{"id":"https://openalex.org/W2981017648","doi":"https://doi.org/10.1016/j.jmb.2019.09.013","title":"Detection of DNA Modifications by Sequence-Specific Transcription Factors","display_name":"Detection of DNA Modifications by Sequence-Specific Transcription Factors","publication_year":2019,"publication_date":"2019-10-15","ids":{"openalex":"https://openalex.org/W2981017648","doi":"https://doi.org/10.1016/j.jmb.2019.09.013","mag":"2981017648","pmid":"https://pubmed.ncbi.nlm.nih.gov/31626807","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7156337"},"language":"en","primary_location":{"id":"doi:10.1016/j.jmb.2019.09.013","doi":"https://doi.org/10.1016/j.jmb.2019.09.013","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jmb.2019.09.013","pdf_url":null,"source":{"id":"https://openalex.org/S46058472","display_name":"Journal of Molecular Biology","issn_l":"0022-2836","issn":["0022-2836","1089-8638"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7156337","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029432491","display_name":"Jie Yang","orcid":"https://orcid.org/0000-0003-2241-5066","observed_orcids":["https://orcid.org/0000-0003-2241-5066"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jie Yang","raw_affiliation_strings":["Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115603671","display_name":"Xing Zhang","orcid":"https://orcid.org/0000-0002-8532-6928","observed_orcids":["https://orcid.org/0000-0002-8532-6928"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xing Zhang","raw_affiliation_strings":["Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070145317","display_name":"Robert Blumenthal","orcid":"https://orcid.org/0000-0002-0873-0724","observed_orcids":["https://orcid.org/0000-0002-0873-0724"]},"institutions":[{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert M. Blumenthal","raw_affiliation_strings":["Department of Medical Microbiology and Immunology, and Program in Bioinformatics, The University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA. Electronic address: robert.blumenthal@utoledo.edu","Department of Medical Microbiology and Immunology, and Program in Bioinformatics, The University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Microbiology and Immunology, and Program in Bioinformatics, The University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA. Electronic address: robert.blumenthal@utoledo.edu","institution_ids":["https://openalex.org/I90871651"]},{"raw_affiliation_string":"Department of Medical Microbiology and Immunology, and Program in Bioinformatics, The University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA","institution_ids":["https://openalex.org/I90871651"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028895511","display_name":"Xiaodong Cheng","orcid":"https://orcid.org/0000-0002-6967-6362","observed_orcids":["https://orcid.org/0000-0002-6967-6362","https://orcid.org/0000-0003-0702-8201"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xiaodong Cheng","raw_affiliation_strings":["Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: xcheng5@mdanderson.org","Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA"],"raw_orcid":"https://orcid.org/0000-0002-6967-6362","affiliations":[{"raw_affiliation_string":"Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: xcheng5@mdanderson.org","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5028895511","https://openalex.org/A5070145317"],"corresponding_institution_ids":["https://openalex.org/I1343551460","https://openalex.org/I90871651"],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":null,"fwci":0.3059,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.29406563,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"432","issue":"6","first_page":"1661","last_page":"1673"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.8690000176429749},{"id":"https://openalex.org/keywords/5-methylcytosine","display_name":"5-methylcytosine","score":0.8840000033378601},{"id":"https://openalex.org/keywords/5-hydroxymethylcytosine","display_name":"5-hydroxymethylcytosine","score":0.9710000157356262},{"id":"https://openalex.org/keywords/5-formylcytosine","display_name":"5-formylcytosine","score":0.9629999995231628},{"id":"https://openalex.org/keywords/5-carboxycytosine","display_name":"5-carboxycytosine","score":0.9470000267028809},{"id":"https://openalex.org/keywords/n6-methyladenine","display_name":"N6-methyladenine","score":0.9520000219345093},{"id":"https://openalex.org/keywords/tet-enzymes","display_name":"TET enzymes","score":0.9369999766349792},{"id":"https://openalex.org/keywords/sam-dependent-methyltransferase","display_name":"SAM-dependent methyltransferase","score":0.8479999899864197},{"id":"https://openalex.org/keywords/bzip-transcription-factors","display_name":"bZIP