{"id":"https://openalex.org/W2980974239","doi":"https://doi.org/10.1161/res.125.suppl_1.579","title":"Abstract 579: Involvement of the Alpha 1A-Adrenergic Receptor in the Cardiac Adaptation to Physiological Stress","display_name":"Abstract 579: Involvement of the Alpha 1A-Adrenergic Receptor in the Cardiac Adaptation to Physiological Stress","publication_year":2019,"publication_date":"2019-08-02","ids":{"openalex":"https://openalex.org/W2980974239","doi":"https://doi.org/10.1161/res.125.suppl_1.579","mag":"2980974239"},"language":"en","primary_location":{"id":"doi:10.1161/res.125.suppl_1.579","doi":"https://doi.org/10.1161/res.125.suppl_1.579","is_oa":false,"landing_page_url":"https://doi.org/10.1161/res.125.suppl_1.579","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085100735","display_name":"Xenia Kaidonis","orcid":"https://orcid.org/0000-0002-2589-2012","observed_orcids":["https://orcid.org/0000-0002-2589-2012"]},"institutions":[{"id":"https://openalex.org/I19514445","display_name":"Victor Chang Cardiac Research Institute","ror":"https://ror.org/03trvqr13","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I19514445"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Xenia Kaidonis","raw_affiliation_strings":["Victor Chang Cardiac Rsch Institute, Sydney, Australia","Xenia Kaidonis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Victor Chang Cardiac Rsch Institute, Sydney, Australia","institution_ids":["https://openalex.org/I19514445"]},{"raw_affiliation_string":"Xenia Kaidonis","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wenxing Niu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19514445","display_name":"Victor Chang Cardiac Research Institute","ror":"https://ror.org/03trvqr13","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I19514445"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Wenxing Niu","raw_affiliation_strings":["Victor Chang Cardiac Rsch Institute, Sydney, Australia","Wenxing Niu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Victor Chang Cardiac Rsch Institute, Sydney, Australia","institution_ids":["https://openalex.org/I19514445"]},{"raw_affiliation_string":"Wenxing Niu","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081826721","display_name":"Andrea Y. Chan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19514445","display_name":"Victor Chang Cardiac Research Institute","ror":"https://ror.org/03trvqr13","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I19514445"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Andrea Y Chan","raw_affiliation_strings":["Victor Chang Cardiac Rsch Institute, Sydney, Australia","Andrea Y Chan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Victor Chang Cardiac Rsch Institute, Sydney, Australia","institution_ids":["https://openalex.org/I19514445"]},{"raw_affiliation_string":"Andrea Y Chan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072072215","display_name":"Scott H. Kesteven","orcid":"https://orcid.org/0000-0001-5433-3060","observed_orcids":["https://orcid.org/0000-0001-5433-3060"]},"institutions":[{"id":"https://openalex.org/I19514445","display_name":"Victor Chang Cardiac Research Institute","ror":"https://ror.org/03trvqr13","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I19514445"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Scott Kesteven","raw_affiliation_strings":["Victor Chang Cardiac Rsch Institute, Sydney, Australia","Scott Kesteven"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Victor Chang Cardiac Rsch Institute, Sydney, Australia","institution_ids":["https://openalex.org/I19514445"]},{"raw_affiliation_string":"Scott Kesteven","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061778419","display_name":"Jianxin Wu","orcid":"https://orcid.org/0000-0002-2335-2557","observed_orcids":["https://orcid.org/0000-0002-2335-2557"]},"institutions":[{"id":"https://openalex.org/I19514445","display_name":"Victor Chang Cardiac Research Institute","ror":"https://ror.org/03trvqr13","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I19514445"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jianxin Wu","raw_affiliation_strings":["Victor Chang Cardiac Rsch Institute, Sydney, Australia","Jianxin Wu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Victor Chang Cardiac Rsch Institute, Sydney, Australia","institution_ids":["https://openalex.org/I19514445"]},{"raw_affiliation_string":"Jianxin Wu","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046322684","display_name":"Siiri E. Iismaa","orcid":"https://orcid.org/0000-0003-2409-7356","observed_orcids":["https://orcid.org/0000-0003-2409-7356"]},"institutions":[{"id":"https://openalex.org/I19514445","display_name":"Victor Chang Cardiac Research Institute","ror":"https://ror.org/03trvqr13","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I19514445"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Siiri