{"id":"https://openalex.org/W2982269472","doi":"https://doi.org/10.1097/01.ee9.0000607724.07951.39","title":"Prenatal exposure to chemical mixtures and inhibition among adolescents in the New Bedford Cohort","display_name":"Prenatal exposure to chemical mixtures and inhibition among adolescents in the New Bedford Cohort","publication_year":2019,"publication_date":"2019-10-01","ids":{"openalex":"https://openalex.org/W2982269472","doi":"https://doi.org/10.1097/01.ee9.0000607724.07951.39","mag":"2982269472"},"language":"en","primary_location":{"id":"doi:10.1097/01.ee9.0000607724.07951.39","doi":"https://doi.org/10.1097/01.ee9.0000607724.07951.39","is_oa":true,"landing_page_url":"https://doi.org/10.1097/01.ee9.0000607724.07951.39","pdf_url":null,"source":{"id":"https://openalex.org/S4210236793","display_name":"Environmental Epidemiology","issn_l":"2474-7882","issn":["2474-7882"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Epidemiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1097/01.ee9.0000607724.07951.39","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001273867","display_name":"A Iokheles","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Iokheles A","raw_affiliation_strings":["Department of Environmental Health, Harvard T.H. Chan School of Public Health","Population Health Sciences, Harvard Graduate School of Arts and Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Health, Harvard T.H. Chan School of Public Health","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Population Health Sciences, Harvard Graduate School of Arts and Sciences","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103552726","display_name":"David C. Bellinger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bellinger D","raw_affiliation_strings":["Boston Children\u2019s Hospital","Department of Environmental Health, Harvard T.H. Chan School of Public Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston Children\u2019s Hospital","institution_ids":["https://openalex.org/I1288882113"]},{"raw_affiliation_string":"Department of Environmental Health, Harvard T.H. Chan School of Public Health","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045303930","display_name":"Brent A. Coull","orcid":"https://orcid.org/0000-0002-1808-4156","observed_orcids":["https://orcid.org/0000-0002-1808-4156"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Coull B","raw_affiliation_strings":["Department of Biostatistics, Harvard T.H. Chan School of Public Health","Department of Environmental Health, Harvard T.H. Chan School of Public Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Harvard T.H. Chan School of Public Health","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Environmental Health, Harvard T.H. Chan School of Public Health","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086410623","display_name":"Marc G. Weisskopf","orcid":"https://orcid.org/0000-0003-4513-9834","observed_orcids":["https://orcid.org/0000-0003-4513-9834"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weisskopf M","raw_affiliation_strings":["Department of Environmental Health, Harvard T.H. Chan School of Public Health","Department of Epidemiology, Harvard T.H. Chan School of Public Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Health, Harvard T.H. Chan School of Public Health","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Epidemiology, Harvard T.H. Chan School of Public Health","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011459523","display_name":"Susan Korrick","orcid":"https://orcid.org/0000-0002-5966-1036","observed_orcids":["https://orcid.org/0000-0002-5966-1036"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Korrick S","raw_affiliation_strings":["Channing Division of Network Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School","Department of Environmental Health, Harvard T.H. Chan School of Public Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Channing Division of Network Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Environmental Health, Harvard T.H. Chan School of Public Health","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1200,"currency":"USD","value_usd":1200},"apc_paid":{"value":1200,"currency":"USD","value_usd":1200},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.11542435,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"3","issue":"Supplement 