{"id":"https://openalex.org/W2981604705","doi":"https://doi.org/10.1093/ofid/ofz360.1967","title":"2289. Bacterial Causes of Acute Bacterial Skin and Skin Structure Infections (ABSSSI) in Patients with Intravenous Drug Use (IVDU): Phase 3 REVIVE Studies","display_name":"2289. Bacterial Causes of Acute Bacterial Skin and Skin Structure Infections (ABSSSI) in Patients with Intravenous Drug Use (IVDU): Phase 3 REVIVE Studies","publication_year":2019,"publication_date":"2019-10-01","ids":{"openalex":"https://openalex.org/W2981604705","doi":"https://doi.org/10.1093/ofid/ofz360.1967","mag":"2981604705"},"language":"en","primary_location":{"id":"doi:10.1093/ofid/ofz360.1967","doi":"https://doi.org/10.1093/ofid/ofz360.1967","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ofid/ofz360.1967","pdf_url":"https://academic.oup.com/ofid/article-pdf/6/Supplement_2/S784/30274483/ofz360.1967.pdf","source":{"id":"https://openalex.org/S2735126445","display_name":"Open Forum Infectious Diseases","issn_l":"2328-8957","issn":["2328-8957"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/ofid/article-pdf/6/Supplement_2/S784/30274483/ofz360.1967.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016570350","display_name":"David B. Huang","orcid":"https://orcid.org/0000-0001-8228-7911","observed_orcids":["https://orcid.org/0000-0001-8228-7911","https://orcid.org/0000-0002-8342-3193"]},"institutions":[{"id":"https://openalex.org/I4402554120","display_name":"Rutgers New Jersey Medical School","ror":"https://ror.org/014ye1258","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4402554120"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David B Huang","raw_affiliation_strings":["Motif Bio / Rutgers New Jersey Medical School, Princeton, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Motif Bio / Rutgers New Jersey Medical School, Princeton, New Jersey","institution_ids":["https://openalex.org/I4402554120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004741643","display_name":"Stephanie Noviello","orcid":"https://orcid.org/0000-0001-5555-9328","observed_orcids":["https://orcid.org/0000-0001-5555-9328"]},"institutions":[{"id":"https://openalex.org/I4210140002","display_name":"Motif BioSciences (United States)","ror":"https://ror.org/04815fk53","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140002"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie S Noviello","raw_affiliation_strings":["Motif BioSciences, Princeton, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Motif BioSciences, Princeton, New Jersey","institution_ids":["https://openalex.org/I4210140002"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080852167","display_name":"Barbara Balser","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405267304","display_name":"Veristat, LLC (United States)","ror":"https://ror.org/023qnpq80","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267304"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barbara Balser","raw_affiliation_strings":["Veristat, Southborough, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veristat, Southborough, Massachusetts","institution_ids":["https://openalex.org/I4405267304"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074573989","display_name":"Amy Scaramucci","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405267304","display_name":"Veristat, LLC (United States)","ror":"https://ror.org/023qnpq80","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267304"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy E Scaramucci","raw_affiliation_strings":["Veristat, Southborough, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veristat, Southborough, Massachusetts","institution_ids":["https://openalex.org/I4405267304"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048314156","display_name":"Eve Desplats","orcid":"https://orcid.org/0000-0002-8781-3615","observed_orcids":["https://orcid.org/0000-0002-8781-3615"]},"institutions":[{"id":"https://openalex.org/I4405267304","display_name":"Veristat, LLC (United States)","ror":"https://ror.org/023qnpq80","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267304"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eve Desplats","raw_affiliation_strings":["Veristat, LLC, Southborough, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veristat, LLC, Southborough, Massachusetts","institution_ids":["https://openalex.org/I4405267304"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062306774","display_name":"G. Ralph