{"id":"https://openalex.org/W2981517841","doi":"https://doi.org/10.1097/aci.0000000000000595","title":"Differential expression and role of S100 proteins in chronic rhinosinusitis","display_name":"Differential expression and role of S100 proteins in chronic rhinosinusitis","publication_year":2019,"publication_date":"2019-10-23","ids":{"openalex":"https://openalex.org/W2981517841","doi":"https://doi.org/10.1097/aci.0000000000000595","mag":"2981517841","pmid":"https://pubmed.ncbi.nlm.nih.gov/31644435","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7179082"},"language":"en","primary_location":{"id":"doi:10.1097/aci.0000000000000595","doi":"https://doi.org/10.1097/aci.0000000000000595","is_oa":false,"landing_page_url":"https://doi.org/10.1097/aci.0000000000000595","pdf_url":null,"source":{"id":"https://openalex.org/S13845130","display_name":"Current Opinion in Allergy and Clinical Immunology","issn_l":"1473-6322","issn":["1473-6322","1528-4050"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Allergy &amp; Clinical Immunology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC7179082","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065729249","display_name":"Jorgen S. Sumsion","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jorgen S. Sumsion","raw_affiliation_strings":["Department of Surgery, Division of Otolaryngology - Head and Neck Surgery, University of Utah School of Medicine, Salt Lake City, Utah, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Division of Otolaryngology - Head and Neck Surgery, University of Utah School of Medicine, Salt Lake City, Utah, USA","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048739696","display_name":"Abigail Pulsipher","orcid":"https://orcid.org/0000-0001-7987-3442","observed_orcids":["https://orcid.org/0000-0001-7987-3442"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Abigail Pulsipher","raw_affiliation_strings":["Department of Surgery, Division of Otolaryngology\u2013Head and Neck Surgery, University of Utah School of Medicine, Salt Lake City, Utah, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Division of Otolaryngology\u2013Head and Neck Surgery, University of Utah School of Medicine, Salt Lake City, Utah, USA","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048168299","display_name":"Jeremiah A. Alt","orcid":"https://orcid.org/0000-0003-0560-5028","observed_orcids":["https://orcid.org/0000-0003-0560-5028"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeremiah A. Alt","raw_affiliation_strings":["Department of Surgery, Division of Otolaryngology \u2013 Head and Neck Surgery, University of Utah School of Medicine, Salt Lake City, Utah, USA","to Jeremiah A. Alt, MD, PhD, FACS, University of Utah School of Medicine, Division of Otolaryngology \u2013 Head and Neck Surgery, 50 North Medical Drive, Room 3C120, Salt Lake City, UT 84132, USA. Tel.: +1 801 585 7143;. fax: +1 801 585 5744; e-mail: [email\u00a0protected]",". fax: +1 801 585 5744","e-mail: [email\u00a0protected]","to Jeremiah A. Alt, MD, PhD, FACS, University of Utah School of Medicine, Division of Otolaryngology \u2013 Head and Neck Surgery, 50 North Medical Drive, Room 3C120, Salt Lake City, UT 84132, USA. Tel.: +1 801 585 7143"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Division of Otolaryngology \u2013 Head and Neck Surgery, University of Utah School of Medicine, Salt Lake City, Utah, USA","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"to Jeremiah A. Alt, MD, PhD, FACS, University of Utah School of Medicine, Division of Otolaryngology \u2013 Head and Neck Surgery, 50 North Medical Drive, Room 3C120, Salt Lake City, UT 84132, USA. Tel.: +1 801 585 7143;. fax: +1 801 585 5744; e-mail: [email\u00a0protected]","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":". fax: +1 801 585 5744","institution_ids":[]},{"raw_affiliation_string":"e-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"to Jeremiah A. Alt, MD, PhD, FACS, University of Utah School of Medicine, Division of Otolaryngology \u2013 Head and Neck Surgery, 50 North Medical Drive, Room 3C120, Salt Lake City, UT 84132, USA. Tel.: +1 801 585 7143","institution_ids":["https://openalex.org/I223532165"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5048739696","https://openalex.org/A5065729249"],"corresponding_institution_ids":["https://openalex.org/I223532165"],"apc_list":null,"apc_paid":null,"fwci":0.2835,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.30673317,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"20","issue":"1","first_page":"14","last_page":"22"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10984","display_name":"Sinusitis and nasal conditions","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10984","display_name":"Sinusitis and nasal conditions","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12030","display_name":"S100 Proteins and Annexins","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-rhinosinusitis","display_name":"chronic rhinosinusitis","score":0.9449999928474426},{"id":"https://openalex.org/keywords/s100-protein","display_name":"S-100 protein","score":0.9950000047683716},{"id":"https://openalex.org/keywords/psoriasin","display_name":"psoriasin","score":0.8450000286102295},{"id":"https://openalex.org/keywords/s100a7","display_name":"S100A7","score":0.9649999737739563},{"id":"https://openalex.org/keywords/calgranulins","display_name":"calgranulins","score":0.9589999914169312},{"id":"https://openalex.org/keywords/s100a8","display_name":"S100A8","score":0.906000018119812},{"id":"https://openalex.org/keywords/s100a9","display_name":"S100A9","score":1.0},{"id":"https://openalex.org/keywords/s100a12","display_name":"S100A12","score":1.0},{"id":"https://openalex.org/keywords/nasal-polyps","display_name":"nasal