{"id":"https://openalex.org/W2982904881","doi":"https://doi.org/10.1182/blood-2019-121120","title":"Sensing and Sensibility: Programming Smarter Chimeric Antigen Receptor T Cells","display_name":"Sensing and Sensibility: Programming Smarter Chimeric Antigen Receptor T Cells","publication_year":2019,"publication_date":"2019-11-13","ids":{"openalex":"https://openalex.org/W2982904881","doi":"https://doi.org/10.1182/blood-2019-121120","mag":"2982904881"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2019-121120","doi":"https://doi.org/10.1182/blood-2019-121120","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2019-121120","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006257775","display_name":"Wendell A. Lim","orcid":"https://orcid.org/0000-0003-4052-8056","observed_orcids":["https://orcid.org/0000-0003-4052-8056"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Wendell Lim","raw_affiliation_strings":["University of California-San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California-San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5006257775"],"corresponding_institution_ids":["https://openalex.org/I180670191"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.1689113,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"134","issue":"Supplement_1","first_page":"SCI","last_page":"24"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chimeric-antigen-receptor-t-cells","display_name":"chimeric antigen receptor T cells","score":0.9710000157356262},{"id":"https://openalex.org/keywords/car-t-cell-engineering","display_name":"CAR-T cell engineering","score":0.847000002861023},{"id":"https://openalex.org/keywords/synthetic-biology","display_name":"synthetic biology","score":0.8299999833106995},{"id":"https://openalex.org/keywords/solid-tumors","display_name":"solid tumors","score":0.8059999942779541},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8619999885559082},{"id":"https://openalex.org/keywords/hematological-cancer","display_name":"hematologic cancer","score":0.6740000247955322},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.578000009059906}],"concepts":[{"id":"https://openalex.org/C3875195","wikidata":"https://www.wikidata.org/wiki/Q5099363","display_name":"Chimeric antigen receptor","level":4,"score":0.8099995851516724},{"id":"https://openalex.org/C101468663","wikidata":"https://www.wikidata.org/wiki/Q1620158","display_name":"Modular design","level":2,"score":0.558745801448822},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5411407947540283},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.49180129170417786},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.4621565639972687},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.438342809677124},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.37560200691223145},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32033461332321167},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3025891184806824},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.30160990357398987},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.23908084630966187},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11301600933074951},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09641119837760925},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood-2019-121120","doi":"https://doi.org/10.1182/blood-2019-121120","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2019-121120","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2587691649","https://openalex.org/W2980723242","https://openalex.org/W4360810408","https://openalex.org/W4281676294","https://openalex.org/W4391780899","https://openalex.org/W3137026498","https://openalex.org/W3044364101","https://openalex.org/W3010985435","https://openalex.org/W4253250212","https://openalex.org/W4206289058"],"abstract_inverted_index":{"CAR":[0],"T":[1,56,96],"cells":[2,61,97],"have":[3],"shown":[4],"remarkable":[5],"outcomes":[6],"when":[7],"targeting":[8,13],"specific":[9],"hematologic":[10],"cancers.":[11],"But":[12],"solid":[14,38,106],"cancers":[15],"has":[16],"proven":[17],"difficult:":[18],"it":[19],"is":[20],"difficult":[21],"to":[22,26,28,31,53,75,93],"identify":[23],"unique":[24],"antigens,":[25],"traffic":[27],"tumors,":[29],"and":[30,68,79,85,103],"mount":[32],"a":[33],"strong":[34],"response":[35,80],"in":[36,122],"the":[37,48],"tumor":[39],"microenvironment.":[40],"To":[41],"overcome":[42],"these":[43],"issues,":[44],"we":[45],"are":[46,59,99],"using":[47],"approaches":[49],"of":[50,66,115],"synthetic":[51],"biology":[52],"engineer":[54],"next-generation":[55],"cells.":[57],"We":[58],"engineering":[60],"that":[62,72,98],"utilize":[63],"new":[64,77,88],"sets":[65],"sensors":[67],"modular":[69],"control":[70],"circuits":[71],"enable":[73],"them":[74],"execute":[76],"recognition":[78],"programs":[81],"with":[82],"higher":[83],"precision":[84],"robustness.":[86],"These":[87],"capabilities":[89],"may":[90],"allow":[91],"us":[92],"develop":[94],"therapeutic":[95],"far":[100],"more":[101],"effective":[102],"safe":[104],"against":[105],"tumors.":[107],"Disclosures":[108],"Lim:":[109],"Cell":[110,116],"Design":[111,117],"Labs:":[112],"Other:":[113],"founder":[114],"Labs;":[118],"acquired":[119],"by":[120],"Gilead":[121],"2017;":[123],"Allogene:":[124],"Consultancy.":[125]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-11-22T00:00:00"}
