{"id":"https://openalex.org/W2980833408","doi":null,"title":"On secondary prevention after acute coronary syndrome : -what, when, and who","display_name":"On secondary prevention after acute coronary syndrome : -what, when, and who","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W2980833408","mag":"2980833408"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:umu-158414","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-158414","pdf_url":null,"source":{"id":"https://openalex.org/S4306400361","display_name":"DiVA at Ume\u00e5 University (Ume\u00e5 University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I90267481","host_organization_name":"Ume\u00e5 University","host_organization_lineage":["https://openalex.org/I90267481"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-158414","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030784328","display_name":"Daniel Huber","orcid":"https://orcid.org/0000-0002-9817-5436","observed_orcids":["https://orcid.org/0000-0002-9817-5436","https://orcid.org/0000-0002-4938-3191"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Daniel Huber","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9817-5436","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5030784328"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11083","display_name":"Cardiac Health and Mental Health","score":0.7929999828338623,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11083","display_name":"Cardiac Health and Mental Health","score":0.7929999828338623,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14212","display_name":"Health Promotion and Cardiovascular Prevention","score":0.05270000174641609,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.04670000076293945,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/secondary-prevention","display_name":"secondary prevention","score":0.6759999990463257},{"id":"https://openalex.org/keywords/acute-coronary-syndrome","display_name":"acute coronary syndrome","score":1.0},{"id":"https://openalex.org/keywords/nurse-led-telephone-follow-up","display_name":"nurse-led telephone follow-up","score":0.9020000100135803},{"id":"https://openalex.org/keywords/risk-factor-management","display_name":"risk factor control","score":0.7649999856948853},{"id":"https://openalex.org/keywords/ldl-cholesterol-targets","display_name":"LDL cholesterol targets","score":0.7329999804496765},{"id":"https://openalex.org/keywords/blood-pressure-control","display_name":"blood pressure control","score":0.7870000004768372},{"id":"https://openalex.org/keywords/statin-adherence","display_name":"statin adherence","score":0.9959999918937683},{"id":"https://openalex.org/keywords/guideline-changes","display_name":"guideline changes","score":0.5149999856948853},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.6060000061988831},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.47099998593330383},{"id":"https://openalex.org/keywords/feasibility","display_name":"feasibility","score":0.578000009059906},{"id":"https://openalex.org/keywords/cardiovascular-disease-prevention","display_name":"cardiovascular disease prevention","score":0.42800000309944153},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.46799999475479126}],"concepts":[{"id":"https://openalex.org/C2777698277","wikidata":"https://www.wikidata.org/wiki/Q266018","display_name":"Acute coronary syndrome","level":3,"score":0.7474780678749084},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6112147569656372},{"id":"https://openalex.org/C3019417119","wikidata":"https://www.wikidata.org/wiki/Q1773974","display_name":"Secondary prevention","level":2,"score":0.4617678225040436},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.40791234374046326},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.37932834029197693},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.33361685276031494},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30580949783325195}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:umu-158414","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-158414","pdf_url":null,"source":{"id":"https://openalex.org/S4306400361","display_name":"DiVA at Ume\u00e5 University (Ume\u00e5 University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I90267481","host_organization_name":"Ume\u00e5 