{"id":"https://openalex.org/W2982258689","doi":null,"title":"Artemether improves type 1 diabetic kidney disease by regulating mitochondrial function.","display_name":"Artemether improves type 1 diabetic kidney disease by regulating mitochondrial function.","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W2982258689","mag":"2982258689","pmid":"https://pubmed.ncbi.nlm.nih.gov/31312396","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6614617"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6614617","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6614617","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6614617","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100318951","display_name":"Yao Wang","orcid":"https://orcid.org/0000-0001-5433-7360","observed_orcids":["https://orcid.org/0000-0001-5433-7360","https://orcid.org/0009-0006-2566-6492"]},"institutions":[{"id":"https://openalex.org/I117532281","display_name":"Guangzhou University of Chinese Medicine","ror":"https://ror.org/03qb7bg95","country_code":"CN","type":"education","lineage":["https://openalex.org/I117532281"]},{"id":"https://openalex.org/I4405273710","display_name":"Shenzhen Traditional Chinese Medicine Hospital","ror":"https://ror.org/00b16vp10","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4405273710"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yao Wang","raw_affiliation_strings":["Department of Nephrology, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen Traditional Chinese Medicine Hospital Shenzhen 518033, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen Traditional Chinese Medicine Hospital Shenzhen 518033, Guangdong, China","institution_ids":["https://openalex.org/I117532281","https://openalex.org/I4405273710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033695590","display_name":"Pengxun Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I117532281","display_name":"Guangzhou University of Chinese Medicine","ror":"https://ror.org/03qb7bg95","country_code":"CN","type":"education","lineage":["https://openalex.org/I117532281"]},{"id":"https://openalex.org/I4405273710","display_name":"Shenzhen Traditional Chinese Medicine Hospital","ror":"https://ror.org/00b16vp10","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4405273710"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pengxun Han","raw_affiliation_strings":["Department of Nephrology, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen Traditional Chinese Medicine Hospital Shenzhen 518033, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen Traditional Chinese Medicine Hospital Shenzhen 518033, Guangdong, China","institution_ids":["https://openalex.org/I117532281","https://openalex.org/I4405273710"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Menghua Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I117532281","display_name":"Guangzhou University of Chinese Medicine","ror":"https://ror.org/03qb7bg95","country_code":"CN","type":"education","lineage":["https://openalex.org/I117532281"]},{"id":"https://openalex.org/I4405273710","display_name":"Shenzhen Traditional Chinese Medicine Hospital","ror":"https://ror.org/00b16vp10","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4405273710"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Menghua Wang","raw_affiliation_strings":["Department of Nephrology, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen Traditional Chinese Medicine Hospital Shenzhen 518033, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen Traditional Chinese Medicine Hospital Shenzhen 518033, Guangdong, China","institution_ids":["https://openalex.org/I117532281","https://openalex.org/I4405273710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005460268","display_name":"Wenci Weng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I117532281","display_name":"Guangzhou University of Chinese Medicine","ror":"https://ror.org/03qb7bg95","country_code":"CN","type":"education","lineage":["https://openalex.org/I117532281"]},{"id":"https://openalex.org/I4405273710","display_name":"Shenzhen Traditional Chinese Medicine Hospital","ror":"https://ror.org/00b16vp10","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4405273710"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenci Weng","raw_affiliation_strings":["Department of Nephrology, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen Traditional Chinese Medicine Hospital Shenzhen 518033, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen Traditional Chinese Medicine Hospital Shenzhen 518033, Guangdong, China","institution_ids":["https://openalex.org/I117532281","https://openalex.org/I4405273710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065250695","display_name":"Hongyue Zhan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I117532281","display_name":"Guangzhou University of Chinese Medicine","ror":"https://ror.org/03qb7bg95","country_code":"CN","type":"education","lineage":["https://openalex.org/I117532281"]},{"id":"https://openalex.org/I4405273710","display_name":"Shenzhen Traditional Chinese Medicine Hospital","ror":"https://ror.org/00b16vp10","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4405273710"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongyue Zhan","raw_affiliation_strings":["Department of Nephrology, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen Traditional Chinese Medicine