{"id":"https://openalex.org/W2982408331","doi":"https://doi.org/10.15264/cpho.2019.26.2.110","title":"A Case of Congenital Hepatoblastoma Presented with Hepatic Osteodystrophy Complicated by Multiple Bone Fractures","display_name":"A Case of Congenital Hepatoblastoma Presented with Hepatic Osteodystrophy Complicated by Multiple Bone Fractures","publication_year":2019,"publication_date":"2019-10-31","ids":{"openalex":"https://openalex.org/W2982408331","doi":"https://doi.org/10.15264/cpho.2019.26.2.110","mag":"2982408331"},"language":"en","primary_location":{"id":"doi:10.15264/cpho.2019.26.2.110","doi":"https://doi.org/10.15264/cpho.2019.26.2.110","is_oa":true,"landing_page_url":"https://doi.org/10.15264/cpho.2019.26.2.110","pdf_url":null,"source":{"id":"https://openalex.org/S4306506404","display_name":"Imsang soa hyeoraek jong-yang/Imsang soa hyeol'aeg jong'yang/Clinical pediatric hematology-oncology","issn_l":"1975-2881","issn":["1975-2881","2233-4580","2233-5250"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","kci-registered"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pediatric Hematology-Oncology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2982408331"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.15264/cpho.2019.26.2.110","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054496850","display_name":"Yoon Heui So","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111277659","display_name":"Chonnam National University","ror":"https://ror.org/05kzjxq56","country_code":"KR","type":"education","lineage":["https://openalex.org/I111277659"]},{"id":"https://openalex.org/I4210148121","display_name":"Chonnam National University Hwasun Hospital","ror":"https://ror.org/054gh2b75","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I111277659","https://openalex.org/I4210092150","https://openalex.org/I4210148121"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yoon Heui So","raw_affiliation_strings":["Department of Pediatrics, Chonnam National University Hwasun Hospital, Hwasun, Korea","Departments of Pediatrics, Chonnam National University Medical School, Gwangju, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Chonnam National University Hwasun Hospital, Hwasun, Korea","institution_ids":["https://openalex.org/I4210148121"]},{"raw_affiliation_string":"Departments of Pediatrics, Chonnam National University Medical School, Gwangju, Korea","institution_ids":["https://openalex.org/I111277659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101607741","display_name":"Dae Sung Kim","orcid":"https://orcid.org/0000-0003-4060-3802","observed_orcids":["https://orcid.org/0000-0003-4060-3802"]},"institutions":[{"id":"https://openalex.org/I4210148121","display_name":"Chonnam National University Hwasun Hospital","ror":"https://ror.org/054gh2b75","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I111277659","https://openalex.org/I4210092150","https://openalex.org/I4210148121"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dae Sung Kim","raw_affiliation_strings":["Department of Pediatrics, Chonnam National University Hwasun Hospital, Hwasun, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Chonnam National University Hwasun Hospital, Hwasun, Korea","institution_ids":["https://openalex.org/I4210148121"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039050817","display_name":"Bo Ae Yoon","orcid":"https://orcid.org/0000-0002-3028-7335","observed_orcids":["https://orcid.org/0000-0002-3028-7335"]},"institutions":[{"id":"https://openalex.org/I4210148121","display_name":"Chonnam National University Hwasun Hospital","ror":"https://ror.org/054gh2b75","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I111277659","https://openalex.org/I4210092150","https://openalex.org/I4210148121"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Bo Ae Yoon","raw_affiliation_strings":["Department of Pediatrics, Chonnam National University Hwasun Hospital, Hwasun, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Chonnam National University Hwasun Hospital, Hwasun, Korea","institution_ids":["https://openalex.org/I4210148121"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087201356","display_name":"Yoo Duk Choi","orcid":"https://orcid.org/0000-0002-4385-1759","observed_orcids":["https://orcid.org/0000-0002-4385-1759"]},"institutions":[{"id":"https://openalex.org/I111277659","display_name":"Chonnam National University","ror":"https://ror.org/05kzjxq56","country_code":"KR","type":"education","lineage":["https://openalex.org/I111277659"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yoo-Duk Choi","raw_affiliation_strings":["Departments of Pathology, Chonnam National University Medical School, Gwangju, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology, Chonnam National University