{"id":"https://openalex.org/W2980809212","doi":"https://doi.org/10.1182/blood-2018-99-118600","title":"The Clinical Utility of Pharmacogenomics Testing in Assessing Tyrosine Kinase Inhibitor Therapy, Intolerance and Responses in Patients with Chronic Myelogenous Leukemia","display_name":"The Clinical Utility of Pharmacogenomics Testing in Assessing Tyrosine Kinase Inhibitor Therapy, Intolerance and Responses in Patients with Chronic Myelogenous Leukemia","publication_year":2018,"publication_date":"2018-11-29","ids":{"openalex":"https://openalex.org/W2980809212","doi":"https://doi.org/10.1182/blood-2018-99-118600","mag":"2980809212"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2018-99-118600","doi":"https://doi.org/10.1182/blood-2018-99-118600","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2018-99-118600","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032947311","display_name":"Darci Zblewski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Darci Zblewski","raw_affiliation_strings":["Division of Hematology, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002643270","display_name":"Naseema Gangat","orcid":"https://orcid.org/0000-0002-9104-6172","observed_orcids":["https://orcid.org/0000-0002-9104-6172"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Naseema Gangat","raw_affiliation_strings":["Division of Hematology, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064374340","display_name":"Michelle Ann Elliott","orcid":"https://orcid.org/0000-0002-7366-9886","observed_orcids":["https://orcid.org/0000-0002-7366-9886"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle A. Elliott","raw_affiliation_strings":["Division of Hematology, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008422091","display_name":"Aref Al\u2010Kali","orcid":"https://orcid.org/0000-0002-0824-3715","observed_orcids":["https://orcid.org/0000-0002-0824-3715"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aref Al-Kali","raw_affiliation_strings":["Division of Hematology, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085360755","display_name":"Mark Robert Litzow","orcid":"https://orcid.org/0000-0002-9816-6302","observed_orcids":["https://orcid.org/0000-0002-9816-6302"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark R. Litzow","raw_affiliation_strings":["Division of Hematology, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013866554","display_name":"C. Christopher Hook","orcid":"https://orcid.org/0000-0002-3971-6183","observed_orcids":["https://orcid.org/0000-0002-3971-6183"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Christopher Hook","raw_affiliation_strings":["Division of Hematology, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042508394","display_name":"Tyler Mielke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Tyler Mielke","raw_affiliation_strings":["Center for Individualized Medicine, Departments of Internal and Laboratory Medicine, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Individualized Medicine, Departments of Internal and Laboratory Medicine, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014945673","display_name":"Alexandra P. Wolanskyj","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alexandra Wolanskyj","raw_affiliation_strings":["Division of Hematology, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084606047","display_name":"William J. Hogan","orcid":"https://orcid.org/0000-0002-5841-4105","observed_orcids":["https://orcid.org/0000-0002-5841-4105"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Willam Hogan","raw_affiliation_strings":["Division of Hematology, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024612499","display_name":"Animesh Dev Pardanani","orcid":"https://orcid.org/0000-0002-9084-4148","observed_orcids":["https://orcid.org/0000-0002-9084-4148"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Animesh Pardanani","raw_affiliation_strings":["Division of Hematology, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020872528","display_name":"Mithun Vinod Shah","orcid":"https://orcid.org/0000-0002-5359-336X","observed_orcids":["https://orcid.org/0000-0002-5359-336X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mithun Vinod Shah","raw_affiliation_strings":["Division of Hematology, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064856519","display_name":"Hassan B. Alkhateeb","orcid":"https://orcid.org/0000-0002-3609-8404","observed_orcids":["https://orcid.org/0000-0002-3609-8404"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hassan B. Alkhateeb","raw_affiliation_strings":["Division of Hematology, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063934598","display_name":"Lindsey Ann Kluck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lindsey Ann Kluck","raw_affiliation_strings":["Division of Hematology, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023760244","display_name":"Adrienne