Hospital Shenzhen 518033, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen Traditional Chinese Medicine Hospital Shenzhen 518033, Guangdong, China","institution_ids":["https://openalex.org/I117532281","https://openalex.org/I4405273710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089257398","display_name":"Xuewen Yu","orcid":"https://orcid.org/0000-0003-4774-7139","observed_orcids":["https://orcid.org/0000-0003-4774-7139"]},"institutions":[{"id":"https://openalex.org/I117532281","display_name":"Guangzhou University of Chinese Medicine","ror":"https://ror.org/03qb7bg95","country_code":"CN","type":"education","lineage":["https://openalex.org/I117532281"]},{"id":"https://openalex.org/I4405273710","display_name":"Shenzhen Traditional Chinese Medicine Hospital","ror":"https://ror.org/00b16vp10","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4405273710"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuewen Yu","raw_affiliation_strings":["Department of Pathology, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen Traditional Chinese Medicine Hospital Shenzhen 518033, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen Traditional Chinese Medicine Hospital Shenzhen 518033, Guangdong, China","institution_ids":["https://openalex.org/I117532281","https://openalex.org/I4405273710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112478857","display_name":"Changjian Yuan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I117532281","display_name":"Guangzhou University of Chinese Medicine","ror":"https://ror.org/03qb7bg95","country_code":"CN","type":"education","lineage":["https://openalex.org/I117532281"]},{"id":"https://openalex.org/I4405273710","display_name":"Shenzhen Traditional Chinese Medicine Hospital","ror":"https://ror.org/00b16vp10","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4405273710"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Changjian Yuan","raw_affiliation_strings":["Department of Nephrology, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen Traditional Chinese Medicine Hospital Shenzhen 518033, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen Traditional Chinese Medicine Hospital Shenzhen 518033, Guangdong, China","institution_ids":["https://openalex.org/I117532281","https://openalex.org/I4405273710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053873070","display_name":"Mumin Shao","orcid":"https://orcid.org/0000-0001-9327-1261","observed_orcids":["https://orcid.org/0000-0001-9327-1261"]},"institutions":[{"id":"https://openalex.org/I117532281","display_name":"Guangzhou University of Chinese Medicine","ror":"https://ror.org/03qb7bg95","country_code":"CN","type":"education","lineage":["https://openalex.org/I117532281"]},{"id":"https://openalex.org/I4405273710","display_name":"Shenzhen Traditional Chinese Medicine Hospital","ror":"https://ror.org/00b16vp10","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4405273710"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mumin Shao","raw_affiliation_strings":["Department of Pathology, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen Traditional Chinese Medicine Hospital Shenzhen 518033, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen Traditional Chinese Medicine Hospital Shenzhen 518033, Guangdong, China","institution_ids":["https://openalex.org/I117532281","https://openalex.org/I4405273710"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091430102","display_name":"Huili Sun","orcid":"https://orcid.org/0000-0002-7101-1087","observed_orcids":["https://orcid.org/0000-0002-7101-1087"]},"institutions":[{"id":"https://openalex.org/I117532281","display_name":"Guangzhou University of Chinese Medicine","ror":"https://ror.org/03qb7bg95","country_code":"CN","type":"education","lineage":["https://openalex.org/I117532281"]},{"id":"https://openalex.org/I4405273710","display_name":"Shenzhen Traditional Chinese Medicine Hospital","ror":"https://ror.org/00b16vp10","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4405273710"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huili Sun","raw_affiliation_strings":["Department of Nephrology, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen Traditional Chinese Medicine Hospital Shenzhen 518033, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen Traditional Chinese Medicine Hospital Shenzhen 518033, Guangdong, China","institution_ids":["https://openalex.org/I117532281","https://openalex.org/I4405273710"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5409,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.81987084,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"11","issue":"6","first_page":"3879","last_page":"3889"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/artemether","display_name":"artemether","score":1.0},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.8640000224113464},{"id":"https://openalex.org/keywords/diabetic-nephropathy","display_name":"diabetic nephropathy","score":0.9980000257492065},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.9739999771118164},{"id":"https://openalex.org/keywords/mitochondrial-ros","display_name":"mitochondrial reactive oxygen species","score":0.8799999952316284},{"id":"https://openalex.org/keywords/redox-homeostasis","display_name":"redox homeostasis","score":0.781000018119812},{"id":"https://openalex.org/keywords/renal-protection","display_name":"renal