{"id":"https://openalex.org/W2980919708","doi":"https://doi.org/10.1186/s12934-019-1225-7","title":"Exploring novel herbicidin analogues by transcriptional regulator overexpression and MS/MS molecular networking","display_name":"Exploring novel herbicidin analogues by transcriptional regulator overexpression and MS/MS molecular networking","publication_year":2019,"publication_date":"2019-10-15","ids":{"openalex":"https://openalex.org/W2980919708","doi":"https://doi.org/10.1186/s12934-019-1225-7","mag":"2980919708","pmid":"https://pubmed.ncbi.nlm.nih.gov/31615513","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6794829"},"language":"en","primary_location":{"id":"doi:10.1186/s12934-019-1225-7","doi":"https://doi.org/10.1186/s12934-019-1225-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12934-019-1225-7","pdf_url":"https://microbialcellfactories.biomedcentral.com/track/pdf/10.1186/s12934-019-1225-7","source":{"id":"https://openalex.org/S171368329","display_name":"Microbial Cell Factories","issn_l":"1475-2859","issn":["1475-2859"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbial Cell Factories","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://microbialcellfactories.biomedcentral.com/track/pdf/10.1186/s12934-019-1225-7","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052675926","display_name":"Yuanyuan Shi","orcid":"https://orcid.org/0000-0003-2997-4573","observed_orcids":["https://orcid.org/0000-0003-2997-4573"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanyuan Shi","raw_affiliation_strings":["CAMS Key Laboratory of Synthetic Biology for Drug Innovation, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, No.1 Tiantan Xili, Beijing, 100050, China","NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, No.1 Tiantan Xili, Beijing, 100050, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CAMS Key Laboratory of Synthetic Biology for Drug Innovation, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, No.1 Tiantan Xili, Beijing, 100050, China","institution_ids":["https://openalex.org/I200296433"]},{"raw_affiliation_string":"NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, No.1 Tiantan Xili, Beijing, 100050, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Renjie Gu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Renjie Gu","raw_affiliation_strings":["NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, No.1 Tiantan Xili, Beijing, 100050, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, No.1 Tiantan Xili, Beijing, 100050, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100709211","display_name":"Yihong Li","orcid":"https://orcid.org/0000-0002-5476-1943","observed_orcids":["https://orcid.org/0000-0002-5476-1943"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yihong Li","raw_affiliation_strings":["CAMS Key Laboratory of Synthetic Biology for Drug Innovation, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, No.1 Tiantan Xili, Beijing, 100050, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CAMS Key Laboratory of Synthetic Biology for Drug Innovation, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, No.1 Tiantan Xili, Beijing, 100050, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100326642","display_name":"Xinwei Wang","orcid":"https://orcid.org/0009-0000-4823-6977","observed_orcids":["https://orcid.org/0009-0000-4823-6977"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinwei Wang","raw_affiliation_strings":["CAMS Key Laboratory of Synthetic Biology for Drug Innovation, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, No.1 Tiantan Xili, Beijing, 100050, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CAMS Key Laboratory of Synthetic Biology for Drug Innovation, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, No.1 Tiantan Xili, Beijing, 100050, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108579157","display_name":"Weicong Ren","orcid":"https://orcid.org/0009-0006-1312-1110","observed_orcids":["https://orcid.org/0009-0006-1312-1110"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weicong Ren","raw_affiliation_strings":["NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, No.1 Tiantan Xili, Beijing, 100050, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, No.1 Tiantan Xili, Beijing, 100050, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100661806","display_name":"Xingxing Li","orcid":"https://orcid.org/0000-0001-6464-0400","observed_orcids":["https://orcid.org/0000-0001-6464-0400","https://orcid.org/0009-0003-1665-4244"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xingxing