{"id":"https://openalex.org/W2981069358","doi":"https://doi.org/10.1161/res.125.suppl_1.722","title":"Abstract 722: Unveiling Ccbe1 Role as a Modulator of Cardiomyocyte Differentiation","display_name":"Abstract 722: Unveiling Ccbe1 Role as a Modulator of Cardiomyocyte Differentiation","publication_year":2019,"publication_date":"2019-08-02","ids":{"openalex":"https://openalex.org/W2981069358","doi":"https://doi.org/10.1161/res.125.suppl_1.722","mag":"2981069358"},"language":"en","primary_location":{"id":"doi:10.1161/res.125.suppl_1.722","doi":"https://doi.org/10.1161/res.125.suppl_1.722","is_oa":false,"landing_page_url":"https://doi.org/10.1161/res.125.suppl_1.722","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016891576","display_name":"Marta M. Silva","orcid":"https://orcid.org/0000-0002-1069-7193","observed_orcids":["https://orcid.org/0000-0002-1069-7193"]},"institutions":[{"id":"https://openalex.org/I4210159117","display_name":"Instituto de Biologia Experimental e Tecnol\u00f3gica","ror":"https://ror.org/0599z7n30","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I4210159117"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Marta M Silva","raw_affiliation_strings":["iBET, Oeiras, Portugal","Marta M Silva"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"iBET, Oeiras, Portugal","institution_ids":["https://openalex.org/I4210159117"]},{"raw_affiliation_string":"Marta M Silva","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070180788","display_name":"Pedro Vicente","orcid":"https://orcid.org/0000-0003-2091-4347","observed_orcids":["https://orcid.org/0000-0003-2091-4347"]},"institutions":[{"id":"https://openalex.org/I4210159117","display_name":"Instituto de Biologia Experimental e Tecnol\u00f3gica","ror":"https://ror.org/0599z7n30","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I4210159117"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Pedro Vicente","raw_affiliation_strings":["iBET, Oeiras, Portugal","Pedro Vicente"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"iBET, Oeiras, Portugal","institution_ids":["https://openalex.org/I4210159117"]},{"raw_affiliation_string":"Pedro Vicente","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080248459","display_name":"Daniel F. Sim\u00e3o","orcid":"https://orcid.org/0000-0002-7532-8081","observed_orcids":["https://orcid.org/0000-0002-7532-8081"]},"institutions":[{"id":"https://openalex.org/I4210159117","display_name":"Instituto de Biologia Experimental e Tecnol\u00f3gica","ror":"https://ror.org/0599z7n30","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I4210159117"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Daniel Sim\u00e3o","raw_affiliation_strings":["iBET, Oeiras, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"iBET, Oeiras, Portugal","institution_ids":["https://openalex.org/I4210159117"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083395399","display_name":"Ana Paula Terrasso","orcid":"https://orcid.org/0000-0002-4369-6277","observed_orcids":["https://orcid.org/0000-0002-4369-6277"]},"institutions":[{"id":"https://openalex.org/I4210159117","display_name":"Instituto de Biologia Experimental e Tecnol\u00f3gica","ror":"https://ror.org/0599z7n30","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I4210159117"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Ana P Terrasso","raw_affiliation_strings":["iBET, Oeiras, Portugal","Ana P Terrasso"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"iBET, Oeiras, Portugal","institution_ids":["https://openalex.org/I4210159117"]},{"raw_affiliation_string":"Ana P Terrasso","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051519843","display_name":"Jose\u0301 Manuel Ina\u0301cio","orcid":"https://orcid.org/0000-0002-9790-8335","observed_orcids":["https://orcid.org/0000-0002-9790-8335"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jos\u00e9 M In\u00e1cio","raw_affiliation_strings":["CEDOC, Lisboa, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CEDOC, Lisboa, Portugal","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049586039","display_name":"Jos\u00e9 Ant\u00f3nio Belo","orcid":"https://orcid.org/0000-0001-7384-0949","observed_orcids":["https://orcid.org/0000-0001-7384-0949"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jos\u00e9 A Belo","raw_affiliation_strings":["CEDOC, Lisboa, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CEDOC, Lisboa, Portugal","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080229946","display_name":"Patr\u00edcia