{"id":"https://openalex.org/W2981850226","doi":"https://doi.org/10.1200/jco.2006.24.18_suppl.13132","title":"Dual targeting of EGFR and HER-2 in breast cancer cell lines","display_name":"Dual targeting of EGFR and HER-2 in breast cancer cell lines","publication_year":2006,"publication_date":"2006-06-20","ids":{"openalex":"https://openalex.org/W2981850226","doi":"https://doi.org/10.1200/jco.2006.24.18_suppl.13132","mag":"2981850226"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2006.24.18_suppl.13132","doi":"https://doi.org/10.1200/jco.2006.24.18_suppl.13132","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2006.24.18_suppl.13132","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021160836","display_name":"Norma O\u2019Donovan","orcid":"https://orcid.org/0000-0003-1113-3872","observed_orcids":["https://orcid.org/0000-0003-1113-3872"]},"institutions":[{"id":"https://openalex.org/I4210115218","display_name":"St. Vincent's University Hospital","ror":"https://ror.org/029tkqm80","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I4210115218"]},{"id":"https://openalex.org/I42934936","display_name":"Dublin City University","ror":"https://ror.org/04a1a1e81","country_code":"IE","type":"education","lineage":["https://openalex.org/I42934936"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"N. O\u2019Donovan","raw_affiliation_strings":["Dublin City University, Dublin, Ireland; St. Vincent\u2019s University Hospital, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dublin City University, Dublin, Ireland; St. Vincent\u2019s University Hospital, Dublin, Ireland","institution_ids":["https://openalex.org/I4210115218","https://openalex.org/I42934936"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043292277","display_name":"John Paul Crown","orcid":"https://orcid.org/0000-0002-3125-7613","observed_orcids":["https://orcid.org/0000-0002-3125-7613"]},"institutions":[{"id":"https://openalex.org/I4210115218","display_name":"St. Vincent's University Hospital","ror":"https://ror.org/029tkqm80","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I4210115218"]},{"id":"https://openalex.org/I42934936","display_name":"Dublin City University","ror":"https://ror.org/04a1a1e81","country_code":"IE","type":"education","lineage":["https://openalex.org/I42934936"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"J. P. Crown","raw_affiliation_strings":["Dublin City University, Dublin, Ireland; St. Vincent\u2019s University Hospital, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dublin City University, Dublin, Ireland; St. Vincent\u2019s University Hospital, Dublin, Ireland","institution_ids":["https://openalex.org/I4210115218","https://openalex.org/I42934936"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077091444","display_name":"MARTIN M. CLYNES","orcid":"https://orcid.org/0000-0002-3093-8185","observed_orcids":["https://orcid.org/0000-0002-3093-8185"]},"institutions":[{"id":"https://openalex.org/I4210115218","display_name":"St. Vincent's University Hospital","ror":"https://ror.org/029tkqm80","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I4210115218"]},{"id":"https://openalex.org/I42934936","display_name":"Dublin City University","ror":"https://ror.org/04a1a1e81","country_code":"IE","type":"education","lineage":["https://openalex.org/I42934936"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"M. Clynes","raw_affiliation_strings":["Dublin City University, Dublin, Ireland; St. Vincent\u2019s University Hospital, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dublin City University, Dublin, Ireland; St. Vincent\u2019s University Hospital, Dublin, Ireland","institution_ids":["https://openalex.org/I4210115218","https://openalex.org/I42934936"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":"18_suppl","first_page":"13132","last_page":"13132"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/egfr","display_name":"EGFR","score":0.6880000233650208},{"id":"https://openalex.org/keywords/her2","display_name":"HER2","score":0.9309999942779541},{"id":"https://openalex.org/keywords/dual-receptor-targeting","display_name":"dual receptor targeting","score":0.6069999933242798},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.890999972820282},{"id":"https://openalex.org/keywords/trastuzumab","display_name":"trastuzumab","score":0.9829999804496765},{"id":"https://openalex.org/keywords/gefitinib","display_name":"gefitinib","score":0.9950000047683716},{"id":"https://openalex.org/keywords/lapatinib","display_name":"lapatinib","score":1.0},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.5550000071525574},{"id":"https://openalex.org/keywords/synergistic-effect","display_name":"synergistic effect","score":0.43700000643730164},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6340000033378601},{"id":"https://openalex.org/keywords/skbr-3-cells","display_name":"SK-BR-3 cells","score":0.703000009059906},{"id":"https://openalex.org/keywords/bt474-cells","display_name":"BT474 cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.843999981880188},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.6980000138282776},{"id":"https://openalex.org/keywords/combination-index","display_name":"combination index","score":0.7279999852180481},{"id":"https://openalex.org/keywords/her2-overexpression","display_name":"HER2 