{"id":"https://openalex.org/W2980925799","doi":"https://doi.org/10.7912/c2/1902","title":"Loss of TIP30 Accelerates Pancreatic Cancer Progression and Metastasis","display_name":"Loss of TIP30 Accelerates Pancreatic Cancer Progression and Metastasis","publication_year":2019,"publication_date":"2019-07-01","ids":{"openalex":"https://openalex.org/W2980925799","doi":"https://doi.org/10.7912/c2/1902","mag":"2980925799"},"language":"en","primary_location":{"id":"pmh:oai:scholarworks.indianapolis.iu.edu:1805/20227","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/1805/20227","pdf_url":null,"source":{"id":"https://openalex.org/S4306400987","display_name":"IUScholarWorks (Indiana University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I592451","host_organization_name":"Indiana University","host_organization_lineage":["https://openalex.org/I592451"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.7912/c2/1902","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009374630","display_name":"Imade Imasuen","orcid":"https://orcid.org/0000-0001-6760-8473","observed_orcids":["https://orcid.org/0000-0001-6760-8473"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Imasuen Williams, Imade E.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5009374630"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.017999999225139618,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tip30","display_name":"TIP30","score":0.9210000038146973},{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9860000014305115},{"id":"https://openalex.org/keywords/pancreatic-cancer-progression","display_name":"pancreatic cancer progression","score":0.671999990940094},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.8370000123977661},{"id":"https://openalex.org/keywords/egfr","display_name":"EGFR","score":0.5979999899864197},{"id":"https://openalex.org/keywords/microrna-10b","display_name":"microRNA-10b","score":0.8560000061988831},{"id":"https://openalex.org/keywords/liver-metastases","display_name":"liver metastasis","score":0.7179999947547913},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.8619999885559082},{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":0.8740000128746033},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.6039999723434448},{"id":"https://openalex.org/keywords/3-utr-regulation","display_name":"3' UTR regulation","score":0.6169999837875366},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.4659999907016754},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.6650000214576721},{"id":"https://openalex.org/keywords/mouse-model-of-pancreatic-cancer","display_name":"mouse model of pancreatic cancer","score":0.5860000252723694}],"concepts":[{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.7751156091690063},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.6161448955535889},{"id":"https://openalex.org/C2992691968","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Cancer metastasis","level":4,"score":0.4990713596343994},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.44148606061935425},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43991440534591675},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.37915611267089844},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3216112554073334},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.268815815448761}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:scholarworks.indianapolis.iu.edu:1805/20227","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/1805/20227","pdf_url":null,"source":{"id":"https://openalex.org/S4306400987","display_name":"IUScholarWorks (Indiana University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I592451","host_organization_name":"Indiana University","host_organization_lineage":["https://openalex.org/I592451"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},{"id":"mag:2980925799","doi":null,"is_oa":false,"landing_page_url":"https://scholarworks.iupui.edu/handle/1805/20227","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"doi:10.7912/c2/1902","doi":"https://doi.org/10.7912/c2/1902","is_oa":true,"landing_page_url":"https://doi.org/10.7912/c2/1902","pdf_url":null,"source":{"id":"https://openalex.org/S7407051850","display_name":"IU Indianapolis University Library","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.7912/c2/1902","doi":"https://doi.org/10.7912/c2/1902","is_oa":true,"landing_page_url":"https://doi.org/10.7912/c2/1902","pdf_url":null,"source":{"id":"https://openalex.org/S7407051850","display_name":"IU Indianapolis University