University","host_organization_lineage":["https://openalex.org/I90267481"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2980833408","doi":null,"is_oa":false,"landing_page_url":"http://umu.diva-portal.org/smash/record.jsf?pid=diva2:1307465","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:umu-158414","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-158414","pdf_url":null,"source":{"id":"https://openalex.org/S4306400361","display_name":"DiVA at Ume\u00e5 University (Ume\u00e5 University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I90267481","host_organization_name":"Ume\u00e5 University","host_organization_lineage":["https://openalex.org/I90267481"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":79,"referenced_works":["https://openalex.org/W60172896","https://openalex.org/W75245760","https://openalex.org/W1547375638","https://openalex.org/W1574781164","https://openalex.org/W1948458971","https://openalex.org/W1971732155","https://openalex.org/W1974005985","https://openalex.org/W1984207232","https://openalex.org/W2006572302","https://openalex.org/W2007015745","https://openalex.org/W2014892421","https://openalex.org/W2015856491","https://openalex.org/W2017509671","https://openalex.org/W2018687700","https://openalex.org/W2020362859","https://openalex.org/W2021073002","https://openalex.org/W2033896075","https://openalex.org/W2034072139","https://openalex.org/W2036245473","https://openalex.org/W2042873619","https://openalex.org/W2054049174","https://openalex.org/W2054796764","https://openalex.org/W2055540109","https://openalex.org/W2057349862","https://openalex.org/W2059196353","https://openalex.org/W2066534456","https://openalex.org/W2074208872","https://openalex.org/W2079134517","https://openalex.org/W2084219024","https://openalex.org/W2088303275","https://openalex.org/W2098466362","https://openalex.org/W2099869131","https://openalex.org/W2103881469","https://openalex.org/W2110052313","https://openalex.org/W2110688030","https://openalex.org/W2115593266","https://openalex.org/W2124338273","https://openalex.org/W2129124334","https://openalex.org/W2134453898","https://openalex.org/W2136145230","https://openalex.org/W2142264046","https://openalex.org/W2143515747","https://openalex.org/W2145689683","https://openalex.org/W2146510843","https://openalex.org/W2148092884","https://openalex.org/W2151739272","https://openalex.org/W2155121555","https://openalex.org/W2155441883","https://openalex.org/W2157629272","https://openalex.org/W2160176359","https://openalex.org/W2161072078","https://openalex.org/W2163207768","https://openalex.org/W2164089346","https://openalex.org/W2168630917","https://openalex.org/W2169252817","https://openalex.org/W2173353222","https://openalex.org/W2181082857","https://openalex.org/W2200285648","https://openalex.org/W2261871796","https://openalex.org/W2286757005","https://openalex.org/W2296138026","https://openalex.org/W2388471644","https://openalex.org/W2416225000","https://openalex.org/W2605597981","https://openalex.org/W2610498431","https://openalex.org/W2736016519","https://openalex.org/W2748800769","https://openalex.org/W2768902046","https://openalex.org/W2777347887","https://openalex.org/W2783807653","https://openalex.org/W2801534920","https://openalex.org/W2802528260","https://openalex.org/W2809720281","https://openalex.org/W2888938001","https://openalex.org/W2916912835","https://openalex.org/W2919797997","https://openalex.org/W3021659692","https://openalex.org/W3021842026","https://openalex.org/W3150595609"],"related_works":["https://openalex.org/W2751518012","https://openalex.org/W2036245473","https://openalex.org/W2981830427","https://openalex.org/W2257082662","https://openalex.org/W4393174202","https://openalex.org/W2807863348","https://openalex.org/W3198568061","https://openalex.org/W4405971585","https://openalex.org/W2752584751","https://openalex.org/W2410256732"],"abstract_inverted_index":{"Background":[0],"Cardiovascular":[1],"disease,":[2],"of":[3,16,23,43,53,89,112,180,299,307,367,390,399,425,429,433,493,517,532,560,624,635,764,788,884,917,940],"which":[4,213],"coronary":[5,102],"heart":[6],"disease":[7,55,845],"constitutes":[8],"the":[9,13,24,39,87,110,113,128,160,173,308,353,360,368,395,404,416,451,462