{"id":"https://openalex.org/W2980600925","doi":"https://doi.org/10.1161/res.125.suppl_1.717","title":"Abstract 717: CGMP Expanded First Trimester Human Umbilical Cord Perivascular Cells (FTM HUCPVC) Induce Significant Angiogenesis, Myocardial Regeneration and Sustained Functional Recovery Exceeding Older MSC Sources in the Rat Myocardial Infarction (MI) Model","display_name":"Abstract 717: CGMP Expanded First Trimester Human Umbilical Cord Perivascular Cells (FTM HUCPVC) Induce Significant Angiogenesis, Myocardial Regeneration and Sustained Functional Recovery Exceeding Older MSC Sources in the Rat Myocardial Infarction (MI) Model","publication_year":2019,"publication_date":"2019-08-02","ids":{"openalex":"https://openalex.org/W2980600925","doi":"https://doi.org/10.1161/res.125.suppl_1.717","mag":"2980600925"},"language":"en","primary_location":{"id":"doi:10.1161/res.125.suppl_1.717","doi":"https://doi.org/10.1161/res.125.suppl_1.717","is_oa":false,"landing_page_url":"https://doi.org/10.1161/res.125.suppl_1.717","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012118300","display_name":"Sz\u00c3\u00a1raz P\u00c3\u00a9ter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sz\u00c3\u00a1raz P\u00c3\u00a9ter","raw_affiliation_strings":["Create Program Inc., Toronto, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Create Program Inc., Toronto, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088378004","display_name":"Alexander J. Johnston","orcid":"https://orcid.org/0009-0006-1518-8300","observed_orcids":["https://orcid.org/0009-0006-1518-8300"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexander Johnston","raw_affiliation_strings":["Create Program Inc., Toronto, Canada","Alexander Johnston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Create Program Inc., Toronto, Canada","institution_ids":[]},{"raw_affiliation_string":"Alexander Johnston","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057994876","display_name":"Farwah Iqbal","orcid":"https://orcid.org/0000-0003-0315-303X","observed_orcids":["https://orcid.org/0000-0003-0315-303X"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Farwah Iqbal","raw_affiliation_strings":["Univ of Toronto, Toronto, Canada","Farwah Iqbal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Toronto, Toronto, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Farwah Iqbal","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112475885","display_name":"Banafshe Hoseini","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Banafshe Hoseini","raw_affiliation_strings":["Create Program Inc., Toronto, Canada","Banafshe Hoseini"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Create Program Inc., Toronto, Canada","institution_ids":[]},{"raw_affiliation_string":"Banafshe Hoseini","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050434880","display_name":"Alexandra Lucato","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexandra Lucato","raw_affiliation_strings":["Create Program Inc., Toronto, Canada","Alexandra Lucato"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Create Program Inc., Toronto, Canada","institution_ids":[]},{"raw_affiliation_string":"Alexandra Lucato","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024962280","display_name":"Poonam Mander","orcid":"https://orcid.org/0009-0003-7533-4179","observed_orcids":["https://orcid.org/0009-0003-7533-4179"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Poonam Mander","raw_affiliation_strings":["Create Program Inc., Toronto, Canada","Poonam Mander"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Create Program Inc., Toronto, Canada","institution_ids":[]},{"raw_affiliation_string":"Poonam Mander","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101751235","display_name":"Jun Wu","orcid":"https://orcid.org/0000-0002-5288-8473","observed_orcids":["https://orcid.org/0000-0002-5288-8473","https://orcid.org/0009-0000-3885-7825"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jun Wu","raw_affiliation_strings":["Univ Health Network, Toronto, Canada","Jun Wu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ Health Network, Toronto, Canada","institution_ids":["https://openalex.org/I1325899441"]},{"raw_affiliation_string":"Jun Wu","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071798015","display_name":"Ren\u2010Ke Li","orcid":"https://orcid.org/0000-0002-2584-060X","observed_orcids":["https://orcid.org/0000-0002-2584-060X"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Ren-Ke Li","raw_affiliation_strings":["Univ Health Network, Toronto, Canada","Ren-Ke Li"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ Health Network, Toronto, Canada","institution_ids":["https://openalex.org/I1325899441"]},{"raw_affiliation_string":"Ren-Ke Li","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005426292","display_name":"Clifford Lawrence Librach","orcid":"https://orcid.org/0000-0002-9699-4059","observed_orcids":["https://orcid.org/0000-0002-9699-4059"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Clifford Librach","raw_affiliation_strings":["Univ of Toronto, Toronto, Canada","Clifford Librach"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Toronto, Toronto, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Clifford Librach","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"125","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9559999704360962},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.9729999899864197},{"id":"https://openalex.org/keywords/cell-therapy","display_name":"cell therapy","score":0.6370000243186951},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.9179999828338623},{"id":"https://openalex.org/keywords/cardiac-regeneration","display_name":"cardiac