Li","raw_affiliation_strings":["CAMS Key Laboratory of Synthetic Biology for Drug Innovation, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, No.1 Tiantan Xili, Beijing, 100050, China","NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, No.1 Tiantan Xili, Beijing, 100050, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CAMS Key Laboratory of Synthetic Biology for Drug Innovation, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, No.1 Tiantan Xili, Beijing, 100050, China","institution_ids":["https://openalex.org/I200296433"]},{"raw_affiliation_string":"NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, No.1 Tiantan Xili, Beijing, 100050, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100636224","display_name":"Lifei Wang","orcid":"https://orcid.org/0000-0003-4046-921X","observed_orcids":["https://orcid.org/0000-0003-4046-921X"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lifei Wang","raw_affiliation_strings":["CAMS Key Laboratory of Synthetic Biology for Drug Innovation, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, No.1 Tiantan Xili, Beijing, 100050, China","NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, No.1 Tiantan Xili, Beijing, 100050, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CAMS Key Laboratory of Synthetic Biology for Drug Innovation, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, No.1 Tiantan Xili, Beijing, 100050, China","institution_ids":["https://openalex.org/I200296433"]},{"raw_affiliation_string":"NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, No.1 Tiantan Xili, Beijing, 100050, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011323890","display_name":"Yunying Xie","orcid":"https://orcid.org/0000-0001-7123-4814","observed_orcids":["https://orcid.org/0000-0001-7123-4814"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yunying Xie","raw_affiliation_strings":["CAMS Key Laboratory of Synthetic Biology for Drug Innovation, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, No.1 Tiantan Xili, Beijing, 100050, China. xieyy@imb.pumc.edu.cn","CAMS Key Laboratory of Synthetic Biology for Drug Innovation, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, No.1 Tiantan Xili, Beijing, 100050, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CAMS Key Laboratory of Synthetic Biology for Drug Innovation, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, No.1 Tiantan Xili, Beijing, 100050, China. xieyy@imb.pumc.edu.cn","institution_ids":["https://openalex.org/I200296433"]},{"raw_affiliation_string":"CAMS Key Laboratory of Synthetic Biology for Drug Innovation, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, No.1 Tiantan Xili, Beijing, 100050, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009946790","display_name":"Bin Hong","orcid":"https://orcid.org/0000-0001-6244-8298","observed_orcids":["https://orcid.org/0000-0001-6244-8298"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Bin Hong","raw_affiliation_strings":["CAMS Key Laboratory of Synthetic Biology for Drug Innovation, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, No.1 Tiantan Xili, Beijing, 100050, China. binhong69@hotmail.com","NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, No.1 Tiantan Xili, Beijing, 100050, China. binhong69@hotmail.com","CAMS Key Laboratory of Synthetic Biology for Drug Innovation, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, No.1 Tiantan Xili, Beijing, 100050, China"],"raw_orcid":"https://orcid.org/0000-0001-6244-8298","affiliations":[{"raw_affiliation_string":"CAMS Key Laboratory of Synthetic Biology for Drug Innovation, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, No.1 Tiantan Xili, Beijing, 100050, China. binhong69@hotmail.com","institution_ids":["https://openalex.org/I200296433"]},{"raw_affiliation_string":"NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, No.1 Tiantan Xili, Beijing, 100050, China. binhong69@hotmail.com","institution_ids":["https://openalex.org/I200296433"]},{"raw_affiliation_string":"CAMS Key Laboratory of Synthetic Biology for Drug Innovation, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, No.1 Tiantan Xili, Beijing, 100050, China","institution_ids":["https://openalex.org/I200296433"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5009946790","https://openalex.org/A5011323890"],"corresponding_institution_ids":["https://openalex.org/I200296433"],"apc_list":{"value":2380,"currency":"USD","value_usd":2380},"apc_paid":{"value":2380,"currency":"USD","value_usd":2380},"fwci":2.1692,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.85996987,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"18","issue":"1","first_page":"175","last_page":"175"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12673","display_name":"Microbial