https://orcid.org/0000-0003-1532-3200"]},"institutions":[{"id":"https://openalex.org/I1295499534","display_name":"Seattle Children's Hospital","ror":"https://ror.org/01njes783","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rebecca Gardner","raw_affiliation_strings":["Seattle Children's Hospital, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seattle Children's Hospital, Seattle, WA","institution_ids":["https://openalex.org/I1295499534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025632410","display_name":"Colleen S. Delaney","orcid":"https://orcid.org/0000-0002-1044-2801","observed_orcids":["https://orcid.org/0000-0002-1044-2801"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Colleen Delaney","raw_affiliation_strings":["Fred Hutchinson Cancer Research Center, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010964073","display_name":"Michael C. Jensen","orcid":"https://orcid.org/0000-0001-7477-3063","observed_orcids":["https://orcid.org/0000-0001-7477-3063"]},"institutions":[{"id":"https://openalex.org/I4405262941","display_name":"Seattle Children's Research Institute","ror":"https://ror.org/00cz0md82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534","https://openalex.org/I4405262941"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael C Jensen","raw_affiliation_strings":["Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA","institution_ids":["https://openalex.org/I4405262941"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5010964073","https://openalex.org/A5082052104","https://openalex.org/A5082827208"],"corresponding_institution_ids":["https://openalex.org/I1295499534","https://openalex.org/I4405262941"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.3401,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.67273586,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"128","issue":"22","first_page":"1159","last_page":"1159"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd19-car-t-cells","display_name":"CD19 CAR T cells","score":0.9879999756813049},{"id":"https://openalex.org/keywords/acute-lymphoblastic-leukemia","display_name":"acute lymphoblastic leukemia","score":0.9200000166893005},{"id":"https://openalex.org/keywords/post-transplant-recurrence","display_name":"post-transplant relapse","score":0.8730000257492065},{"id":"https://openalex.org/keywords/graft-versus-host-disease-prophylaxis","display_name":"graft-versus-host disease prophylaxis","score":0.7310000061988831},{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.7940000295639038},{"id":"https://openalex.org/keywords/tacrolimus","display_name":"tacrolimus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mycophenolate-mofetil","display_name":"mycophenolate mofetil","score":0.9990000128746033},{"id":"https://openalex.org/keywords/donor-t-cells","display_name":"donor T cells","score":0.503000020980835},{"id":"https://openalex.org/keywords/measurable-residual-disease","display_name":"minimal residual disease","score":0.578000009059906},{"id":"https://openalex.org/keywords/adoptive-immunotherapy","display_name":"adoptive immunotherapy","score":0.5669999718666077}],"concepts":[{"id":"https://openalex.org/C3875195","wikidata":"https://www.wikidata.org/wiki/Q5099363","display_name":"Chimeric antigen receptor","level":4,"score":0.5967810750007629},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5450735688209534},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5411789417266846},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.4895349442958832},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.48936623334884644},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4684253931045532},{"id":"https://openalex.org/C2779823535","wikidata":"https://www.wikidata.org/wiki/Q6865356","display_name":"Minimal residual disease","level":3,"score":0.4496975541114807},{"id":"https://openalex.org/C10882517","wikidata":"https://www.wikidata.org/wiki/Q15268054","display_name":"Cell therapy","level":3,"score":0.4324837327003479},{"id":"https://openalex.org/C2777408962","wikidata":"https://www.wikidata.org/wiki/Q1128050","display_name":"Hematopoietic stem cell