{"id":"https://openalex.org/W2980709459","doi":null,"title":"Examining the Role of Jagn1 in Pancreatic \u03b2-Cells","display_name":"Examining the Role of Jagn1 in Pancreatic \u03b2-Cells","publication_year":2014,"publication_date":"2014-11-01","ids":{"openalex":"https://openalex.org/W2980709459","mag":"2980709459"},"language":"en","primary_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/69073","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/69073","pdf_url":"https://utoronto.scholaris.ca/bitstreams/751ec145-68bc-4fd3-a610-c1b489ea1a72/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://utoronto.scholaris.ca/bitstreams/751ec145-68bc-4fd3-a610-c1b489ea1a72/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024544656","display_name":"Courtney Nosak","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Courtney Nosak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5024544656"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.9437999725341797,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.9437999725341797,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.0560000017285347,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-beta-cells","display_name":"pancreatic beta cells","score":0.9369999766349792},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.9890000224113464},{"id":"https://openalex.org/keywords/unfolded-protein-response","display_name":"unfolded protein response","score":1.0},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.7919999957084656},{"id":"https://openalex.org/keywords/proinsulin-biosynthesis","display_name":"proinsulin biosynthesis","score":0.9049999713897705},{"id":"https://openalex.org/keywords/insulinoma","display_name":"insulinoma","score":0.5910000205039978},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9340000152587891},{"id":"https://openalex.org/keywords/er-membrane-proteins","display_name":"ER membrane proteins","score":0.8190000057220459},{"id":"https://openalex.org/keywords/ins-1-832-13-cells","display_name":"INS-1 832/13 cells","score":0.8240000009536743}],"concepts":[{"id":"https://openalex.org/C90061646","wikidata":"https://www.wikidata.org/wiki/Q426173","display_name":"Proinsulin","level":3,"score":0.9340002536773682},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.9041666984558105},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.8337794542312622},{"id":"https://openalex.org/C2780053029","wikidata":"https://www.wikidata.org/wiki/Q1501239","display_name":"Insulinoma","level":3,"score":0.6746824979782104},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.6224839687347412},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.584186851978302},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5772144794464111},{"id":"https://openalex.org/C2779855799","wikidata":"https://www.wikidata.org/wiki/Q728309","display_name":"Pancreatic islets","level":4,"score":0.5083391070365906},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.47678497433662415},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.4712947607040405},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4404542148113251},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.42872148752212524},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4078768491744995},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3981545865535736},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3498155474662781},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.34567365050315857},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.2021072804927826},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16502532362937927},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12979045510292053},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10151425004005432},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:utoronto.scholaris.ca:1807/69073","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/69073","pdf_url":"https://utoronto.scholaris.ca/bitstreams/751ec145-68bc-4fd3-a610-c1b489ea1a72/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:2980709459","doi":null,"is_oa":false,"landing_page_url":"https://tspace.library.utoronto.ca/bitstream/1807/69073/3/Nosak_Courtney_201411_MSc_thesis.