{"id":"https://openalex.org/W2980903157","doi":"https://doi.org/10.1016/j.jalz.2019.06.2633","title":"P2\u2010226: SUBJECT FACTORS RELATED TO CSF DYNAMICS CONFOUND MEASUREMENT OF CSF BIOMARKERS IN ADNI","display_name":"P2\u2010226: SUBJECT FACTORS RELATED TO CSF DYNAMICS CONFOUND MEASUREMENT OF CSF BIOMARKERS IN ADNI","publication_year":2019,"publication_date":"2019-07-01","ids":{"openalex":"https://openalex.org/W2980903157","doi":"https://doi.org/10.1016/j.jalz.2019.06.2633","mag":"2980903157"},"language":"en","primary_location":{"id":"doi:10.1016/j.jalz.2019.06.2633","doi":"https://doi.org/10.1016/j.jalz.2019.06.2633","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jalz.2019.06.2633","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2019.06.2633","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2019.06.2633","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084693399","display_name":"Ryan A. Townley","orcid":"https://orcid.org/0000-0002-3566-3969","observed_orcids":["https://orcid.org/0000-0002-3566-3969"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ryan A. Townley","raw_affiliation_strings":["Mayo Clinic  Rochester MN USA","Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic  Rochester MN USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013894575","display_name":"Jeffrey L. Gunter","orcid":"https://orcid.org/0000-0001-7813-9078","observed_orcids":["https://orcid.org/0000-0001-7813-9078"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey L. Gunter","raw_affiliation_strings":["Mayo Clinic  Rochester MN USA","Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic  Rochester MN USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005572080","display_name":"Jonathan Graff\u2010Radford","orcid":"https://orcid.org/0000-0003-2770-0691","observed_orcids":["https://orcid.org/0000-0003-2770-0691"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan Graff-Radford","raw_affiliation_strings":["Mayo Clinic  Rochester MN USA","Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic  Rochester MN USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112476693","display_name":"Heather J. Wiste","orcid":"https://orcid.org/0009-0002-8833-2693","observed_orcids":["https://orcid.org/0009-0002-8833-2693"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heather J. Wiste","raw_affiliation_strings":["Mayo Clinic  Rochester MN USA","Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic  Rochester MN USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050718938","display_name":"Matthew L. Senjem","orcid":"https://orcid.org/0000-0001-9308-9275","observed_orcids":["https://orcid.org/0000-0001-9308-9275"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew L. Senjem","raw_affiliation_strings":["Mayo Clinic  Rochester MN USA","Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic  Rochester MN USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005099850","display_name":"Clifford R. Jack","orcid":"https://orcid.org/0000-0001-7916-622X","observed_orcids":["https://orcid.org/0000-0001-7916-622X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clifford R. Jack","raw_affiliation_strings":["Mayo Clinic  Rochester MN USA","Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic  Rochester MN USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063489595","display_name":"David Thomas Jones","orcid":"https://orcid.org/0000-0002-4807-9833","observed_orcids":["https://orcid.org/0000-0002-4807-9833"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David T. Jones","raw_affiliation_strings":["Mayo Clinic  Rochester MN USA","Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic  Rochester MN USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5084693399"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":{"value":3150,"currency":"USD","value_usd":3150},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.17698541,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":"7S_Part_13","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.5170999765396118,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.5170999765396118,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11406","display_name":"Cerebrospinal fluid and hydrocephalus","score":0.44510000944137573,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.025499999523162842,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cerebrospinal-fluid-dynamics","display_name":"cerebrospinal fluid dynamics","score":0.7419999837875366},{"id":"https://openalex.org/keywords/alzheimer-s-disease-biomarkers","display_name":"Alzheimer's disease biomarkers","score":0.8330000042915344}],"concepts":[{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.7672882080078125},{"id":"https://openalex.org/C45664433","wikidata":"https://www.wikidata.org/wiki/Q17029420","display_name":"Imaging biomarker","level":3,"score":0.6466864347457886},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.6416171193122864},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5901678204536438},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.5815839171409607},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.5614705085754395},{"id":"https://openalex.org/C2775842073","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Positron