{"id":"https://openalex.org/W2980729111","doi":"https://doi.org/10.3389/fnins.2019.01117","title":"Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells","display_name":"Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells","publication_year":2019,"publication_date":"2019-10-18","ids":{"openalex":"https://openalex.org/W2980729111","doi":"https://doi.org/10.3389/fnins.2019.01117","mag":"2980729111","pmid":"https://pubmed.ncbi.nlm.nih.gov/31680844","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6813431"},"language":"en","primary_location":{"id":"doi:10.3389/fnins.2019.01117","doi":"https://doi.org/10.3389/fnins.2019.01117","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnins.2019.01117","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnins.2019.01117/pdf","source":{"id":"https://openalex.org/S115201632","display_name":"Frontiers in Neuroscience","issn_l":"1662-453X","issn":["1662-453X","1662-4548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fnins.2019.01117/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068215085","display_name":"Kimberlee P. Giffen","orcid":"https://orcid.org/0000-0001-9332-3498","observed_orcids":["https://orcid.org/0000-0001-9332-3498"]},"institutions":[{"id":"https://openalex.org/I114493937","display_name":"Creighton University","ror":"https://ror.org/05wf30g94","country_code":"US","type":"education","lineage":["https://openalex.org/I114493937"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kimberlee P. Giffen","raw_affiliation_strings":["Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE, United States","institution_ids":["https://openalex.org/I114493937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045754048","display_name":"Huizhan Liu","orcid":"https://orcid.org/0000-0003-2400-3284","observed_orcids":["https://orcid.org/0000-0003-2400-3284"]},"institutions":[{"id":"https://openalex.org/I114493937","display_name":"Creighton University","ror":"https://ror.org/05wf30g94","country_code":"US","type":"education","lineage":["https://openalex.org/I114493937"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huizhan Liu","raw_affiliation_strings":["Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE, United States","institution_ids":["https://openalex.org/I114493937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088403731","display_name":"Kenneth L. Kramer","orcid":"https://orcid.org/0009-0003-0668-7595","observed_orcids":["https://orcid.org/0009-0003-0668-7595","https://orcid.org/0000-0002-5930-1612"]},"institutions":[{"id":"https://openalex.org/I114493937","display_name":"Creighton University","ror":"https://ror.org/05wf30g94","country_code":"US","type":"education","lineage":["https://openalex.org/I114493937"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth L. Kramer","raw_affiliation_strings":["Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE, United States","institution_ids":["https://openalex.org/I114493937"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011210102","display_name":"David Z. Z. He","orcid":"https://orcid.org/0000-0001-8383-9634","observed_orcids":["https://orcid.org/0000-0001-8383-9634"]},"institutions":[{"id":"https://openalex.org/I114493937","display_name":"Creighton University","ror":"https://ror.org/05wf30g94","country_code":"US","type":"education","lineage":["https://openalex.org/I114493937"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David Z. He","raw_affiliation_strings":["Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE, United States","institution_ids":["https://openalex.org/I114493937"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5011210102","https://openalex.org/A5068215085"],"corresponding_institution_ids":["https://openalex.org/I114493937"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":1.1441,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.73484312,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"13","issue":null,"first_page":"1117","last_page":"1117"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hair-cell-regeneration","display_name":"hair cell regeneration","score":0.8450000286102295},{"id":"https://openalex.org/keywords/mouse-inner-ear","display_name":"mouse inner ear","score":0.8370000123977661},{"id":"https://openalex.org/keywords/orthologs","display_name":"orthologs","score":0.7229999899864197},{"id":"https://openalex.org/keywords/deiters-cells","display_name":"Deiters' cells","score":0.8519999980926514},{"id":"https://openalex.org/keywords/pillar-cells","display_name":"pillar cells","score":0.9660000205039978},{"id":"https://openalex.org/keywords/transdifferentiation","display_name":"transdifferentiation","score":0.8679999709129333},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.597000002861023},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.8080000281333923},{"id":"https://openalex.org/keywords/cell-fate-determination","display_name":"cell