E Iismaa","raw_affiliation_strings":["Victor Chang Cardiac Rsch Institute, Sydney, Australia","Siiri E Iismaa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Victor Chang Cardiac Rsch Institute, Sydney, Australia","institution_ids":["https://openalex.org/I19514445"]},{"raw_affiliation_string":"Siiri E Iismaa","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025247920","display_name":"Michael Patrick Feneley","orcid":"https://orcid.org/0000-0002-6650-8865","observed_orcids":["https://orcid.org/0000-0002-6650-8865"]},"institutions":[{"id":"https://openalex.org/I19514445","display_name":"Victor Chang Cardiac Research Institute","ror":"https://ror.org/03trvqr13","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I19514445"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Michael Feneley","raw_affiliation_strings":["Victor Chang Cardiac Rsch Institute, Sydney, Australia","Michael Feneley"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Victor Chang Cardiac Rsch Institute, Sydney, Australia","institution_ids":["https://openalex.org/I19514445"]},{"raw_affiliation_string":"Michael Feneley","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021863838","display_name":"Robert M. Graham","orcid":"https://orcid.org/0000-0002-1042-2587","observed_orcids":["https://orcid.org/0000-0002-1042-2587"]},"institutions":[{"id":"https://openalex.org/I19514445","display_name":"Victor Chang Cardiac Research Institute","ror":"https://ror.org/03trvqr13","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I19514445"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Robert M Graham","raw_affiliation_strings":["Victor Chang Cardiac Rsch Institute, Sydney, Australia","Robert M Graham"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Victor Chang Cardiac Rsch Institute, Sydney, Australia","institution_ids":["https://openalex.org/I19514445"]},{"raw_affiliation_string":"Robert M Graham","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I19514445"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"125","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.5303000211715698,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.5303000211715698,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11922","display_name":"Cardiovascular Effects of Exercise","score":0.1995999962091446,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.07090000063180923,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha1a-adrenergic-receptor","display_name":"alpha1A-adrenergic receptor","score":0.9350000023841858},{"id":"https://openalex.org/keywords/cardiac-hypertrophy","display_name":"cardiac hypertrophy","score":0.7020000219345093},{"id":"https://openalex.org/keywords/physiological-stress","display_name":"physiological stress","score":0.5830000042915344},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.675000011920929},{"id":"https://openalex.org/keywords/cardiac-function","display_name":"cardiac function","score":0.5759999752044678},{"id":"https://openalex.org/keywords/positive-inotropic-effect","display_name":"positive inotropic effect","score":0.6729999780654907},{"id":"https://openalex.org/keywords/beta1-adrenergic-receptor","display_name":"beta1-adrenergic receptor","score":0.6819999814033508},{"id":"https://openalex.org/keywords/cardiac-adaptation-to-exercise","display_name":"cardiac adaptation to exercise","score":0.628000020980835},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.6230000257492065},{"id":"https://openalex.org/keywords/sympathetic-activation","display_name":"sympathetic activation","score":0.5130000114440918}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7476855516433716},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7270519137382507},{"id":"https://openalex.org/C2779178603","wikidata":"https://www.wikidata.org/wiki/Q356257","display_name":"Adenylyl cyclase","level":3,"score":0.5579772591590881},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5578624606132507},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4918506145477295},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.4762958586215973},{"id":"https://openalex.org/C2775894120","wikidata":"https://www.wikidata.org/wiki/Q271663","display_name":"Catecholamine","level":2,"score":0.4713080823421478},{"id":"https://openalex.org/C158453852","wikidata":"https://www.wikidata.org/wiki/Q4684738","display_name":"Adrenergic","level":3,"score":0.45739516615867615},{"id":"https://openalex.org/C167414201","wikidata":"https://www.wikidata.org/wiki/Q1955391","display_name":"Muscle hypertrophy","level":2,"score":0.4506604075431824},{"id":"https://openalex.org/C40465926","wikidata":"https://www.wikidata.org/wiki/Q410568","display_name":"Adrenergic receptor","level":3,"score":0.44167301058769226},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.4247794449329376},{"id":"https://openalex.org/C2776410257","wikidata":"https://www.wikidata.org/wiki/Q14901714","display_name":"Caveolin 