{"id":"https://openalex.org/W2982003193","doi":"https://doi.org/10.1158/1078-0432.ccr-19-1729","title":"Fumarate Metabolic Signature for the Detection of Reed Syndrome in Humans","display_name":"Fumarate Metabolic Signature for the Detection of Reed Syndrome in Humans","publication_year":2019,"publication_date":"2019-10-21","ids":{"openalex":"https://openalex.org/W2982003193","doi":"https://doi.org/10.1158/1078-0432.ccr-19-1729","mag":"2982003193","pmid":"https://pubmed.ncbi.nlm.nih.gov/31636096"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.ccr-19-1729","doi":"https://doi.org/10.1158/1078-0432.ccr-19-1729","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-19-1729","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1158/1078-0432.ccr-19-1729","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044226325","display_name":"Ruth Therese Casey","orcid":"https://orcid.org/0000-0003-4058-3135","observed_orcids":["https://orcid.org/0000-0003-4058-3135","https://orcid.org/0009-0006-9938-8819"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]},{"id":"https://openalex.org/I34931013","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08","country_code":"GB","type":"government","lineage":["https://openalex.org/I34931013"]},{"id":"https://openalex.org/I4210089382","display_name":"Cancer Research UK Cambridge Center","ror":"https://ror.org/0068m0j38","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2801316944","https://openalex.org/I4210089382"]},{"id":"https://openalex.org/I4389425352","display_name":"NIHR Cambridge Biomedical Research Centre","ror":"https://ror.org/05m8dr349","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2802466933","https://openalex.org/I34931013","https://openalex.org/I4389425352"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Ruth T. Casey","raw_affiliation_strings":["1Department of Medical Genetics, University of Cambridge and NIHR Cambridge Biomedical Research Centre and Cancer Research UK Cambridge Centre, Cambridge, United Kingdom","2Department of Endocrinology, Cambridge University NHS Foundation Trust, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Medical Genetics, University of Cambridge and NIHR Cambridge Biomedical Research Centre and Cancer Research UK Cambridge Centre, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749","https://openalex.org/I2801316944","https://openalex.org/I34931013","https://openalex.org/I4210089382","https://openalex.org/I4389425352"]},{"raw_affiliation_string":"2Department of Endocrinology, Cambridge University NHS Foundation Trust, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042960230","display_name":"Mary Anne McLean","orcid":"https://orcid.org/0000-0002-3752-0179","observed_orcids":["https://orcid.org/0000-0002-3752-0179"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210089382","display_name":"Cancer Research UK Cambridge Center","ror":"https://ror.org/0068m0j38","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2801316944","https://openalex.org/I4210089382"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mary A. McLean","raw_affiliation_strings":["3Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210089382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008681928","display_name":"Benjamin Challis","orcid":"https://orcid.org/0000-0002-1130-2851","observed_orcids":["https://orcid.org/0000-0002-1130-2851"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Benjamin G. Challis","raw_affiliation_strings":["2Department of Endocrinology, Cambridge University NHS Foundation Trust, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Endocrinology, Cambridge University NHS Foundation Trust, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078535536","display_name":"Terri Patricia McVeigh","orcid":"https://orcid.org/0000-0001-9201-9216","observed_orcids":["https://orcid.org/0000-0001-9201-9216"]},"institutions":[{"id":"https://openalex.org/I1325846038","display_name":"Royal Marsden NHS Foundation Trust","ror":"https://ror.org/0008wzh48","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038"]},{"id":"https://openalex.org/I4210121186","display_name":"Royal Marsden Hospital","ror":"https://ror.org/034vb5t35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Terri P. McVeigh","raw_affiliation_strings":["4Cancer Genetics Unit, Royal Marsden NHS Foundation Trust, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Cancer Genetics Unit, Royal Marsden NHS Foundation Trust, London, United Kingdom","institution_ids":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047188789","display_name":"Anne Yvonne Warren","orcid":"https://orcid.org/0000-0002-1170-7867","observed_orcids":["https://orcid.org/0000-0002-1170-7867"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]},{"id":"https://openalex.org/I4210089382","display_name":"Cancer Research UK Cambridge Center","ror":"https://ror.org/0068m0j38","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2801316944","https://openalex.org/I4210089382"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anne Y. Warren","raw_affiliation_strings":["5Department of Histopathology, Cambridge University NHS Foundation Trust and Cancer Research UK Cambridge Centre, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Department of Histopathology, Cambridge University NHS Foundation Trust and Cancer Research UK Cambridge Centre, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749","https://openalex.org/I2801316944","https://openalex.org/I4210089382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073855842","display_name":"Lee