Gomes\u2010Alves","orcid":"https://orcid.org/0000-0001-7245-6785","observed_orcids":["https://orcid.org/0000-0001-7245-6785"]},"institutions":[{"id":"https://openalex.org/I4405278324","display_name":"Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica Ant\u00f3nio Xavier","ror":"https://ror.org/05qd25g49","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4405278324","https://openalex.org/I83558840"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Patr\u00edcia Gomes-Alves","raw_affiliation_strings":["iBET/ITQB NOVA, Oeiras, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"iBET/ITQB NOVA, Oeiras, Portugal","institution_ids":["https://openalex.org/I4405278324"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017548375","display_name":"Margarida Serra","orcid":"https://orcid.org/0000-0001-5013-6625","observed_orcids":["https://orcid.org/0000-0001-5013-6625"]},"institutions":[{"id":"https://openalex.org/I4405278324","display_name":"Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica Ant\u00f3nio Xavier","ror":"https://ror.org/05qd25g49","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4405278324","https://openalex.org/I83558840"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Margarida Serra","raw_affiliation_strings":["iBET/ITQB NOVA, Oeiras, Portugal","Margarida Serra"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"iBET/ITQB NOVA, Oeiras, Portugal","institution_ids":["https://openalex.org/I4405278324"]},{"raw_affiliation_string":"Margarida Serra","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041231390","display_name":"Paula M. Alves","orcid":"https://orcid.org/0000-0003-1445-3556","observed_orcids":["https://orcid.org/0000-0003-1445-3556"]},"institutions":[{"id":"https://openalex.org/I4405278324","display_name":"Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica Ant\u00f3nio Xavier","ror":"https://ror.org/05qd25g49","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4405278324","https://openalex.org/I83558840"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Paula M Alves","raw_affiliation_strings":["iBET/ITQB NOVA, Oeiras, Portugal","Paula M Alves"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"iBET/ITQB NOVA, Oeiras, Portugal","institution_ids":["https://openalex.org/I4405278324"]},{"raw_affiliation_string":"Paula M Alves","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"125","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.7813000082969666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.7813000082969666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.20960000157356262,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ccbe1","display_name":"CCBE1","score":0.9929999709129333},{"id":"https://openalex.org/keywords/cardiomyocyte-differentiation","display_name":"cardiomyocyte differentiation","score":0.9789999723434448},{"id":"https://openalex.org/keywords/human-induced-pluripotent-stem-cells","display_name":"human induced pluripotent stem cells","score":0.8610000014305115},{"id":"https://openalex.org/keywords/crispr-interference","display_name":"CRISPR interference","score":0.828000009059906},{"id":"https://openalex.org/keywords/cardiac-regeneration","display_name":"cardiac regeneration","score":0.43700000643730164},{"id":"https://openalex.org/keywords/chronic-heart-failure","display_name":"chronic heart failure","score":0.8309999704360962},{"id":"https://openalex.org/keywords/endothelial-cell-differentiation","display_name":"endothelial differentiation","score":0.6700000166893005},{"id":"https://openalex.org/keywords/cardiomyocyte-ultrastructure","display_name":"cardiomyocyte ultrastructure","score":0.7260000109672546},{"id":"https://openalex.org/keywords/cardiac-troponin","display_name":"cardiac troponin","score":0.6179999709129333},{"id":"https://openalex.org/keywords/cardiac-mesoderm","display_name":"cardiac mesoderm","score":0.7519999742507935},{"id":"https://openalex.org/keywords/cardiac-progenitor-cells","display_name":"cardiac progenitor