{"id":"https://openalex.org/W2981069158","doi":"https://doi.org/10.1530/joe-19-0213e","title":"Voluntary exercise is motivated by ghrelin, possibly related to the central reward circuit","display_name":"Voluntary exercise is motivated by ghrelin, possibly related to the central reward circuit","publication_year":2019,"publication_date":"2019-10-18","ids":{"openalex":"https://openalex.org/W2981069158","doi":"https://doi.org/10.1530/joe-19-0213e","mag":"2981069158","pmid":"https://pubmed.ncbi.nlm.nih.gov/31629323","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6859445"},"language":"en","primary_location":{"id":"doi:10.1530/joe-19-0213e","doi":"https://doi.org/10.1530/joe-19-0213e","is_oa":true,"landing_page_url":"https://doi.org/10.1530/joe-19-0213e","pdf_url":"https://joe.bioscientifica.com/downloadpdf/journals/joe/249/3/JOE-19-0213e.pdf","source":{"id":"https://openalex.org/S34842069","display_name":"Journal of Endocrinology","issn_l":"0022-0795","issn":["0022-0795","1479-6805"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://joe.bioscientifica.com/downloadpdf/journals/joe/249/3/JOE-19-0213e.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087708451","display_name":"Hiroharu Mifune","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I105296287","display_name":"Kurume University","ror":"https://ror.org/057xtrt18","country_code":"JP","type":"education","lineage":["https://openalex.org/I105296287"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroharu Mifune","raw_affiliation_strings":["1Institute of Animal Experimentation, Kurume University School of Medicine, Kurume, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Institute of Animal Experimentation, Kurume University School of Medicine, Kurume, Japan","institution_ids":["https://openalex.org/I105296287"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054484769","display_name":"Yuji Tajiri","orcid":"https://orcid.org/0000-0001-8266-2080","observed_orcids":["https://orcid.org/0000-0001-8266-2080"]},"institutions":[{"id":"https://openalex.org/I105296287","display_name":"Kurume University","ror":"https://ror.org/057xtrt18","country_code":"JP","type":"education","lineage":["https://openalex.org/I105296287"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yuji Tajiri","raw_affiliation_strings":["2Division of Endocrinology and Metabolism, Kurume University School of Medicine, Kurume, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Division of Endocrinology and Metabolism, Kurume University School of Medicine, Kurume, Japan","institution_ids":["https://openalex.org/I105296287"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yusuke Sakai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I105296287","display_name":"Kurume University","ror":"https://ror.org/057xtrt18","country_code":"JP","type":"education","lineage":["https://openalex.org/I105296287"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yusuke Sakai","raw_affiliation_strings":["1Institute of Animal Experimentation, Kurume University School of Medicine, Kurume, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Institute of Animal Experimentation, Kurume University School of Medicine, Kurume, Japan","institution_ids":["https://openalex.org/I105296287"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109571969","display_name":"Yukie Kawahara","orcid":"https://orcid.org/0000-0003-1680-038X","observed_orcids":["https://orcid.org/0000-0003-1680-038X"]},"institutions":[{"id":"https://openalex.org/I105296287","display_name":"Kurume University","ror":"https://ror.org/057xtrt18","country_code":"JP","type":"education","lineage":["https://openalex.org/I105296287"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yukie Kawahara","raw_affiliation_strings":["3Department of Pharmacology, Kurume University School of Medicine, Kurume, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Pharmacology, Kurume University School of Medicine, Kurume, Japan","institution_ids":["https://openalex.org/I105296287"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108655743","display_name":"Kento Hara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I105296287","display_name":"Kurume University","ror":"https://ror.org/057xtrt18","country_code":"JP","type":"education","lineage":["https://openalex.org/I105296287"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kento Hara","raw_affiliation_strings":["2Division of Endocrinology and Metabolism, Kurume University School of Medicine, Kurume, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Division of Endocrinology and Metabolism, Kurume University School of Medicine, Kurume, Japan","institution_ids":["https://openalex.org/I105296287"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041029803","display_name":"Takahiro Sato","orcid":"https://orcid.org/0000-0003-4364-2110","observed_orcids":["https://orcid.org/0000-0003-4364-2110"]},"institutions":[{"id":"https://openalex.org/I105296287","display_name":"Kurume