Library","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":294,"referenced_works":["https://openalex.org/W6231026","https://openalex.org/W122685959","https://openalex.org/W131928997","https://openalex.org/W202086936","https://openalex.org/W901067443","https://openalex.org/W1504049064","https://openalex.org/W1509191294","https://openalex.org/W1552867725","https://openalex.org/W1572640016","https://openalex.org/W1586539673","https://openalex.org/W1601681275","https://openalex.org/W1611210979","https://openalex.org/W1707766907","https://openalex.org/W1768274470","https://openalex.org/W1816281481","https://openalex.org/W1830287761","https://openalex.org/W1848490583","https://openalex.org/W1849836964","https://openalex.org/W1856947902","https://openalex.org/W1859252938","https://openalex.org/W1863845456","https://openalex.org/W1898589533","https://openalex.org/W1931508686","https://openalex.org/W1946441967","https://openalex.org/W1964720421","https://openalex.org/W1965402114","https://openalex.org/W1965855881","https://openalex.org/W1966116114","https://openalex.org/W1966451921","https://openalex.org/W1967287827","https://openalex.org/W1967603759","https://openalex.org/W1968812902","https://openalex.org/W1969201526","https://openalex.org/W1969514229","https://openalex.org/W1970222596","https://openalex.org/W1971141723","https://openalex.org/W1972586311","https://openalex.org/W1973378645","https://openalex.org/W1974219858","https://openalex.org/W1974351257","https://openalex.org/W1974504452","https://openalex.org/W1974651909","https://openalex.org/W1977224241","https://openalex.org/W1977467011","https://openalex.org/W1977966461","https://openalex.org/W1978103068","https://openalex.org/W1978651988","https://openalex.org/W1979647722","https://openalex.org/W1980095448","https://openalex.org/W1980741832","https://openalex.org/W1985324647","https://openalex.org/W1985780641","https://openalex.org/W1988301059","https://openalex.org/W1989531492","https://openalex.org/W1991028764","https://openalex.org/W1991949008","https://openalex.org/W1992928961","https://openalex.org/W1992995822","https://openalex.org/W1993055783","https://openalex.org/W1993799748","https://openalex.org/W1995068068","https://openalex.org/W1996912024","https://openalex.org/W1998249477","https://openalex.org/W1998608669","https://openalex.org/W1999132074","https://openalex.org/W2000241906","https://openalex.org/W2001960844","https://openalex.org/W2002355858","https://openalex.org/W2003207229","https://openalex.org/W2003379778","https://openalex.org/W2003705213","https://openalex.org/W2005574904","https://openalex.org/W2006252261","https://openalex.org/W2007099293","https://openalex.org/W2007897263","https://openalex.org/W2009105978","https://openalex.org/W2012527595","https://openalex.org/W2013102168","https://openalex.org/W2014340954","https://openalex.org/W2014721239","https://openalex.org/W2014783572","https://openalex.org/W2015751470","https://openalex.org/W2016006035","https://openalex.org/W2018159884","https://openalex.org/W2018764844","https://openalex.org/W2019214567","https://openalex.org/W2019264784","https://openalex.org/W2019517037","https://openalex.org/W2023757563","https://openalex.org/W2023887187","https://openalex.org/W2024394230","https://openalex.org/W2024644719","https://openalex.org/W2025242282","https://openalex.org/W2025970479","https://openalex.org/W2026810302","https://openalex.org/W2027414176","https://openalex.org/W2028980015","https://openalex.org/W2031385223","https://openalex.org/W2033166921","https://openalex.org/W2033329729","https://openalex.org/W2033413864","https://openalex.org/W2034269086","https://openalex.org/W2039210293","https://openalex.org/W2039225116","https://openalex.org/W2039270476","https://openalex.org/W2044967196","https://openalex.org/W2046231757","https://openalex.org/W2047710313","https://openalex.org/W2049063465","https://openalex.org/W2049522382","https://openalex.org/W2050175422","https://openalex.org/W2050643752","https://openalex.org/W2051143438","https://openalex.org/W2051227958","https://openalex.org/W2051369708","https://openalex.org/W2052869455","https://openalex.org/W2053265248","https://openalex.org/W2053676985","https://openalex.org/W2053863057","https://openalex.org/W2055007285","https://openalex.org/W2055091294","https://openalex.org/W2056200154","https://openalex.org/W2057980261","https://openalex.org/W2059022111","https://openalex.org/W2059124791","https://openalex.org/W2059352612","https://openalex.org/W2060164296","https://openalex.org/W2062567955","https://openalex.org/W2063140987","https://openalex.org/W2063551078","https://openalex.org/W2064178094","https://openalex.org/W2065247841","https://openalex.org/W2066135299","https://openalex.org/W2066503677","https://openalex.org/W2067826589","https://openalex.org/W2068190035","https://openalex.org/W2068948163","https://openalex.org/W2069269337","https://openalex.org/W2070058781","https://openalex.org/W2070