fate determination","score":0.6499999761581421},{"id":"https://openalex.org/keywords/self-renewal","display_name":"self-renewal","score":0.796999990940094},{"id":"https://openalex.org/keywords/comparative-genomics","display_name":"comparative genomics","score":0.492000013589859}],"concepts":[{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.9663338661193848},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7926677465438843},{"id":"https://openalex.org/C60870556","wikidata":"https://www.wikidata.org/wiki/Q2300675","display_name":"Transdifferentiation","level":3,"score":0.7143634557723999},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6691944599151611},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.6439019441604614},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4464171826839447},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4409932494163513},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.33040115237236023},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.19679364562034607}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fnins.2019.01117","doi":"https://doi.org/10.3389/fnins.2019.01117","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnins.2019.01117","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnins.2019.01117/pdf","source":{"id":"https://openalex.org/S115201632","display_name":"Frontiers in Neuroscience","issn_l":"1662-453X","issn":["1662-453X","1662-4548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6813431","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6813431","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Neurosci","raw_type":"Text"},{"id":"pmid:31680844","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31680844","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:812e30362bb84009a497586ba3ea8135","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/812e30362bb84009a497586ba3ea8135","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Neuroscience, Vol 13 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fnins.2019.01117","doi":"https://doi.org/10.3389/fnins.2019.01117","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnins.2019.01117","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnins.2019.01117/pdf","source":{"id":"https://openalex.org/S115201632","display_name":"Frontiers in Neuroscience","issn_l":"1662-453X","issn":["1662-453X","1662-4548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3003486864","display_name":"Biophysics and Development of Cochlear Hair Cells","funder_award_id":"R01DC004696","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"},{"id":"https://openalex.org/G7743621958","display_name":"The Molecular Biology of Neurosensory Systems","funder_award_id":"P30GM110768","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8156802188","display_name":"Mechanisms of Biological Aging of Cochlear Hair Cells","funder_award_id":"R01DC016807","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"}],"funders":[{"id":"https://openalex.org/F4320309641","display_name":"Creighton University","ror":"https://ror.org/05wf30g94"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337352","display_name":"National Institute on Deafness and Other Communication Disorders","ror":"https://ror.org/04mhx6838"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2980729111.pdf","grobid_xml":"https://content.openalex.org/works/W2980729111.grobid-xml"},"referenced_works_count":87,"referenced_works":["https://openalex.org/W67081778","https://openalex.org/W1493367564","https://openalex.org/W1529918890","https://openalex.org/W1881984790","https://openalex.org/W1964139506","https://openalex.org/W1965060087","https://openalex.org/W1968637495","https://openalex.org/W1970619629","https://openalex.org/W1971462103","https://openalex.org/W1979509265","https://openalex.org/W1981239255","https://openalex.org/W1983498842","https://openalex.org/W1987096821","https://openalex.org/W1995912317","https://openalex.org/W1997130867","https://openalex.org/W2000396551","https://openalex.org/W2004505240","https://openalex.org/W2004856995","https://openalex.org/W2005947296","https://openalex.org/W2011540182","https://openalex.org/W2021274718","https://openalex.org/W2023914268","https://openalex.org/W2027705175","https://openalex.org/W2028665355","https://openalex.org/W2034654482","https://openalex.org/W2038440214","https://openalex.org/W2045431994","https://openalex.org/W2048625654","https://openalex.org/W2055648999","https://openalex.org/W2057452063","https://openalex.org/W2059216629","https://openalex.org/W2059499001","https://openalex.org/W2061424770","https://openalex.org/W2063464173","https://openalex.org/W2064813976","https://openalex.org/W2065427389","https://openalex.org/W2066187005","https