Metabolism and Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12530","display_name":"Bioactive Natural Diterpenoids Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/streptomyces-mobaraensis","display_name":"Streptomyces mobaraensis","score":0.8489999771118164},{"id":"https://openalex.org/keywords/biosynthetic-gene-clusters","display_name":"biosynthetic gene clusters","score":0.8299999833106995},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.6169999837875366},{"id":"https://openalex.org/keywords/secondary-metabolites","display_name":"secondary metabolites","score":0.5759999752044678},{"id":"https://openalex.org/keywords/molecular-networking","display_name":"molecular networking","score":0.7350000143051147},{"id":"https://openalex.org/keywords/new-natural-products","display_name":"new natural products","score":0.5989999771118164},{"id":"https://openalex.org/keywords/genome-mining","display_name":"genome mining","score":0.5440000295639038},{"id":"https://openalex.org/keywords/dna-binding-motifs","display_name":"DNA-binding motifs","score":0.6909999847412109}],"concepts":[{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.7184744477272034},{"id":"https://openalex.org/C36857842","wikidata":"https://www.wikidata.org/wiki/Q1501261","display_name":"Gene cluster","level":3,"score":0.6289514899253845},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.610933244228363},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5697434544563293},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.513969361782074},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.4845232367515564},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4776417315006256},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.4683282673358917},{"id":"https://openalex.org/C165525559","wikidata":"https://www.wikidata.org/wiki/Q224180","display_name":"Homology (biology)","level":3,"score":0.4482979476451874},{"id":"https://openalex.org/C2781196521","wikidata":"https://www.wikidata.org/wiki/Q24965710","display_name":"Response regulator","level":4,"score":0.4476463496685028},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.3838643729686737},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.38285031914711},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3213728666305542},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2042868733406067},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005810","descriptor_name":"Multigene Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011684","descriptor_name":"Purine Nucleosides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011684","descriptor_name":"Purine Nucleosides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013302","descriptor_name":"Streptomyces","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013302","descriptor_name":"Streptomyces","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12934-019-1225-7","doi":"https://doi.org/10.1186/s12934-019-1225-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12934-019-1225-7","pdf_url":"https://microbialcellfactories.biomedcentral.com/track/pdf/10.1186/s12934-019-1225-7","source":{"id":"https://openalex.org/S171368329","display_name":"Microbial Cell Factories","issn_l":"1475-2859","issn":["1475-2859"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbial Cell Factories","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6794829","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6794829","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microb Cell Fact","raw_type":"Text"},{"id":"pmid:31615513","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31615513","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbial cell factories","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:29d79dafb1c24bc1801a6010865ba2a7","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/29d79dafb1c24bc1801a6010865ba2a7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Microbial Cell Factories, Vol 18, Iss 1, Pp 1-17 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12934-019-1225-7","doi":"https://doi.org/10.1186/s12934-019-1225-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12934-019-1225-7","pdf_url":"https://microbialcellfactories.biomedcentral.com/track/pdf/10.1186/s12934-019-1225-7","source":{"id":"https://openalex.org/S171368329","display_name":"Microbial Cell