regeneration","score":0.984000027179718},{"id":"https://openalex.org/keywords/infarct-scar","display_name":"infarct scar","score":0.6610000133514404},{"id":"https://openalex.org/keywords/macrophage-polarization","display_name":"macrophage polarization","score":0.7179999947547913},{"id":"https://openalex.org/keywords/extracellular-matrix-remodeling","display_name":"extracellular matrix remodeling","score":0.8500000238418579},{"id":"https://openalex.org/keywords/serca","display_name":"SERCA","score":0.7129999995231628},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5370000004768372},{"id":"https://openalex.org/keywords/xeno-free-culture","display_name":"xeno-free culture","score":0.6940000057220459}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.672450602054596},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.4977014362812042},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.49492019414901733},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4254385530948639},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3705790042877197},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3490001857280731},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.32846254110336304}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/res.125.suppl_1.717","doi":"https://doi.org/10.1161/res.125.suppl_1.717","is_oa":false,"landing_page_url":"https://doi.org/10.1161/res.125.suppl_1.717","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2801884334","https://openalex.org/W2945950154","https://openalex.org/W2017532099","https://openalex.org/W2329540809","https://openalex.org/W2980722039","https://openalex.org/W4241137841","https://openalex.org/W2946087412","https://openalex.org/W2163211682","https://openalex.org/W3145672856","https://openalex.org/W185142050"],"abstract_inverted_index":{"Introduction:":[0],"FTM":[1,14,37,44,77,140,169,209,267,298],"HUCPVC":[2,15,38,45,48,141,170,235,268,299],"are":[3,300],"a":[4,301,305],"novel":[5,306],"source":[6],"of":[7,34,168,189,219,261],"young,":[8],"immunoprivileged":[9],"mesenchymal":[10],"stromal":[11],"cells":[12],"(MSC).":[13],"demonstrate":[16],"significant":[17,212],"homing,":[18],"angiogenic":[19],"and":[20,46,60,93,108,116,125,148,197,213,233,240,255,275,290],"tissue":[21],"remodelling":[22,100],"capacities":[23],"in":[24,51,216,238,257],"vitro":[25],".":[26],"We":[27],"aimed":[28],"to":[29,157,227,244,279,293],"explore":[30],"the":[31,165],"therapeutic":[32],"potential":[33],"cGMP":[35,52],"compliant":[36,53],"for":[39,291,309],"myocardial":[40],"infarction":[41],"(MI).":[42],"Methods:":[43],"term":[47,79,234],"were":[49,71,112,131,242,285],"expanded":[50],"xeno-free":[54,288],"(5%":[55],"HPL)":[56],"multilayer":[57],"cultures":[58],"(Corning)":[59],"Quantum":[61],"Bioreactor":[62],"(Terumo).":[63],"One":[64],"week":[65],"post-MI":[66],"Fox":[67],"rnu":[68],"rats":[69],"(n=6)":[70],"intramyocardially":[72],"injected":[73],"with":[74],"3":[75],"million":[76],"HUCPVC,":[78,80],"bone":[81],"marrow":[82],"MSC":[83,281],"(BMSC)":[84],"or":[85],"basal":[86],"media.":[87],"Cardiac":[88],"function":[89,221],"(echocardiography,":[90],"pressure/volume":[91],"catheter":[92],"ECG":[94],"telemetry),":[95],"infarct":[96,149],"scar":[97],"(Trichrome),":[98],"ECM":[99],"activity":[101],"(DQ":[102],"collagenase":[103],"substrate)":[104],"vascular":[105],"density":[106,183],"(IB4)":[107],"contractile":[109,190,220],"proteins":[110],"(SarcA)":[111],"quantified":[113],"4":[114,152],"weeks":[115,153],"6":[117,245,294],"months":[118,246,295],"after":[119,136,270],"cell":[120,137,307],"implantation.":[121],"Myocardial":[122],"apoptosis":[123,144],"(caspase-3)":[124],"macrophage":[126,177],"infiltration":[127],"(eNOS,":[128],"CD68,":[129],"CD80)":[130],"assessed":[132],"at":[133,145,151],"5":[134,146],"days":[135,147],"treatment.":[138],"Results:":[139],"significantly":[142,174],"reduced":[143],"size":[150],"(5.3\u00b11.1,":[154],"p<0.05)":[155],"compared":[156,278],"other":[158,206],"treatment":[159,269],"groups.":[160,208],"Histological":[161],"analysis":[162],"showed":[163],"that":[164,284],"infarcted":[166],"region":[167],"treated":[171],"hearts":[172],"displayed":[173],"higher:":[175],"M2":[176],"ratio,":[178],"perivascular":[179],"gelatinase":[180],"activity,":[181],"capillary":[182],"(543.4\u00b1118.6":[184],"vs.":[185,194,203],"276.5\u00b142.69;":[186],"p<0.05),":[187,196],"abundance":[188],"sarcomeric":[191],"actinin":[192],"(48.9\u00b16.1":[193],"19.5\u00b17.0;":[195],"Ca":[198],"2+":[199],"pump":[200],"SERCA":[201],"(69.9\u00b15.9":[202],"49.8\u00b13.7)":[204],"over":[205],"experimental":[207],"HUCPVCs":[210],"induced":[211],"superior":[214,273],"improvements":[215],"all":[217],"measures":[218],"(ESV,":[222],"EF,":[223],"dPdt,":[224],"tau)":[225],"relative":[226],"cell-free":[228],"media":[229],"(p<0.001),":[230],"BMSC":[231],"(p<0.001)":[232],"(p<0.001).":[236],"Improvements":[237],"inotropy":[239],"lusitropy":[241],"maintained":[243,286],"(\u03b4":[247],"dPdt":[248,252],"max":[249],"3.8\u00b16.0;":[250],"\u03b4":[251],"min":[253],"3.2\u00b18.78)":[254],"resulted":[256],"near":[258],"complete":[259],"abolishment":[260],"premature":[262],"ventricular":[263],"contractions":[264],"(<1/min).":[265],"Conclusion:":[266],"MI":[271],"induces":[272],"structural":[274],"functional":[276],"recovery":[277],"older":[280],"sources;":[282],"characteristics":[283],"during":[287],"upscaling":[289],"up":[292],"post":[296],"injection.":[297],"promising":[302],"option":[303],"as":[304],"therapy":[308],"optimal":[310],"cardiovascular":[311],"regeneration.":[312]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-10-25T00:00:00"}