{"id":"https://openalex.org/W2980760737","doi":null,"title":"Mitochondria, reactive oxygen species and apoptosis","display_name":"Mitochondria, reactive oxygen species and apoptosis","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W2980760737","mag":"2980760737"},"language":"en","primary_location":{"id":"mag:2980760737","doi":null,"is_oa":false,"landing_page_url":"http://europepmc.org/abstract/CBA/347703","pdf_url":null,"source":{"id":"https://openalex.org/S62847986","display_name":"PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS","issn_l":"1000-3282","issn":["1000-3282"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-4","vabb-shw"],"host_organization":"https://openalex.org/P4310319982","host_organization_name":"Science Press","host_organization_lineage":["https://openalex.org/P4310319982"],"host_organization_lineage_names":["Science Press"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102033973","display_name":"Yungang Zhao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yungang Zhao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5100888463","display_name":"Jian-Xing Xu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jian-Xing Xu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0962,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.34814898,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"28","issue":"2","first_page":"168","last_page":"171"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.8398000001907349,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.8398000001907349,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.15189999341964722,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitochondria","display_name":"mitochondria","score":0.9990000128746033},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":1.0},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/superoxide-radicals","display_name":"superoxide","score":0.9729999899864197},{"id":"https://openalex.org/keywords/mitochondrial-uncoupling","display_name":"mitochondrial uncoupling","score":0.9359999895095825},{"id":"https://openalex.org/keywords/mitochondrial-permeability-transition-pore","display_name":"mitochondrial permeability transition pore","score":0.9440000057220459},{"id":"https://openalex.org/keywords/mitochondrial-permeability-transition","display_name":"mitochondrial permeability transition","score":0.6809999942779541},{"id":"https://openalex.org/keywords/cytochrome-c-release","display_name":"cytochrome c release","score":0.9879999756813049},{"id":"https://openalex.org/keywords/antioxidant-function","display_name":"antioxidant function","score":0.7670000195503235},{"id":"https://openalex.org/keywords/ros-signaling","display_name":"ROS signaling","score":0.8149999976158142}],"concepts":[{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.8306242227554321},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.7391573786735535},{"id":"https://openalex.org/C2780795997","wikidata":"https://www.wikidata.org/wiki/Q413283","display_name":"Superoxide","level":3,"score":0.6368398070335388},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6196971535682678},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.6034661531448364},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5994491577148438},{"id":"https://openalex.org/C29311851","wikidata":"https://www.wikidata.org/wiki/Q408223","display_name":"Cytochrome c","level":3,"score":0.5908340811729431},{"id":"https://openalex.org/C3020377403","wikidata":"https://www.wikidata.org/wiki/Q211016","display_name":"Respiratory chain","level":3,"score":0.5518374443054199},{"id":"https://openalex.org/C24840226","wikidata":"https://www.wikidata.org/wiki/Q211016","display_name":"Electron transport chain","level":2,"score":0.5370619893074036},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5273160338401794},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.46164411306381226},{"id":"https://openalex.org/C66517615","wikidata":"https://www.wikidata.org/wiki/Q912751","display_name":"Cellular respiration","level":3,"score":0.44893109798431396},{"id":"https://openalex.org/C3020761558","wikidata":"https://www.wikidata.org/wiki/Q211016","display_name":"Mitochondrial respiratory chain","level":3,"score":0.4445464015007019},{"id":"https://openalex.org/C2780768313","wikidata":"https://www.wikidata.org/wiki/Q408068","display_name":"Cytochrome","level":3,"score":0.4369751214981079},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3749290108680725},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29347288608551025},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.08426198363304138},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2980760737","doi":null,"is_oa":false,"landing_page_url":"http://europepmc.org/abstract/CBA/347703","pdf_url":null,"source":{"id":"https://openalex.org/S62847986","display_name":"PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS","issn_l":"1000-3282","issn":["1000-3282"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-4","vabb-shw"],"host_organization":"https://openalex.org/P4310319982","host_organization_name":"Science Press","host_organization_lineage":["https://openalex.org/P4310319982"],"host_organization_lineage_names":["Science Press"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2038372638","https://openalex.org/W2386479028","https://openalex.org/W2087790613","https://openalex.org/W2093384103","https://openalex.org/W2106292206","https://openalex.org/W4237580162","https://openalex.org/W2082376575","https://openalex.org/W2519639778","https://openalex.org/W1498521935","https://openalex.org/W2021693564"],"abstract_inverted_index":{"Mitochondria":[0],"are":[1],"involved":[2],"not":[3],"only":[4],"in":[5,10,37,43,49,57,90],"energy":[6],"metabolism":[7],"but":[8],"also":[9],"free":[11],"radical":[12],"metabolism.":[13],"Superoxide":[14],"anion":[15],"can":[16,34],"be":[17,35],"generated":[18],"through":[19],"a":[20],"way":[21],"of":[22,25,41,47,59,62,66,75,86,93],"electron":[23,60],"leak":[24,61],"respiratory":[26,63],"chain":[27],"and":[28,52,80],"the":[29,38,91],"reactive":[30],"oxygen":[31],"species":[32],"(ROS)":[33],"formed":[36],"further":[39],"reactions":[40],"O~(.)_(2)":[42],"mitochondria.":[44],"The":[45,83],"role":[46],"mitochondria":[48,79],"anti-oxidant":[50],"functions":[51],"cell":[53,94],"apotosis":[54],"is":[55,88],"discussed":[56],"terms":[58],"chain,":[64],"uncoupling":[65],"oxidative":[67],"phosphorelation,":[68],"mitochondrial":[69],"pore,":[70],"Box-":[71],"or/and":[72],"PTP-mediated":[73],"release":[74],"cytochrome":[76],"c":[77],"from":[78],"so":[81],"on.":[82],"signaling":[84],"act":[85],"ROS":[87],"emphasized":[89],"regulation":[92],"apoptosis.":[95]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-07-14T05:52:30.601657","created_date":"2019-10-25T00:00:00"}