transcription factors","score":0.765999972820282},{"id":"https://openalex.org/keywords/ap-1","display_name":"AP-1","score":0.8479999899864197},{"id":"https://openalex.org/keywords/c-ebpbeta","display_name":"C/EBP\u03b2","score":0.9129999876022339},{"id":"https://openalex.org/keywords/bhlh-transcription-factors","display_name":"bHLH transcription factors","score":0.9829999804496765},{"id":"https://openalex.org/keywords/max","display_name":"Max","score":0.9279999732971191},{"id":"https://openalex.org/keywords/tcf4","display_name":"TCF4","score":0.9980000257492065},{"id":"https://openalex.org/keywords/dna-polymerase","display_name":"DNA polymerase","score":0.6769999861717224},{"id":"https://openalex.org/keywords/rna-polymerase","display_name":"RNA polymerase","score":0.9959999918937683},{"id":"https://openalex.org/keywords/base-pairing","display_name":"base pairing","score":0.777999997138977},{"id":"https://openalex.org/keywords/dna-repair-enzymes","display_name":"DNA repair enzymes","score":0.7960000038146973}],"concepts":[{"id":"https://openalex.org/C2777721518","wikidata":"https://www.wikidata.org/wiki/Q4727610","display_name":"AlkB","level":4,"score":0.7794692516326904},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.6849356889724731},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6208014488220215},{"id":"https://openalex.org/C2775926025","wikidata":"https://www.wikidata.org/wiki/Q238563","display_name":"5-Methylcytosine","level":5,"score":0.5459867119789124},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.5162336826324463},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.5084930658340454},{"id":"https://openalex.org/C2776023528","wikidata":"https://www.wikidata.org/wiki/Q178425","display_name":"Cytosine","level":3,"score":0.4557613134384155},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.45209887623786926},{"id":"https://openalex.org/C91965660","wikidata":"https://www.wikidata.org/wiki/Q415875","display_name":"Methyltransferase","level":4,"score":0.4498802125453949},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.42750316858291626},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.42612919211387634},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.38428014516830444},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.3242349624633789},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.22413337230682373},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1016/j.jmb.2019.09.013","doi":"https://doi.org/10.1016/j.jmb.2019.09.013","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jmb.2019.09.013","pdf_url":null,"source":{"id":"https://openalex.org/S46058472","display_name":"Journal of Molecular Biology","issn_l":"0022-2836","issn":["0022-2836","1089-8638"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Biology","raw_type":"journal-article"},{"id":"pmid:31626807","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31626807","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of molecular biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7156337","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7156337","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Mol Biol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7156337","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7156337","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Mol Biol","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3640193544","display_name":"DNA Methylation: Structures, Functions and Regulation","funder_award_id":"R01GM049245","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7366879244","display_name":"Recruitment of Established Investigators","funder_award_id":"RR160029","funder_id":"https://openalex.org/F4320308129","funder_display_name":"Cancer Prevention and Research Institute of Texas"}],"funders":[{"id":"https://openalex.org/F4320308129","display_name":"Cancer Prevention and Research Institute of Texas","ror":"https://ror.org/0003xa228"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":146,"referenced_works":["https://openalex.org/W88733460","https://openalex.org/W247508261","https://openalex.org/W1422283187","https://openalex.org/W1585086833","https://openalex.org/W1770731112","https://openalex.org/W1820296753","https://openalex.org/W1839035480","https://openalex.org/W1924093405","https://openalex.org/W1959952659","https://openalex.org/W1967384725","https://openalex.org/W1969391774","https://openalex.org/W1974124243","https://openalex.org/W1975815181","https://openalex.org/W1977711073","https://openalex.org/W1978867062","https://openalex.org/W1983255679","https://openalex.org/W1984783889","https://openalex.org/W1987189614","https://openalex.org/W1987981719","https://openalex.org/W1991072716","https://openalex.org/W1992672580","https://