://openalex.org/W2071315178","https://openalex.org/W2075288501","https://openalex.org/W2075739422","https://openalex.org/W2078309249","https://openalex.org/W2083571191","https://openalex.org/W2085595067","https://openalex.org/W2085832582","https://openalex.org/W2089946206","https://openalex.org/W2098412979","https://openalex.org/W2101777268","https://openalex.org/W2103017472","https://openalex.org/W2105389823","https://openalex.org/W2105493567","https://openalex.org/W2106301904","https://openalex.org/W2106303663","https://openalex.org/W2108871359","https://openalex.org/W2121405816","https://openalex.org/W2123200224","https://openalex.org/W2124096393","https://openalex.org/W2124675599","https://openalex.org/W2145100181","https://openalex.org/W2146247758","https://openalex.org/W2147821804","https://openalex.org/W2150146216","https://openalex.org/W2151934941","https://openalex.org/W2152953538","https://openalex.org/W2155611926","https://openalex.org/W2156310646","https://openalex.org/W2156396097","https://openalex.org/W2160947509","https://openalex.org/W2163992327","https://openalex.org/W2169514219","https://openalex.org/W2280991339","https://openalex.org/W2321121782","https://openalex.org/W2413520294","https://openalex.org/W2541675757","https://openalex.org/W2565466068","https://openalex.org/W2566074090","https://openalex.org/W2740111268","https://openalex.org/W2767645678","https://openalex.org/W2771465962","https://openalex.org/W2792770106","https://openalex.org/W2894826826","https://openalex.org/W2895044356","https://openalex.org/W2903808414","https://openalex.org/W2913423814","https://openalex.org/W2950595506","https://openalex.org/W3184869969","https://openalex.org/W4250359879","https://openalex.org/W6798861114"],"related_works":["https://openalex.org/W4220833397","https://openalex.org/W4313545884","https://openalex.org/W4391290298","https://openalex.org/W4400959629","https://openalex.org/W1971462103","https://openalex.org/W3178194816","https://openalex.org/W4292646808","https://openalex.org/W4394725553","https://openalex.org/W2151216916","https://openalex.org/W2369779734"],"abstract_inverted_index":{"Non-mammalian":[0],"vertebrates,":[1],"including":[2],"zebrafish,":[3,235],"retain":[4],"the":[5,52,62,80,117,148],"ability":[6],"to":[7,13,27,59,111,158,232,239],"regenerate":[8],"hair":[9],"cells":[10,25],"(HCs)":[11],"due":[12],"unknown":[14],"molecular":[15,203],"mechanisms":[16],"that":[17,207],"regulate":[18],"proliferation":[19,53,227],"and":[20,54,82,97,99,104,107,131,140,151,154,164,197,210,228],"conversion":[21],"of":[22,38,56,67,79,91,121,180,205,220,230,241],"non-sensory":[23,101],"supporting":[24,102],"(nsSCs)":[26],"HCs.":[28,214],"This":[29],"regenerative":[30],"capacity":[31],"is":[32],"not":[33],"conserved":[34],"in":[35,43,51,61,128,137,175,184,226,234,247],"mammals.":[36,248],"Identification":[37],"uniquely":[39,173,182],"expressed":[40,127,136,144,183],"orthologous":[41,68,223],"genes":[42,70,145,171,181],"zebrafish":[44,57,81,95,129,149,176],"nsSCs":[45,58,96,130,150,185,206,231],"may":[46,237],"reveal":[47],"gene":[48,113],"candidates":[49],"involved":[50,225],"transdifferentiation":[55,211,229],"HCs":[60,233],"inner":[63,93],"ear.":[64],"A":[65],"list":[66],"protein-coding":[69],"was":[71],"generated":[72],"based":[73],"on":[74],"an":[75],"Ensembl":[76],"Biomart":[77],"comparison":[78],"mouse":[83,100,138,152],"genomes.":[84],"Our":[85,215],"previously":[86],"published":[87],"RNA-seq-based":[88],"transcriptome":[89],"datasets":[90],"isolated":[92],"ear":[94],"HCs,":[98,108,160],"pillar":[103,139,153],"Deiters'":[105,141,155],"cells,":[106,156],"were":[109,126,135,172],"merged":[110],"analyze":[112],"expression":[114],"patterns":[115],"between":[116],"two":[118],"species.":[119],"Out":[120],"17,498":[122],"total":[123],"orthologs,":[124],"11,752":[125],"over":[132,169],"10,000":[133],"orthologs":[134],"cells.":[142],"Differentially":[143],"common":[146],"among":[147],"compared":[157],"species-specific":[159],"included":[161],"306":[162],"downregulated":[163],"314":[165],"upregulated":[166,174],"genes;":[167],"however,":[168],"1,500":[170],"nsSCs.":[177],"Functional":[178],"analysis":[179],"identified":[186],"several":[187],"transcription":[188],"factors":[189],"associated":[190],"with":[191],"cell":[192,195],"fate":[193],"determination,":[194],"differentiation":[196],"nervous":[198],"system":[199],"development,":[200],"indicating":[201],"inherent":[202],"properties":[204],"promote":[208],"self-renewal":[209],"into":[212],"new":[213],"study":[216],"provides":[217],"a":[218],"means":[219],"characterizing":[221],"these":[222],"genes,":[224],"which":[236],"lead":[238],"identification":[240],"potential":[242],"targets":[243],"for":[244],"HC":[245],"regeneration":[246]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2019-10-25T00:00:00"}
