{"id":"https://openalex.org/W2981704537","doi":null,"title":"[Cartilage/chondrocyte research and osteoarthritis. Current topics and future of ligament regeneration therapy.]","display_name":"[Cartilage/chondrocyte research and osteoarthritis. Current topics and future of ligament regeneration therapy.]","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2981704537","mag":"2981704537","pmid":"https://pubmed.ncbi.nlm.nih.gov/29848827"},"language":"ja","primary_location":{"id":"pmid:29848827","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29848827","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical calcium","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087570685","display_name":"Ryo Nakamichi","orcid":"https://orcid.org/0000-0002-0145-2135","observed_orcids":["https://orcid.org/0000-0002-0145-2135"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryo Nakamichi","raw_affiliation_strings":["Department of Molecular Medicine, The Scripps Research Institute, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, The Scripps Research Institute, USA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kensuke Kataoka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kensuke Kataoka","raw_affiliation_strings":["Department of Systems Biomedicine, Tokyo Medical and Dental University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems Biomedicine, Tokyo Medical and Dental University, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065427229","display_name":"Hiroshi Asahara","orcid":"https://orcid.org/0000-0002-5215-8745","observed_orcids":["https://orcid.org/0000-0002-5215-8745"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Hiroshi Asahara","raw_affiliation_strings":["Department of Molecular Medicine, The Scripps Research Institute, USA/Department of Systems Biomedicine, Tokyo Medical and Dental University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, The Scripps Research Institute, USA/Department of Systems Biomedicine, Tokyo Medical and Dental University, Japan","institution_ids":["https://openalex.org/I123431417","https://openalex.org/I125602781"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"28","issue":"6","first_page":"809","last_page":"816"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11068","display_name":"Tendon Structure and Treatment","score":0.9092000126838684,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11068","display_name":"Tendon Structure and Treatment","score":0.9092000126838684,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.08810000121593475,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ligament-regeneration","display_name":"ligament regeneration","score":0.9879999756813049},{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":0.8349999785423279},{"id":"https://openalex.org/keywords/cartilage","display_name":"cartilage","score":0.6610000133514404},{"id":"https://openalex.org/keywords/chondrocytes","display_name":"chondrocytes","score":0.9900000095367432},{"id":"https://openalex.org/keywords/tendon-development","display_name":"tendon development","score":0.7239999771118164},{"id":"https://openalex.org/keywords/stem-cells","display_name":"stem cells","score":0.6510000228881836},{"id":"https://openalex.org/keywords/type-i-collagen","display_name":"type I collagen","score":0.9079999923706055},{"id":"https://openalex.org/keywords/musculoskeletal-injuries","display_name":"musculoskeletal injuries","score":0.5130000114440918}],"concepts":[{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.6959078311920166},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.6107715964317322},{"id":"https://openalex.org/C2779753412","wikidata":"https://www.wikidata.org/wiki/Q39888","display_name":"Ligament","level":2,"score":0.5996937155723572},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5942544341087341},{"id":"https://openalex.org/C2781403057","wikidata":"https://www.wikidata.org/wiki/Q775480","display_name":"Chondrocyte","level":3,"score":0.5832821726799011},{"id":"https://openalex.org/C2780105995","wikidata":"https://www.wikidata.org/wiki/Q232358","display_name":"Tendon","level":2,"score":0.553349494934082},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.5481321811676025},{"id":"https://openalex.org/C3020332539","wikidata":"https://www.wikidata.org/wiki/Q2014564","display_name":"Articular cartilage","level":4,"score":0.49674564599990845},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4711272418498993},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3982565104961395},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.34992313385009766},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2678833603858948},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17714500427246094},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002358","descriptor_name":"Cartilage, Articular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008022","descriptor_name":"Ligaments","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012038","descriptor_name":"Regeneration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013710","descriptor_name":"Tendons","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024042","descriptor_name":"Collagen Type I","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:29848827","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29848827","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical calcium","raw_type":"Journal Article"},{"id":"mag:2981704537","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29848827","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W41516964","https://openalex.org/W58690323","https://openalex.org/W93053989","https://openalex.org/W1501473386","https://openalex.org/W1547733031","https://openalex.org/W1594144334","https://openalex.org/W2008492357","https://openalex.org/W2014707628","https://openalex.org/W2045562495","https://openalex.org/W2066613071","https://openalex.org/W2098511755","https://openalex.org/W2100604852","https://openalex.org/W2101503666","https://openalex.org/W2105894548","https://openalex.org/W2142099365","https://openalex.org/W2144930991","https://openalex.org/W2150891147","https://openalex.org/W2172421250","https://openalex.org/W2337485820","https://openalex.org/W2409360547","https://openalex.org/W2409679560","https://openalex.org/W2414044484","https://openalex.org/W2508997451","https://openalex.org/W2520211681","https://openalex.org/W2542822064","https://openalex.org/W2769671204","https://openalex.org/W2791309620","https://openalex.org/W2895903821","https://openalex.org/W2909894833","https://openalex.org/W2981617674","https://openalex.org/W2990840371","https://openalex.org/W3016852213","https://openalex.org/W3016940380","https://openalex.org/W3025259451","https://openalex.org/W3028330817","https://openalex.org/W3034225365","https://openalex.org/W3035467903","https://openalex.org/W3036451283","https://openalex.org/W3092541624","https://openalex.org/W3147479802","https://openalex.org/W6776928405"],"related_works":["https://openalex.org/W2799378902","https://openalex.org/W4412724758","https://openalex.org/W2626891185","https://openalex.org/W3081040727","https://openalex.org/W2084107113","https://openalex.org/W2059328928","https://openalex.org/W2067295210","https://openalex.org/W2120212876","https://openalex.org/W2050975386","https://openalex.org/W2828663997"],"abstract_inverted_index":{"Ligaments":[0],"of":[1,7,28,39,46,54,56,74,109],"joint":[2],"have":[3,49,84],"an":[4],"essential":[5],"role":[6],"proper":[8],"mobilization":[9],"and":[10,14,23,31,72,76,78,93],"stabilization":[11],"between":[12],"bone":[13],"bone.":[15],"Damage":[16],"to":[17,35,87,91,96],"ligaments":[18],"caused":[19],"by":[20],"ageing,":[21],"injury,":[22],"arthritis":[24],"induce":[25,88],"a":[26,33],"disability":[27],"musculoskeletal":[29],"system":[30],"has":[32,66,113],"problem":[34],"reduce":[36],"our":[37,117],"quality":[38],"life.":[40],"To":[41],"aim":[42],"for":[43,69],"the":[44,52,57,62,70,107,110],"regeneration":[45],"ligaments,":[47,77],"we":[48,83,105],"researched":[50],"from":[51],"point":[53],"view":[55],"developmet,":[58],"found":[59],"out":[60],"that":[61,112],"transcription":[63],"factor":[64],"Mohawk":[65],"been":[67,114],"important":[68],"development":[71,111],"homeostasis":[73],"tendons":[75],"analyzed":[79],"its":[80],"function.":[81],"Furthermore,":[82],"also":[85],"attempted":[86],"stem":[89],"cells":[90,95],"tendon":[92],"ligament":[94],"produce":[97],"type":[98],"\u2160":[99],"collagen":[100],"fibers.":[101],"In":[102],"this":[103],"article,":[104],"outline":[106],"mechanism":[108],"reported":[115],"including":[116],"approaches.":[118]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2019-11-01T00:00:00"}