N. Nedved","orcid":"https://orcid.org/0009-0005-5667-4543","observed_orcids":["https://orcid.org/0009-0005-5667-4543"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Adrienne Nedved","raw_affiliation_strings":["Division of Pharmacology, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pharmacology, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076034488","display_name":"Kristen Beth McCullough","orcid":"https://orcid.org/0000-0003-4252-2619","observed_orcids":["https://orcid.org/0000-0003-4252-2619"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kristen McCullough","raw_affiliation_strings":["Division of Pharmacology, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pharmacology, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047262255","display_name":"Matthew D. Smith","orcid":"https://orcid.org/0000-0001-6614-569X","observed_orcids":["https://orcid.org/0000-0001-6614-569X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Matthew Smith","raw_affiliation_strings":["Division of Pharmacology, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pharmacology, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025982995","display_name":"Tammy M. McAllister","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Tammy McAllister","raw_affiliation_strings":["Center for Individualized Medicine, Departments of Internal and Laboratory Medicine, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Individualized Medicine, Departments of Internal and Laboratory Medicine, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080744006","display_name":"Konstantinos Lazaridis","orcid":"https://orcid.org/0000-0003-4386-2578","observed_orcids":["https://orcid.org/0000-0003-4386-2578"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Konstantinos Lazaridis","raw_affiliation_strings":["Center for Individualized Medicine, Departments of Internal and Laboratory Medicine, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Individualized Medicine, Departments of Internal and Laboratory Medicine, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103917786","display_name":"A. Keith Stewart","orcid":"https://orcid.org/0009-0000-7276-8631","observed_orcids":["https://orcid.org/0009-0000-7276-8631"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Keith Stewart","raw_affiliation_strings":["Center for Individualized Medicine, Departments of Internal and Laboratory Medicine, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Individualized Medicine, Departments of Internal and Laboratory Medicine, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072463255","display_name":"Mrinal M. Patnaik","orcid":"https://orcid.org/0000-0001-6998-662X","observed_orcids":["https://orcid.org/0000-0001-6998-662X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mrinal M. Patnaik","raw_affiliation_strings":["Division of Hematology, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5014945673","https://openalex.org/A5020872528","https://openalex.org/A5023760244","https://openalex.org/A5025982995","https://openalex.org/A5032947311","https://openalex.org/A5042508394","https://openalex.org/A5047262255","https://openalex.org/A5064856519","https://openalex.org/A5076034488","https://openalex.org/A5080744006"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"132","issue":"Supplement 1","first_page":"5440","last_page":"5440"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.774399995803833,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.774399995803833,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.21070000529289246,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-myeloid-leukemia","display_name":"chronic myeloid leukemia","score":0.9900000095367432},{"id":"https://openalex.org/keywords/pharmacogenetic-testing","display_name":"pharmacogenetic testing","score":0.8299999833106995},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.9909999966621399},{"id":"https://openalex.org/keywords/imatinib","display_name":"imatinib","score":0.9509999752044678},{"id":"https://openalex.org/keywords/dasatinib","display_name":"dasatinib","score":0.9679999947547913},{"id":"https://openalex.org/keywords/nilotinib","display_name":"nilotinib","score":0.9629999995231628},{"id":"https://openalex.org/keywords/bosutinib","display_name":"bosutinib","score":0.8130000233650208},{"id":"https://openalex.org/keywords/ponatinib","display_name":"ponatinib","score":0.9900000095367432},{"id":"https://openalex.org/keywords/drug-intolerance","display_name":"drug