1","first_page":"175","last_page":"176"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.35600000619888306,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.35600000619888306,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.25270000100135803,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.20340000092983246,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inhibition","display_name":"inhibition","score":0.6000000238418579},{"id":"https://openalex.org/keywords/executive-function","display_name":"executive function","score":0.9909999966621399},{"id":"https://openalex.org/keywords/organochlorine-compounds","display_name":"organochlorine compounds","score":0.8999999761581421},{"id":"https://openalex.org/keywords/polychlorinated-biphenyls","display_name":"polychlorinated biphenyls","score":0.9200000166893005},{"id":"https://openalex.org/keywords/dde","display_name":"DDE","score":0.871999979019165},{"id":"https://openalex.org/keywords/hexachlorobenzene","display_name":"hexachlorobenzene","score":0.9599999785423279},{"id":"https://openalex.org/keywords/lead","display_name":"lead","score":0.6069999933242798},{"id":"https://openalex.org/keywords/manganese","display_name":"manganese","score":0.996999979019165},{"id":"https://openalex.org/keywords/mercury","display_name":"mercury","score":0.8510000109672546},{"id":"https://openalex.org/keywords/arsenic","display_name":"arsenic","score":1.0},{"id":"https://openalex.org/keywords/metals","display_name":"metals","score":0.3370000123977661},{"id":"https://openalex.org/keywords/new-bedford-harbor","display_name":"New Bedford Harbor","score":0.5709999799728394},{"id":"https://openalex.org/keywords/superfund-sites","display_name":"Superfund sites","score":0.8339999914169312},{"id":"https://openalex.org/keywords/adolescents","display_name":"adolescents","score":0.49300000071525574},{"id":"https://openalex.org/keywords/cognitive-development","display_name":"cognitive development","score":0.5870000123977661},{"id":"https://openalex.org/keywords/color-word-interference","display_name":"color-word interference","score":0.6669999957084656},{"id":"https://openalex.org/keywords/non-verbal-fluency","display_name":"non-verbal fluency","score":0.8859999775886536},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.5389999747276306}],"concepts":[{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.6696973443031311},{"id":"https://openalex.org/C3018923374","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Prenatal exposure","level":4,"score":0.5320775508880615},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5312820672988892},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.4529418647289276},{"id":"https://openalex.org/C97530452","wikidata":"https://www.wikidata.org/wiki/Q7920939","display_name":"Verbal fluency test","level":4,"score":0.45029211044311523},{"id":"https://openalex.org/C2776319443","wikidata":"https://www.wikidata.org/wiki/Q421177","display_name":"Cotinine","level":3,"score":0.4118748605251312},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.3987637758255005},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.35746851563453674},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.20807281136512756},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2075638473033905},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.16412433981895447},{"id":"https://openalex.org/C14216870","wikidata":"https://www.wikidata.org/wiki/Q3872","display_name":"Neuropsychology","level":3,"score":0.1608302891254425},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.09987953305244446},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08410748839378357},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2779547902","wikidata":"https://www.wikidata.org/wiki/Q28086552","display_name":"Nicotine","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1097/01.ee9.0000607724.07951.39","doi":"https://doi.org/10.1097/01.ee9.0000607724.07951.39","is_oa":true,"landing_page_url":"https://doi.org/10.1097/01.ee9.0000607724.07951.39","pdf_url":null,"source":{"id":"https://openalex.org/S4210236793","display_name":"Environmental