{"id":"https://openalex.org/W2981237474","doi":"https://doi.org/10.1161/res.125.suppl_1.136","title":"Abstract 136: The Role of Glucose as a Promoter for Cardiac Regeneration","display_name":"Abstract 136: The Role of Glucose as a Promoter for Cardiac Regeneration","publication_year":2019,"publication_date":"2019-08-02","ids":{"openalex":"https://openalex.org/W2981237474","doi":"https://doi.org/10.1161/res.125.suppl_1.136","mag":"2981237474"},"language":"en","primary_location":{"id":"doi:10.1161/res.125.suppl_1.136","doi":"https://doi.org/10.1161/res.125.suppl_1.136","is_oa":false,"landing_page_url":"https://doi.org/10.1161/res.125.suppl_1.136","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046843469","display_name":"Viviana M. Fajardo","orcid":"https://orcid.org/0000-0002-9000-7032","observed_orcids":["https://orcid.org/0000-0002-9000-7032"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Viviana Fajardo","raw_affiliation_strings":["Univ of California Los Angeles (UCLA), Los Angeles, CA","Viviana Fajardo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of California Los Angeles (UCLA), Los Angeles, CA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Viviana Fajardo","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005101429","display_name":"Haruko Nakano","orcid":"https://orcid.org/0000-0001-5807-9127","observed_orcids":["https://orcid.org/0000-0001-5807-9127"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haruko Nakano","raw_affiliation_strings":["Univ of California Los Angeles (UCLA), Los Angeles, CA","Haruko Nakano"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of California Los Angeles (UCLA), Los Angeles, CA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Haruko Nakano","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062266072","display_name":"Ellen Lien","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ellen Lien","raw_affiliation_strings":["Children Hosp Los Angeles (CHLA), Los Angeles, CA","Ellen Lien"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children Hosp Los Angeles (CHLA), Los Angeles, CA","institution_ids":["https://openalex.org/I1336910626"]},{"raw_affiliation_string":"Ellen Lien","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029700686","display_name":"Rong Tian","orcid":"https://orcid.org/0000-0002-3676-3830","observed_orcids":["https://orcid.org/0000-0002-3676-3830"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rong Tian","raw_affiliation_strings":["Univ of Washington, Seattle, WA","Rong Tian"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Washington, Seattle, WA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Rong Tian","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103784185","display_name":"Chen Bao","orcid":"https://orcid.org/0009-0002-9133-7583","observed_orcids":["https://orcid.org/0009-0002-9133-7583"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bao Chen","raw_affiliation_strings":["Univ of California Los Angeles (UCLA), Los Angeles, CA","Bao Chen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of California Los Angeles (UCLA), Los Angeles, CA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Bao Chen","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033947031","display_name":"Peter M. Clark","orcid":"https://orcid.org/0000-0002-0786-9054","observed_orcids":["https://orcid.org/0000-0002-0786-9054"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Clark","raw_affiliation_strings":["Univ of California Los Angeles (UCLA), Los Angeles, CA","Peter Clark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of California Los Angeles (UCLA), Los Angeles, CA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Peter Clark","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006104310","display_name":"Austin Nakano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Austin Nakano","raw_affiliation_strings":["Univ of California Los Angeles (UCLA), Los Angeles, CA","Austin Nakano"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of California Los Angeles (UCLA), Los Angeles, CA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Austin Nakano","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"125","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucose","display_name":"glucose","score":0.781000018119812},{"id":"https://openalex.org/keywords/cardiac-regeneration","display_name":"cardiac regeneration","score":0.9879999756813049},{"id":"https://openalex.org/keywords/cardiomyocyte-proliferation","display_name":"cardiomyocyte proliferation","score":0.7900000214576721},{"id":"https://openalex.org/keywords/glucose-transporter-1","display_name":"glucose transporter 1","score":0.7839999794960022},{"id":"https://openalex.org/keywords/cryoinjury","display_name":"cryoinjury","score":0.7059999704360962},{"id":"https://openalex.org/keywords/cardiomyocyte-maturation","display_name":"cardiomyocyte maturation","score":0.8610000014305115},{"id":"https://openalex.org/keywords/myocardial-fibrosis","display_name":"myocardial fibrosis","score":0.7900000214576721},{"id":"https://openalex.org/keywords/neovascularization","display_name":"neovascularization","score":0.9070000052452087},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.9039999842643738},{"id":"https://openalex.org/keywords/congenital-cardiomyopathy","display_name":"congenital cardiomyopathy","score":0.8029999732971191},{"id":"https://openalex.org/keywords/diabetes-in-pregnancy","display_name":"diabetes in