3","level":4,"score":0.41282349824905396},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.330721914768219},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.18184393644332886},{"id":"https://openalex.org/C49866891","wikidata":"https://www.wikidata.org/wiki/Q1051872","display_name":"Caveolae","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/res.125.suppl_1.579","doi":"https://doi.org/10.1161/res.125.suppl_1.579","is_oa":false,"landing_page_url":"https://doi.org/10.1161/res.125.suppl_1.579","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3135757787","https://openalex.org/W2143766037","https://openalex.org/W7099055656","https://openalex.org/W3107994083","https://openalex.org/W7100852682","https://openalex.org/W2105330325","https://openalex.org/W2102421606","https://openalex.org/W58396671","https://openalex.org/W2064621829","https://openalex.org/W2102692867"],"abstract_inverted_index":{"The":[0],"\u2018fight":[1],"or":[2,146,229],"flight\u2019":[3],"response,":[4,290],"involving":[5],"sympathetic":[6],"nervous":[7],"system":[8],"activation":[9,18],"and":[10,165,178,185,193,214,237,257],"catecholamine":[11],"release,":[12],"is":[13,55],"central":[14],"to":[15,31,37,106,303,327],"survival.":[16],"Resulting":[17],"of":[19,50,62,72,110,139],"adrenergic":[20],"receptors":[21],"(ARs)":[22],"drives":[23],"physiological":[24,90,208,328],"responses,":[25],"such":[26],"as":[27,265,267],"positive":[28],"inotropy,":[29],"which":[30],"date":[32],"has":[33],"been":[34],"attributed":[35],"solely":[36],"\u03b2":[38,140,143],"1":[39,141],"-AR/Gs/adenylyl":[40],"cyclase/protein":[41],"kinase":[42],"A":[43,151],"pathway-activation.":[44],"We":[45],"previously":[46],"demonstrated":[47],"that":[48],"overexpression":[49],"the":[51,60,87],"\u03b1":[52,73,82,96,128,147,294,314],"1A":[53,74,83,97,129,295,315],"-AR":[54,75,98,130,149,296],"cardioprotective":[56],"in":[57,59,68,120,126,137,171,203,225,241,270,278,321,325],"rodents":[58],"setting":[61],"pathological":[63],"cardiac":[64,104,127,161,323],"stress;":[65],"a":[66,93,121,268,287,304],"finding":[67],"agreement":[69],"with":[70,115,133,163,200,207,222,281,292,312],"studies":[71],"inactivation.":[76],"However,":[77],"it":[78],"remains":[79],"unknown":[80],"if":[81],"-ARs":[84,316],"also":[85],"protect":[86],"heart":[88,172],"from":[89],"stress.":[91,329],"Using":[92],"tamoxifen-inducible,":[94],"cardiomyocyte-specific":[95,293],"knockdown":[99],"mouse":[100],"model,":[101],"we":[102],"evaluated":[103],"responses":[105],"swim":[107,157,306],"exercise.":[108],"Treatment":[109],"adult":[111],"(8-12":[112],"week)":[113],"mice":[114,167,291],"4-OH":[116],"tamoxifen":[117],"(Tam)":[118],"resulted":[119],"7.4":[122],"fold":[123,216],"decrease":[124,269],"(p<0.001)":[125],"mRNA":[131,211],"levels,":[132],"no":[134,201,223],"compensatory":[135],"changes":[136],"expression":[138],"-,":[142],"2":[144,148],"-":[145],"subtypes.":[150],"90":[152],"minute,":[153],"twice":[154],"daily,":[155],"four-week":[156],"challenge":[158],"induced":[159],"eccentric":[160],"hypertrophy,":[162,209],"Tam-":[164,279],"vehicle-treated":[166,282],"displaying":[168],"similar":[169,288],"increases":[170,240],"weight/tibia":[173],"length":[174],"(mean":[175,190],"increase:":[176,191],"1.4":[177],"1.6mg/mm,":[179],"respectively;":[180,195],"p<0.001":[181,196],"vs":[182,197,218,246,254,262,275],"sedentary":[183,198,219],"mice)":[184,199],"left":[186],"ventricular":[187],"chamber":[188],"radius":[189],"0.16":[192],"0.17mm,":[194],"change":[202],"wall":[204],"thickness.":[205],"Consistent":[206],"Igf-1":[210],"increased":[212],"1.7":[213],"0.7":[215],"(p=0.004":[217],"mice),":[220],"respectively,":[221],"increase":[224],"Nppb":[226],",":[227],"Myh7":[228],"Acta1":[230],"mRNA.":[231],"Cardiac":[232],"function,":[233],"assessed":[234],"by":[235],"micromanometry":[236],"echocardiography,":[238],"showed":[239,298],"dP/dt":[242],"min/EDV":[243],"(mean:":[244,252,260,273],"-117":[245],"-150":[247],"mmHg/s/\u03bcL;":[248],"p=0.011),":[249],"end-diastolic":[250],"volume":[251,259],"76.9":[253],"68.0\u03bcL;":[255],"p=0.038)":[256],"end-systolic":[258],"29.4":[261],"21.9\u03bcL;":[263],"p=0.018),":[264],"well":[266],"ejection":[271],"fraction":[272],"63":[274],"68%;":[276],"p=0.046)":[277],"compared":[280],"mice,":[283],"respectively.":[284],"Thus,":[285],"despite":[286],"hypertrophic":[289],"inactivation":[297],"an":[299,318],"impaired":[300],"contractile":[301],"response":[302,326],"sustained":[305],"challenge.":[307],"These":[308],"findings":[309],"are":[310],"consistent":[311],"cardiomyocyte":[313],"playing":[317],"important":[319],"role":[320],"maintaining":[322],"contractility":[324]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2019-10-25T00:00:00"}