398835","https://openalex.org/W2070779203","https://openalex.org/W2071379789","https://openalex.org/W2072761181","https://openalex.org/W2076211055","https://openalex.org/W2077297619","https://openalex.org/W2078283135","https://openalex.org/W2079251691","https://openalex.org/W2080232352","https://openalex.org/W2080719056","https://openalex.org/W2081236313","https://openalex.org/W2081341738","https://openalex.org/W2081681778","https://openalex.org/W2084239507","https://openalex.org/W2084255175","https://openalex.org/W2084480556","https://openalex.org/W2084659308","https://openalex.org/W2086331407","https://openalex.org/W2086894535","https://openalex.org/W2087393295","https://openalex.org/W2088035579","https://openalex.org/W2088110734","https://openalex.org/W2089370460","https://openalex.org/W2091001933","https://openalex.org/W2091079694","https://openalex.org/W2092520899","https://openalex.org/W2093921289","https://openalex.org/W2096173332","https://openalex.org/W2097606117","https://openalex.org/W2099023480","https://openalex.org/W2100519108","https://openalex.org/W2100801124","https://openalex.org/W2101645151","https://openalex.org/W2102257270","https://openalex.org/W2103031848","https://openalex.org/W2104010513","https://openalex.org/W2104662829","https://openalex.org/W2104975387","https://openalex.org/W2105877961","https://openalex.org/W2106246776","https://openalex.org/W2106738771","https://openalex.org/W2106755467","https://openalex.org/W2107277218","https://openalex.org/W2107441200","https://openalex.org/W2107780185","https://openalex.org/W2109167795","https://openalex.org/W2109494998","https://openalex.org/W2109564400","https://openalex.org/W2110598677","https://openalex.org/W2111895881","https://openalex.org/W2114622275","https://openalex.org/W2114843025","https://openalex.org/W2115886998","https://openalex.org/W2117064395","https://openalex.org/W2117692326","https://openalex.org/W2120724429","https://openalex.org/W2121240873","https://openalex.org/W2122241065","https://openalex.org/W2122419604","https://openalex.org/W2122769974","https://openalex.org/W2122954568","https://openalex.org/W2124608032","https://openalex.org/W2125292670","https://openalex.org/W2125536365","https://openalex.org/W2125747506","https://openalex.org/W2126663928","https://openalex.org/W2127498557","https://openalex.org/W2127686099","https://openalex.org/W2128077493","https://openalex.org/W2129140055","https://openalex.org/W2130464657","https://openalex.org/W2131170195","https://openalex.org/W2132576834","https://openalex.org/W2135896412","https://openalex.org/W2138582833","https://openalex.org/W2139909490","https://openalex.org/W2140651090","https://openalex.org/W2140946995","https://openalex.org/W2142129456","https://openalex.org/W2145981915","https://openalex.org/W2145990138","https://openalex.org/W2147287018","https://openalex.org/W2148078342","https://openalex.org/W2149441684","https://openalex.org/W2151253787","https://openalex.org/W2151410975","https://openalex.org/W2151917132","https://openalex.org/W2152433837","https://openalex.org/W2152509860","https://openalex.org/W2152793262","https://openalex.org/W2152897535","https://openalex.org/W2154568166","https://openalex.org/W2154953378","https://openalex.org/W2156375592","https://openalex.org/W2157364449","https://openalex.org/W2157923000","https://openalex.org/W2159603425","https://openalex.org/W2162369060","https://openalex.org/W2163958696","https://openalex.org/W2164034599","https://openalex.org/W2166471103","https://openalex.org/W2166865219","https://openalex.org/W2169354377","https://openalex.org/W2169895148","https://openalex.org/W2170785598","https://openalex.org/W2171653205","https://openalex.org/W2171841329","https://openalex.org/W2172334166","https://openalex.org/W2172766143","https://openalex.org/W2177948512","https://openalex.org/W2179112409","https://openalex.org/W2232697670","https://openalex.org/W2297256877","https://openalex.org/W2315243978","https://openalex.org/W2323751645","https://openalex.org/W2324844328","https://openalex.org/W2326556597","https://openalex.org/W2328346739","https://openalex.org/W2331628193","https://openalex.org/W2397171404","https://openalex.org/W2409114741","https://openalex.org/W2420247920","https://openalex.org/W2461513545","https://openalex.org/W2469065915","https://openalex.org/W2483904221","https://openalex.org/W2529386894","https://openalex.org/W2566818766","https://openalex.org/W2568407733","https://openalex.org/W2590390825","https://openalex.org/W2591628935","https://openalex.org/W2598140087","https://openalex.org/W2601014096","https://openalex.org/W2606001457","https://openalex.org/W2613604676","https://openalex.org/W2615250694","https://openalex.org/W2683486796","https://openalex.org/W2743061229","