Factories","issn_l":"1475-2859","issn":["1475-2859"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbial Cell Factories","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1324997841","display_name":null,"funder_award_id":"2016-I2M-3-012","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2422609926","display_name":null,"funder_award_id":"2018ZX09711001","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G3078038023","display_name":null,"funder_award_id":"2018-I2M-3-005","funder_id":"https://openalex.org/F4320323137","funder_display_name":"Chinese Academy of Medical Sciences"},{"id":"https://openalex.org/G3193009534","display_name":null,"funder_award_id":"2016-I2M-3-012","funder_id":"https://openalex.org/F4320323137","funder_display_name":"Chinese Academy of Medical Sciences"},{"id":"https://openalex.org/G3238403494","display_name":null,"funder_award_id":"2018YFA0902000","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3424583492","display_name":null,"funder_award_id":"2016-I2M-2-002","funder_id":"https://openalex.org/F4320323137","funder_display_name":"Chinese Academy of Medical Sciences"},{"id":"https://openalex.org/G3839806414","display_name":null,"funder_award_id":"7172137","funder_id":"https://openalex.org/F4320322919","funder_display_name":"Natural Science Foundation of Beijing Municipality"},{"id":"https://openalex.org/G3993944383","display_name":null,"funder_award_id":"81703398","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5742853516","display_name":null,"funder_award_id":"2018ZX09711001-006-011","funder_id":"https://openalex.org/F4320321540","funder_display_name":"Ministry of Science and Technology of the People's Republic of China"},{"id":"https://openalex.org/G770229095","display_name":null,"funder_award_id":"2018ZX09711001-007-001","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7807438883","display_name":null,"funder_award_id":"81621064","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7923041710","display_name":null,"funder_award_id":"2016-I2M-2-002","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7994577146","display_name":null,"funder_award_id":"7184227","funder_id":"https://openalex.org/F4320322919","funder_display_name":"Natural Science Foundation of Beijing Municipality"},{"id":"https://openalex.org/G8065680562","display_name":"\u6d77\u6d0b\u5fae\u751f\u7269\u6765\u6e90\u65b0\u578b\u6297\u6d41\u611f\u75c5\u6bd2\u5148\u5bfc\u5206\u5b50\u7684\u53d1\u73b0\u4e0e\u4f5c\u7528\u673a\u5236\u7814\u7a76","funder_award_id":"81630089","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8186707783","display_name":null,"funder_award_id":"81803410","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8426340378","display_name":null,"funder_award_id":"2018YFA0902000","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G8778714188","display_name":null,"funder_award_id":"2018ZX09711001-007-001","funder_id":"https://openalex.org/F4320321540","funder_display_name":"Ministry of Science and Technology of the People's Republic of China"},{"id":"https://openalex.org/G8845961566","display_name":null,"funder_award_id":"81872780","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321540","display_name":"Ministry of Science and Technology of the People's Republic of China","ror":"https://ror.org/027s68j25"},{"id":"https://openalex.org/F4320322919","display_name":"Natural Science Foundation of Beijing Municipality","ror":null},{"id":"https://openalex.org/F4320323137","display_name":"Chinese Academy of Medical Sciences","ror":"https://ror.org/03cve4549"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2980919708.pdf","grobid_xml":"https://content.openalex.org/works/W2980919708.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1592870802","https://openalex.org/W1827848435","https://openalex.org/W1934507893","https://openalex.org/W1969682507","https://openalex.org/W1972990098","https://openalex.org/W1995995599","https://openalex.org/W2027542986","https://openalex.org/W2029467907","https://openalex.org/W2057877546","https://openalex.org/W2079415431","https://openalex.org/W2112001696","https://openalex.org/W2132760186","https://openalex.org/W2140808855","https://openalex.org/W2140952049","https://openalex.org/W2144634347","https://openalex.org/W2144803530","https://openalex.org/W2157952888","https://openalex.org/W2159675211","https://openalex.org/W2161485064","https://openalex.org/W2161546116","https://openalex.org/W2168974130","https://openalex.org/W2170792798","https://openalex.org/W2171555414","https://openalex.org/W2412466935","https://openalex.org/W2472580507","https://openalex.org/W2555163954","https://openalex