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/69073","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/69073","pdf_url":"https://utoronto.scholaris.ca/bitstreams/751ec145-68bc-4fd3-a610-c1b489ea1a72/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2980709459.pdf","grobid_xml":"https://content.openalex.org/works/W2980709459.grobid-xml"},"referenced_works_count":85,"referenced_works":["https://openalex.org/W121450932","https://openalex.org/W1505761263","https://openalex.org/W1566239132","https://openalex.org/W1567911976","https://openalex.org/W1570888466","https://openalex.org/W1580161657","https://openalex.org/W1598254642","https://openalex.org/W1605496649","https://openalex.org/W1837943983","https://openalex.org/W1970090817","https://openalex.org/W1970303002","https://openalex.org/W1970420856","https://openalex.org/W1971386540","https://openalex.org/W1975915247","https://openalex.org/W1979733074","https://openalex.org/W1985732052","https://openalex.org/W1988988264","https://openalex.org/W1993401552","https://openalex.org/W2003755766","https://openalex.org/W2005129842","https://openalex.org/W2011058633","https://openalex.org/W2014182850","https://openalex.org/W2014473343","https://openalex.org/W2024475665","https://openalex.org/W2026703925","https://openalex.org/W2027727753","https://openalex.org/W2028754125","https://openalex.org/W2036377986","https://openalex.org/W2038961236","https://openalex.org/W2039420809","https://openalex.org/W2041129796","https://openalex.org/W2047038614","https://openalex.org/W2048086508","https://openalex.org/W2048456744","https://openalex.org/W2064950130","https://openalex.org/W2067018477","https://openalex.org/W2068208419","https://openalex.org/W2071010185","https://openalex.org/W2074549465","https://openalex.org/W2080787730","https://openalex.org/W2080901528","https://openalex.org/W2082515526","https://openalex.org/W2087497757","https://openalex.org/W2089198803","https://openalex.org/W2089894176","https://openalex.org/W2091503047","https://openalex.org/W2092115819","https://openalex.org/W2095333345","https://openalex.org/W2099529905","https://openalex.org/W2100649872","https://openalex.org/W2101369715","https://openalex.org/W2103334789","https://openalex.org/W2104988047","https://openalex.org/W2106314483","https://openalex.org/W2107395755","https://openalex.org/W2124073775","https://openalex.org/W2124282046","https://openalex.org/W2125599080","https://openalex.org/W2127848114","https://openalex.org/W2127906377","https://openalex.org/W2131875219","https://openalex.org/W2133644385","https://openalex.org/W2136729555","https://openalex.org/W2139568257","https://openalex.org/W2143069340","https://openalex.org/W2144482148","https://openalex.org/W2144487953","https://openalex.org/W2146397440","https://openalex.org/W2152187155","https://openalex.org/W2152377123","https://openalex.org/W2153134360","https://openalex.org/W2154381322","https://openalex.org/W2156576736","https://openalex.org/W2157926318","https://openalex.org/W2158837517","https://openalex.org/W2160159279","https://openalex.org/W2161604602","https://openalex.org/W2162679859","https://openalex.org/W2163470744","https://openalex.org/W2165064047","https://openalex.org/W2168854535","https://openalex.org/W2170275764","https://openalex.org/W2170772645","https://openalex.org/W2188687303","https://openalex.org/W7098392294"],"related_works":["https://openalex.org/W2287232851","https://openalex.org/W7172219708","https://openalex.org/W1974558745","https://openalex.org/W1627109034","https://openalex.org/W2472189914","https://openalex.org/W4386793956","https://openalex.org/W7094689514","https://openalex.org/W2283933805","https://openalex.org/W2039420809","https://openalex.org/W2053012958"],"abstract_inverted_index":{"Endoplasmic":[0],"Reticulum":[1],"(ER)":[2],"stress":[3,44],"and":[4,82,85,112],"activation":[5],"of":[6,25,68,96,121,129],"the":[7,23,66],"Unfolded":[8],"Protein":[9],"Response":[10],"(UPR)":[11],"has":[12],"been":[13],"implicated":[14],"in":[15,32,40,60,70,78,90,98,104,107,145],"causing":[16],"pancreatic":[17,71,146],"beta":[18,72,147],"cell":[19,80],"dysfunction":[20],"leading":[21],"to":[22,42,92,116],"development":[24],"Type":[26],"II":[27],"diabetes.":[28],"Jagn1":[29,50,69,74,97,131,140],"was":[30,76],"identified":[31],"a":[33],"proteomic":[34],"screen":[35],"as":[36],"an":[37,52,57,105],"upregulated":[38],"protein":[39,55,125],"response":[41,91],"ER":[43,53,93,113,150],"caused":[45],"by":[46],"mutant":[47,130],"proinsulin":[48,110],"production.":[49],"is":[51],"membrane":[54],"with":[56],"unknown":[58],"function":[59],"mammalian":[61],"cells.":[62,73,118],"This":[63],"thesis":[64],"examined":[65],"role":[67],"mRNA":[75],"detected":[77],"insulinoma":[79,101],"lines":[81],"rodent":[83],"islets":[84],"its":[86],"levels":[87],"were":[88],"increased":[89],"stress.":[94,151],"Knock-down":[95],"INS-1":[99],"832/13":[100],"cells":[102,148],"resulted":[103],"increase":[106],"insulin":[108,124,143],"secretion,":[109],"biosynthesis":[111,144],"content":[114],"compared":[115],"control":[117],"Conversely,":[119],"overexpression":[120,128],"myc-Jagn1":[122],"decreased":[123],"levels,":[126],"whereas":[127],"had":[132],"no":[133],"effect.":[134],"Overall,":[135],"these":[136],"results":[137],"suggest":[138],"that":[139],"may":[141],"regulate":[142],"undergoing":[149]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-10-25T00:00:00"}