https://openalex.org/W2748710555","https://openalex.org/W2765585947","https://openalex.org/W2767281692","https://openalex.org/W2772812510","https://openalex.org/W2784433219","https://openalex.org/W2787016559","https://openalex.org/W2789603724","https://openalex.org/W2793201050","https://openalex.org/W2794474315","https://openalex.org/W2798231099","https://openalex.org/W2804291108","https://openalex.org/W2808174981","https://openalex.org/W2884298725","https://openalex.org/W2905592635","https://openalex.org/W2911297768","https://openalex.org/W2928820443","https://openalex.org/W3134530972","https://openalex.org/W7075739058"],"related_works":["https://openalex.org/W1816281481","https://openalex.org/W2885696000","https://openalex.org/W4235672330","https://openalex.org/W7100279560","https://openalex.org/W872051831","https://openalex.org/W3150866123","https://openalex.org/W4290704733","https://openalex.org/W7205671916","https://openalex.org/W7002097384","https://openalex.org/W3211949302"],"abstract_inverted_index":{"Pancreatic":[0],"ductal":[1],"adenocarcinoma":[2],"(PDAC)":[3],"is":[4,18,67],"currently":[5],"the":[6,14,39,61,104,183,221,275],"fourth":[7],"leading":[8],"cause":[9],"of":[10,32,81,96,106,168,214,235,278,289],"cancer-related":[11],"death":[12],"in":[13,84,143,148,164,269,281],"United":[15],"States,":[16],"and":[17,28,38,47,54,93,126,135,137,162,197,223,238,241,266,283],"characterized":[19],"by":[20,113],"key":[21],"driver":[22],"mutations":[23],"(e.g.":[24],"KRAS,":[25],"TP53,":[26],"CDKN2A,":[27],"SMAD4),":[29],"elevated":[30],"expression":[31,79,105],"growth":[33],"factors":[34],"such":[35],"as":[36],"TGF-\u03b2s":[37],"EGF":[40],"receptor":[41],"(EGFR),":[42],"a":[43,48,129,165,260,286],"markedly":[44],"desmoplastic":[45],"stroma,":[46],"propensity":[49],"to":[50,74,182,220,285],"develop":[51,75],"multi-organ":[52],"metastases":[53],"chemoresistance.":[55],"Consistent":[56],"with":[57,89,177,186,230],"its":[58,115],"aggressive":[59],"nature,":[60],"5-year":[62],"survival":[63,92],"rate":[64],"for":[65],"PDAC":[66,85,160,192,282],"8-9%,":[68],"which":[69],"demonstrates":[70],"an":[71,231],"urgent":[72],"need":[73],"novel":[76],"therapies.":[77],"High":[78],"levels":[80,268],"microRNA-10b":[82],"(miR-10b)":[83],"tissues":[86],"are":[87],"associated":[88],"decreased":[90],"patient":[91],"earlier":[94],"appearance":[95],"metastatic":[97],"disease":[98],"following":[99],"neoadjuvant":[100],"chemoradiotherapy.":[101],"miR-10b":[102],"downregulates":[103],"transcription":[107],"coactivator":[108],"Tat-Interacting":[109],"Protein":[110],"30":[111],"(TIP30)":[112],"targeting":[114],"3\u2019UTR.":[116],"TIP30":[117,122,144,256,279],"has":[118],"multiple":[119,149],"reported":[120,147],"functions.":[121],"suppresses":[123],"tumor":[124],"formation":[125],"metastasis,":[127],"forms":[128],"complex":[130],"that":[131,157,255],"regulates":[132],"EGFR":[133,249,267],"trafficking":[134],"degradation,":[136],"transcriptionally":[138],"upregulates":[139],"pro-apoptotic":[140],"genes.":[141],"Alterations":[142],"have":[145,259],"been":[146],"human":[150],"cancers,":[151],"including":[152],"pancreatic":[153,204,290],"cancer.":[154],"We":[155,190],"hypothesized":[156],"Tip30-deficiency":[158],"accelerates":[159],"progression":[161],"metastasis":[163,265],"murine":[166],"model":[167],"PDAC.":[169],"To":[170],"test":[171],"this":[172],"hypothesis,":[173],"we":[174],"crossed":[175],"mice":[176,188,227],"oncogenic":[178],"Kras":[179],"(KC)":[180],"localized":[181],"pancreas":[184],"epithelium,":[185],"Tip30-deficient":[187],"(K30C).":[189],"compared":[191],"histopathology":[193],"between":[194],"Tip30-heterozygous":[195],"(K30+/-C)":[196],"Tip30-null":[198],"(K30-/-C)":[199],"mice.":[200],"Tip30-heterozygosity":[201],"accelerated":[202],"PDAC-lesion-associated":[203],"cancer":[205,291],"cell":[206],"(PCC)":[207],"pulmonary":[208],"seeding.":[209],"By":[210],"contrast,":[211],"total":[212],"loss":[213,280],"Tip30":[215],"enhanced":[216],"PCC":[217],"micrometastatic":[218],"seeding":[219],"liver":[222],"hepatic":[224],"metastasis.":[225,292],"K30+/-C":[226,245],"also":[228],"presented":[229],"early,":[232],"increased":[233,248],"penetrance":[234],"lung":[236,239],"lesions":[237],"adenocarcinoma;":[240],"PCCs":[242],"isolated":[243],"from":[244],"pancreata":[246],"exhibited":[247],"protein":[250],"levels.":[251],"These":[252],"findings":[253],"suggest":[254],"deficiency":[257],"can":[258],"dose-dependent":[261],"effect":[262],"on":[263],"organotropic":[264],"PCCs.":[270],"Future":[271],"studies":[272],"will":[273],"delineate":[274],"molecular":[276],"consequences":[277],"contribute":[284],"broader":[287],"understanding":[288]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2019-10-25T00:00:00"}