protection","score":0.7300000190734863},{"id":"https://openalex.org/keywords/albuminuria","display_name":"albuminuria","score":0.8859999775886536},{"id":"https://openalex.org/keywords/renal-hypertrophy","display_name":"renal hypertrophy","score":0.796999990940094},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.8270000219345093},{"id":"https://openalex.org/keywords/antimalarial-drugs","display_name":"antimalarial drugs","score":0.640999972820282},{"id":"https://openalex.org/keywords/glucagon-insulin-ratio","display_name":"glucagon/insulin ratio","score":0.9049999713897705},{"id":"https://openalex.org/keywords/islets","display_name":"islets","score":0.46299999952316284}],"concepts":[{"id":"https://openalex.org/C2778118209","wikidata":"https://www.wikidata.org/wiki/Q416199","display_name":"Artemether","level":5,"score":0.8339437246322632},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6946650743484497},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5946765542030334},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5519480109214783},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.5290704369544983},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5202111601829529},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.4758700728416443},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.47212228178977966},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.44935911893844604},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4324556589126587},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.10846823453903198},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.0913102924823761},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.053564488887786865},{"id":"https://openalex.org/C2776120307","wikidata":"https://www.wikidata.org/wiki/Q426921","display_name":"Artemisinin","level":4,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:6614617","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6614617","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},{"id":"pmid:31312396","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31312396","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of translational research","raw_type":"Journal Article"},{"id":"mag:2982258689","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31312396","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6614617","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6614617","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1574602595","https://openalex.org/W2110174113","https://openalex.org/W2127006232","https://openalex.org/W2130176433","https://openalex.org/W2133770419","https://openalex.org/W2142693924","https://openalex.org/W2276476475","https://openalex.org/W2295446298","https://openalex.org/W2500727927","https://openalex.org/W2507547513","https://openalex.org/W2557659496","https://openalex.org/W2568510753","https://openalex.org/W2592871963","https://openalex.org/W2736029153","https://openalex.org/W2751635377","https://openalex.org/W2788432017","https://openalex.org/W2794972088","https://openalex.org/W2798146738","https://openalex.org/W2803302591","https://openalex.org/W2803593737","https://openalex.org/W2885417402","https://openalex.org/W2897764155","https://openalex.org/W2903051467"],"related_works":["https://openalex.org/W2983650191","https://openalex.org/W4280643568","https://openalex.org/W4306668006","https://openalex.org/W4213392738","https://openalex.org/W2148289342","https://openalex.org/W4210777505","https://openalex.org/W4210891675","https://openalex.org/W4224708310","https://openalex.org/W3035560830","https://openalex.org/W2785599253"],"abstract_inverted_index":{"Many":[0],"patients":[1],"with":[2,24,57,62],"type":[3,49,125],"1":[4,50,126],"diabetes":[5,59,127],"mellitus":[6],"suffer":[7],"from":[8,27],"progressive":[9],"diabetic":[10],"kidney":[11],"disease":[12],"(DKD).":[13],"The":[14],"progression":[15],"of":[16,68],"DKD":[17,51],"is":[18],"largely":[19],"attributed":[20],"to":[21,133],"mitochondrial":[22,28,108,135],"dysfunction,":[23],"key":[25],"contributions":[26],"reactive":[29],"oxygen":[30],"species.":[31],"Recent":[32],"studies":[33],"have":[34],"revealed":[35],"that":[36,105,119],"the":[37,53],"antimalarial":[38],"drug":[39],"artemether":[40,87,106,120],"has":[41],"antidiabetic":[42],"effects.":[43],"To":[44],"identify":[45],"potential":[46],"effects":[47],"on":[48],"in":[52,101,114,124],"present":[54],"study,":[55],"mice":[56],"streptozotocin-induced":[58],"were":[60],"treated":[61],"artemether.":[63],"Treatment":[64],"reduced":[65],"urinary":[66],"excretion":[67],"albumin":[69,76],"and":[70,77,81,95,98,110],"tubular":[71],"injury":[72],"biomarkers,":[73],"increased":[74],"serum":[75,92],"total":[78],"protein":[79],"levels,":[80,94],"attenuated":[82],"renal":[83,122],"hypertrophy.":[84],"In":[85],"addition,":[86],"treatment":[88],"prevented":[89],"hyperglycemia,":[90],"raised":[91],"insulin":[93],"restored":[96],"glucagon/insulin":[97],"somatostatin/insulin":[99],"ratios":[100],"islets.":[102],"We":[103],"found":[104],"improved":[107,134],"function":[109],"regulated":[111],"redox":[112],"balance":[113],"kidney.":[115],"These":[116],"results":[117],"demonstrate":[118],"provides":[121],"protection":[123],"mellitus,":[128],"which":[129],"may":[130],"be":[131],"due":[132],"function.":[136]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2019-11-01T00:00:00"}