University","ror":"https://ror.org/057xtrt18","country_code":"JP","type":"education","lineage":["https://openalex.org/I105296287"]},{"id":"https://openalex.org/I4210111488","display_name":"Life Science Institute","ror":"https://ror.org/01yeyd808","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210111488"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takahiro Sato","raw_affiliation_strings":["4Molecular Genetics, Life Science Institute, Kurume University, Kurume, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Molecular Genetics, Life Science Institute, Kurume University, Kurume, Japan","institution_ids":["https://openalex.org/I105296287","https://openalex.org/I4210111488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073797114","display_name":"Yoshihiro Nishi","orcid":"https://orcid.org/0000-0001-7529-1103","observed_orcids":["https://orcid.org/0000-0001-7529-1103"]},"institutions":[{"id":"https://openalex.org/I105296287","display_name":"Kurume University","ror":"https://ror.org/057xtrt18","country_code":"JP","type":"education","lineage":["https://openalex.org/I105296287"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshihiro Nishi","raw_affiliation_strings":["5Department of Physiology, Kurume University School of Medicine, Kurume, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Department of Physiology, Kurume University School of Medicine, Kurume, Japan","institution_ids":["https://openalex.org/I105296287"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086720984","display_name":"Akinori Nishi","orcid":"https://orcid.org/0000-0001-5056-5809","observed_orcids":["https://orcid.org/0000-0001-5056-5809"]},"institutions":[{"id":"https://openalex.org/I105296287","display_name":"Kurume University","ror":"https://ror.org/057xtrt18","country_code":"JP","type":"education","lineage":["https://openalex.org/I105296287"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akinori Nishi","raw_affiliation_strings":["3Department of Pharmacology, Kurume University School of Medicine, Kurume, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Pharmacology, Kurume University School of Medicine, Kurume, Japan","institution_ids":["https://openalex.org/I105296287"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108807948","display_name":"Ryouichi Mitsuzono","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I105296287","display_name":"Kurume University","ror":"https://ror.org/057xtrt18","country_code":"JP","type":"education","lineage":["https://openalex.org/I105296287"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryouichi Mitsuzono","raw_affiliation_strings":["6Department of Exercise Physiology, Institute of Health and Sports Science, Kurume University, Kurume, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Department of Exercise Physiology, Institute of Health and Sports Science, Kurume University, Kurume, Japan","institution_ids":["https://openalex.org/I105296287"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087888150","display_name":"Tatsuyuki Kakuma","orcid":"https://orcid.org/0000-0002-3713-3099","observed_orcids":["https://orcid.org/0000-0002-3713-3099"]},"institutions":[{"id":"https://openalex.org/I105296287","display_name":"Kurume University","ror":"https://ror.org/057xtrt18","country_code":"JP","type":"education","lineage":["https://openalex.org/I105296287"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tatsuyuki Kakuma","raw_affiliation_strings":["7Bostatistics Center, Kurume University, Kurume, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7Bostatistics Center, Kurume University, Kurume, Japan","institution_ids":["https://openalex.org/I105296287"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101951891","display_name":"Masayasu Kojima","orcid":"https://orcid.org/0000-0002-3153-0341","observed_orcids":["https://orcid.org/0000-0002-3153-0341"]},"institutions":[{"id":"https://openalex.org/I105296287","display_name":"Kurume University","ror":"https://ror.org/057xtrt18","country_code":"JP","type":"education","lineage":["https://openalex.org/I105296287"]},{"id":"https://openalex.org/I4210111488","display_name":"Life Science Institute","ror":"https://ror.org/01yeyd808","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210111488"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masayasu Kojima","raw_affiliation_strings":["4Molecular Genetics, Life Science Institute, Kurume University, Kurume, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Molecular Genetics, Life Science Institute, Kurume University, Kurume, Japan","institution_ids":["https://openalex.org/I105296287","https://openalex.org/I4210111488"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5054484769"],"corresponding_institution_ids":["https://openalex.org/I105296287"],"apc_list":null,"apc_paid":null,"fwci":1.0402,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.72589141,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"244","issue":"1","first_page":"123","last_page":"132"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ghrelin","display_name":"ghrelin","score":0.9309999942779541},{"id":"https://openalex.org/keywords/voluntary-exercise","display_name":"voluntary