{"id":"https://openalex.org/W2982153174","doi":"https://doi.org/10.1038/s41467-019-12793-3","title":"Maternal insulin resistance multigenerationally impairs synaptic plasticity and memory via gametic mechanisms","display_name":"Maternal insulin resistance multigenerationally impairs synaptic plasticity and memory via gametic mechanisms","publication_year":2019,"publication_date":"2019-10-22","ids":{"openalex":"https://openalex.org/W2982153174","doi":"https://doi.org/10.1038/s41467-019-12793-3","mag":"2982153174","pmid":"https://pubmed.ncbi.nlm.nih.gov/31641124","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6805915"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-019-12793-3","doi":"https://doi.org/10.1038/s41467-019-12793-3","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-019-12793-3","pdf_url":"https://www.nature.com/articles/s41467-019-12793-3.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-019-12793-3.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016550975","display_name":"Salvatore Fusco","orcid":"https://orcid.org/0000-0003-3294-0016","observed_orcids":["https://orcid.org/0000-0003-3294-0016"]},"institutions":[{"id":"https://openalex.org/I103320735","display_name":"Universit\u00e0 Cattolica del Sacro Cuore","ror":"https://ror.org/03h7r5v07","country_code":"IT","type":"education","lineage":["https://openalex.org/I103320735"]},{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Salvatore Fusco","raw_affiliation_strings":["Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168, Rome, Italy. salvatore.fusco@unicatt.it","Institute of Human Physiology, Universit\u00e0 Cattolica del Sacro Cuore, 00168, Rome, Italy. salvatore.fusco@unicatt.it","Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168, Rome, Italy"],"raw_orcid":"https://orcid.org/0000-0003-3294-0016","affiliations":[{"raw_affiliation_string":"Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168, Rome, Italy. salvatore.fusco@unicatt.it","institution_ids":["https://openalex.org/I2802557943"]},{"raw_affiliation_string":"Institute of Human Physiology, Universit\u00e0 Cattolica del Sacro Cuore, 00168, Rome, Italy. salvatore.fusco@unicatt.it","institution_ids":["https://openalex.org/I103320735"]},{"raw_affiliation_string":"Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168, Rome, Italy","institution_ids":["https://openalex.org/I2802557943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069830664","display_name":"Matteo Spinelli","orcid":"https://orcid.org/0000-0001-5776-988X","observed_orcids":["https://orcid.org/0000-0001-5776-988X"]},"institutions":[{"id":"https://openalex.org/I103320735","display_name":"Universit\u00e0 Cattolica del Sacro Cuore","ror":"https://ror.org/03h7r5v07","country_code":"IT","type":"education","lineage":["https://openalex.org/I103320735"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Matteo Spinelli","raw_affiliation_strings":["Institute of Human Physiology, Universit\u00e0 Cattolica del Sacro Cuore, 00168, Rome, Italy"],"raw_orcid":"https://orcid.org/0000-0001-5776-988X","affiliations":[{"raw_affiliation_string":"Institute of Human Physiology, Universit\u00e0 Cattolica del Sacro Cuore, 00168, Rome, Italy","institution_ids":["https://openalex.org/I103320735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072824299","display_name":"Sara Cocco","orcid":"https://orcid.org/0000-0002-9769-1519","observed_orcids":["https://orcid.org/0000-0002-9769-1519"]},"institutions":[{"id":"https://openalex.org/I103320735","display_name":"Universit\u00e0 Cattolica del Sacro Cuore","ror":"https://ror.org/03h7r5v07","country_code":"IT","type":"education","lineage":["https://openalex.org/I103320735"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sara Cocco","raw_affiliation_strings":["Institute of Human Physiology, Universit\u00e0 Cattolica del Sacro Cuore, 00168, Rome, Italy"],"raw_orcid":"https://orcid.org/0000-0002-9769-1519","affiliations":[{"raw_affiliation_string":"Institute of Human Physiology, Universit\u00e0 Cattolica del Sacro Cuore, 00168, Rome, Italy","institution_ids":["https://openalex.org/I103320735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047306271","display_name":"Cristian Ripoli","orcid":"https://orcid.org/0000-0002-5315-0163","observed_orcids":["https://orcid.org/0000-0002-5315-0163"]},"institutions":[{"id":"https://openalex.org/I103320735","display_name":"Universit\u00e0 Cattolica del Sacro Cuore","ror":"https://ror.org/03h7r5v07","country_code":"IT","type":"education","lineage":["https://openalex.org/I103320735"]},{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Cristian