pregnancy","score":0.9190000295639038},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.49000000953674316}],"concepts":[{"id":"https://openalex.org/C2777952866","wikidata":"https://www.wikidata.org/wiki/Q24722601","display_name":"GLUT1","level":4,"score":0.7337638139724731},{"id":"https://openalex.org/C4224716","wikidata":"https://www.wikidata.org/wiki/Q10859258","display_name":"Immunostaining","level":3,"score":0.6757842302322388},{"id":"https://openalex.org/C161573976","wikidata":"https://www.wikidata.org/wiki/Q420277","display_name":"Glucose transporter","level":3,"score":0.6013192534446716},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5681397318840027},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.5372607111930847},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.5237538814544678},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.523237407207489},{"id":"https://openalex.org/C2777866211","wikidata":"https://www.wikidata.org/wiki/Q5572349","display_name":"Glucose uptake","level":3,"score":0.500685453414917},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.49764612317085266},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4947037398815155},{"id":"https://openalex.org/C2778921608","wikidata":"https://www.wikidata.org/wiki/Q2002035","display_name":"Ventricle","level":2,"score":0.4934183657169342},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41498565673828125},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.39276322722435},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24805200099945068},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.2114030122756958},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0716448426246643},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/res.125.suppl_1.136","doi":"https://doi.org/10.1161/res.125.suppl_1.136","is_oa":false,"landing_page_url":"https://doi.org/10.1161/res.125.suppl_1.136","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8399999737739563}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3152515249","https://openalex.org/W2993237245","https://openalex.org/W4379467229","https://openalex.org/W4403246888","https://openalex.org/W2896353762","https://openalex.org/W4402146209","https://openalex.org/W22776397","https://openalex.org/W2109762329","https://openalex.org/W7100232547","https://openalex.org/W2924096835"],"abstract_inverted_index":{"Heart":[0],"failure":[1],"is":[2,11,92,96,262],"the":[3,29,72,112,115,132,136,167,175,197,206,210,217,249,263,267],"leading":[4],"cause":[5],"of":[6,32,114,125,138,177,216,251,270],"death":[7],"worldwide.":[8],"Our":[9,50,94],"focus":[10],"on":[12],"non-genetic":[13],"mechanisms":[14],"by":[15,156,160,179,187],"which":[16],"cardiac":[17,122,228,276],"regeneration":[18,48,91,102,277],"can":[19,44,84],"be":[20,45,85],"lengthened":[21],"or":[22],"enhanced.":[23],"Specifically,":[24],"we":[25,173],"are":[26],"interested":[27],"in":[28,34,63,76,103,118,196,226,257],"cyto-protective":[30],"effects":[31],"glucose":[33,55,98,202,271],"cardiomyocyte":[35,57,61,139,192,258],"growth,":[36],"differentiation":[37],"and":[38,40,59,121,148,152,163,182,185,278],"proliferation":[39,58,141,193],"how":[41],"this":[42,82],"knowledge":[43],"applied":[46],"to":[47,111,231,241,254,265],"therapies.":[49],"preliminary":[51],"data":[52],"showed":[53,245],"that":[54,97,221],"induces":[56],"inhibits":[60],"maturation":[62,215],"human":[64],"embryonic":[65],"stem":[66],"cells":[67],"derived":[68],"cardiomyocytes":[69,157],"(hESC-CM)":[70],"via":[71,144],"Pentose":[73],"Phosphate":[74],"Pathway":[75],"a":[77,86,104,273,280],"dose":[78],"dependent":[79],"manner.":[80],"Whether":[81],"pathway":[83],"therapeutic":[87],"target":[88],"for":[89,275,283],"heart":[90,101],"unknown.":[93],"hypothesis":[95],"promotes":[99],"neonatal":[100],"murine":[105],"model.":[106],"Non-Transmural":[107],"cryoinjury":[108],"was":[109,142,158,194],"performed":[110],"apex":[113],"left":[116],"ventricle":[117],"wild-type":[119],"pups":[120],"specific":[123],"overexpression":[124,224],"Glucose":[126,154],"Transporter":[127],"1":[128],"Transgenic":[129,198],"pups.":[130,200],"In":[131,166],"acute":[133],"phase":[134,169],"(P1-P7),":[135],"level":[137,176],"cell":[140],"measured":[143,159],"flow":[145],"cytometry":[146],"analysis":[147],"immunostaining":[149,188],"with":[150,189,214,287],"PH3":[151],"cTnnt.":[153],"uptake":[155,203],"18F-FDG":[161],"assay":[162],"Glut1":[164,199,222,243],"immunostaining.":[165],"chronic":[168],"(P14,":[170],"P21,":[171],"P40),":[172],"quantified":[174],"fibrosis":[178],"histology":[180],"(H&E":[181],"Picrosirius":[183],"Red)":[184],"neovascularization":[186],"PECAM.":[190],"Increased":[191],"observed":[195,220],"Myocardial":[201],"declines":[204],"from":[205],"muscular":[207],"layer":[208],"towards":[209],"trabecular":[211],"layer,":[212],"corresponding":[213],"heart.":[218],"We":[219],"cardiomyocyte-specific":[223],"resulted":[225],"improved":[227],"repair":[229],"compared":[230],"wild":[232],"type":[233],"(WT)":[234],"mice":[235],"at":[236],"21":[237],"days":[238],"postnatally.":[239],"Compared":[240],"wild-type,":[242],"hearts":[244],"increased":[246],"angiogenesis":[247],"around":[248],"site":[250],"injury":[252],"secondary":[253],"an":[255],"increase":[256],"proliferation.":[259],"This":[260],"study":[261],"first":[264],"demonstrate":[266],"potential":[268,281],"role":[269],"as":[272],"promoter":[274],"reveal":[279],"mechanism":[282],"congenital":[284],"cardiomyopathy":[285],"associated":[286],"diabetic":[288],"pregnancy.":[289]},"counts_by_year":[],"updated_date":"2026-10-22T18:32:59.640997","created_date":"2019-10-25T00:00:00"}