Corey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G R Corey","raw_affiliation_strings":["Duke University, Durham, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University, Durham, North Carolina","institution_ids":["https://openalex.org/I170897317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4053,"currency":"USD","value_usd":4053},"apc_paid":{"value":4053,"currency":"USD","value_usd":4053},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.16410749,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"6","issue":"Supplement_2","first_page":"S784","last_page":"S785"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.2581000030040741,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.2581000030040741,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11153","display_name":"Streptococcal Infections and Treatments","score":0.1949000060558319,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11080","display_name":"Surgical site infection prevention","score":0.0828000009059906,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-bacterial-skin-and-skin-structure-infections","display_name":"acute bacterial skin and skin structure infections","score":0.9919999837875366},{"id":"https://openalex.org/keywords/injection-drug-use","display_name":"intravenous drug use","score":0.9940000176429749},{"id":"https://openalex.org/keywords/bacterial-etiology","display_name":"bacterial etiology","score":0.7940000295639038},{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.9649999737739563},{"id":"https://openalex.org/keywords/methicillin-resistant-staphylococcus-aureus","display_name":"methicillin-resistant Staphylococcus aureus","score":0.9729999899864197},{"id":"https://openalex.org/keywords/cellulitis","display_name":"cellulitis","score":0.7310000061988831},{"id":"https://openalex.org/keywords/wound-infection","display_name":"wound infection","score":0.6380000114440918},{"id":"https://openalex.org/keywords/abscess","display_name":"abscess","score":0.7609999775886536},{"id":"https://openalex.org/keywords/iclaprim","display_name":"iclaprim","score":0.7680000066757202},{"id":"https://openalex.org/keywords/vancomycin","display_name":"vancomycin","score":0.9890000224113464},{"id":"https://openalex.org/keywords/opioid-use-disorder","display_name":"opioid use disorder","score":0.6029999852180481},{"id":"https://openalex.org/keywords/microbial-culture","display_name":"microbial cultivation","score":0.5659999847412109}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9365540742874146},{"id":"https://openalex.org/C2777238321","wikidata":"https://www.wikidata.org/wiki/Q876887","display_name":"Cellulitis","level":2,"score":0.6052122116088867},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.48769745230674744},{"id":"https://openalex.org/C2779443120","wikidata":"https://www.wikidata.org/wiki/Q650912","display_name":"Bacteremia","level":3,"score":0.48619717359542847},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.46617698669433594},{"id":"https://openalex.org/C2781414143","wikidata":"https://www.wikidata.org/wiki/Q411377","display_name":"Linezolid","level":5,"score":0.4585672616958618},{"id":"https://openalex.org/C2778980435","wikidata":"https://www.wikidata.org/wiki/Q424027","display_name":"Vancomycin","level":4,"score":0.4515518248081207},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43558192253112793},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4209752082824707},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.25080400705337524},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.20097312331199646},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/ofid/ofz360.1967","doi":"https://doi.org/10.1093/ofid/ofz360.1967","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ofid/ofz360.1967","pdf_url":"https://academic.oup.com/ofid/article-pdf/6/Supplement_2/S784/30274483/ofz360.1967.pdf","source":{"id":"https://openalex.org/S2735126445","display_name":"Open Forum Infectious Diseases","issn_l":"2328-8957","issn":["2328-8957"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infectious Diseases","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6810018","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6810018","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infect