Ripoli","raw_affiliation_strings":["Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168, Rome, Italy","Institute of Human Physiology, Universit\u00e0 Cattolica del Sacro Cuore, 00168, Rome, Italy"],"raw_orcid":"https://orcid.org/0000-0002-5315-0163","affiliations":[{"raw_affiliation_string":"Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168, Rome, Italy","institution_ids":["https://openalex.org/I2802557943"]},{"raw_affiliation_string":"Institute of Human Physiology, Universit\u00e0 Cattolica del Sacro Cuore, 00168, Rome, Italy","institution_ids":["https://openalex.org/I103320735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038184253","display_name":"Alessia Mastrodonato","orcid":"https://orcid.org/0000-0003-3999-5159","observed_orcids":["https://orcid.org/0000-0003-3999-5159"]},"institutions":[{"id":"https://openalex.org/I103320735","display_name":"Universit\u00e0 Cattolica del Sacro Cuore","ror":"https://ror.org/03h7r5v07","country_code":"IT","type":"education","lineage":["https://openalex.org/I103320735"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessia Mastrodonato","raw_affiliation_strings":["Institute of Human Physiology, Universit\u00e0 Cattolica del Sacro Cuore, 00168, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Human Physiology, Universit\u00e0 Cattolica del Sacro Cuore, 00168, Rome, Italy","institution_ids":["https://openalex.org/I103320735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078980276","display_name":"Francesca Natale","orcid":"https://orcid.org/0000-0001-7856-930X","observed_orcids":["https://orcid.org/0000-0001-7856-930X"]},"institutions":[{"id":"https://openalex.org/I103320735","display_name":"Universit\u00e0 Cattolica del Sacro Cuore","ror":"https://ror.org/03h7r5v07","country_code":"IT","type":"education","lineage":["https://openalex.org/I103320735"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesca Natale","raw_affiliation_strings":["Institute of Human Physiology, Universit\u00e0 Cattolica del Sacro Cuore, 00168, Rome, Italy"],"raw_orcid":"https://orcid.org/0000-0001-7856-930X","affiliations":[{"raw_affiliation_string":"Institute of Human Physiology, Universit\u00e0 Cattolica del Sacro Cuore, 00168, Rome, Italy","institution_ids":["https://openalex.org/I103320735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083461022","display_name":"Marco Rinaudo","orcid":"https://orcid.org/0000-0002-6130-7335","observed_orcids":["https://orcid.org/0000-0002-6130-7335"]},"institutions":[{"id":"https://openalex.org/I103320735","display_name":"Universit\u00e0 Cattolica del Sacro Cuore","ror":"https://ror.org/03h7r5v07","country_code":"IT","type":"education","lineage":["https://openalex.org/I103320735"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marco Rinaudo","raw_affiliation_strings":["Institute of Human Physiology, Universit\u00e0 Cattolica del Sacro Cuore, 00168, Rome, Italy"],"raw_orcid":"https://orcid.org/0000-0002-6130-7335","affiliations":[{"raw_affiliation_string":"Institute of Human Physiology, Universit\u00e0 Cattolica del Sacro Cuore, 00168, Rome, Italy","institution_ids":["https://openalex.org/I103320735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059027153","display_name":"Giulia Livrizzi","orcid":"https://orcid.org/0000-0001-8787-7777","observed_orcids":["https://orcid.org/0000-0001-8787-7777"]},"institutions":[{"id":"https://openalex.org/I103320735","display_name":"Universit\u00e0 Cattolica del Sacro Cuore","ror":"https://ror.org/03h7r5v07","country_code":"IT","type":"education","lineage":["https://openalex.org/I103320735"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giulia Livrizzi","raw_affiliation_strings":["Institute of Human Physiology, Universit\u00e0 Cattolica del Sacro Cuore, 00168, Rome, Italy"],"raw_orcid":"https://orcid.org/0000-0001-8787-7777","affiliations":[{"raw_affiliation_string":"Institute of Human Physiology, Universit\u00e0 Cattolica del Sacro Cuore, 00168, Rome, Italy","institution_ids":["https://openalex.org/I103320735"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036926288","display_name":"Claudio Grassi","orcid":"https://orcid.org/0000-0001-7253-1685","observed_orcids":["https://orcid.org/0000-0001-7253-1685"]},"institutions":[{"id":"https://openalex.org/I103320735","display_name":"Universit\u00e0 Cattolica del Sacro Cuore","ror":"https://ror.org/03h7r5v07","country_code":"IT","type":"education","lineage":["https://openalex.org/I103320735"]},{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Claudio