{"id":"https://openalex.org/W2982688232","doi":"https://doi.org/10.1136/heartjnl-2019-315622","title":"Use of troponins in clinical practice: Evidence in favour of use of troponins in clinical practice","display_name":"Use of troponins in clinical practice: Evidence in favour of use of troponins in clinical practice","publication_year":2019,"publication_date":"2019-10-31","ids":{"openalex":"https://openalex.org/W2982688232","doi":"https://doi.org/10.1136/heartjnl-2019-315622","mag":"2982688232","pmid":"https://pubmed.ncbi.nlm.nih.gov/31672780"},"language":"en","primary_location":{"id":"doi:10.1136/heartjnl-2019-315622","doi":"https://doi.org/10.1136/heartjnl-2019-315622","is_oa":false,"landing_page_url":"https://doi.org/10.1136/heartjnl-2019-315622","pdf_url":null,"source":{"id":"https://openalex.org/S191565391","display_name":"Heart","issn_l":"1355-6037","issn":["1355-6037","1468-201X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heart","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015528174","display_name":"Paul O. Collinson","orcid":"https://orcid.org/0000-0002-7000-5996","observed_orcids":["https://orcid.org/0000-0002-7000-5996"]},"institutions":[{"id":"https://openalex.org/I1310053265","display_name":"St George's Hospital","ror":"https://ror.org/0001ke483","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1310053265","https://openalex.org/I2801196673"]},{"id":"https://openalex.org/I165862685","display_name":"St George's, University of London","ror":"https://ror.org/040f08y74","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I165862685","https://openalex.org/I4401726869"]},{"id":"https://openalex.org/I2801196673","display_name":"St George\u2019s University Hospitals NHS Foundation Trust","ror":"https://ror.org/039zedc16","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801196673"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Paul O Collinson","raw_affiliation_strings":["Clinical Blood Sciences and Cardiology, St Georges University Hospitals NHS Foundation Trust and St Georges\"s University of London, London, UK","St Georges Hospital, London SW17 0QT, UK"],"raw_orcid":"https://orcid.org/0000-0002-7000-5996","affiliations":[{"raw_affiliation_string":"Clinical Blood Sciences and Cardiology, St Georges University Hospitals NHS Foundation Trust and St Georges\"s University of London, London, UK","institution_ids":["https://openalex.org/I165862685","https://openalex.org/I2801196673"]},{"raw_affiliation_string":"St Georges Hospital, London SW17 0QT, UK","institution_ids":["https://openalex.org/I1310053265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068500647","display_name":"Fred S. Apple","orcid":"https://orcid.org/0000-0002-5920-6498","observed_orcids":["https://orcid.org/0000-0002-5920-6498"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I2802288015","display_name":"Hennepin County Medical Center","ror":"https://ror.org/01k7a6660","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802288015"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fred Apple","raw_affiliation_strings":["Hennepin County Medical Center University of Minnesota - School of Medicine, Minneapolis, Minnesota, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hennepin County Medical Center University of Minnesota - School of Medicine, Minneapolis, Minnesota, USA","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I2802288015"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075187080","display_name":"Allan S. Jaffe","orcid":"https://orcid.org/0000-0003-1183-3959","observed_orcids":["https://orcid.org/0000-0003-1183-3959"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allan S Jaffe","raw_affiliation_strings":["Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5015528174"],"corresponding_institution_ids":["https://openalex.org/I1310053265","https://openalex.org/I165862685","https://openalex.org/I2801196673"],"apc_list":null,"apc_paid":null,"fwci":0.5456,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.7152934,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"106","issue":"4","first_page":"253","last_page":"255"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/3607","display_name":"Medical Laboratory Technology"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10372","display_name":"Cardiac Imaging and Diagnostics","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-sensitivity-cardiac-troponin","display_name":"high-sensitivity troponin","score":0.8579999804496765},{"id":"https://openalex.org/keywords/cardiac-troponin-assays","display_name":"cardiac troponin assays","score":0.871999979019165},{"id":"https://openalex.org/keywords/myocardial-infarction-diagnosis","display_name":"myocardial infarction diagnosis","score":0.8299999833106995},{"id":"https://openalex.org/keywords/myocardial-injury","display_name":"myocardial injury","score":0.8769999742507935},{"id":"https://openalex.org/keywords/assay-imprecision","display_name":"assay imprecision","score":0.6769999861717224},{"id":"https://openalex.org/keywords/coefficient-of-variation","display_name":"coefficient of variation","score":0.6859999895095825},{"id":"https://openalex.org/keywords/detection-limit","display_name":"detection limit","score":0.7590000033378601},{"id":"https://openalex.org/keywords/diagnostic-algorithm","display_name":"diagnostic algorithm","score":0.7749999761581421}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8788125514984131},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.7240819931030273},{"id":"https://openalex.org/C36036425","wikidata":"https://www.wikidata.org/wiki/Q7846262","display_name":"Troponin","level":3,"score":0.6547002792358398},{"id":"https://openalex.org/C2779974597","wikidata":"https://www.wikidata.org/wiki/Q28448986","display_name":"Clinical