exercise","score":0.9750000238418579},{"id":"https://openalex.org/keywords/wheel-running","display_name":"wheel running","score":0.7300000190734863},{"id":"https://openalex.org/keywords/feeding-behavior","display_name":"feeding behavior","score":0.5600000023841858},{"id":"https://openalex.org/keywords/appetite-regulation","display_name":"appetite regulation","score":0.5730000138282776},{"id":"https://openalex.org/keywords/dopamine","display_name":"dopamine","score":0.5569999814033508},{"id":"https://openalex.org/keywords/reward-systems","display_name":"reward systems","score":0.7599999904632568},{"id":"https://openalex.org/keywords/ghrelin-receptor-agonist","display_name":"ghrelin receptor agonist","score":0.972000002861023},{"id":"https://openalex.org/keywords/time-restricted-feeding","display_name":"time-restricted feeding","score":0.9039999842643738},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.5709999799728394},{"id":"https://openalex.org/keywords/exercise-motivation","display_name":"exercise motivation","score":0.5299999713897705}],"concepts":[{"id":"https://openalex.org/C2779357093","wikidata":"https://www.wikidata.org/wiki/Q422269","display_name":"Ghrelin","level":3,"score":0.9680967926979065},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.821497917175293},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8181208968162537},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.6554355025291443},{"id":"https://openalex.org/C26077564","wikidata":"https://www.wikidata.org/wiki/Q1910318","display_name":"Turnover","level":2,"score":0.6198565363883972},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.6100585460662842},{"id":"https://openalex.org/C75908981","wikidata":"https://www.wikidata.org/wiki/Q28578","display_name":"Appetite","level":2,"score":0.47764718532562256},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.46281731128692627},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3846200406551361},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3488277196884155},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34495723247528076},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C187736073","wikidata":"https://www.wikidata.org/wiki/Q2920921","display_name":"Management","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005247","descriptor_name":"Feeding Behavior","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009042","descriptor_name":"Motivation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009043","descriptor_name":"Motor Activity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D012201","descriptor_name":"Reward","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054439","descriptor_name":"Ghrelin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D054440","descriptor_name":"Receptors, Ghrelin","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1530/joe-19-0213e","doi":"https://doi.org/10.1530/joe-19-0213e","is_oa":true,"landing_page_url":"https://doi.org/10.1530/joe-19-0213e","pdf_url":"https://joe.bioscientifica.com/downloadpdf/journals/joe/249/3/JOE-19-0213e.pdf","source":{"id":"https://openalex.org/S34842069","display_name":"Journal of Endocrinology","issn_l":"0022-0795","issn":["0022-0795","1479-6805"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Endocrinology","raw_type":"journal-article"},{"id":"doi:10.1530/joe-19-0213","doi":"https://doi.org/10.1530/joe-19-0213","is_oa":true,"landing_page_url":"https://doi.org/10.1530/joe-19-0213","pdf_url":"https://joe.bioscientifica.com/downloadpdf/journals/joe/244/1/JOE-19-0213.pdf","source":{"id":"https://openalex.org/S34842069","display_name":"Journal of Endocrinology","issn_l":"0022-0795","issn":["0022-0795","1479-6805"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Endocrinology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6859445","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6859445","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Endocrinol","raw_type":"Text"},{"id":"pmid:31629323","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31629323","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of endocrinology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1530/joe-19-0213e","doi":"https://doi.org/10.1530/joe-19-0213e","is_oa":true,"landing_page_url":"https://doi.org/10.1530/joe-19-0213e","pdf_url":"https://joe.bioscientifica.com/downloadpdf/journals/joe/249/3/JOE-19-0213e.pdf","source":{"id":"https://openalex.org/S34842069","display_name":"Journal of Endocrinology","issn_l":"0022-0795","issn":["0022-0795","1479-6805"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Endocrinology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8199999928474426,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7730252136","display_name":"Pharmacological treatment of depression: development of novel therapeutics targeting the dopamine neuronal system","funder_award_id":"19H03410","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8296254232","display_name":"The mechanism in control of voluntary exercise by ghrelin, a feeding-stimulating hormone","funder_award_id":"25350914","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8539300203","display_name":"The role of ghrelin, an appetite-promoting hormone on abnormal feeding behavior in obesity","funder_award_id":"25504019","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2981069158.pdf","grobid_xml":"https://content.openalex.org/works/W2981069158.