Epidemiology","issn_l":"2474-7882","issn":["2474-7882"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Epidemiology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1097/01.ee9.0000607724.07951.39","doi":"https://doi.org/10.1097/01.ee9.0000607724.07951.39","is_oa":true,"landing_page_url":"https://doi.org/10.1097/01.ee9.0000607724.07951.39","pdf_url":null,"source":{"id":"https://openalex.org/S4210236793","display_name":"Environmental Epidemiology","issn_l":"2474-7882","issn":["2474-7882"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Epidemiology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3212056485","https://openalex.org/W3208918550","https://openalex.org/W3217142530","https://openalex.org/W3168270080","https://openalex.org/W4411573829","https://openalex.org/W3217788980","https://openalex.org/W2888943036","https://openalex.org/W4224316571","https://openalex.org/W2981955674","https://openalex.org/W2990677193"],"abstract_inverted_index":{"TPS":[0],"732:":[1],"Neurological":[2],"effects":[3],"in":[4,32,53,92,159,230,242,253],"adults,":[5],"Exhibition":[6],"Hall,":[7],"Ground":[8],"floor,":[9],"August":[10],"27,":[11],"2019,":[12],"3:00":[13],"PM":[14,17],"-":[15],"4:30":[16],"Background/Aim:":[18],"Few":[19],"studies":[20],"have":[21],"assessed":[22,99],"whether":[23],"prenatal":[24,68,169,299],"exposure":[25,69,141,196,258],"to":[26,70,119,187,287,312],"chemical":[27,300],"mixtures":[28,142,301],"has":[29],"cognitive":[30,86],"impacts":[31],"adolescence.":[33,93],"Methods:":[34],"The":[35],"New":[36,48],"Bedford":[37,49],"Cohort":[38],"(NBC)":[39],"is":[40],"a":[41,85,120,160],"birth":[42,189],"cohort":[43],"of":[44,65,67,122,125,168,194,256,282,298,308],"residents":[45],"near":[46],"the":[47,59,63,101,257],"Harbor":[50],"Superfund":[51],"site":[52],"Massachusetts.":[54],"Among":[55],"528":[56],"adolescents":[57,151],"from":[58],"NBC,":[60],"we":[61],"investigated":[62],"association":[64],"biomarkers":[66],"organochlorines":[71],"(OCs:":[72],"DDE,":[73],"HCB,":[74],"PCBs)":[75],"and":[76,110,139,157,173,181,236,284,289],"metals":[77,288],"(Pb,":[78],"Mn,":[79],"MeHg,":[80],"As)":[81],"with":[82,100,116,154,204,214,266,273,291,302,306],"executive":[83,304],"function,":[84],"skill":[87],"that":[88],"undergoes":[89],"substantial":[90],"development":[91],"This":[94],"analysis":[95],"focused":[96],"on":[97],"inhibition,":[98],"Delis-Kaplan":[102],"Executive":[103],"Function":[104],"System":[105],"Design":[106,205,267],"Fluency":[107,206,268],"(non-verbal":[108],"task)":[109,114],"Color-Word":[111,216,274],"Interference":[112],"(verbal":[113],"subtests":[115],"scores":[117,217],"standardized":[118],"mean":[121],"10,":[123],"SD":[124],"3.":[126],"Confounder-adjusted":[127],"associations":[128,203,265,272,281,297],"were":[129,184,199,212,221,261],"examined":[130],"for":[131,140,224],"individual":[132,283],"exposures":[133,286],"using":[134,143],"generalized":[135],"additive":[136],"models":[137,193,255],"(GAMs)":[138],"Bayesian":[144],"Kernel":[145],"Machine":[146],"Regression":[147],"(BKMR).":[148],"Results:":[149],"NBC":[150],"are":[152],"diverse":[153],"31%":[155],"non-white":[156],"32%":[158],"low-income":[161],"household":[162],"at":[163],"birth.":[164],"Their":[165],"biomarker":[166],"levels":[167,183],"OC":[170],"(cord":[171,175],"serum)":[172],"metal":[174],"blood":[176],"or":[177],"maternal":[178],"peripartum":[179],"hair":[180],"toenail)":[182],"generally":[185],"similar":[186],"other":[188,303],"cohorts.":[190],"In":[191],"GAM":[192],"all":[195],"biomarkers,":[197],"there":[198,260],"no":[200,262],"significant":[201,263],"adverse":[202,264,271,280],"but":[207,269],"increasing":[208],"cord":[209],"serum":[210],"PCBs":[211],"associated":[213],"poorer":[215],"(smooth":[218],"p=0.047)":[219],"as":[220],"linear":[222],"terms":[223],"Mn":[225],"(\u03b2":[226,238],"per":[227,239],"IQR":[228,240],"increase":[229,241],"Mn=-0.30,":[231],"95%":[232,244],"CI":[233,245],"=-0.72,":[234],"0.12)":[235],"As":[237],"As=-0.05,":[243],"=-0.23,":[246],"0.13),":[247],"although":[248],"not":[249],"statistically":[250],"significantly.":[251],"Similarly,":[252],"BKMR":[254],"mixture,":[259],"suggestive":[270],"scores.":[275],"Conclusion:":[276],"We":[277],"observed":[278],"modest":[279],"joint":[285],"OCs":[290],"inhibition.":[292],"Future":[293],"work":[294],"will":[295],"assess":[296],"functions,":[305],"consideration":[307],"potential":[309],"differential":[310],"sensitivity":[311],"verbal":[313],"versus":[314],"non-verbal":[315],"tasks.":[316]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2019-11-01T00:00:00"}