,467,513,518,522,533,546,563,570,590,603,613,620,625,629,636,653,677,688,692,709,730,742,758,771,777,793,802,808,841,851,877,901],"lion\u2019s":[10],"share,":[11],"is":[12,72,927],"leading":[14],"cause":[15],"premature":[17],"morbidity":[18],"and":[19,32,50,145,198,277,297,301,324,347,351,372,388,392,406,431,439,457,476,490,499,551,639,662,673,697,705,713,722,750,774,846,870,895,935],"mortality":[20,33],"worldwide.":[21],"Management":[22],"condition":[25],"has":[26,34,189],"evolved":[27],"rapidly":[28],"in":[29,38,65,96,120,310,317,332,376,415,450,472,508,521,562,589,602,612,676,687,708,729,757,770,776,807,821,840,850,876,900,932],"recent":[30],"decades,":[31],"more":[35,77,131,485,928],"than":[36,133],"halved":[37],"western":[40],"world.":[41],"Because":[42],"intense":[44],"research,":[45],"solid":[46],"evidence":[47],"supports":[48],"effective":[49,78,132],"inexpensive":[51],"means":[52],"preventing":[54],"progression.":[56],"However,":[57],"secondary":[58,93,910],"prevention":[59,911],"still":[60],"yields":[61],"disappointingly":[62],"low":[63],"success":[64],"meeting":[66],"guideline-recommended":[67],"risk":[68,79,138,864,883,942],"factor":[69,80,139,943],"targets.":[70],"It":[71],"therefore":[73],"vital":[74],"to":[75,85,108,115,117,125,157,165,177,237,251,338,410,496,530,543,600,633,671,703,737,766,782,805,923,930,937],"develop":[76],"management.":[81],"Aims":[82],"We":[83,122,383],"aimed":[84,124,156],"assess":[86],"feasibility":[88],"a":[90,118,238,244,312,330,437,440,504,785,816,826,856,872,914],"nurse-led,":[91],"telephone-based,":[92],"preventive":[94,263],"intervention":[95,114,129,161,309,346,369,405,523,564,591,614,626,647,654,689,731,759,772,794,842,878,902],"an":[97,220,892,918],"unselected":[98],"population":[99],"with":[100,233,241,319,321,401,420,427,448,484,510,829,859],"acute":[101],"syndrome":[103],"(ACS).":[104],"Furthermore,":[105],"we":[106,155],"sought":[107],"evaluate":[109,126],"flexibility":[111],"adapt":[116],"change":[119,314,331],"guidelines.":[121],"also":[123,502],"whether":[127,159],"was":[130,219,270,288,315,413,566,574,579,608,642,718,746,819,837],"usual":[134,924],"care":[135],"at":[136,272,283,421,584,798],"improving":[137],"levels":[140,342,389],"for":[141,254,262,282,357,435,558,569,595,617,650,659,664,681,694,699,815,834,862,865,871,881,896,909],"blood":[142],"pressure":[143],"(BP)":[144],"low-density":[146],"lipoprotein":[147],"cholesterol":[148],"(LDL-C)":[149],"12":[150,280,397,684,740],"months":[151,281,398,424],"after":[152,182,193,200,275,329,352,540,667,733],"discharge.":[153],"Finally,":[154],"measure":[158],"improved":[162,948],"long-term":[163],"adherence":[164,765],"statins.":[166],"Methods":[167],"All":[168,203,248],"papers":[169],"are":[170,205],"based":[171,206],"on":[172,207,370],"Nurse-based":[174],"Age-independent":[175],"Intervention":[176],"Limit":[178],"Evolution":[179],"Disease":[181],"ACS":[183,201,255,323,449,920],"(NAILED-ACS)":[184],"trial.":[185],"The":[186,217,305,365,555,812,831],"NAILED":[187],"trail":[188],"two":[190],"arms,":[191],"one":[192,199],"stroke/transient":[194],"ischemic":[195],"attack":[196],"(NAILED-Stroke)":[197],"(NAILED-ACS).":[202],"studies":[204],"NAILED-ACS":[208],"aside":[209],"from":[210,335],"study":[211,418],"II":[212],"includes":[214],"both":[215,322,436,822],"arms.":[216],"trial":[218,227],"open,":[221],"1:1":[222],"randomized,":[223],"controlled,":[224],"parallel":[225],"group":[226,240,524,565,592,615,627,679,690,711,732,773,779,810,843,853],"that":[228,575],"compared":[229,344,495,529,599,632,670,702,736,804],"nurse-led":[230,906],"telephone":[231],"follow-up":[232,242,787],"medical":[234,582],"titration":[235,669,735],"(intervention)":[236],"control":[239,348,407,535,571,604,637,678,710,778,809,852],"by":[243,265],"general":[245],"practitioner":[246],"(control).":[247],"patients":[249,291,318,349,377,447,480,501,520,536,648],"admitted":[250,292,378],"\u00d6stersund":[252],"Hospital":[253],"during":[256,394,784,801],"2010\u20132014":[257],"were":[258,303,343,363,374,455,465,470,481,549,780,867,886],"eligible":[259],"if":[260],"available":[261],"management":[264],"telephone.":[266],"A":[267,905],"baseline":[268,668],"assessment":[269,763],"made":[271],"1":[273,585],"month":[274,586],"discharge":[276],"