polyps","score":0.9570000171661377},{"id":"https://openalex.org/keywords/sinonasal-inflammation","display_name":"sinonasal inflammation","score":0.7710000276565552},{"id":"https://openalex.org/keywords/disease-severity","display_name":"disease severity","score":0.7549999952316284},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.878000020980835},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.8069999814033508}],"concepts":[{"id":"https://openalex.org/C2781390199","wikidata":"https://www.wikidata.org/wiki/Q8055111","display_name":"Nasal polyps","level":2,"score":0.8717585802078247},{"id":"https://openalex.org/C2776307749","wikidata":"https://www.wikidata.org/wiki/Q18031354","display_name":"S100A9","level":3,"score":0.781946063041687},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6860517263412476},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6851128935813904},{"id":"https://openalex.org/C2778557267","wikidata":"https://www.wikidata.org/wiki/Q20969990","display_name":"S100A8","level":3,"score":0.6293004155158997},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6186332702636719},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6127628087997437},{"id":"https://openalex.org/C2780194698","wikidata":"https://www.wikidata.org/wiki/Q6005429","display_name":"Immune dysregulation","level":3,"score":0.5279663801193237},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5090691447257996},{"id":"https://openalex.org/C2780851604","wikidata":"https://www.wikidata.org/wiki/Q596366","display_name":"S100 protein","level":3,"score":0.4882810115814209},{"id":"https://openalex.org/C3019717275","wikidata":"https://www.wikidata.org/wiki/Q183344","display_name":"Chronic rhinosinusitis","level":2,"score":0.48728811740875244},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.48253294825553894},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4748647212982178},{"id":"https://openalex.org/C2777768476","wikidata":"https://www.wikidata.org/wiki/Q183344","display_name":"Sinusitis","level":2,"score":0.42408424615859985},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3141791820526123},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19700083136558533},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.19567573070526123},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18045026063919067},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.15184777975082397},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07437801361083984},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009298","descriptor_name":"Nasal Polyps","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009298","descriptor_name":"Nasal Polyps","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009298","descriptor_name":"Nasal Polyps","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009298","descriptor_name":"Nasal Polyps","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009298","descriptor_name":"Nasal Polyps","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009298","descriptor_name":"Nasal Polyps","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009418","descriptor_name":"S100 Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009418","descriptor_name":"S100 Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009418","descriptor_name":"S100 Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012220","descriptor_name":"Rhinitis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012220","descriptor_name":"Rhinitis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012220","descriptor_name":"Rhinitis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012220","descriptor_name":"Rhinitis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012220","descriptor_name":"Rhinitis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012220","descriptor_name":"Rhinitis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012852","descriptor_name":"Sinusitis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012852","descriptor_name":"Sinusitis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012852","descriptor_name":"Sinusitis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012852","descriptor_name":"Sinusitis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012852","descriptor_name":"Sinusitis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012852","descriptor_name":"Sinusitis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014420","descriptor_name":"Turbinates","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014420","descriptor_name":"Turbinates","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014420","descriptor_name":"Turbinates","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1097/aci.0000000000000595","doi":"https://doi.org/10.1097/aci.0000000000000595","is_oa":false,"landing_page_url":"https://doi.org/10.1097/aci.0000000000000595","pdf_url":null,"source":{"id":"https://openalex.org/S13845130","display_name":"Current Opinion in Allergy and Clinical Immunology","issn_l":"1473-6322","issn":["1473-6322","1528-4050"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Allergy &amp; Clinical Immunology","raw_type":"journal-article"},{"id":"pmid:31644435","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31644435","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in allergy and clinical immunology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:6756273","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC7179082","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:7179082","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7179082","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Curr