{"id":"https://openalex.org/W2980935472","doi":"https://doi.org/10.1097/md.0000000000017189","title":"Does splitting a tablet obtain the accurate dose?","display_name":"Does splitting a tablet obtain the accurate dose?","publication_year":2019,"publication_date":"2019-10-01","ids":{"openalex":"https://openalex.org/W2980935472","doi":"https://doi.org/10.1097/md.0000000000017189","mag":"2980935472","pmid":"https://pubmed.ncbi.nlm.nih.gov/31626083","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6824647"},"language":"en","primary_location":{"id":"doi:10.1097/md.0000000000017189","doi":"https://doi.org/10.1097/md.0000000000017189","is_oa":true,"landing_page_url":"https://doi.org/10.1097/md.0000000000017189","pdf_url":null,"source":{"id":"https://openalex.org/S28966261","display_name":"Medicine","issn_l":"0025-7974","issn":["0025-7974","1536-5964"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1097/md.0000000000017189","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066215679","display_name":"Kanika Chaudhri","orcid":"https://orcid.org/0000-0002-3453-0769","observed_orcids":["https://orcid.org/0000-0002-3453-0769"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]},{"id":"https://openalex.org/I4210087284","display_name":"St Vincent's Hospital Sydney","ror":"https://ror.org/000ed3w25","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210087284"]},{"id":"https://openalex.org/I4210110309","display_name":"The George Institute for Global Health","ror":"https://ror.org/023331s46","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210110309"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Kanika Chaudhri","raw_affiliation_strings":["Department of Clinical Pharmacology and Toxicology, St Vincent's Hospital, Darlinghurst","Faculty of Medicine, UNSW Sydney","The George Institute for Global Health, Sydney","Department of Clinical Pharmacology and Toxicology, St Vincent's Hospital, Darlinghurst; Faculty of Medicine, UNSW Sydney; The George Institute for Global Health, Sydney"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology and Toxicology, St Vincent's Hospital, Darlinghurst","institution_ids":["https://openalex.org/I4210087284"]},{"raw_affiliation_string":"Faculty of Medicine, UNSW Sydney","institution_ids":["https://openalex.org/I31746571"]},{"raw_affiliation_string":"The George Institute for Global Health, Sydney","institution_ids":["https://openalex.org/I4210110309"]},{"raw_affiliation_string":"Department of Clinical Pharmacology and Toxicology, St Vincent's Hospital, Darlinghurst; Faculty of Medicine, UNSW Sydney; The George Institute for Global Health, Sydney","institution_ids":["https://openalex.org/I31746571","https://openalex.org/I4210087284","https://openalex.org/I4210110309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002772523","display_name":"Madeleine Kearney","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110309","display_name":"The George Institute for Global Health","ror":"https://ror.org/023331s46","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210110309"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Madeleine Kearney","raw_affiliation_strings":["The George Institute for Global Health, Sydney"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The George Institute for Global Health, Sydney","institution_ids":["https://openalex.org/I4210110309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056130529","display_name":"Gian Luca Di Tanna","orcid":"https://orcid.org/0000-0002-5470-3567","observed_orcids":["https://orcid.org/0000-0002-5470-3567"]},"institutions":[{"id":"https://openalex.org/I4210110309","display_name":"The George Institute for Global Health","ror":"https://ror.org/023331s46","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210110309"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Gian Luca Di Tanna","raw_affiliation_strings":["The George Institute for Global Health, Sydney"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The George Institute for Global Health, Sydney","institution_ids":["https://openalex.org/I4210110309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067007569","display_name":"Richard Osborne Day","orcid":"https://orcid.org/0000-0002-6045-6937","observed_orcids":["https://orcid.org/0000-0002-6045-6937"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]},{"id":"https://openalex.org/I4210087284","display_name":"St Vincent's Hospital Sydney","ror":"https://ror.org/000ed3w25","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210087284"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Richard