Mendil","orcid":"https://orcid.org/0000-0003-4110-8061","observed_orcids":["https://orcid.org/0000-0003-4110-8061"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210089382","display_name":"Cancer Research UK Cambridge Center","ror":"https://ror.org/0068m0j38","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2801316944","https://openalex.org/I4210089382"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Lee Mendil","raw_affiliation_strings":["3Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210089382"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Richard Houghton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210089382","display_name":"Cancer Research UK Cambridge Center","ror":"https://ror.org/0068m0j38","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2801316944","https://openalex.org/I4210089382"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Richard Houghton","raw_affiliation_strings":["3Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210089382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057091797","display_name":"Stefano de Sanctis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]},{"id":"https://openalex.org/I4210089382","display_name":"Cancer Research UK Cambridge Center","ror":"https://ror.org/0068m0j38","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2801316944","https://openalex.org/I4210089382"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Stefano De Sanctis","raw_affiliation_strings":["5Department of Histopathology, Cambridge University NHS Foundation Trust and Cancer Research UK Cambridge Centre, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Department of Histopathology, Cambridge University NHS Foundation Trust and Cancer Research UK Cambridge Centre, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749","https://openalex.org/I2801316944","https://openalex.org/I4210089382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017267546","display_name":"Vasilis Kosmoliaptsis","orcid":"https://orcid.org/0000-0001-7298-1387","observed_orcids":["https://orcid.org/0000-0001-7298-1387"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2802466933","display_name":"Cambridge University Hospitals NHS Foundation Trust","ror":"https://ror.org/04v54gj93","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933"]},{"id":"https://openalex.org/I4389425352","display_name":"NIHR Cambridge Biomedical Research Centre","ror":"https://ror.org/05m8dr349","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2802466933","https://openalex.org/I34931013","https://openalex.org/I4389425352"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Vasilis Kosmoliaptsis","raw_affiliation_strings":["6Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749","https://openalex.org/I2802466933","https://openalex.org/I4389425352"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102726540","display_name":"Richard N. Sandford","orcid":"https://orcid.org/0000-0002-7437-0560","observed_orcids":["https://orcid.org/0000-0002-7437-0560"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]},{"id":"https://openalex.org/I34931013","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08","country_code":"GB","type":"government","lineage":["https://openalex.org/I34931013"]},{"id":"https://openalex.org/I4210089382","display_name":"Cancer Research UK Cambridge Center","ror":"https://ror.org/0068m0j38","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2801316944","https://openalex.org/I4210089382"]},{"id":"https://openalex.org/I4389425352","display_name":"NIHR Cambridge Biomedical Research Centre","ror":"https://ror.org/05m8dr349","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2802466933","https://openalex.org/I34931013","https://openalex.org/I4389425352"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Richard N. Sandford","raw_affiliation_strings":["1Department of Medical Genetics, University of Cambridge and NIHR Cambridge Biomedical Research Centre and Cancer Research UK Cambridge Centre, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Medical Genetics, University of Cambridge and NIHR Cambridge Biomedical Research Centre and Cancer Research UK Cambridge Centre, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749","https://openalex.org/I2801316944","https://openalex.org/I34931013","https://openalex.org/I4210089382","https://openalex.org/I4389425352"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053955142","display_name":"Ferdia Aidan Gallagher","orcid":"https://orcid.org/0000-0003-4784-5230","observed_orcids":["https://orcid.org/0000-0003-4784-5230"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2802466933","display_name":"Cambridge University Hospitals NHS Foundation Trust","ror":"https://ror.org/04v54gj93","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933"]},{"id":"https://openalex.org/I4210089382","display_name":"Cancer Research UK Cambridge Center","ror":"https://ror.org/0068m0j38","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2801316944","https://openalex.org/I4210089382"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ferdia A. Gallagher","raw_affiliation_strings":["3Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, United Kingdom","7Department of Radiology, Cambridge University NHS Foundation Trust, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210089382"]},{"raw_affiliation_string":"7Department of Radiology, Cambridge University NHS Foundation Trust, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749","https://openalex.org/I2802466933"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056034710","display_name":"Eamonn