Grassi","raw_affiliation_strings":["Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168, Rome, Italy. claudio.grassi@unicatt.it","Institute of Human Physiology, Universit\u00e0 Cattolica del Sacro Cuore, 00168, Rome, Italy. claudio.grassi@unicatt.it","Institute of Human Physiology, Universit\u00e0 Cattolica del Sacro Cuore, 00168, Rome, Italy"],"raw_orcid":"https://orcid.org/0000-0001-7253-1685","affiliations":[{"raw_affiliation_string":"Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168, Rome, Italy. claudio.grassi@unicatt.it","institution_ids":["https://openalex.org/I2802557943"]},{"raw_affiliation_string":"Institute of Human Physiology, Universit\u00e0 Cattolica del Sacro Cuore, 00168, Rome, Italy. claudio.grassi@unicatt.it","institution_ids":["https://openalex.org/I103320735"]},{"raw_affiliation_string":"Institute of Human Physiology, Universit\u00e0 Cattolica del Sacro Cuore, 00168, Rome, Italy","institution_ids":["https://openalex.org/I103320735"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5016550975","https://openalex.org/A5036926288"],"corresponding_institution_ids":["https://openalex.org/I103320735","https://openalex.org/I2802557943"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":{"value":5200,"currency":"USD","value_usd":5200},"fwci":8.818,"has_fulltext":true,"cited_by_count":61,"citation_normalized_percentile":{"value":0.98417844,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"10","issue":"1","first_page":"4799","last_page":"4799"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.9282000064849854,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.9282000064849854,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.015200000256299973,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.011500000022351742,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/maternal-insulin-resistance","display_name":"maternal insulin resistance","score":0.8349999785423279},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.9110000133514404},{"id":"https://openalex.org/keywords/intergenerational-transmission","display_name":"intergenerational transmission","score":0.6930000185966492},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"synaptic plasticity","score":0.8849999904632568},{"id":"https://openalex.org/keywords/learning-and-memory","display_name":"learning and memory","score":0.968999981880188},{"id":"https://openalex.org/keywords/brain-derived-neurotrophic-factor","display_name":"brain-derived neurotrophic factor","score":0.9919999837875366},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.8180000185966492},{"id":"https://openalex.org/keywords/male-germline","display_name":"male germline","score":0.8289999961853027},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.9100000262260437},{"id":"https://openalex.org/keywords/environmental-enrichment","display_name":"environmental enrichment","score":0.8489999771118164},{"id":"https://openalex.org/keywords/p66shc","display_name":"p66Shc","score":0.9739999771118164},{"id":"https://openalex.org/keywords/maternal-diet","display_name":"maternal diet","score":0.4830000102519989},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.5350000262260437}],"concepts":[{"id":"https://openalex.org/C112672928","wikidata":"https://www.wikidata.org/wiki/Q239526","display_name":"Offspring","level":3,"score":0.7461985945701599},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.705710768699646},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.7040860056877136},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6289637088775635},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.6035811305046082},{"id":"https://openalex.org/C98229152","wikidata":"https://www.wikidata.org/wiki/Q1551556","display_name":"Synaptic plasticity","level":3,"score":0.5918282866477966},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5601997971534729},{"id":"https://openalex.org/C109825262","wikidata":"https://www.wikidata.org/wiki/Q1139164","display_name":"Germline","level":3,"score":0.545663058757782},{"id":"https://openalex.org/C200170125","wikidata":"https://www.wikidata.org/wiki/Q969316","display_name":"Neurotransmission","level":3,"score":0.5245257019996643},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5041903257369995},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.44545769691467285},{"id":"https://openalex.org/C2776035688","wikidata":"https://www.wikidata.org/wiki/Q1606558","display_name":"Affect (linguistics)","level":2,"score":0.4226382076740265},{"id":"https://openalex.org/C47611674","wikidata":"https://www.wikidata.org/wiki/Q849491","display_name":"Neuroplasticity","level":2,"score":0.4161826968193054},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3402038812637329},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2174340784549713},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2023528516292572},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.19129431247711182},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.1889660656452179},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12402594089508057},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07731655240058899},{"id":"https://openalex.org/C46312422","wikidata":"https://www.wikidata.org/wiki/Q11024","display_name":"Communication","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000071316","descriptor_name":"Forkhead Box Protein O3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000071425","descriptor_name":"Src Homology 2 Domain-Containing, Transforming Protein 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007858","descriptor_name":"Learning","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008568","descriptor_name":"Memory","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009473","descriptor_name":"Neuronal Plasticity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010053","descriptor_name":"Ovary","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017362","descriptor_name":"Cyclic AMP Response Element-Binding Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017362","descriptor_name":"Cyclic AMP Response Element-Binding Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019208","descriptor_name":"Brain-Derived Neurotrophic Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019208","descriptor_name":"Brain-Derived Neurotrophic Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056464","descriptor_name":"Histone Deacetylase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056565","descriptor_name":"Sirtuin 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D059305","descriptor_name":"Diet, High-Fat","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true}],"locations_count":9,"locations":[{"id":"doi:10.1038/s41467-019-12793-3","doi":"https://doi.org/10.1038/s41467-019-12793-3","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-019-12793-3","pdf_url":"https://www.nature.com/articles/s41467-019-12793-3.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5765539","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6805915","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6805915","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6805915","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmid:31641124","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31641124","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-12793-3","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41467-019-12793-3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:21abd2321c064cc1bcd4e8902f94be5d","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/21abd2321c064cc1bcd4e8902f94be5d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:4cb241068bf443d786239ed236081505","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/4cb241068bf443d786239ed236081505","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)","raw_type":"article"},{"id":"pmh:oai:iris.uniss.it:11388/327952","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11388/327952","pdf_url":null,"source":{"id":"https://openalex.org/S4306401147","display_name":"UnissResearch (Universit\u00e0 degli Studi di Sassari)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I159650629","host_organization_name":"University of Sassari","host_organization_lineage":["https://openalex.org/I159650629"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:publicatt.unicatt.it:10807/144578","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10807/144578","pdf_url":null,"source":{"id":"https://openalex.org/S4306400564","display_name":"PubliCatt (Universit\u00e0 Cattolica del Sacro Cuore)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1038/s41467-019-12793-3","doi":"https://doi.org/10.1038/s41467-019-12793-3","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-019-12793-3","pdf_url":"https://www.nature.com/articles/s41467-019-12793-3.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321781","display_name":"Ministero della Salute","ror":"https://ror.org/00789fa95"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2982153174.pdf","grobid_xml":"https://content.openalex.org/works/W2982153174.