O. Day","raw_affiliation_strings":["Department of Clinical Pharmacology and Toxicology, St Vincent's Hospital, Darlinghurst","Faculty of Medicine, UNSW Sydney"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology and Toxicology, St Vincent's Hospital, Darlinghurst","institution_ids":["https://openalex.org/I4210087284"]},{"raw_affiliation_string":"Faculty of Medicine, UNSW Sydney","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015704931","display_name":"Anthony Rodgers","orcid":"https://orcid.org/0000-0003-1282-1896","observed_orcids":["https://orcid.org/0000-0003-1282-1896"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]},{"id":"https://openalex.org/I4210110309","display_name":"The George Institute for Global Health","ror":"https://ror.org/023331s46","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210110309"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Anthony Rodgers","raw_affiliation_strings":["Faculty of Medicine, UNSW Sydney","The George Institute for Global Health, Sydney"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, UNSW Sydney","institution_ids":["https://openalex.org/I31746571"]},{"raw_affiliation_string":"The George Institute for Global Health, Sydney","institution_ids":["https://openalex.org/I4210110309"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005705114","display_name":"Emily Atkins","orcid":"https://orcid.org/0000-0003-2522-3510","observed_orcids":["https://orcid.org/0000-0003-2522-3510"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I27158533","display_name":"National Heart Foundation of Australia","ror":"https://ror.org/039d9wr27","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I27158533"]},{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]},{"id":"https://openalex.org/I4210110309","display_name":"The George Institute for Global Health","ror":"https://ror.org/023331s46","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210110309"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Emily R. Atkins","raw_affiliation_strings":["Faculty of Medicine, UNSW Sydney","The George Institute for Global Health, Sydney","Westmead Clinical School, University of Sydney, Sydney, Australia","KC is supported by the RTP postgraduate scholarship from UNSW Sydney. Dr Emily Atkins is supported by a postdoctoral fellowship (PdF 101884) from the National Heart Foundation of Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, UNSW Sydney","institution_ids":["https://openalex.org/I31746571"]},{"raw_affiliation_string":"The George Institute for Global Health, Sydney","institution_ids":["https://openalex.org/I4210110309"]},{"raw_affiliation_string":"Westmead Clinical School, University of Sydney, Sydney, Australia","institution_ids":["https://openalex.org/I129604602"]},{"raw_affiliation_string":"KC is supported by the RTP postgraduate scholarship from UNSW Sydney. Dr Emily Atkins is supported by a postdoctoral fellowship (PdF 101884) from the National Heart Foundation of Australia","institution_ids":["https://openalex.org/I27158533"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5066215679"],"corresponding_institution_ids":["https://openalex.org/I31746571","https://openalex.org/I4210087284","https://openalex.org/I4210110309"],"apc_list":{"value":1950,"currency":"USD","value_usd":1950},"apc_paid":{"value":1950,"currency":"USD","value_usd":1950},"fwci":2.6687,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.88855491,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":98},"biblio":{"volume":"98","issue":"42","first_page":"e17189","last_page":"e17189"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13970","display_name":"Pharmacy and Medical Practices","score":0.7113999724388123,"subfield":{"id":"https://openalex.org/subfields/3611","display_name":"Pharmacy"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13970","display_name":"Pharmacy and Medical Practices","score":0.7113999724388123,"subfield":{"id":"https://openalex.org/subfields/3611","display_name":"Pharmacy"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10508","display_name":"Patient Safety and Medication Errors","score":0.21389999985694885,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.027699999511241913,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tablet-splitting","display_name":"tablet splitting","score":0.9980000257492065},{"id":"https://openalex.org/keywords/dose-accuracy","display_name":"dose accuracy","score":0.9789999723434448},{"id":"https://openalex.org/keywords/weight-variation","display_name":"weight