thereafter":[278],"every":[279],"least":[284,422,799],"3":[285],"years.":[286],"Feasibility":[287],"assessed":[289],"among":[290,646],"until":[293,379],"31":[294,380],"January":[295],"2013,":[296],"predictors":[298,434],"exclusion":[300],"non-participation":[302],"identified.":[304],"performance":[306],"implementing":[311],"guideline":[313,354,514],"evaluated":[316],"diabetes":[320],"stroke":[325],"as":[326,891,945,947],"inclusion":[327,875,899],"events":[328],"LDLC":[333],"target":[334,361,541,561,594,631,693],"<2.5":[336,527],"mmol/L":[337,528,610,644],"<1.8":[339,544],"mmol/L.":[340],"LDL-C":[341,373,391,526,596,607,630,641],"between":[345,403],"before":[350],"changed.":[355],"Reasons":[356],"not":[358],"reaching":[359,386],"level":[362,492],"recorded.":[364],"outcomes":[366],"BP":[371,393,661,666,696,717,725,745,753],"studied":[375],"December":[381],"2013.":[382],"measured":[384,414],"proportions":[385,548],"targets":[387,658,944],"first":[396,438,452,817,873],"follow-up,":[400,426],"comparisons":[402],"groups.":[408],"Adherence":[409],"statin":[411,767],"treatment":[412,783,933],"entire":[417],"cohort,":[419],"36":[423],"classification":[428],"reasons":[430,469],"analysis":[432],"permanent":[441,835,897],"discontinuation.":[442],"Results":[443],"Of":[444],"907":[445],"screened":[446],"study,":[453],"72.9%":[454],"included,":[456],"11%":[458],"declined":[459],"participation.":[460],"Among":[461],"16.1%":[463],"who":[464],"excluded,":[466],"predominant":[468,556],"participation":[471],"other":[473],"trial,":[474],"dementia,":[475],"advanced":[477],"disease.":[478],"Non-included":[479],"significantly":[482],"older,":[483],"comorbidities,":[486],"decreased":[487],"functional":[488],"capability,":[489],"lower":[491,611,645,721,728,749,756],"education":[494],"included.":[497,511],"Excluded":[498],"declining":[500],"had":[503],"reduced":[505,882],"oneyear":[506],"survival":[507],"comparison":[509],"Before":[512],"changed,":[515],"96%":[516],"101":[519],"reached":[525,691],"70%":[531],"100":[534],"(p<0.001).":[537,554,791],"One":[538],"year":[539],"reduction":[542],"mmol/L,":[545],"same":[547],"65%":[550],"36%,":[552],"respectively":[553],"reason":[557,814,833],"nonattainment":[559],"full-dose":[567],"treatment;":[568],"group,":[572,638,655,795],"it":[573,926],"no":[576],"medication":[577,949],"adjustment":[578],"made.":[580],"After":[581],"titration,":[583],"(baseline),":[587],"94.1%":[588],"achieved":[593,657],"(<2.5":[597],"mmol/L)":[598],"68.4%":[601],"group.":[605,760,879,903],"Mean":[606,715],"0.38":[609],"(p<0.05":[616,649,680],"both).":[618,651,682],"At":[619,683,739],"12-month":[621],"assessment,":[622],"77.7%":[623],"attained":[628],"63.2%":[634],"mean":[640,723,743,751,786],"0.3":[643],"In":[652,761,792],"91.9%":[656],"systolic":[660,695,716,744],"96.2%":[663],"diastolic":[665,700,724,752],"65.6%":[672],"82.0%,":[674],"respectively,":[675,707],"months,":[685,741],"68.9%":[686],"88.1%":[698],"BP,":[701],"63.7%":[704],"82.8%,":[706],"(p=0.125":[712],"<0.05).":[714],"7":[719],"mmHg":[720,727,748,755],"4":[726],"1-month":[734],"controls.":[738],"1.5":[747],"2.1":[754],"our":[762],"treatment,":[768],"89.3%":[769],"81.7%":[775],"adherent":[781],"3.9":[789],"years":[790],"27.8%":[796],"discontinued":[797],"once":[800],"period,":[803],"20.8%":[806],"(p<0.05).":[811],"main":[813,832],"discontinuation":[818,836,866],"avoidable":[820,849],"groups:":[823],"sideeffects":[824],"without":[825,855],"compelling":[827,857],"association":[828,858],"treatment.":[830],"predominantly":[838],"non-avoidable":[839],"(advanced":[844],"dementia)":[847],"but":[848],"(sideeffects":[854],"treatment).":[860],"Predictors":[861,880],"increased":[863],"female":[868],"sex,":[869],"event,":[874,894],"non-adherence":[885],"ST":[887],"elevation":[888],"myocardial":[889],"infarction":[890],"including":[893],"discontinuation,":[898],"Conclusion":[904],"telephone-based":[907],"method":[908],"can":[912],"encompass":[913],"large":[915],"proportion":[916],"ordinary":[919],"cohort.":[921],"Compared":[922],"care,":[925],"adaptable":[929],"changes":[931],"guidelines":[934],"leads":[936],"better":[938],"achievement":[939],"major":[941],"well":[946],"adherence.":[950]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2019-10-25T00:00:00"}
