{"id":"https://openalex.org/W2982783641","doi":"https://doi.org/10.1093/neuonc/noz175.847","title":"QOLP-27. CLINICAL FACTORS AND MOLECULAR MARKERS ASSOCIATED WITH POSTOPERATIVE SEIZURES IN GLIOBLASTOMA","display_name":"QOLP-27. CLINICAL FACTORS AND MOLECULAR MARKERS ASSOCIATED WITH POSTOPERATIVE SEIZURES IN GLIOBLASTOMA","publication_year":2019,"publication_date":"2019-11-01","ids":{"openalex":"https://openalex.org/W2982783641","doi":"https://doi.org/10.1093/neuonc/noz175.847","mag":"2982783641"},"language":"en","primary_location":{"id":"doi:10.1093/neuonc/noz175.847","doi":"https://doi.org/10.1093/neuonc/noz175.847","is_oa":false,"landing_page_url":"https://doi.org/10.1093/neuonc/noz175.847","pdf_url":null,"source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6847732","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061547590","display_name":"Ankush Chandra","orcid":"https://orcid.org/0000-0003-1843-3894","observed_orcids":["https://orcid.org/0000-0003-1843-3894"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ankush Chandra","raw_affiliation_strings":["University of California, San Francisco, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035752690","display_name":"Ishan Kanungo","orcid":"https://orcid.org/0000-0002-3447-2909","observed_orcids":["https://orcid.org/0000-0002-3447-2909"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ishan Kanungo","raw_affiliation_strings":["University of California, San Francisco, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009012028","display_name":"Jonathan W. Rick","orcid":"https://orcid.org/0000-0002-9132-8313","observed_orcids":["https://orcid.org/0000-0002-9132-8313"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan Rick","raw_affiliation_strings":["University of California, San Francisco, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084063845","display_name":"John K. Yue","orcid":"https://orcid.org/0000-0001-9694-7722","observed_orcids":["https://orcid.org/0000-0001-9694-7722"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Yue","raw_affiliation_strings":["University of California, San Francisco, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015991286","display_name":"Fara Dayani","orcid":"https://orcid.org/0000-0002-1426-4328","observed_orcids":["https://orcid.org/0000-0002-1426-4328"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fara Dayani","raw_affiliation_strings":["University of California, San Francisco, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083744064","display_name":"Alan T. Nguyen","orcid":"https://orcid.org/0000-0001-6790-2568","observed_orcids":["https://orcid.org/0000-0001-6790-2568"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan Nguyen","raw_affiliation_strings":["University of California, San Francisco, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067174675","display_name":"Patrick Michael Flanigan","orcid":"https://orcid.org/0000-0002-3611-8575","observed_orcids":["https://orcid.org/0000-0002-3611-8575"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick Flanigan","raw_affiliation_strings":["Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091099837","display_name":"Edward F. Chang","orcid":"https://orcid.org/0000-0003-2480-4700","observed_orcids":["https://orcid.org/0000-0003-2480-4700"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward Chang","raw_affiliation_strings":["Department of Neurological Surgery, University of California, San Francisco, San Francisco, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, University of California, San Francisco, San Francisco, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103875966","display_name":"Mike McDermott","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mike McDermott","raw_affiliation_strings":["University of California, San Francisco, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006262715","display_name":"Mitchel Stuart Berger","orcid":"https://orcid.org/0000-0003-1983-4892","observed_orcids":["https://orcid.org/0000-0003-1983-4892"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mitchel Berger","raw_affiliation_strings":["University of California, San Francisco, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049126969","display_name":"Manish Kumar Aghi","orcid":"https://orcid.org/0000-0002-2949-2227","observed_orcids":["https://orcid.org/0000-0002-2949-2227"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Manish Aghi","raw_affiliation_strings":["University of California, San Francisco, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5132,"currency":"USD","value_usd":5132},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"Supplement_6","first_page":"vi203","last_page":"vi203"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.0066999997943639755,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.8420000076293945},{"id":"https://openalex.org/keywords/postoperative-seizures","display_name":"postoperative seizures","score":0.9990000128746033},{"id":"https://openalex.org/keywords/seizure-prophylaxis","display_name":"seizure prevention","score":0.7599999904632568},{"id":"https://openalex.org/keywords/phenytoin","display_name":"phenytoin","score":0.9509999752044678},{"id":"https://openalex.org/keywords/extent-of-resection","display_name":"extent of resection","score":0.7889999747276306},{"id":"https://openalex.org/keywords/gross-total-resection","display_name":"gross total resection","score":0.7760000228881836},{"id":"https://openalex.org/keywords/subtotal-resection","display_name":"subtotal resection","score":0.7239999771118164},{"id":"https://openalex.org/keywords/recurrent-glioblastoma","display_name":"recurrent glioblastoma","score":0.8759999871253967},{"id":"https://openalex.org/keywords/egfr-amplification","display_name":"EGFR