transplantation","level":3,"score":0.4260946810245514},{"id":"https://openalex.org/C2778957590","wikidata":"https://www.wikidata.org/wiki/Q798033","display_name":"CD19","level":3,"score":0.4245932400226593},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.42304131388664246},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.39243051409721375},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3779231011867523},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.33573487401008606},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3209933638572693},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.31099164485931396},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27339911460876465},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2499600350856781},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.21723908185958862},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v128.22.1159.1159","doi":"https://doi.org/10.1182/blood.v128.22.1159.1159","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v128.22.1159.1159","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2905007407","https://openalex.org/W3139020419","https://openalex.org/W2520356485","https://openalex.org/W3213817406","https://openalex.org/W2520006799","https://openalex.org/W2908853594","https://openalex.org/W3085240243","https://openalex.org/W4416767421","https://openalex.org/W3002455460","https://openalex.org/W2396292102"],"abstract_inverted_index":{"Abstract":[0],"Introduction:":[1],"Relapse":[2],"of":[3,24,46,65,72,78,122,132,258,270,281,298,330,384,423,464,493,498,526,590,639,703,751],"CD19+":[4],"acute":[5],"lymphoblastic":[6],"leukemia":[7],"(ALL)":[8],"post-hematopoietic":[9],"cell":[10,40,81,225,274,373,574,687],"transplant":[11],"(HCT)":[12],"portends":[13],"a":[14,107,177,215,251,359],"dismal":[15],"prognosis":[16],"and":[17,130,140,158,171,186,190,219,229,304,348,400,452,457,468,495,544,565,604,657,678,717],"opportunities":[18],"to":[19,60,96,111,120,204,263,355,418,442,479,508,555,563,572,608,668,676,685,721],"intensify":[20],"the":[21,44,63,70,76,149,255,259,271,279,420,462,477,491,505,573,596,686,709],"anti-tumor":[22],"potency":[23],"HCT":[25],"are":[26,91,118,415],"limited":[27,88],"by":[28,302,317,377,403,520,633],"regimen":[29],"related":[30],"toxicities.":[31],"While":[32],"pre-transplant":[33],"CD19":[34,370],"chimeric":[35],"antigen":[36,371,585,698],"receptor":[37,275],"(CAR)":[38],"T":[39,80,115,207,265,273,428,447,482,530,534,643,647],"therapy":[41,94],"can":[42],"increase":[43],"numbers":[45],"patients":[47,90],"who":[48],"achieve":[49],"minimal":[50],"residual":[51],"disease":[52,101,510],"negative":[53],"remissions,":[54],"there":[55],"remains":[56],"an":[57,748],"unmet":[58],"need":[59],"further":[61],"reduce":[62],"incidence":[64],"early":[66],"post-HCT":[67],"relapses":[68],"through":[69],"use":[71,77],"adoptive":[73],"immunotherapy.":[74],"However,":[75],"CAR":[79,427],"therapies":[82],"in":[83,183,230,313,416,430,459,461,487,490,504],"this":[84,136,502],"setting":[85,507],"is":[86,176],"severely":[87],"as":[89,315,375,561,622,674,735],"on":[92,106,747],"immunosuppressive":[93,465],"(IST)":[95],"prevent":[97],"graft":[98],"versus":[99],"host":[100],"(GVHD).":[102],"Here,":[103],"we":[104],"report":[105],"multiplexed":[108,285,425,439],"engineering":[109,440],"strategy":[110],"generate":[112,443,480],"donor-derived":[113],"CD19CAR":[114,211,366,408,472,564,592,609,677,705,722],"cells":[116,208,266,353,368,385,390,406,429,483,535,586,593,648,699,706],"that":[117,484],"resistant":[119,198,598,711],"combinations":[121],"cyclosporine":[123],"(CSA)/Tacrolimus":[124],"(FK506)":[125],"and/or":[126],"mycophenolate":[127],"mofetil":[128],"(MMF),":[129],"devoid":[131],"GVHD":[133],"reactivity":[134],"for":[135,188,224,267,321,350,501,524,538,546,637,651,659],"patient":[137],"population.":[138],"Methods":[139],"Results:":[141],"We":[142,241,436],"developed":[143,182],"CNA22":[144,404,451],"or":[145,753],"CNA12-P2A-IMPDH2\u0394-T2A-Her2tG":[146],"vectors":[147,300],"using":[148,194,233,250],"CNA22,":[150],"CNA12":[151],"[Brewin":[152],"M,":[153],"et":[154,162,237],"al,":[155,163,238],"Blood":[156,239],"2009]":[157],"IMPDH2\u0394":[159,357,453,557,670],"[Jonnalagadda":[160],"J,":[161],"PLoS":[164],"One":[165],"2013]":[166],"mutants":[167,454],"conferring":[168],"CSA,":[169],"FK506":[170],"MMF":[172,311],"resistance,":[173],"respectively.":[174],"Her2tG":[175,305,319],"truncated":[178,220],"HER2":[179],"extracellular":[180],"protein":[181,222],"our":[184,210],"lab":[185],"used":[187,203,438],"selection":[189,537,650],"transduction":[191,227,244,297,518,631],"efficiency