variation","score":0.8700000047683716},{"id":"https://openalex.org/keywords/dose-adjustment","display_name":"dose adjustment","score":0.41499999165534973},{"id":"https://openalex.org/keywords/primary-care-prescribing","display_name":"primary care prescribing","score":0.5339999794960022},{"id":"https://openalex.org/keywords/drug-administration","display_name":"medication administration","score":0.4059999883174896},{"id":"https://openalex.org/keywords/cost-reduction","display_name":"cost reduction","score":0.7110000252723694}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.919257640838623},{"id":"https://openalex.org/C2781145037","wikidata":"https://www.wikidata.org/wiki/Q5011772","display_name":"CINAHL","level":3,"score":0.7553339600563049},{"id":"https://openalex.org/C2780385302","wikidata":"https://www.wikidata.org/wiki/Q367158","display_name":"Protocol (science)","level":3,"score":0.6916531920433044},{"id":"https://openalex.org/C2776478404","wikidata":"https://www.wikidata.org/wiki/Q1105187","display_name":"Cochrane Library","level":3,"score":0.6895659565925598},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.6639909148216248},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.5279375910758972},{"id":"https://openalex.org/C2780598303","wikidata":"https://www.wikidata.org/wiki/Q65921492","display_name":"Flexibility (engineering)","level":2,"score":0.447932630777359},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.35821712017059326},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.2528224587440491},{"id":"https://openalex.org/C27415008","wikidata":"https://www.wikidata.org/wiki/Q7256382","display_name":"Psychological intervention","level":2,"score":0.1691296100616455},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.13957366347312927},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10509011149406433},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.08682432770729065},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000078202","descriptor_name":"Systematic Reviews as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013607","descriptor_name":"Tablets","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D013607","descriptor_name":"Tablets","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1097/md.0000000000017189","doi":"https://doi.org/10.1097/md.0000000000017189","is_oa":true,"landing_page_url":"https://doi.org/10.1097/md.0000000000017189","pdf_url":null,"source":{"id":"https://openalex.org/S28966261","display_name":"Medicine","issn_l":"0025-7974","issn":["0025-7974","1536-5964"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5822586","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6824647","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6824647","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6824647","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine (Baltimore)","raw_type":"Text"},{"id":"pmid:31626083","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31626083","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine","raw_type":"Journal Article"},{"id":"pmh:oai:unsworks.library.unsw.edu.au:1959.4/unsworks_63336","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1959.4/unsworks_63336","pdf_url":"https://unsworks.unsw.edu.au/bitstreams/c1875193-3d6b-4bd4-b2e8-b5c6beb02bb9/download","source":{"id":"https://openalex.org/S4377196481","display_name":"UNSWorks (UNSW Sydney)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I31746571","host_organization_name":"UNSW Sydney","host_organization_lineage":["https://openalex.org/I31746571"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Medicine, 98, 42, e17189","raw_type":"http://purl.org/coar/resource_type/c_6501"}],"best_oa_location":{"id":"doi:10.1097/md.0000000000017189","doi":"https://doi.org/10.1097/md.0000000000017189","is_oa":true,"landing_page_url":"https://doi.org/10.1097/md.0000000000017189","pdf_url":null,"source":{"id":"https://openalex.org/S28966261","display_name":"Medicine","issn_l":"0025-7974","issn":["0025-7974","1536-5964"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[{"id":"https://openalex.org/study-designs/study-protocol","display_name":"Study Protocol"}],"awards":[{"id":"https://openalex.org/G1743844297","display_name":null,"funder_award_id":"101884","funder_id":"https://openalex.org/F4320320442","funder_display_name":"National Heart Foundation of Australia"}],"funders":[{"id":"https://openalex.org/F4320320442","display_name":"National Heart Foundation of Australia","ror":"https://ror.org/039d9wr27"},{"id":"https://openalex.org/F4320320965","display_name":"University of New South Wales","ror":"https://ror.org/03r8z3t63"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2980935472.pdf","grobid_xml":"https://content.openalex.org/works/W2980935472.