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W132259741","https://openalex.org/W1492946553","https://openalex.org/W1545854379","https://openalex.org/W1636230558","https://openalex.org/W1964173716","https://openalex.org/W1967238924","https://openalex.org/W1973549360","https://openalex.org/W1974961250","https://openalex.org/W1982889157","https://openalex.org/W1983365668","https://openalex.org/W1991386832","https://openalex.org/W2002637584","https://openalex.org/W2003665687","https://openalex.org/W2004654171","https://openalex.org/W2006716163","https://openalex.org/W2007371413","https://openalex.org/W2018570511","https://openalex.org/W2029226240","https://openalex.org/W2031269976","https://openalex.org/W2035616108","https://openalex.org/W2039696546","https://openalex.org/W2049616256","https://openalex.org/W2054023762","https://openalex.org/W2054942267","https://openalex.org/W2061482726","https://openalex.org/W2062329659","https://openalex.org/W2067902437","https://openalex.org/W2070058996","https://openalex.org/W2071213636","https://openalex.org/W2074810352","https://openalex.org/W2082121151","https://openalex.org/W2087579364","https://openalex.org/W2092765329","https://openalex.org/W2094692905","https://openalex.org/W2094839705","https://openalex.org/W2102419243","https://openalex.org/W2119754857","https://openalex.org/W2120053143","https://openalex.org/W2123870375","https://openalex.org/W2127456840","https://openalex.org/W2127691612","https://openalex.org/W2130431039","https://openalex.org/W2130597092","https://openalex.org/W2130685024","https://openalex.org/W2135826654","https://openalex.org/W2136156874","https://openalex.org/W2137116499","https://openalex.org/W2137777741","https://openalex.org/W2142654785","https://openalex.org/W2152497080","https://openalex.org/W2170760271","https://openalex.org/W2171184117","https://openalex.org/W2171767359","https://openalex.org/W2177979502","https://openalex.org/W2258837799","https://openalex.org/W2273793349","https://openalex.org/W2294215996","https://openalex.org/W2520701010","https://openalex.org/W2583517509","https://openalex.org/W2592917838","https://openalex.org/W2606513998","https://openalex.org/W2608541752","https://openalex.org/W2613930978","https://openalex.org/W2773659498","https://openalex.org/W2886660326","https://openalex.org/W2888850090","https://openalex.org/W2902964933"],"related_works":["https://openalex.org/W3098867420","https://openalex.org/W2780470543","https://openalex.org/W4327975472","https://openalex.org/W3194367603","https://openalex.org/W2898301693","https://openalex.org/W593885235","https://openalex.org/W4400105462","https://openalex.org/W4293659694","https://openalex.org/W2444481702","https://openalex.org/W2138000394"],"abstract_inverted_index":{"Metabolic":[0],"diseases":[1],"harm":[2],"brain":[3,15,111,127],"health":[4,128],"and":[5,39,44,50,58,80],"cognitive":[6,85],"functions,":[7],"but":[8],"whether":[9],"maternal":[10,27,48,121],"metabolic":[11],"unbalance":[12],"may":[13],"affect":[14],"plasticity":[16],"of":[17,60,64,84,110],"next":[18,89],"generations":[19],"is":[20],"still":[21],"unclear.":[22],"Here,":[23],"we":[24],"demonstrate":[25],"that":[26,120],"high":[28],"fat":[29],"diet":[30,122],"(HFD)-dependent":[31],"insulin":[32,45,98],"resistance":[33],"multigenerationally":[34,123],"impairs":[35],"synaptic":[36],"plasticity,":[37],"learning":[38],"memory.":[40],"HFD":[41,66],"downregulates":[42],"BDNF":[43,53,91],"signaling":[46],"in":[47,55,76,100],"tissues":[49],"epigenetically":[51],"inhibits":[52],"expression":[54],"both":[56],"germline":[57,79],"hippocampus":[59],"progeny.":[61,115],"Notably,":[62],"exposure":[63],"the":[65,77,82,88,107,114],"offspring":[67],"to":[68,87,93,113,133],"novel":[69],"enriched":[70],"environment":[71],"restores":[72],"Bdnf":[73],"epigenetic":[74],"activation":[75],"male":[78],"counteracts":[81],"transmission":[83,109],"impairment":[86],"generations.":[90],"administration":[92],"HFD-fed":[94,101],"mothers":[95],"or":[96],"preserved":[97],"sensitivity":[99],"p66Shc":[102],"KO":[103],"mice":[104],"also":[105],"prevents":[106],"intergenerational":[108],"damage":[112],"Collectively,":[116],"our":[117],"data":[118],"suggest":[119],"impacts":[124],"on":[125],"descendants'":[126],"via":[129],"gametic":[130],"mechanisms":[131],"susceptible":[132],"lifestyle.":[134]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-11-01T00:00:00"}