Richard Maher","orcid":"https://orcid.org/0000-0002-6226-6918","observed_orcids":["https://orcid.org/0000-0002-6226-6918","https://orcid.org/0000-0002-6023-8462"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]},{"id":"https://openalex.org/I34931013","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08","country_code":"GB","type":"government","lineage":["https://openalex.org/I34931013"]},{"id":"https://openalex.org/I4210089382","display_name":"Cancer Research UK Cambridge Center","ror":"https://ror.org/0068m0j38","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2801316944","https://openalex.org/I4210089382"]},{"id":"https://openalex.org/I4389425352","display_name":"NIHR Cambridge Biomedical Research Centre","ror":"https://ror.org/05m8dr349","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2802466933","https://openalex.org/I34931013","https://openalex.org/I4389425352"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Eamonn R. Maher","raw_affiliation_strings":["1Department of Medical Genetics, University of Cambridge and NIHR Cambridge Biomedical Research Centre and Cancer Research UK Cambridge Centre, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Medical Genetics, University of Cambridge and NIHR Cambridge Biomedical Research Centre and Cancer Research UK Cambridge Centre, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749","https://openalex.org/I2801316944","https://openalex.org/I34931013","https://openalex.org/I4210089382","https://openalex.org/I4389425352"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5044226325"],"corresponding_institution_ids":["https://openalex.org/I241749","https://openalex.org/I2801316944","https://openalex.org/I34931013","https://openalex.org/I4210089382","https://openalex.org/I4389425352"],"apc_list":null,"apc_paid":null,"fwci":0.9925,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.7248894,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"26","issue":"2","first_page":"391","last_page":"396"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.43309998512268066,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.43309998512268066,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.15029999613761902,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.06459999829530716,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hereditary-leiomyomatosis-and-renal-cell-cancer-syndrome","display_name":"hereditary leiomyomatosis and renal cell cancer syndrome","score":0.9629999995231628},{"id":"https://openalex.org/keywords/fumarate-accumulation","display_name":"fumarate accumulation","score":0.9340000152587891},{"id":"https://openalex.org/keywords/fumarate-hydratase","display_name":"fumarate hydratase","score":0.796999990940094},{"id":"https://openalex.org/keywords/succinate-dehydrogenase","display_name":"succinate dehydrogenase","score":0.9869999885559082},{"id":"https://openalex.org/keywords/oncometabolites","display_name":"oncometabolites","score":0.7929999828338623},{"id":"https://openalex.org/keywords/1h-nmr-spectroscopy","display_name":"1H NMR","score":0.9120000004768372},{"id":"https://openalex.org/keywords/non-invasive-cancer-detection","display_name":"non-invasive cancer detection","score":0.7730000019073486},{"id":"https://openalex.org/keywords/functional-biomarkers","display_name":"functional markers","score":0.8610000014305115},{"id":"https://openalex.org/keywords/germline-pathogenic-variants","display_name":"germline pathogenic variants","score":0.8009999990463257},{"id":"https://openalex.org/keywords/renal-cell-carcinoma","display_name":"renal cell carcinoma","score":0.7110000252723694}],"concepts":[{"id":"https://openalex.org/C2779696439","wikidata":"https://www.wikidata.org/wiki/Q7512811","display_name":"Signature (topology)","level":2,"score":0.5180309414863586},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4444361925125122},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3910198211669922},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.37601566314697266},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.09787365794181824},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005649","descriptor_name":"Fumarate Hydratase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005649","descriptor_name":"Fumarate Hydratase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005650","descriptor_name":"Fumarates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009386","descriptor_name":"Neoplastic Syndromes, Hereditary","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D009386","descriptor_name":"Neoplastic Syndromes, Hereditary","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013385","descriptor_name":"Succinate Dehydrogenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014594","descriptor_name":"Uterine Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D014594","descriptor_name":"Uterine Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018095","descriptor_name":"Germ-Line Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018231","descriptor_name":"Leiomyomatosis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D018231","descriptor_name":"Leiomyomatosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D066244","descriptor_name":"Proton Magnetic Resonance Spectroscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1158/1078-0432.ccr-19-1729","doi":"https://doi.org/10.1158/1078-0432.ccr-19-1729","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-19-1729","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},{"id":"pmid:31636096","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31636096","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Case