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W45943111","https://openalex.org/W1970238764","https://openalex.org/W1986673622","https://openalex.org/W2083891807","https://openalex.org/W2084339881","https://openalex.org/W2086808185","https://openalex.org/W2098923148","https://openalex.org/W2104675861","https://openalex.org/W2133564174","https://openalex.org/W2145750528","https://openalex.org/W2146030020","https://openalex.org/W2157437898","https://openalex.org/W2158001049","https://openalex.org/W2186976419","https://openalex.org/W2335195420","https://openalex.org/W2530928758","https://openalex.org/W2562844738","https://openalex.org/W2563046258","https://openalex.org/W2588681363","https://openalex.org/W2599076725","https://openalex.org/W2758974635","https://openalex.org/W2788530542","https://openalex.org/W2916841405"],"related_works":["https://openalex.org/W4319975563","https://openalex.org/W3212452015","https://openalex.org/W7154998246","https://openalex.org/W1986673622","https://openalex.org/W4213455169","https://openalex.org/W2059907227","https://openalex.org/W2323501235","https://openalex.org/W2210822219","https://openalex.org/W1536272772","https://openalex.org/W2083891807"],"abstract_inverted_index":{"BACKGROUND:":[0],"Physical":[1],"manipulation":[2],"of":[3,16,80,108,146,160,172,174,200,206,215,246],"the":[4,62,66,75,78,102,106,118,147,204,247],"manufactured":[5],"dose":[6,25,39,84,158,210],"form":[7],"is":[8,155],"a":[9,14,28,161,198,225,255],"common":[10],"practice,":[11],"with":[12],"almost":[13],"quarter":[15],"all":[17],"drugs":[18],"administered":[19],"in":[20,58,69,95,228,254],"primary":[21],"care":[22],"having":[23],"their":[24],"altered.":[26],"Splitting":[27],"tablet":[29,81,119,163,207,226],"can":[30,52],"be":[31,90,123,177,187,252],"advantageous":[32],"as":[33],"it":[34],"facilitates":[35],"swallowing,":[36],"allows":[37],"for":[38,241],"flexibility":[40],"and":[41,101,132,151],"provides":[42],"cost":[43],"reductions.":[44],"However,":[45],"there":[46],"are":[47],"concerns":[48],"these":[49],"physical":[50],"changes":[51],"lead":[53],"to":[54,73,156,221],"inaccurate":[55],"portions":[56],"resulting":[57],"significant":[59],"variations":[60],"from":[61,105],"prescribed":[63],"dose.":[64,232],"Thus,":[65],"review":[67,249],"described":[68,192,250],"this":[70,194,242],"protocol":[71,195],"aims":[72],"summarise":[74],"literature":[76],"assessing":[77,203],"effect":[79,205],"splitting":[82,208,224],"on":[83,209],"accuracy.":[85,211],"METHODS:":[86],"Relevant":[87],"studies":[88,131],"will":[89,122,128,140,176,186,196,218,251],"identified":[91],"through":[92],"electronic":[93],"searches":[94],"databases":[96,109],"including":[97],"EMBASE,":[98],"MEDLINE,":[99],"CINAHL,":[100],"Cochrane":[103],"Library,":[104],"beginning":[107],"until":[110],"January":[111],"2020.":[112],"Studies":[113],"investigating":[114],"any":[115],"drug,":[116],"where":[117],"was":[120,238],"split,":[121],"potentially":[124],"eligible.":[125],"Two":[126],"reviewers":[127],"independently":[129],"screen":[130],"extract":[133],"data":[134],"using":[135],"standardised":[136],"forms.":[137],"Data":[138],"extracted":[139],"include":[141],"general":[142],"study":[143,180,191,217],"information,":[144],"characteristics":[145,150],"study,":[148],"intervention":[149],"outcomes.":[152],"Primary":[153],"outcome":[154],"assess":[157],"accuracy":[159],"split":[162],"measured":[164],"by":[165],"drug":[166],"content":[167],"or":[168],"weight":[169],"variability.":[170],"Assessment":[171],"risk":[173],"bias":[175],"dependent":[178],"upon":[179],"design.":[181],"If":[182],"deemed":[183],"feasible,":[184],"meta-analysis":[185],"performed.":[188],"RESULTS:":[189],"The":[190,213,244],"within":[193],"provide":[197,219],"synthesis":[199],"current":[201],"evidence":[202,220],"CONCLUSION:":[212],"conclusion":[214],"our":[216],"judge":[222],"whether":[223],"results":[227,245],"an":[229],"accurate":[230],"half":[231],"ETHICS":[233],"AND":[234],"DISSEMINATION:":[235],"Ethics":[236],"approval":[237],"not":[239],"required":[240],"study.":[243],"systematic":[248],"published":[253],"peer-reviewed":[256],"journal.":[257],"REGISTRATION":[258],"DETAILS:":[259],"PROSPERO":[260],"CRD42018106252.":[261]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2019-10-25T00:00:00"}