Medical School, Gwangju, Korea","institution_ids":["https://openalex.org/I111277659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050312791","display_name":"Hee Jo Baek","orcid":"https://orcid.org/0000-0003-3830-8134","observed_orcids":["https://orcid.org/0000-0003-3830-8134"]},"institutions":[{"id":"https://openalex.org/I111277659","display_name":"Chonnam National University","ror":"https://ror.org/05kzjxq56","country_code":"KR","type":"education","lineage":["https://openalex.org/I111277659"]},{"id":"https://openalex.org/I4210148121","display_name":"Chonnam National University Hwasun Hospital","ror":"https://ror.org/054gh2b75","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I111277659","https://openalex.org/I4210092150","https://openalex.org/I4210148121"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hee Jo Baek","raw_affiliation_strings":["Department of Pediatrics, Chonnam National University Hwasun Hospital, Hwasun, Korea","Departments of Pediatrics, Chonnam National University Medical School, Gwangju, Korea"],"raw_orcid":"https://orcid.org/0000-0003-3830-8134","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Chonnam National University Hwasun Hospital, Hwasun, Korea","institution_ids":["https://openalex.org/I4210148121"]},{"raw_affiliation_string":"Departments of Pediatrics, Chonnam National University Medical School, Gwangju, Korea","institution_ids":["https://openalex.org/I111277659"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059758700","display_name":"Hoon Kook","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111277659","display_name":"Chonnam National University","ror":"https://ror.org/05kzjxq56","country_code":"KR","type":"education","lineage":["https://openalex.org/I111277659"]},{"id":"https://openalex.org/I4210148121","display_name":"Chonnam National University Hwasun Hospital","ror":"https://ror.org/054gh2b75","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I111277659","https://openalex.org/I4210092150","https://openalex.org/I4210148121"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hoon Kook","raw_affiliation_strings":["Department of Pediatrics, Chonnam National University Hwasun Hospital, Hwasun, Korea","Departments of Pediatrics, Chonnam National University Medical School, Gwangju, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Chonnam National University Hwasun Hospital, Hwasun, Korea","institution_ids":["https://openalex.org/I4210148121"]},{"raw_affiliation_string":"Departments of Pediatrics, Chonnam National University Medical School, Gwangju, Korea","institution_ids":["https://openalex.org/I111277659"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"2","first_page":"110","last_page":"114"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.3158999979496002,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.3158999979496002,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12460","display_name":"Pediatric Hepatobiliary Diseases and Treatments","score":0.25369998812675476,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.08889999985694885,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatic-osteodystrophy","display_name":"hepatic osteodystrophy","score":0.9879999756813049},{"id":"https://openalex.org/keywords/bone-fractures","display_name":"bone fractures","score":0.6320000290870667},{"id":"https://openalex.org/keywords/rickets","display_name":"rickets","score":0.7649999856948853},{"id":"https://openalex.org/keywords/cholestasis","display_name":"cholestasis","score":0.8399999737739563},{"id":"https://openalex.org/keywords/vitamin-d-supplementation","display_name":"vitamin D supplementation","score":0.7680000066757202},{"id":"https://openalex.org/keywords/fat-soluble-vitamins","display_name":"fat-soluble vitamins","score":0.9179999828338623},{"id":"https://openalex.org/keywords/bisphosphonates","display_name":"bisphosphonates","score":0.8320000171661377},{"id":"https://openalex.org/keywords/infants","display_name":"infants","score":0.5400000214576721},{"id":"https://openalex.org/keywords/prenatal-ultrasound","display_name":"prenatal ultrasound","score":0.6309999823570251},{"id":"https://openalex.org/keywords/pretext-staging","display_name":"PRETEXT staging","score":0.5870000123977661},{"id":"https://openalex.org/keywords/direct-hyperbilirubinemia","display_name":"direct hyperbilirubinemia","score":0.6850000023841858}],"concepts":[{"id":"https://openalex.org/C2776304256","wikidata":"https://www.wikidata.org/wiki/Q1607658","display_name":"Hepatoblastoma","level":2,"score":0.9499104619026184},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5771404504776001},{"id":"https://openalex.org/C2781000923","wikidata":"https://www.wikidata.org/wiki/Q3357466","display_name":"Osteodystrophy","level":2,"score":0.5238014459609985},{"id":"https://openalex.org/C2776699218","wikidata":"https://www.wikidata.org/wiki/Q822598","display_name":"Renal