amplification","score":0.8489999771118164},{"id":"https://openalex.org/keywords/chromosome-10-deletion","display_name":"chromosome 10 deletion","score":0.9549999833106995},{"id":"https://openalex.org/keywords/hyponatremia","display_name":"hyponatremia","score":0.9950000047683716},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.8880000114440918},{"id":"https://openalex.org/keywords/molecular-markers","display_name":"molecular markers","score":0.8740000128746033},{"id":"https://openalex.org/keywords/craniotomy","display_name":"craniotomy","score":0.7279999852180481},{"id":"https://openalex.org/keywords/newly-diagnosed-glioblastoma","display_name":"newly diagnosed glioblastoma","score":0.6669999957084656}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9136878252029419},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.5660784840583801},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.5493287444114685},{"id":"https://openalex.org/C2776703092","wikidata":"https://www.wikidata.org/wiki/Q824292","display_name":"Hyponatremia","level":2,"score":0.547191858291626},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.5285968780517578},{"id":"https://openalex.org/C2778871575","wikidata":"https://www.wikidata.org/wiki/Q514921","display_name":"Craniotomy","level":2,"score":0.4797010123729706},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.4677669405937195},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.42592185735702515},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.36969923973083496},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25558310747146606},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/neuonc/noz175.847","doi":"https://doi.org/10.1093/neuonc/noz175.847","is_oa":false,"landing_page_url":"https://doi.org/10.1093/neuonc/noz175.847","pdf_url":null,"source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6847732","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6847732","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro Oncol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6847732","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6847732","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro Oncol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7488528","https://openalex.org/W3112992235","https://openalex.org/W4386813583","https://openalex.org/W4367304300","https://openalex.org/W3099154489","https://openalex.org/W4377093476","https://openalex.org/W2782686543","https://openalex.org/W2216071306","https://openalex.org/W2587910667","https://openalex.org/W4327608483"],"abstract_inverted_index":{"Abstract":[0],"INTRODUCTION":[1],"Glioblastoma":[2],"has":[3],"a":[4],"poor":[5],"prognosis,":[6],"further":[7],"complicated":[8],"by":[9],"postoperative":[10,18,76,105,220,276],"seizures.":[11],"We":[12,214],"analyzed":[13],"various":[14],"factors":[15,165,184,218],"associated":[16],"with":[17,63,78,98,136,147],"seizures":[19,44,77,106,158,168,187,221,277],"in":[20,222,266,279],"glioblastoma.":[21],"METHODS":[22],"Retrospective":[23],"chart":[24],"review":[25],"of":[26,53,59,66,85,149,226,241],"932":[27],"patients":[28,91,118,129,171,190,269],"who":[29],"underwent":[30],"craniotomy":[31],"for":[32,166,169,185,188,219,237,275],"glioblastoma":[33,223,268],"(777=83.4%":[34],"newly":[35],"diagnosed;":[36],"155=16.6%":[37],"recurrent)":[38],"at":[39,272],"our":[40],"institution":[41],"(2002\u20132014).":[42],"Postoperative":[43],"were":[45,100,119,153,191,228,245],"defined":[46],"as":[47,138,231],"those":[48,96,109,146],"occurring":[49],"within":[50,201],"14":[51],"days":[52,87,204],"surgery.":[54],"RESULTS":[55],"Our":[56],"cohort":[57],"consisted":[58],"49.9%":[60],"(n=465)":[61],"males":[62],"mean":[64,79,202],"age":[65],"55.8":[67],"(range":[68],"9\u201391)":[69],"years.":[70],"In":[71],"total,":[72],"69":[73],"(7.4%)":[74],"had":[75],"time":[80],"from":[81],"surgery":[82,208],"to":[83,103,108,122,126,156,249,256,282],"seizure":[84,94,137],"3.1":[86],"(IQR=1\u20134).":[88],"Of":[89],"536":[90],"(57.5%)":[92],"receiving":[93],"prophylaxis,":[95,238],"treated":[97],"Keppra":[99],"more":[101,154],"likely":[102,121,155],"have":[104,157,253],"compared":[107,125],"on":[110],"Dilantin":[111],"(10.9%":[112],"vs":[113,131,142,161,180,196,210],"5.0%;":[114],"p=0.022).":[115,182],"Primary":[116],"tumor":[117,128],"less":[120],"seize":[123],"postoperatively":[124,159],"recurrent":[127,189],"(9.7%":[130],"19%;":[132],"p=0.016).":[133],"Patients":[134],"presenting":[135],"chief":[139,232],"complaint":[140],"(12.1%":[141],"5.1%;":[143],"p=0.025)":[144],"and":[145,199,239,247,278],">20%":[148],"Chromosome":[150],"10":[151],"deletion":[152],"(12.4%":[160],"6.1%;":[162],"p=0.0029).":[163],"Risk":[164,183],"postop":[167,186],"newly-diagnosed":[170],"included":[172],"subtotal":[173],"resection":[174,178],"versus":[175],"gross":[176],"total":[177],"(28.0%":[179],"7.1%;":[181,211],">5%":[192],"EGFR":[193],"amplification":[194],"(23.5%":[195],"5.8%;":[197],"p=0.0021)":[198],"hyponatremia":[200],"2.5":[203],"(IQR":[205],"0\u20131)":[206],"after":[207],"(20.8%":[209],"p=0.035).":[212],"CONCLUSION":[213],"identified":[215],"several":[216],"risk":[217,274],"patients,":[224],"most":[225],"which":[227],"clinical":[229],"(seizure":[230],"complaint,":[233],"the":[234],"antiepileptic":[235],"chosen":[236],"extent":[240],"resection),":[242],"while":[243],"some":[244],"molecular":[246],"linked":[248],"genes":[250],"whose":[251],"products":[252],"demonstrated":[254],"links":[255],"epileptogeneicity":[257],"(Chromosome":[258],"10,":[259],"EGFR).":[260],"These":[261],"findings":[262],"may":[263],"assist":[264],"physicians":[265],"detecting":[267],"that":[270],"are":[271],"higher":[273],"providing":[280],"prophylaxis":[281],"reduce":[283],"morbidity.":[284]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-11-22T00:00:00"}