Reports"},{"id":"pmh:oai:www.repository.cam.ac.uk:1810/298059","doi":null,"is_oa":false,"landing_page_url":"https://www.repository.cam.ac.uk/handle/1810/298059","pdf_url":null,"source":{"id":"https://openalex.org/S4306401777","display_name":"Apollo (University of Cambridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I241749","host_organization_name":"University of Cambridge","host_organization_lineage":["https://openalex.org/I241749"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"doi:10.17863/cam.45114","doi":"https://doi.org/10.17863/cam.45114","is_oa":true,"landing_page_url":"https://doi.org/10.17863/cam.45114","pdf_url":null,"source":{"id":"https://openalex.org/S7407050737","display_name":"Apollo","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.ccr-19-1729","doi":"https://doi.org/10.1158/1078-0432.ccr-19-1729","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-19-1729","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[{"id":"https://openalex.org/G2074713107","display_name":"NIHR Senior Investigator Award","funder_award_id":"NF-SI-0616-10035","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G2474488143","display_name":null,"funder_award_id":"BRC 2012-2017","funder_id":"https://openalex.org/F4320321578","funder_display_name":"Cambridge University Hospitals"},{"id":"https://openalex.org/G309794119","display_name":null,"funder_award_id":"PDF-2016-09-065","funder_id":"https://openalex.org/F8052206035","funder_display_name":"NIHR Academy"},{"id":"https://openalex.org/G339189699","display_name":null,"funder_award_id":"27150","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G4066711114","display_name":"Computational assessment of Human Leukocyte Antigen immunogenicity to improve donor-recipient histocompatibility and inform allocation policy in kidney transplantation and beyond","funder_award_id":"PDF-2016-09-065","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G8483921658","display_name":null,"funder_award_id":"C12912/A27150","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G8760544084","display_name":null,"funder_award_id":"22310","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G996761087","display_name":null,"funder_award_id":"16628","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"}],"funders":[{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320321578","display_name":"Cambridge University Hospitals","ror":"https://ror.org/04v54gj93"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"},{"id":"https://openalex.org/F8052206035","display_name":"NIHR Academy","ror":"https://ror.org/02nv4he32"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W11675579","https://openalex.org/W1777600820","https://openalex.org/W1851247610","https://openalex.org/W1967291345","https://openalex.org/W1988497076","https://openalex.org/W2025719835","https://openalex.org/W2033094821","https://openalex.org/W2057322654","https://openalex.org/W2061662711","https://openalex.org/W2068892354","https://openalex.org/W2093711185","https://openalex.org/W2110394707","https://openalex.org/W2167537549","https://openalex.org/W2308064764","https://openalex.org/W2400586155","https://openalex.org/W2596790234","https://openalex.org/W2791527077","https://openalex.org/W2795138001","https://openalex.org/W2801588305","https://openalex.org/W2884857090"],"related_works":["https://openalex.org/W2008279952","https://openalex.org/W2190340505","https://openalex.org/W2795138001","https://openalex.org/W4378901907","https://openalex.org/W6906590276","https://openalex.org/W7162112161","https://openalex.org/W7213538612","https://openalex.org/W2089554929","https://openalex.org/W4399737952","https://openalex.org/W2141526363"],"abstract_inverted_index":{"Abstract":[0],"Purpose:":[1],"Inherited":[2],"pathogenic":[3],"variants":[4],"in":[5,32,47,57,129,136],"genes":[6],"encoding":[7],"the":[8,51,58],"metabolic":[9],"enzymes":[10],"succinate":[11,37],"dehydrogenase":[12],"(SDH)":[13],"and":[14,26,65,86,92,116],"fumarate":[15,127,140],"hydratase":[16],"predispose":[17],"to":[18],"tumor":[19,36,93],"development":[20],"through":[21,124],"accumulation":[22,128],"of":[23,35,54,60,104,113,126,139],"oncometabolites":[24],"(succinate":[25],"fumarate,":[27],"respectively;":[28],"ref.":[29],"1).":[30],"Noninvasive":[31],"vivo":[33,137],"detection":[34,125,138],"by":[38],"proton":[39],"magnetic":[40],"resonance":[41,78],"spectroscopy":[42,79],"(1H-MRS)":[43,80],"has":[44],"been":[45],"reported":[46],"SDH-deficient":[48],"tumors,":[49],"but":[50],"potential":[52],"utility":[53],"this":[55],"approach":[56],"management":[59],"patients":[61],"with":[62,88],"hereditary":[63,114],"leiomyomatosis":[64,115],"renal":[66,117],"cell":[67,118],"cancer":[68,119],"syndrome":[69,72,120,123],"or":[70,121],"Reed":[71,122],"is":[73],"unknown.":[74],"Experimental":[75],"Design:":[76],"Magnetic":[77],"was":[81],"performed":[82],"on":[83],"three":[84],"cases":[85],"correlated":[87],"germline":[89],"genetic":[90],"results":[91],"IHC":[94],"when":[95],"available.":[96],"Results:":[97],"Here,":[98],"we":[99],"have":[100],"demonstrated":[101],"a":[102,110,145],"proof":[103],"principle":[105],"that":[106,135],"1H-MRS":[107],"can":[108],"provide":[109],"noninvasive":[111],"diagnosis":[112],"vivo.":[130],"Conclusions:":[131],"This":[132],"study":[133],"demonstrates":[134],"could":[141],"be":[142],"employed":[143],"as":[144],"functional":[146],"biomarker.":[147]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-11-01T00:00:00"}