osteodystrophy","level":3,"score":0.4481731951236725},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2845272719860077},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.15264/cpho.2019.26.2.110","doi":"https://doi.org/10.15264/cpho.2019.26.2.110","is_oa":true,"landing_page_url":"https://doi.org/10.15264/cpho.2019.26.2.110","pdf_url":null,"source":{"id":"https://openalex.org/S4306506404","display_name":"Imsang soa hyeoraek jong-yang/Imsang soa hyeol'aeg jong'yang/Clinical pediatric hematology-oncology","issn_l":"1975-2881","issn":["1975-2881","2233-4580","2233-5250"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","kci-registered"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pediatric Hematology-Oncology","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:71ad33629785411da74c5734facc2055","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/71ad33629785411da74c5734facc2055","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical Pediatric Hematology-Oncology, Vol 26, Iss 2, Pp 110-114 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.15264/cpho.2019.26.2.110","doi":"https://doi.org/10.15264/cpho.2019.26.2.110","is_oa":true,"landing_page_url":"https://doi.org/10.15264/cpho.2019.26.2.110","pdf_url":null,"source":{"id":"https://openalex.org/S4306506404","display_name":"Imsang soa hyeoraek jong-yang/Imsang soa hyeol'aeg jong'yang/Clinical pediatric hematology-oncology","issn_l":"1975-2881","issn":["1975-2881","2233-4580","2233-5250"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","kci-registered"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pediatric Hematology-Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1991487948","https://openalex.org/W2051089091","https://openalex.org/W2062209874","https://openalex.org/W2078528031","https://openalex.org/W2086008847","https://openalex.org/W2095271346","https://openalex.org/W2097641440","https://openalex.org/W2108544522","https://openalex.org/W2127617253","https://openalex.org/W2337771488","https://openalex.org/W2773526263","https://openalex.org/W2794498230","https://openalex.org/W4236479130"],"related_works":["https://openalex.org/W2027239420","https://openalex.org/W7119332458","https://openalex.org/W4301378238","https://openalex.org/W1591551495","https://openalex.org/W2794498230","https://openalex.org/W2212767681","https://openalex.org/W2037789957","https://openalex.org/W4413733986","https://openalex.org/W2051675398","https://openalex.org/W7038316445"],"abstract_inverted_index":{"Hepatic":[0],"osteodystrophy":[1,25,168],"is":[2,169],"frequent":[3],"complication":[4],"in":[5,123,171],"patients":[6,172],"with":[7,12,20,88,119,159,173],"chronic":[8,13],"liver":[9],"disease,":[10],"particularly":[11],"cholestasis.":[14],"We":[15],"report":[16],"a":[17,48],"male":[18],"infant":[19],"congenital":[21],"hepatoblastoma,":[22,61,174],"who":[23],"had":[24],"complicated":[26],"by":[27,43,54,141],"multiple":[28,133],"bone":[29,69,134],"fractures":[30,135],"despite":[31],"adequate":[32],"supplementation":[33],"of":[34,47,74,83,114,130,151,156,163,167],"fat-soluble":[35,90],"vitamins":[36],"including":[37],"vitamin":[38,81,157],"D.":[39],"He":[40],"was":[41,60,86,107],"born":[42],"Caesarean":[44],"section":[45],"because":[46],"7":[49],"cm\u2013sized":[50],"abdominal":[51],"mass":[52],"detected":[53],"prenatal":[55],"ultrasonography.":[56],"The":[57],"pathologic":[58],"diagnosis":[59,75],"PRETEXT":[62],"staging":[63],"III":[64],"or":[65],"IV.":[66],"Whole":[67],"body":[68],"scan":[70],"at":[71,102],"the":[72],"time":[73],"showed":[76],"no":[77],"abnormal":[78],"uptake.":[79],"Oral":[80],"D3":[82],"2,000":[84],"IU/day":[85],"administered":[87],"other":[89],"vitamins.":[91],"Serum":[92],"direct":[93],"bilirubin":[94],"level":[95,162],"gradually":[96,147],"increased":[97],"up":[98],"to":[99],"28.9":[100],"mg/dL":[101,110],"postnatal":[103],"6":[104],"days":[105,113,129],"and":[106,132,153,165],"above":[108],"5":[109],"until":[111],"110":[112],"age.":[115],"Bony":[116],"changes":[117],"consistent":[118],"rickets":[120],"became":[121],"apparent":[122],"left":[124],"proximal":[125],"humerus":[126],"since":[127],"48":[128],"age,":[131],"developed":[136],"thereafter.":[137],"With":[138],"resolving":[139],"cholestasis":[140,177],"chemotherapy,":[142],"his":[143],"bony":[144],"lesions":[145],"improved":[146],"after":[148],"add-on":[149],"treatment":[150],"bisphosphonate":[152],"parenteral":[154],"administration":[155],"D":[158],"calcium.":[160],"High":[161],"suspicion":[164],"prevention":[166],"needed":[170],"especially":[175],"when":[176],"persists.":[178]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2019-11-08T00:00:00"}