Dis","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/ofid/ofz360.1967","doi":"https://doi.org/10.1093/ofid/ofz360.1967","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ofid/ofz360.1967","pdf_url":"https://academic.oup.com/ofid/article-pdf/6/Supplement_2/S784/30274483/ofz360.1967.pdf","source":{"id":"https://openalex.org/S2735126445","display_name":"Open Forum Infectious Diseases","issn_l":"2328-8957","issn":["2328-8957"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infectious Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2981604705.pdf","grobid_xml":"https://content.openalex.org/works/W2981604705.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2940825000","https://openalex.org/W2463093251","https://openalex.org/W7026933265","https://openalex.org/W2981961965","https://openalex.org/W3001447726","https://openalex.org/W2747183563","https://openalex.org/W2981533946","https://openalex.org/W1839761211","https://openalex.org/W2081837424","https://openalex.org/W3119363372"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Opioid":[2],"addiction":[3],"in":[4,26,137,225,254],"the":[5,18,38,78,101,114,121,134,162,180,226,246],"United":[6],"States":[7],"has":[8],"reached":[9],"epidemic":[10],"proportions":[11],"threatening":[12],"public":[13],"health.":[14],"This":[15,74],"analysis":[16,76],"evaluates":[17],"baseline":[19,79,163],"characteristics":[20],"and":[21,66,72,124,175,212,241],"bacterial":[22,80,217,250],"causes":[23,81,218,251],"of":[24,40,47,82,103,113,120,219,252],"ABSSSI":[25,83,89,165,220,253],"patients":[27,49,255],"who":[28,50,256,268],"were":[29,51,68,96,166,172,177,195,245],"IVDU":[30,52,153,186,222,267],"from":[31,53],"two":[32,54],"parallel":[33,55],"Phase":[34,56],"3":[35,119],"trials":[36,64],"comparing":[37],"treatment":[39],"iclaprim":[41],"with":[42,187,270],"vancomycin.":[43],"Methods":[44],"A":[45],"total":[46],"621":[48],"3,":[57],"double-blind,":[58],"randomized":[59],"(1:1),":[60],"active-controlled,":[61],"multinational,":[62],"multicenter":[63],"(REVIVE-1":[65],"REVIVE-2)":[67],"analyzed":[69],"both":[70],"separately":[71],"pooled.":[73],"post-hoc":[75],"summarizes":[77],"identified":[84,249],"among":[85,221,266],"IVDU.":[86,258],"Per":[87],"protocol,":[88],"(major":[90],"abscesses,":[91],"cellulitis,":[92],"or":[93,105,109,116],"wound":[94,115,135],"infections)":[95],"defined":[97,155],"as":[98],"having":[99],"either":[100],"presence":[102],"purulent":[104],"seropurulent":[106],"drainage":[107],"before":[108],"after":[110],"surgical":[111],"intervention":[112],"at":[117,129],"least":[118,130],"following":[122],"signs":[123],"symptoms:":[125],"discharge,":[126],"erythema":[127],"(extending":[128],"2":[131],"cm":[132],"beyond":[133],"edge":[136],"any":[138],"direction),":[139],"swelling":[140],"and/or":[141,144,147,149],"induration,":[142],"heat":[143],"localized":[145],"warmth,":[146],"pain":[148],"tenderness":[150],"to":[151,179,235],"palpation.":[152],"was":[154,191,200],"based":[156],"on":[157],"subjected-reported":[158],"medical":[159],"history.":[160],"At":[161],"visit,":[164],"sampled":[167],"for":[168],"microbiological":[169],"culture.":[170],"Cultures":[171],"performed":[173],"locally,":[174],"isolates":[176],"submitted":[178],"central":[181],"microbiology":[182],"laboratory.":[183],"Results":[184],"Among":[185],"ABSSSI,":[188],"average":[189,197],"age":[190],"44":[192],"years,":[193],"67.6%":[194],"male,":[196],"lesion":[198],"size":[199],"322":[201],"cm2,":[202],"10.8%":[203],"had":[204,214],"abnormal":[205],"renal":[206],"function":[207],"(CrCl":[208],"\u2264":[209],"90":[210],"mL/minute),":[211],"3.9%":[213],"bacteremia.":[215],"The":[216],"are":[223,233,257],"shown":[224],"Table.":[227],"Conclusion":[228],"IVDU,":[229],"a":[230],"growing":[231],"population,":[232],"vulnerable":[234],"ABSSSI.":[236,272],"S.":[237,242],"aureus,":[238],"including":[239],"MRSA,":[240],"anginosus":[243],"group":[244],"most":[247],"commonly":[248],"Therefore,":[259],"antibiotic":[260],"selection":[261],"should":[262],"cover":[263],"these":[264],"bacteria":[265],"present":[269],"an":[271],"Disclosures":[273],"All":[274],"authors:":[275],"No":[276],"reported":[277],"disclosures.":[278]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2019-11-01T00:00:00"}