intolerance","score":0.7950000166893005},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.5809999704360962},{"id":"https://openalex.org/keywords/cyp3a4-5","display_name":"CYP3A4/5","score":0.7490000128746033},{"id":"https://openalex.org/keywords/cyp2c9","display_name":"CYP2C9","score":0.7929999828338623},{"id":"https://openalex.org/keywords/cyp2c19","display_name":"CYP2C19","score":0.9319999814033508},{"id":"https://openalex.org/keywords/cyp2d6","display_name":"CYP2D6","score":0.8980000019073486},{"id":"https://openalex.org/keywords/ugt1a1","display_name":"UGT1A1","score":0.9810000061988831},{"id":"https://openalex.org/keywords/p-glycoprotein","display_name":"P-glycoprotein","score":0.7599999904632568},{"id":"https://openalex.org/keywords/bcr-abl1","display_name":"BCR-ABL1","score":0.6769999861717224},{"id":"https://openalex.org/keywords/treatment-selection","display_name":"treatment selection","score":0.36800000071525574},{"id":"https://openalex.org/keywords/drug-metabolism-polymorphisms","display_name":"drug metabolism polymorphisms","score":0.4440000057220459}],"concepts":[{"id":"https://openalex.org/C2777413986","wikidata":"https://www.wikidata.org/wiki/Q412327","display_name":"Nilotinib","level":4,"score":0.9095876216888428},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8664911985397339},{"id":"https://openalex.org/C2778208673","wikidata":"https://www.wikidata.org/wiki/Q894611","display_name":"Bosutinib","level":5,"score":0.8631880283355713},{"id":"https://openalex.org/C2779536868","wikidata":"https://www.wikidata.org/wiki/Q419940","display_name":"Dasatinib","level":4,"score":0.8475514650344849},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6348522305488586},{"id":"https://openalex.org/C170734499","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenomics","level":2,"score":0.6045901775360107},{"id":"https://openalex.org/C2780381907","wikidata":"https://www.wikidata.org/wiki/Q198728","display_name":"Ponatinib","level":5,"score":0.5924545526504517},{"id":"https://openalex.org/C2778820342","wikidata":"https://www.wikidata.org/wiki/Q906415","display_name":"Tyrosine-kinase inhibitor","level":3,"score":0.5827941298484802},{"id":"https://openalex.org/C2777583451","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib","level":3,"score":0.5477913022041321},{"id":"https://openalex.org/C2776960273","wikidata":"https://www.wikidata.org/wiki/Q729735","display_name":"Chronic myelogenous leukemia","level":3,"score":0.5417786836624146},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.48563066124916077},{"id":"https://openalex.org/C3019892230","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib mesylate","level":4,"score":0.48257842659950256},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.43425557017326355},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.33872663974761963},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2922119200229645},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.203997403383255}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood-2018-99-118600","doi":"https://doi.org/10.1182/blood-2018-99-118600","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2018-99-118600","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3176610232","https://openalex.org/W2551175296","https://openalex.org/W2142609621","https://openalex.org/W4310161355","https://openalex.org/W2987085572","https://openalex.org/W3031135913","https://openalex.org/W4362667376","https://openalex.org/W4385667213","https://openalex.org/W2402397817","https://openalex.org/W2791310037"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"Chronic":[2],"myelogenous":[3],"leukemia":[4],"(CML)":[5],"is":[6,67,70,82],"a":[7,105,457,486,503,576],"BCR-ABL1":[8],"driven":[9],"myeloid":[10],"neoplasm,":[11],"with":[12,85,128,161,210,276,349,390,430,471,498,515,596],"excellent":[13],"response":[14],"rates":[15],"to":[16,62,109,143,176,201,282,511,526],"tyrosine":[17],"kinase":[18],"inhibitors":[19],"(TKI).":[20],"TKI":[21,54,63,114,163,183,382,550,585],"such":[22,92],"as":[23,93,456,502],"imatinib":[24],"(IM),":[25],"dasatinib":[26],"(DAS),":[27],"nilotinib":[28],"(NIL),":[29],"bosutinib":[30],"(BOS),":[31],"and":[32,53,117,172,232,257,265,296,302,304,308,327,341,353,367,388,393,414,420,469,473,507,542,563,594],"ponatinib":[33],"(PON)":[34],"currently":[35,573,601],"US":[36],"FDA":[37],"approved,":[38],"have":[39,512],"dramatically":[40],"changed":[41],"survival":[42],"outcomes.":[43],"That":[44],"being":[45,278,351,355,396],"said,":[46],"two":[47,398],"main":[48],"challenges":[49],"exist;":[50],"suboptimal":[51,118,166],"responses":[52,119,167],"intolerance.":[55],"The":[56,77],"reason":[57],"why":[58],"some":[59],"patients":[60,127,157,209,271,317,378,429,483,592],"tolerate/respond":[61],"better":[64],"than":[65],"others":[66,152],"unknown,":[68],"but":[69],"potentially":[71],"explainable":[72],"based":[73,372,529],"on":[74,373,530,559],"drug":[75,598],"metabolism.":[76],"field":[78],"of":[79,113,156,190,269,425,481,490,549,590],"pharmacogenomics":[80],"(PGX)":[81],"rapidly":[83,88,540],"evolving,":[84],"commercial":[86],"panel's":[87],"assessing":[89],"metabolic":[90,250,561],"pathways":[91,251,261,275],"cytochrome":[94],"P450":[95],"(CYP),":[96],"UGTA1A,":[97],"p-glycoprotein/ABCB1.":