overexpression","score":0.7450000047683716},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.31299999356269836}],"concepts":[{"id":"https://openalex.org/C2777329042","wikidata":"https://www.wikidata.org/wiki/Q420323","display_name":"Lapatinib","level":5,"score":0.9486345052719116},{"id":"https://openalex.org/C191560914","wikidata":"https://www.wikidata.org/wiki/Q7390592","display_name":"SKBR3","level":5,"score":0.9475935697555542},{"id":"https://openalex.org/C2779786085","wikidata":"https://www.wikidata.org/wiki/Q412616","display_name":"Trastuzumab","level":4,"score":0.9031914472579956},{"id":"https://openalex.org/C2780580887","wikidata":"https://www.wikidata.org/wiki/Q417824","display_name":"Gefitinib","level":4,"score":0.8846653699874878},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7593053579330444},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7113370895385742},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5660206079483032},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5281379818916321},{"id":"https://openalex.org/C2779707156","wikidata":"https://www.wikidata.org/wiki/Q5611758","display_name":"Growth inhibition","level":3,"score":0.5240654945373535},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4376481771469116},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4208248257637024},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4094493091106415},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.332206130027771},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22620689868927002},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.14294004440307617},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05485853552818298},{"id":"https://openalex.org/C2994423619","wikidata":"https://www.wikidata.org/wiki/Q9103","display_name":"Human breast","level":4,"score":0.04919379949569702}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2006.24.18_suppl.13132","doi":"https://doi.org/10.1200/jco.2006.24.18_suppl.13132","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2006.24.18_suppl.13132","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8500000238418579,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1969653304","https://openalex.org/W2336389733","https://openalex.org/W2060062311","https://openalex.org/W2144503474","https://openalex.org/W2130840817","https://openalex.org/W2247603156","https://openalex.org/W1973009975","https://openalex.org/W2095720296","https://openalex.org/W2115007832","https://openalex.org/W2394638656"],"abstract_inverted_index":{"13132":[0],"Background:":[1],"ErbB2":[2,18,34,52,54,74,235,258,276],"is":[3,19,133,151,169,277],"overexpressed":[4],"in":[5,53,72,136,142,154,160,171,189,200,252,283],"approximately":[6],"25\u201330%":[7],"of":[8,17,25,38,46,49,62,125,232,238,255,272],"breast":[9,56,78],"cancers.":[10],"Recent":[11],"studies":[12],"have":[13],"shown":[14],"that":[15,28,229,261,270],"overexpression":[16],"also":[20,262],"frequently":[21],"associated":[22],"with":[23,129,147,165,202,209,236,257],"expression":[24,30],"ErbB1":[26,29,50,76,233,274],"and":[27,51,67,75,83,94,114,131,139,149,157,167,179,199,213,234,243,275],"influences":[31],"response":[32,249],"to":[33,42,123,220,250,279],"inhibition.":[35],"The":[36,105],"aim":[37],"this":[39],"study":[40],"was":[41,96],"investigate":[43],"the":[44,90,99,239,266],"effects":[45],"dual":[47,127,230],"targeting":[48,128,164,231],"overexpressing":[55,259],"cancer":[57,79],"cell":[58,80,173],"lines.":[59,174],"Methods:":[60],"Combinations":[61],"Trastuzumab":[63,130,148,175,203,210,242],"(Herceptin),":[64],"Gefitinib":[65,132,180,214],"(Iressa)":[66],"Lapatinib":[68,150,168,193,221],"(GW572016)":[69],"were":[70,87,116],"tested":[71],"two":[73],"positive":[77],"lines,":[81],"SKBR3":[82,137,155,190],"BT474.":[84],"Proliferation":[85],"assays":[86,268],"performed":[88],"using":[89,98,118],"acid":[91],"phosphatase":[92],"assay":[93],"apoptosis":[95,188,198,205,218,267,282],"measured":[97],"Cell":[100],"Death":[101],"Detection":[102],"ELISA":[103],"(Roche).":[104],"average":[106],"combinations":[107,237],"index":[108],"(CI)":[109],"values":[110],"at":[111],"ED25,":[112],"ED50":[113],"ED75":[115],"determined":[117],"CalcuSyn.":[119],"Results:":[120],"With":[121],"regard":[122],"inhibition":[124,271],"proliferation,":[126],"additive":[134,158],"(CI=0.8)":[135],"cells":[138,156,191,284],"synergistic":[140,152],"(CI=0.6)":[141],"BT474":[143,161],"cells.":[144,162],"Combined":[145,207],"treatment":[146,208,251],"(CI=0.5)":[153],"(CI=1.0)":[159],"Dual":[163],"Gefinitib":[166],"antagonistic":[170],"both":[172,273,287],"(10":[176,211],"nM)":[177,212],"alone":[178,183,196,222],"(5":[181,215],"\u03bcM)":[182,195,216],"did":[184],"not":[185],"induce":[186,281],"significant":[187],"whereas":[192],"(0.75":[194,223],"induced":[197,217],"combination":[201],"enhanced":[204],"induction.":[206],"comparable":[219],"\u03bcM).":[224],"Conclusions:":[225],"Our":[226],"results":[227],"suggest":[228,269],"monoclonal":[240],"antibody,":[241],"tyrosine":[244],"kinase":[245],"inhibitors":[246],"may":[247],"improve":[248],"a":[253],"sub-group":[254],"patients":[256],"tumours":[260],"express":[263,286],"ErbB1.":[264],"Interestingly,":[265],"required":[278],"efficiently":[280],"which":[285],"receptors.":[288],"[Table:":[289],"see":[290],"text]":[291]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2019-11-01T00:00:00"}