.org/W2609551972","https://openalex.org/W2617238595","https://openalex.org/W2619604348","https://openalex.org/W2767313424","https://openalex.org/W2788768443","https://openalex.org/W2790225116","https://openalex.org/W2790648044","https://openalex.org/W2803789025","https://openalex.org/W2804007336","https://openalex.org/W2908219766","https://openalex.org/W2915048576","https://openalex.org/W2942829220"],"related_works":["https://openalex.org/W6939865534","https://openalex.org/W2767313424","https://openalex.org/W2915048576","https://openalex.org/W2553275235","https://openalex.org/W1968208538","https://openalex.org/W7095460281","https://openalex.org/W2895672507","https://openalex.org/W1984256629","https://openalex.org/W1990469612","https://openalex.org/W2796432384"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Herbicidin":[2,207],"F":[3,249,284],"has":[4],"an":[5,328],"undecose":[6],"tricyclic":[7],"furano-pyrano-pyran":[8],"structure":[9],"with":[10,126,258,307],"post-decorations.":[11],"It":[12],"was":[13,54,63,156,209,225,237,250],"detected":[14,157],"from":[15,272],"Streptomyces":[16],"mobaraensis":[17,52,229],"US-43":[18,53],"fermentation":[19],"broth":[20],"as":[21,105,107,239],"a":[22,57,127,149,192,232],"trace":[23],"component":[24],"by":[25,214,253],"HPLC\u2013MS":[26],"analysis.":[27],"As":[28,191],"herbicidins":[29],"exhibit":[30],"herbicidal,":[31],"antibacterial,":[32],"antifungal":[33],"and":[34,56,72,96,212,244,323],"antiparasitic":[35],"activities,":[36],"we":[37,178],"are":[38],"attracted":[39],"to":[40,172,182,331],"explore":[41,183],"more":[42],"analogues":[43,186,196,268],"for":[44,339],"further":[45,210],"development.":[46],"Results":[47],"The":[48,65,280],"genome":[49],"of":[50,79,93,101,154,234,247,255,276,282,292,317,319,341],"S.":[51,228],"sequenced":[55],"herbicidin":[58,94,185,195,220,248,262,267,283,343],"biosynthetic":[59,221,296,336],"gene":[60,222,297,337],"cluster":[61,66,223],"(hcd)":[62,224],"localized.":[64],"contains":[67],"structural":[68,103,136],"genes,":[69],"one":[70,303],"transporter":[71,109],"three":[73,81],"potential":[74],"transcription":[75],"regulatory":[76],"genes.":[77],"Overexpression":[78],"the":[80,91,99,108,118,140,173,240,245,273,293,315,333],"regulators":[82],"respectively":[83],"showed":[84,134],"that":[85,169,314],"only":[86],"hcdR2":[87,129,188,277,320],"overexpression":[88,189,254,278,318],"significantly":[89],"improved":[90],"production":[92,246],"F,":[95],"obviously":[97],"increased":[98,252],"transcripts":[100],"7":[102],"genes":[104],"well":[106],"gene.":[110],"After":[111],"performing":[112],"homology":[113],"searches":[114],"using":[115],"BLASTP":[116],"in":[117,139,162,187,227,290],"GenBank":[119],"database,":[120],"14":[121],"hcd-like":[122],"clusters":[123,338],"were":[124,201,269,288],"found":[125],"cluster-situated":[128],"homologue.":[130],"These":[131,311],"HcdR2":[132,155,170,287],"orthologues":[133,281],"overall":[135],"similarity,":[137],"especially":[138],"C-terminal":[141],"DNA":[142],"binding":[143,152,305],"domain.":[144],"Based":[145],"on":[146,204],"bioinformatics":[147],"analysis,":[148],"21-bp":[150],"consensus":[151,175,304],"motif":[153,306],"within":[158],"30":[159],"promoter":[160],"regions":[161],"these":[163],"genome-mined":[164,294],"clusters.":[165],"EMSA":[166],"results":[167,312],"verified":[168],"bound":[171],"predicted":[174],"sequence.":[176],"Additionally,":[177],"employed":[179],"molecular":[180,259,324],"networking":[181,325],"novel":[184,266,342],"strain.":[190,279],"result,":[193],"ten":[194,261],"including":[197,264],"six":[198,265],"new":[199],"compounds":[200],"identified":[202,226,238],"based":[203],"MS/MS":[205],"fragments.":[206],"O":[208],"purified":[211],"confirmed":[213],"1H":[215],"NMR":[216],"spectrum.":[217],"Conclusions":[218],"A":[219],"US-43.":[230],"HcdR2,":[231],"member":[233],"LuxR":[235,308],"family,":[236],"pathway-specific":[241,285],"positive":[242],"regulator,":[243],"dramatically":[251],"hcdR2.":[256],"Combined":[257],"networking,":[260],"congeners":[263],"picked":[270],"out":[271],"secondary":[274],"metabolites":[275],"regulator":[286,322],"present":[289],"most":[291],"homologous":[295],"clusters,":[298],"which":[299],"possessed":[300],"at":[301],"least":[302],"family":[309],"characteristic.":[310],"indicated":[313],"combination":[316],"orthologous":[321],"might":[326],"be":[327],"effective":[329],"way":[330],"exploit":[332],"\u201ccryptic\u201d":[334],"herbicidin-related":[335],"discovery":[340],"analogues.":[344]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-10-25T00:00:00"}