cells","score":0.781000018119812},{"id":"https://openalex.org/keywords/lymphangiogenesis","display_name":"lymphangiogenesis","score":0.671999990940094}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6527424454689026},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.49706438183784485},{"id":"https://openalex.org/C2776636583","wikidata":"https://www.wikidata.org/wiki/Q6708231","display_name":"Lymphangiogenesis","level":4,"score":0.45916610956192017},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4493105113506317},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.42797982692718506},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17508208751678467},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1359541118144989},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.1253097653388977},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/res.125.suppl_1.722","doi":"https://doi.org/10.1161/res.125.suppl_1.722","is_oa":false,"landing_page_url":"https://doi.org/10.1161/res.125.suppl_1.722","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8700000047683716,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2039953935","https://openalex.org/W2327104266","https://openalex.org/W2033054833","https://openalex.org/W1574354188","https://openalex.org/W4361253380","https://openalex.org/W4361254037","https://openalex.org/W2372472560","https://openalex.org/W1991386745","https://openalex.org/W884037226","https://openalex.org/W2030201335"],"abstract_inverted_index":{"Chronic":[0],"heart":[1,106],"failure":[2],"is":[3,27,122,260],"a":[4,20,28,82,192],"major":[5,21],"unmet":[6],"clinical":[7],"need":[8,29],"arising":[9],"from":[10],"the":[11,39,59,117,125,146,157,195,204,224,228,231,246,251,254,265,286],"loss":[12],"of":[13,23,114,119,149,159,197,206,245,258,288],"viable":[14],"and":[15,34,66,73,90,139,152,202,208,242,248,271,275],"functional":[16],"cardiac":[17,64,103,110,130,164,175,198,269,272,292,306],"muscle,":[18],"representing":[19],"cause":[22],"mortality":[24],"worldwide.":[25],"There":[26],"to":[30,57,101,123,144,191,263],"identify":[31,264],"key":[32,266],"molecules":[33],"signaling":[35],"pathways":[36,127],"acting":[37],"on":[38,194,203],"coronary":[40],"vasculature":[41],"system":[42],"towards":[43,156,303],"regenerative":[44,165,307],"therapies.":[45,308],"Human":[46],"induced":[47],"pluripotent":[48],"stem":[49],"cells":[50],"(hiPSC)":[51],"are":[52],"an":[53,216],"attractive":[54],"cell":[55],"source":[56],"understand":[58,124],"regulatory":[60],"networks":[61],"involved":[62],"in":[63,132,253,291],"commitment":[65,111,131],"cardiomyocyte":[67],"(CM)":[68],"differentiation.":[69],"Particularly,":[70],"CCBE1":[71,96,171,188,211,221,238,259],"(collagen":[72],"calcium-EGF":[74],"biding":[75],"domain":[76],"1)":[77],"has":[78],"been":[79],"studied":[80],"as":[81],"secreted":[83],"protein":[84],"critical":[85],"for":[86,163,285,297],"lymphatic/cardiac":[87],"vascular":[88],"development":[89,158],"recent":[91],"reports":[92],"have":[93],"proposed":[94],"that":[95,220],"may":[97,222,295],"potentially":[98],"be":[99],"used":[100,178],"restore":[102],"tissue":[104],"upon":[105],"injury,":[107],"through":[108],"CCBE1-mediated":[109,160],"and/or":[112],"augmentation":[113],"lymphangiogenesis.":[115],"Therefore,":[116],"goal":[118],"our":[120],"work":[121,281],"molecular":[126,147],"underlying":[128],"CCBE1-based":[129],"loss-of-function":[133],"studies.":[134],"By":[135],"exploring":[136],"gene":[137],"editing":[138],"\u201comics\u201d":[140],"tools":[141],"we":[142,177],"aim":[143],"unveil":[145],"basis":[148],"CCBE1-induced":[150],"cardiogenesis":[151],"provide":[153],"novel":[154,298],"insights":[155],"therapeutic":[161],"strategies":[162],"medicine.":[166],"To":[167],"selectively":[168],"knock-down":[169],"(KD)":[170],"expression":[172,196],"along":[173,250],"hiPSC":[174,180],"differentiation,":[176],"modified":[179],"line":[181],"with":[182,278],"CRISPR":[183],"interference":[184],"technology":[185],"(CRISPRi-hiPSC).":[186],"The":[187,210],"KD":[189],"led":[190],"reduction":[193],"troponin":[199],"marker":[200],"TNNT2":[201],"ratios":[205],"MYH7:MYH6":[207],"TNNI3:TNNI1.":[209],"KD-derived":[212],"CMs":[213],"also":[214],"presented":[215],"immature-related":[217],"ultrastructure,":[218],"suggesting":[219],"modulate":[223],"CM":[225],"phenotype.":[226],"On":[227],"other":[229],"hand,":[230],"EC":[232],"differentiation":[233,252],"was":[234],"not":[235],"impaired":[236],"by":[237],"KD.":[239],"A":[240],"comprehensive":[241],"integrated":[243],"characterization":[244],"transcriptome":[247],"proteome":[249],"presence":[255],"or":[256,300],"absence":[257],"being":[261],"pursued":[262],"players":[267],"at":[268],"mesoderm":[270],"progenitors":[273],"stages":[274],"their":[276],"interactions":[277],"CCBE1.":[279],"This":[280],"opens":[282],"new":[283],"avenues":[284],"identification":[287],"CCBE1-modulated":[289],"proteins/pathways":[290],"commitment,":[293],"which":[294],"contribute":[296],"cell-based":[299],"cell-free":[301],"approaches":[302],"more":[304],"efficacious":[305]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2025-10-10T00:00:00"}