":[192,228],"determination":[193],"Herceptin.":[195],"The":[196],"drug":[197,337,341,577,597,690,710],"lentivirus":[199],"packaged":[200],"vector":[201,212,599,712],"was":[202,570,683],"co-transduce":[205],"human":[206],"with":[209,245,294,388,470,583,587,595,696,700,708],"which":[213],"includes":[214],"4-1BB":[216],"co-stimulatory":[217],"domain":[218],"EGFR":[221],"(EGFRt)":[223],"selection,":[226],"vivo":[231,413,488],"suicide":[232],"Erbitux":[234],"[Wang,":[235],"X,":[236],"2011].":[240],"coupled":[242],"dual":[243,296,517,630],"mRNA":[246,521,634],"TALEN":[247,252,522,635],"transfection":[248,523,636],"technology":[249],"pair":[253],"targeting":[254],"first":[256],"exon":[257],"TcR\u03b1":[260],"constant":[261],"region":[262],"transfect":[264],"efficient":[268],"knockout":[269],"endogenous":[272],"(TcR)":[276],"thus":[277],"eliminating":[278],"risk":[280],"causing":[282],"GVHD.":[283],"Our":[284],"technologies":[286],"yield":[287],"CD3/TcR":[288],"knockouts":[289],"rates":[290],"greater":[291],"than":[292],"80%":[293],"successful":[295,516,629],"both":[299],"demonstrated":[301,310,344,369],"EGFRt":[303],"expression":[306,320],"(Figure":[307,364,410],"A).":[308],"Cells":[309,449,514,553,627,666],"resistance":[312],"vitro":[314,460],"evidenced":[316],"increased":[318,602,715],"culture":[322,346,362],"purification":[323],"following":[324,386,407],"mycophenolic":[325],"acid":[326],"(MPA,":[327],"active":[328],"metabolite":[329],"MMF)":[331],"exposure.":[332],"In":[333,412],"addition,":[334],"prolonged":[335],"MPA":[336,469,551,664],"exposure":[338],"at":[339,391,549,662],"multiple":[340,392],"concentrations":[342,394,589,702],"(0-10uM)":[343],"improved":[345,559,672],"expansion":[347,458,560,673],"viability":[349],"cultures":[351],"containing":[352],"transduced":[354,554,594,667,707],"express":[356,556,669],"over":[358],"21":[360,547,660],"day":[361],"period":[363],"B).":[365],"expressing":[367,405,450],"targeted":[372,471],"lysis":[374],"evaluated":[376],"chromium":[378],"release":[379],"assay.":[380],"Furthermore,":[381],"cytokine":[382],"evaluations":[383],"co-culturing":[387],"target":[389],"CSA":[393,467,588,701],"(0-1000ng/ml)":[395],"yielded":[396],"sustained":[397],"IL-2,":[398],"IFNg":[399,603,716],"TNFa":[401],"secretion":[402],"activation":[409,456],"C).":[411],"experiments":[414],"progress":[417],"assess":[419],"functional":[421,486],"attributes":[422],"these":[424],"engineered":[426],"relevant":[431],"murine":[432],"model":[433],"systems.":[434],"Conclusions:":[435],"successfully":[437],"strategies":[441],"CD3/TcR-":[444,527,640],"CD19CAR+EGFRt+":[445,528,641],"CNA22-IMPDH2\u0394-HER2tG+":[446,529,642],"cells.":[448,531,568,611,644,681,724],"exhibited":[455,558,671],"presence":[463,492],"agents":[466],"activity.":[473],"These":[474],"studies":[475],"suggest":[476],"ability":[478],"modified":[481],"remain":[485],"even":[489],"IST":[494],"without":[496],"induction":[497],"GVHD,":[499],"allowing":[500],"approach":[503],"post-transplant":[506],"prevent/treat":[509],"relapse.":[511],"Figure":[512],"A)":[513,626],"underwent":[515,536,628,649],"followed":[519,632],"development":[525,638],"B)":[532,645],"Transduced":[533,646],"their":[539,652],"respective":[540,653],"markers,":[541,654],"were":[542,655],"stimulated":[543,656],"cultured":[545,658],"days":[548,661],"varying":[550,663],"concentrations.":[552,665],"compared":[562,607,675,720],"mock":[566,679],"control":[567,578,680,691],"Data":[569,682],"normalized":[571,684],"group's":[575,688],"no":[576,689],"expansion.":[579,692],"C)":[580,693],"Following":[581,694],"co-culture":[582,695],"K562-CD19":[584,697],"0-1000ng/ml":[591,704],"secreted":[600,713],"significantly":[601,714],"IL-2":[605,718],"levels":[606,719],"only":[610,723],"NS":[612,725],"=":[613,726],"not":[614,727],"significant;":[615,728],"Horizontal":[616,729],"bars":[617,730],"indicate":[618,731],"statistical":[619,732],"significance":[620,733],"defined":[621,734],"p-value":[623,736],"<0.05.":[624,737],"Figure.":[625],"Disclosures":[738],"Jensen:":[739],"Juno":[740],"Therapeutics,":[741],"Inc:":[742],"Consultancy,":[743],"Equity":[744],"Ownership,":[745],"Membership":[746],"entity's":[749],"Board":[750],"Directors":[752],"advisory":[754],"committees,":[755],"Research":[756],"Funding.":[757]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-09-22T17:25:34.749102","created_date":"2019-11-22T00:00:00"}