Opin Allergy Clin Immunol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:6756273","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC7179082","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.7799999713897705,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3474220746","display_name":"A Novel Glycosaminoglycan-Based Therapeutic for Chronic Rhinosinusitis","funder_award_id":"R44AI126987","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":69,"referenced_works":["https://openalex.org/W12078422","https://openalex.org/W21518469","https://openalex.org/W97964526","https://openalex.org/W1066859258","https://openalex.org/W1880127774","https://openalex.org/W1950981769","https://openalex.org/W1963571079","https://openalex.org/W1963588374","https://openalex.org/W1967504120","https://openalex.org/W1970680425","https://openalex.org/W1978415870","https://openalex.org/W1982658369","https://openalex.org/W1987287925","https://openalex.org/W1990761952","https://openalex.org/W1990852282","https://openalex.org/W1993889471","https://openalex.org/W1994699793","https://openalex.org/W1996267528","https://openalex.org/W1997246021","https://openalex.org/W1998994115","https://openalex.org/W2002107602","https://openalex.org/W2002600662","https://openalex.org/W2003710928","https://openalex.org/W2008011385","https://openalex.org/W2023538665","https://openalex.org/W2034537334","https://openalex.org/W2036380708","https://openalex.org/W2036867429","https://openalex.org/W2038425733","https://openalex.org/W2050805027","https://openalex.org/W2062152303","https://openalex.org/W2067520762","https://openalex.org/W2071675524","https://openalex.org/W2078433449","https://openalex.org/W2079394385","https://openalex.org/W2082443736","https://openalex.org/W2092663747","https://openalex.org/W2095518569","https://openalex.org/W2097599737","https://openalex.org/W2099573376","https://openalex.org/W2101380530","https://openalex.org/W2102400094","https://openalex.org/W2127620487","https://openalex.org/W2128790793","https://openalex.org/W2140816250","https://openalex.org/W2140917767","https://openalex.org/W2142832537","https://openalex.org/W2149116105","https://openalex.org/W2156658768","https://openalex.org/W2169535061","https://openalex.org/W2182047966","https://openalex.org/W2191801277","https://openalex.org/W2219022509","https://openalex.org/W2225620250","https://openalex.org/W2229592293","https://openalex.org/W2242373566","https://openalex.org/W2289316671","https://openalex.org/W2295678160","https://openalex.org/W2346075988","https://openalex.org/W2412046841","https://openalex.org/W2508533199","https://openalex.org/W2553652103","https://openalex.org/W2564504700","https://openalex.org/W2567558689","https://openalex.org/W2808406129","https://openalex.org/W2810825273","https://openalex.org/W6687056241","https://openalex.org/W6697573892","https://openalex.org/W6715355533"],"related_works":["https://openalex.org/W2128790793","https://openalex.org/W7160775042","https://openalex.org/W2810825273","https://openalex.org/W2242373566","https://openalex.org/W3089475104","https://openalex.org/W2090825598","https://openalex.org/W2078567980","https://openalex.org/W2054435113","https://openalex.org/W2123708467","https://openalex.org/W4308006494"],"abstract_inverted_index":{"PURPOSE":[0],"OF":[1],"REVIEW:":[2],"Immune":[3],"system":[4],"modulators":[5],"have":[6,32],"been":[7,33],"under":[8],"investigation":[9],"to":[10,39,97],"help":[11],"elucidate":[12],"the":[13,42,49,78,110,171,188],"underlying":[14],"pathophysiologies":[15],"of":[16,44,55,71,81,114,127,141,160,174,185,190],"chronic":[17],"rhinosinusitis":[18],"(CRS).":[19],"Psoriasin":[20],"(S100A7)":[21],"and":[22,26,52,62,73,88,104,124,131,139,143,151,182,194],"calgranulins":[23,144],"(S100A8,":[24],"S100A9,":[25,103],"S100A12)":[27],"are":[28],"S100":[29,56,147,175],"proteins":[30,57,148,176],"that":[31,146],"studied":[34],"for":[35,196],"their":[36],"immune-mediating":[37],"responses":[38],"pathogens":[40],"within":[41],"context":[43],"CRS.":[45,161],"This":[46],"review":[47],"highlights":[48],"expression":[50,91,137],"patterns":[51,138],"proposed":[53],"roles":[54,153],"in":[58,77,92,109,121,154,157,177],"CRS":[59,186],"with":[60,83,86,116,119,129],"(CRSwNP)":[61],"without":[63],"(CRSsNP)":[64],"nasal":[65,111],"polyps.":[66],"RECENT":[67],"FINDINGS:":[68],"Elevated":[69],"levels":[70,106],"S100A7":[72],"S100A12":[74,90],"were":[75,107],"measured":[76],"sinonasal":[79],"tissues":[80,113,126],"patients":[82,115,128],"CRSsNP":[84,93,130],"compared":[85,118],"CRSwNP":[87,117],"controls.":[89,132],"was":[94],"significantly":[95],"correlated":[96],"disease":[98,183],"severity.":[99],"Contrastingly,":[100],"increased":[101],"S100A8,":[102],"S100A8/A9":[105],"demonstrated":[108],"polyp":[112],"those":[120],"inferior":[122],"turbinate":[123],"uncinate":[125],"SUMMARY:":[133],"The":[134],"reported":[135],"differential":[136],"activities":[140],"psoriasin":[142],"suggest":[145],"exert":[149],"unique":[150],"concerted":[152],"mediating":[155],"immunity":[156],"different":[158,178],"subtypes":[159],"These":[162],"studies":[163],"will":[164],"enable":[165],"further":[166],"investigations":[167],"focused":[168],"on":[169],"understanding":[170],"immune-modulating":[172],"mechanisms":[173],"inflammatory":[179],"signaling":[180],"pathways":[181],"phenotypes":[184],"toward":[187],"pursuit":[189],"identifying":[191],"new":[192],"biomarkers":[193],"targets":[195],"improved":[197],"outcomes.":[198]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":9},{"year":2022,"cited_by_count":7}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2019-11-01T00:00:00"}