Practice","level":2,"score":0.5800196528434753},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5025067329406738},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43742167949676514},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.43216589093208313},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.41461992263793945},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.13087305426597595},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000787","descriptor_name":"Angina Pectoris","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000787","descriptor_name":"Angina Pectoris","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009202","descriptor_name":"Cardiomyopathies","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D009202","descriptor_name":"Cardiomyopathies","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014336","descriptor_name":"Troponin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D017202","descriptor_name":"Myocardial Ischemia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D017202","descriptor_name":"Myocardial Ischemia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1136/heartjnl-2019-315622","doi":"https://doi.org/10.1136/heartjnl-2019-315622","is_oa":false,"landing_page_url":"https://doi.org/10.1136/heartjnl-2019-315622","pdf_url":null,"source":{"id":"https://openalex.org/S191565391","display_name":"Heart","issn_l":"1355-6037","issn":["1355-6037","1468-201X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heart","raw_type":"journal-article"},{"id":"pmid:31672780","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31672780","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heart (British Cardiac Society)","raw_type":"Journal Article"},{"id":"pmh:oai:open-archive.highwire.org:heartjnl:106/4/253","doi":null,"is_oa":false,"landing_page_url":"http://heart.bmj.com/cgi/content/short/106/4/253","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1978752792","https://openalex.org/W2000787220","https://openalex.org/W2105397247","https://openalex.org/W2114635119","https://openalex.org/W2163055393","https://openalex.org/W2377353977","https://openalex.org/W2420656435","https://openalex.org/W2888543854","https://openalex.org/W2907714182","https://openalex.org/W2920852657"],"related_works":["https://openalex.org/W2120196385","https://openalex.org/W2139243268","https://openalex.org/W7006693587","https://openalex.org/W2610480446","https://openalex.org/W2084344641","https://openalex.org/W2217854679","https://openalex.org/W2220435668","https://openalex.org/W2529588191","https://openalex.org/W2114073501","https://openalex.org/W2151231511"],"abstract_inverted_index":{"All":[0],"troponin":[1,20],"assays":[2,7,27,71,137,167,193],"are":[3,8,64,194,239],"equal":[4,10],"but":[5,204],"some":[6],"more":[9],"than":[11],"others":[12],"(with":[13],"apologies":[14],"to":[15,99,188],"George":[16],"Orwell).\n\nMeasurement":[17],"of":[18,39,43,52,58,68,104,112,129,146,148,165,181,201,231,248,274,283,287],"cardiac":[19],"(cTn)":[21],"using":[22],"\u2018high":[23],"sensitivity\u2019":[24],"cTn":[25,70],"(hs-cTn)":[26],"is":[28,34,93,138,161,176,270],"supported":[29],"by":[30,96],"evidence-based":[31],"medicine":[32],"and":[33,76,108,143,173,266,276],"incorporated":[35],"into":[36,72,170],"the":[37,40,48,66,84,97,117,127,132,144,149,199,209,232,246,272,281,284],"guidelines":[38],"European":[41],"Society":[42],"Cardiology1":[44],"as":[45,47,205],"well":[46],"Fourth":[49],"Universal":[50],"Definition":[51],"Myocardial":[53],"Infarction":[54],"(2018).2":[55],"The":[56],"majority":[57],"diagnostic":[59,249],"companies":[60],"have":[61],"launched":[62],"or":[63],"in":[65,79],"process":[67],"launching":[69],"routine":[73,171],"clinical":[74,125,172],"practice":[75],"for":[77,86,135,198],"use":[78,175,247],"research":[80,174],"trials,":[81],"which":[82,153],"meet":[83],"criteria":[85],"high":[87,90],"sensitivity.":[88],"A":[89],"sensitivity":[91],"assay":[92,150],"defined":[94],"analytically3":[95],"ability":[98],"measure":[100],"at":[101,116,131,258],"least":[102],"50%":[103],"a":[105,179,228],"reference":[106,121],"population":[107],"an":[109,252],"imprecision":[110,128],"(coefficient":[111],"variation":[113],"(%CV))":[114],"<10%":[115],"99th":[118,133],"percentile":[119,134],"upper":[120],"limit":[122,145],"(URL).":[123],"In":[124],"practice,":[126],"measurement":[130,254,257],"most":[136],"typically":[139],"much":[140],"lower,":[141],"<5%,":[142],"detection":[147,200],"(the":[151],"concentration":[152],"can":[154],"be":[155,189],"reliably":[156],"distinguished":[157],"from":[158,292],"background":[159],"noise)":[160],"very":[162],"low.\n\nThe":[163],"advent":[164],"hs-cTn":[166,223,278],"moving":[168],"globally":[169],"associated":[177],"with":[178,217,222,241,255],"number":[180],"challenges.":[182],"For":[183,235,261],"front-line":[184],"clinicians,":[185],"there":[186,238,269],"needs":[187],"acceptance":[190],"that":[191],"these":[192],"exceptionally":[195],"sensitive":[196],"tools":[197],"myocardial":[202,211,218],"injury":[203,212],"has":[206],"always":[207,215],"been":[208],"case,":[210],"does":[213],"not":[214],"equate":[216],"infarction":[219],"(MI).":[220],"Indeed,":[221],"assays,":[224],"MI":[225],"subsumes":[226],"only":[227],"modest":[229],"percentage":[230],"increases":[233],"observed.4":[234],"laboratory":[236],"medicine,":[237],"challenges":[240],"service":[242],"delivery":[243],"based":[244],"on":[245,280],"algorithms":[250],"incorporating":[251],"admission":[253],"repeat":[256],"1\u20133\u2009hours":[259],"post-admission.1":[260],"journals,":[262],"including":[263],"readers,":[264],"editors":[265],"their":[267],"reviewers,":[268],"also":[271],"challenge":[273],"understanding":[275],"educating":[277],"users":[279],"nature":[282],"improved":[285],"analytics":[286],"hs-assays,":[288],"how":[289],"they":[290],"differ":[291],"\u2026":[293]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-11-08T00:00:00"}