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W815531246","https://openalex.org/W1544616348","https://openalex.org/W1616806865","https://openalex.org/W1915088265","https://openalex.org/W1964081706","https://openalex.org/W1964415301","https://openalex.org/W1973839604","https://openalex.org/W1973864352","https://openalex.org/W1973955359","https://openalex.org/W1983423338","https://openalex.org/W1989605260","https://openalex.org/W1997112237","https://openalex.org/W2001379930","https://openalex.org/W2003569865","https://openalex.org/W2011692478","https://openalex.org/W2018127398","https://openalex.org/W2028839831","https://openalex.org/W2047759232","https://openalex.org/W2048053645","https://openalex.org/W2054689428","https://openalex.org/W2054841494","https://openalex.org/W2056753538","https://openalex.org/W2066461763","https://openalex.org/W2080750021","https://openalex.org/W2085372550","https://openalex.org/W2086886531","https://openalex.org/W2086950122","https://openalex.org/W2086977100","https://openalex.org/W2097546680","https://openalex.org/W2097596167","https://openalex.org/W2107620313","https://openalex.org/W2108800627","https://openalex.org/W2123319274","https://openalex.org/W2142775584","https://openalex.org/W2145982623","https://openalex.org/W2149446586","https://openalex.org/W2159653910","https://openalex.org/W2163383667","https://openalex.org/W2163865122","https://openalex.org/W2335072138","https://openalex.org/W2788384677","https://openalex.org/W2945792041"],"related_works":["https://openalex.org/W2548228296","https://openalex.org/W2549997678","https://openalex.org/W815531246","https://openalex.org/W1552965236","https://openalex.org/W2086950122","https://openalex.org/W1991141677","https://openalex.org/W2407056368","https://openalex.org/W2076987777","https://openalex.org/W4385669016","https://openalex.org/W7112001669"],"abstract_inverted_index":{"We":[0,54],"previously":[1],"reported":[2],"that":[3,219],"voluntary":[4,64,95,179,214,237],"exercise":[5,32,65,238],"contributed":[6],"to":[7,39,51,107,154,241],"the":[8,43,56,77,83,86,90,108,115,123,158,162,175,182,190,198,205,210,220,229,234,242],"amelioration":[9],"of":[10,18,25,58,63,85,110,137,148,161,184,200,207,222,231,236],"abnormal":[11],"feeding":[12,69],"behavior":[13],"with":[14,79,94],"a":[15,22,28,145,225],"concomitant":[16],"restoration":[17],"ghrelin":[19,59,73,112,138,201,208,223],"production":[20],"in":[21,42,89,100,114,122,152,174,189,209,228],"rat":[23],"model":[24],"obesity,":[26],"suggesting":[27,204],"possible":[29],"relationship":[30],"between":[31],"and":[33,143],"appetite-regulating":[34],"hormones.":[35],"Ghrelin":[36],"is":[37],"known":[38],"be":[40],"involved":[41],"brain":[44],"reward":[45,211],"circuits":[46],"via":[47],"dopamine":[48,166,244],"neurons":[49],"related":[50,240],"motivational":[52],"properties.":[53],"investigated":[55],"relevance":[57,206],"as":[60,66,68],"an":[61],"initiator":[62],"well":[67],"behavior.":[70],"The":[71],"plasma":[72,111],"concentration":[74,113],"fluctuates":[75],"throughout":[76],"day":[78],"its":[80],"peak":[81,109],"at":[82],"beginning":[84],"dark":[87],"period":[88],"wild-type":[91],"(WT)":[92],"mice":[93,126,177],"exercise.":[96,180,215],"Although":[97,181],"predominant":[98],"increases":[99],"wheel":[101,149],"running":[102,150],"activity":[103],"were":[104,119,169,186,194],"observed":[105],"accordant":[106],"WT":[116,176],"mice,":[117,192],"those":[118],"severely":[120],"attenuated":[121],"ghrelin-knockout":[124],"(GKO)":[125],"under":[127,178,213],"either":[128],"ad":[129],"libitum":[130],"or":[131],"time-restricted":[132],"feeding.":[133],"A":[134],"single":[135],"injection":[136],"receptor":[139,202],"agonist":[140],"brought":[141],"about":[142],"reproduced":[144],"marked":[146],"enhancement":[147],"activity,":[151],"contrast":[153],"no":[155],"effect":[156],"by":[157],"continuous":[159],"administration":[160,199],"same":[163],"drug.":[164],"Brain":[165],"levels":[167],"(DAs)":[168],"enhanced":[170],"after":[171,197],"food":[172],"consumption":[173],"acceleration":[183],"DAs":[185],"apparently":[187],"blunted":[188],"GKO":[191],"they":[193],"dramatically":[195],"revived":[196],"agonist,":[203],"circuit":[212],"These":[216],"findings":[217],"emphasize":[218],"surge":[221],"plays":[224],"crucial":[226],"role":[227],"formation":[230],"motivation":[232],"for":[233],"initiation":[235],"possibly":[239],"central":[243],"system.":[245]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2019-10-25T00:00:00"}