emission tomography","level":2,"score":0.5449650287628174},{"id":"https://openalex.org/C2780062018","wikidata":"https://www.wikidata.org/wiki/Q1319792","display_name":"Striatum","level":3,"score":0.5400667190551758},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4928183853626251},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48794835805892944},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3960549235343933},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.30322742462158203},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.20945072174072266},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.11221793293952942},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.06177783012390137},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jalz.2019.06.2633","doi":"https://doi.org/10.1016/j.jalz.2019.06.2633","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jalz.2019.06.2633","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2019.06.2633","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.jalz.2019.06.2633","doi":"https://doi.org/10.1016/j.jalz.2019.06.2633","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jalz.2019.06.2633","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2019.06.2633","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7799999713897705}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2980903157.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2060257772","https://openalex.org/W2058773221","https://openalex.org/W2003001535","https://openalex.org/W2327340211","https://openalex.org/W2027542625","https://openalex.org/W4292199793","https://openalex.org/W2081363855","https://openalex.org/W2006682989","https://openalex.org/W2282195379","https://openalex.org/W1628671467"],"abstract_inverted_index":{"CSF":[0,15,30,51,70,104,116,126,139,181,210,234,296,304],"biomarkers":[1,128,236],"for":[2,129,155,233,262],"Alzheimer's":[3],"disease":[4],"(AD)":[5],"are":[6],"routinely":[7],"used":[8,111],"in":[9,19,225],"clinical":[10,21],"and":[11,29,44,142,157,162,213,242,283,302],"research":[12],"settings.":[13],"Altered":[14],"dynamics":[16,105,117],"can":[17,47],"result":[18],"the":[20,167,186,189,199],"syndrome":[22],"of":[23,50,64,68,86,102,115,151,220,292],"idiopathic":[24],"normal":[25],"pressure":[26],"hydrocephalus":[27,76],"(iNPH)":[28],"biomarker":[31,183],"changes":[32,298],"(low":[33],"Ab1-42,":[34],"low":[35,38,171,241],"pTau":[36,251],"and/or":[37],"tTau).1":[39],"Given":[40],"this":[41,108],"confound,":[42],"structural":[43,143],"metabolic":[45],"neuroimaging":[46,214],"aid":[48],"interpretation":[49],"biomarkers.":[52,305],"We":[53,146,165],"have":[54,81],"previously":[55,82],"reported":[56,83],"on":[57,89,300],"a":[58,84,98,148],"magnetic":[59],"resonance":[60],"imaging":[61,113],"(MRI)":[62],"method":[63],"detecting":[65],"one":[66],"variation":[67],"altered":[69,103],"dynamics:":[71],"disproportionately":[72],"enlarged":[73],"subarachnoid":[74],"space":[75],"(DESH).2":[77],"In":[78,107],"addition,":[79],"we":[80,110,184],"pattern":[85],"striatal":[87],"hypometabolism":[88,294],"Fluorodeoxyglucose":[90],"(FDG)-positron":[91],"emission":[92],"tomography":[93],"(PET)":[94],"being":[95,196],"associated":[96,124],"with":[97,125,195,279,295],"clinically":[99],"symptomatic":[100],"variant":[101],"(iNPH).3":[106],"study,":[109],"these":[112],"markers":[114],"disorders":[118],"to":[119,169,175],"see":[120],"if":[121],"they":[122],"were":[123,132,193,237,260],"derived":[127],"AD.":[130],"There":[131],"827":[133],"ADNI-GO/2":[134],"participants":[135],"who":[136],"had":[137],"FDG-PET,":[138],"AD":[140,182,211,235],"biomarkers,":[141],"MRI":[144,264,280,301],"studies.":[145],"fitted":[147],"linear":[149],"model":[150],"striatum":[152,172,177,244,273,293],"metabolism":[153,161,245,274],"corrected":[154],"age":[156],"Jagust":[158],"ROI":[159],"FDG":[160],"calculated":[163],"residuals.":[164,178],"dichotomized":[166],"data":[168],"evaluate":[170],"residuals":[173],"compared":[174],"high":[176,243],"For":[179],"each":[180],"tested":[185],"hypothesis":[187],"that":[188],"group-wise":[190],"cumulative":[191,229],"distribution":[192,202],"consistent":[194,303],"drawn":[197],"from":[198],"same":[200],"parent":[201],"using":[203],"an":[204,290],"empirical":[205],"Kolmogorov-Smirnov":[206],"test.":[207],"Baseline":[208],"demographics,":[209],"biomarker,":[212],"values":[215],"divided":[216],"by":[217],"diagnostic":[218],"group":[219],"our":[221],"cohort,":[222],"is":[223,287],"shown":[224,288],"Table":[226],"1.":[227],"The":[228],"distributions":[230],"(Figure":[231,281,285],"1)":[232],"significantly":[238],"different":[239,271],"between":[240,272],"groups":[246],"(Ab1-42":[247],"p":[248,252],"<":[249,253,256],"0.01,":[250],"0.001,":[254],"tTau":[255],"0.001).":[257],"Similar":[258],"results":[259],"found":[261],"DESH":[263],"groups.":[265,275],"Amyloid":[266],"PET":[267],"was":[268],"not":[269],"statistically":[270],"An":[276],"ADNI":[277],"participant":[278],"2A)":[282],"FDG-PET":[284],"2B)":[286],"as":[289],"exemplar":[291],"dynamic":[297],"evident":[299]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2025-10-10T00:00:00"}