[98],"We":[99],"carried":[100],"out":[101],"this":[102],"study":[103],"using":[104],"22":[106],"gene-PGX":[107],"panel":[108],"assess":[110,144,177],"potential":[111],"causes":[112],"related":[115],"intolerance":[116,184,324,387,586],"in":[120,192,204,339,461,495,546,570],"compliant":[121],"patients.":[122],"Methods:":[123],"Twenty-nine":[124],"Mayo":[125],"Clinic":[126],"CML":[129,211],"were":[130,138,158,212,236,287,294,306,371,412,418,476,524],"prospectively":[131,213],"recruited":[132],"after":[133],"informed":[134],"consent.":[135],"Buccal":[136],"swabs":[137],"utilized":[139],"for":[140,253,290,300,311,386,403,415,552],"PGX":[141,179,318,360,374,443,531,537],"testing":[142,180,319,361,444,538],"variations/polymorphisms":[145],"involving":[146],"CYP3A4/5,":[147],"1A2,":[148],"2C9,":[149],"UGT1A1,":[150],"amongst":[151],"(www.Oneome.com).":[153],"Three":[154],"groups":[155],"recruited,":[159],"those":[160],"i)":[162],"intolerance,":[164,472],"ii)":[165],"by":[168,575],"ELN":[169],"criteria,":[170],"iii)":[171],"newly":[173,193],"diagnosed":[174,194],"cases,":[175,521],"if":[178],"could":[181],"explain":[182,323,365,448,584],"or":[185,187,325,449,587],"resistance,":[186],"alter":[188,450],"choice":[189],"therapy":[191,383,551],"cases.":[195,206],"A":[196],"pharmacology":[197],"review":[198],"was":[199,337,346,454,493],"obtained":[200],"interpret":[202],"reports":[203],"all":[205,314,474,520],"Results:":[207],"29":[208],"enrolled,":[214],"median":[215],"age":[216],"64":[217],"years,":[218],"15":[219],"(52%)":[220],"male.":[221],"At":[222],"last":[223],"follow":[224],"up":[225],"(median":[226],"21":[227],"months),":[228],"3":[229,462],"(10%)":[230],"deaths":[231],"no":[233,368,516,522],"disease":[234,514],"progressions":[235],"documented.":[237],"82%":[238],"received":[239,245,379],"first":[240,246],"line":[241,247,335,381,441,459,505],"IM,":[242],"whereas":[243,292],"18%":[244,340],"DAS.":[248],"Major":[249],"assessed":[252,345],"IM":[254,270,315],"included,":[255],"CYP3A4":[256,478,500],"5,":[258],"while":[259,410,536,554],"minor":[260,284,560],"included":[262],"2C19,":[263,291],"2C9":[264,301],"2D6.":[266,312],"Majority":[267],"(83%)":[268],"had":[272,406],"normal":[273,352,407,419,477],"major":[274,343],"17%":[277],"intermediate-normal.":[279],"With":[280],"regards":[281],"the":[283,342,397,439,508,547],"pathways,":[285],"25%":[286],"rapid":[288],"metabolizers":[289,299,310],"29%":[293],"intermediate":[295,307,356,413,499],"4%":[297],"poor":[298,309],"50%":[303],"16%":[305],"In":[313,438,519,534],"treated":[316,428],"did":[320,328,362,445,581],"not":[321,329,363,446,582],"completely":[322,364,447,583],"resistance":[326],"change":[330],"clinical":[331],"decision":[332],"making.":[333],"Front":[334],"DAS":[336,391],"used":[338,455,494],"pathway":[344],"CYP":[347],"3A4,":[348],"80%":[350,417],"20%":[354,421],"metabolizers.":[357,479],"Once":[358,401],"again":[359,402],"intolerance/resistance":[366],"therapeutic":[369],"changes":[370,523],"analysis.":[375],"Seventeen":[376],"(59%)":[377],"second":[380,440],"(50%":[384],"each":[385],"resistance),":[389],"(58%)":[392],"NIL":[394,416,427,567],"(29%),":[395],"most":[399],"common.":[400],"DAS,":[404],"90%":[405],"3A4":[408],"metabolism":[409,501],"10%":[411],"intermediate.":[422],"Only":[423],"one":[424,470,496],"2":[426,465],"UGTA1A":[431],"polymorphisms":[432],"developed":[433,484],"indirect":[434],"hyperbilirubinemia":[435],"(grade":[436],"1).":[437],"setting,":[442],"treatment":[451],"decisions.":[452],"BOS":[453],"third":[458],"agent":[460,506],"(>10%)":[463],"patients,":[464],"who":[466],"remained":[467],"refractory":[468,513],"three":[475],"None":[480],"these":[482],"diarrhea":[485],"common":[487],"side":[488,564],"effect":[489],"BOS.":[491],"PON":[492],"patient":[497,509],"5th":[504],"continues":[510],"thrombotic":[517],"events.":[518],"made":[525],"concomitant":[527],"medications":[528],"testing.":[532],"Conclusion:":[533],"conclusion,":[535],"has":[539],"evolved":[541],"become":[543],"commercially":[544],"available,":[545],"context":[548],"CML,":[553],"it":[555,580],"offers":[556],"useful":[557],"insights":[558],"derangements":[562],"effects":[565],"like":[566],"induced":[568],"hyperbilirubinemia,":[569],"our":[571],"study,":[572],"limited":[574],"small":[577],"sample":[578],"size,":[579],"resistance.":[588],"Recruitment":[589],"additional":[591],"(n=100)":[593],"correlations":[595],"plasma":[597],"levels":[599],"are":[600],"ongoing.":[602],"Table.":[603,604],"Disclosures":[605],"Al-Kali:":[606],"Novartis:":[607],"Research":[608,616],"Funding.":[609],"Stewart:Amgen":[610],"Inc.,":[611,619],"Celgene,":[612,621],"Roche,":[613,623],"Seattle":[614,624],"Genetics:":[615],"Funding;":[617],"Amgen":[618],"BMS,":[620],"Takeda,":[622],"Genetics,":[625],"Janssen,":[626],"Ono:":[627],"Consultancy.":[628]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2019-10-25T00:00:00"}