openalex.org/W1994600118","https://openalex.org/W1997453048","https://openalex.org/W2003063544","https://openalex.org/W2004477171","https://openalex.org/W2005800236","https://openalex.org/W2005820729","https://openalex.org/W2009747800","https://openalex.org/W2012701284","https://openalex.org/W2015586003","https://openalex.org/W2015616819","https://openalex.org/W2017086224","https://openalex.org/W2024162802","https://openalex.org/W2036224418","https://openalex.org/W2038449573","https://openalex.org/W2039113975","https://openalex.org/W2040169968","https://openalex.org/W2042976701","https://openalex.org/W2047603136","https://openalex.org/W2049114614","https://openalex.org/W2049722378","https://openalex.org/W2050791777","https://openalex.org/W2052561020","https://openalex.org/W2060822442","https://openalex.org/W2061801549","https://openalex.org/W2068219372","https://openalex.org/W2068788433","https://openalex.org/W2072319964","https://openalex.org/W2075151834","https://openalex.org/W2075563645","https://openalex.org/W2076255761","https://openalex.org/W2091931541","https://openalex.org/W2093126985","https://openalex.org/W2093683538","https://openalex.org/W2099167511","https://openalex.org/W2101636211","https://openalex.org/W2103083046","https://openalex.org/W2107038650","https://openalex.org/W2108664872","https://openalex.org/W2108828818","https://openalex.org/W2113512805","https://openalex.org/W2114150529","https://openalex.org/W2114716625","https://openalex.org/W2118608526","https://openalex.org/W2120191983","https://openalex.org/W2123711411","https://openalex.org/W2129270269","https://openalex.org/W2131829335","https://openalex.org/W2133620956","https://openalex.org/W2145810780","https://openalex.org/W2149142276","https://openalex.org/W2150750072","https://openalex.org/W2152451432","https://openalex.org/W2156738105","https://openalex.org/W2157458089","https://openalex.org/W2169241308","https://openalex.org/W2170807476","https://openalex.org/W2213860101","https://openalex.org/W2225733508","https://openalex.org/W2246141446","https://openalex.org/W2260563813","https://openalex.org/W2290890274","https://openalex.org/W2313190268","https://openalex.org/W2318835682","https://openalex.org/W2333716116","https://openalex.org/W2346485333","https://openalex.org/W2346946467","https://openalex.org/W2406807376","https://openalex.org/W2550848750","https://openalex.org/W2553864120","https://openalex.org/W2554471469","https://openalex.org/W2559026422","https://openalex.org/W2565154125","https://openalex.org/W2583980052","https://openalex.org/W2598659870","https://openalex.org/W2610903912","https://openalex.org/W2611407987","https://openalex.org/W2614347829","https://openalex.org/W2625488274","https://openalex.org/W2626966859","https://openalex.org/W2744844702","https://openalex.org/W2749178326","https://openalex.org/W2758012596","https://openalex.org/W2761407992","https://openalex.org/W2766704091","https://openalex.org/W2767572999","https://openalex.org/W2768929279","https://openalex.org/W2773146760","https://openalex.org/W2774541277","https://openalex.org/W2784757192","https://openalex.org/W2791154320","https://openalex.org/W2799591361","https://openalex.org/W2802376483","https://openalex.org/W2807744873","https://openalex.org/W2883632697","https://openalex.org/W2894749997","https://openalex.org/W2895991294","https://openalex.org/W2898871895","https://openalex.org/W2899958367","https://openalex.org/W2903803657","https://openalex.org/W2904540038","https://openalex.org/W2905196328","https://openalex.org/W2905560848","https://openalex.org/W2913877478","https://openalex.org/W2924857274","https://openalex.org/W2935937662","https://openalex.org/W2939392127","https://openalex.org/W2942552883","https://openalex.org/W2945641679","https://openalex.org/W2945691382","https://openalex.org/W2948302201","https://openalex.org/W2949348780","https://openalex.org/W2949609803","https://openalex.org/W2949932581","https://openalex.org/W2951695227","https://openalex.org/W2962780260","https://openalex.org/W2962848798","https://openalex.org/W2968854070","https://openalex.org/W2973193392","https://openalex.org/W4213320379","https://openalex.org/W4236512674","https://openalex.org/W4247447075","https://openalex.org/W4247875838","https://openalex.org/W6609409581","https://openalex.org/W6766635089","https://openalex.org/W7100020194"],"related_works":["https://openalex.org/W88733460","https://openalex.org/W2883632697","https://openalex.org/W1841647688","https://openalex.org/W3188414287","https://openalex.org/W2944950731","https://openalex.org/W2625488274","https://openalex.org/W6963072268","https://openalex.org/W2084200091","https://openalex.org/W2983170455","https://openalex.org/W6887956724"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-10-25T00:00:00"}