{"id":"https://openalex.org/W2980588461","doi":null,"title":"Thymoquinone potentiates chemoprotective effect of Vitamin D3 against colon cancer: a pre-clinical finding.","display_name":"Thymoquinone potentiates chemoprotective effect of Vitamin D3 against colon cancer: a pre-clinical finding.","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W2980588461","mag":"2980588461","pmid":"https://pubmed.ncbi.nlm.nih.gov/28337306","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5340713"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:4211847","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5340713","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5340713","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103066724","display_name":"Amr M. Mohamed","orcid":"https://orcid.org/0000-0003-4330-3151","observed_orcids":["https://orcid.org/0000-0003-4330-3151"]},"institutions":[{"id":"https://openalex.org/I199693650","display_name":"Umm al-Qura University","ror":"https://ror.org/01xjqrm90","country_code":"SA","type":"education","lineage":["https://openalex.org/I199693650"]},{"id":"https://openalex.org/I91041137","display_name":"Assiut University","ror":"https://ror.org/01jaj8n65","country_code":"EG","type":"education","lineage":["https://openalex.org/I91041137"]}],"countries":["EG","SA"],"is_corresponding":false,"raw_author_name":"Amr M Mohamed","raw_affiliation_strings":["Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura UniversityMakkah, Kingdom of Saudi Arabia; Clinical Laboratory Diagnosis, Department of Animal Medicine, Faculty of Veterinary Medicine, Assiut UniversityAssiut, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura UniversityMakkah, Kingdom of Saudi Arabia; Clinical Laboratory Diagnosis, Department of Animal Medicine, Faculty of Veterinary Medicine, Assiut UniversityAssiut, Egypt","institution_ids":["https://openalex.org/I199693650","https://openalex.org/I91041137"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017880181","display_name":"Bassem Refaat","orcid":"https://orcid.org/0000-0003-4267-1016","observed_orcids":["https://orcid.org/0000-0003-4267-1016"]},"institutions":[{"id":"https://openalex.org/I199693650","display_name":"Umm al-Qura University","ror":"https://ror.org/01xjqrm90","country_code":"SA","type":"education","lineage":["https://openalex.org/I199693650"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Bassem A Refaat","raw_affiliation_strings":["Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia","institution_ids":["https://openalex.org/I199693650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081701632","display_name":"Adel Galal El-Shemi","orcid":"https://orcid.org/0000-0002-4772-8416","observed_orcids":["https://orcid.org/0000-0002-4772-8416"]},"institutions":[{"id":"https://openalex.org/I199693650","display_name":"Umm al-Qura University","ror":"https://ror.org/01xjqrm90","country_code":"SA","type":"education","lineage":["https://openalex.org/I199693650"]},{"id":"https://openalex.org/I91041137","display_name":"Assiut University","ror":"https://ror.org/01jaj8n65","country_code":"EG","type":"education","lineage":["https://openalex.org/I91041137"]}],"countries":["EG","SA"],"is_corresponding":false,"raw_author_name":"Adel G El-Shemi","raw_affiliation_strings":["Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura UniversityMakkah, Kingdom of Saudi Arabia; Department of Pharmacology, Faculty of Medicine, Assiut UniversityAssiut, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura UniversityMakkah, Kingdom of Saudi Arabia; Department of Pharmacology, Faculty of Medicine, Assiut UniversityAssiut, Egypt","institution_ids":["https://openalex.org/I199693650","https://openalex.org/I91041137"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004939765","display_name":"Osama Adnan Kensara","orcid":"https://orcid.org/0009-0009-3627-3274","observed_orcids":["https://orcid.org/0009-0009-3627-3274"]},"institutions":[{"id":"https://openalex.org/I199693650","display_name":"Umm al-Qura University","ror":"https://ror.org/01xjqrm90","country_code":"SA","type":"education","lineage":["https://openalex.org/I199693650"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Osama A Kensara","raw_affiliation_strings":["Department of Clinical Nutrition, Faculty of Applied Medical Sciences, Umm Al-Qura University Makkah, Kingdom of Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Nutrition, Faculty of Applied Medical Sciences, Umm Al-Qura University Makkah, Kingdom of Saudi Arabia","institution_ids":["https://openalex.org/I199693650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089565677","display_name":"Jawwad Ahmad","orcid":"https://orcid.org/0000-0002-0949-1155","observed_orcids":["https://orcid.org/0000-0002-0949-1155"]},"institutions":[{"id":"https://openalex.org/I199693650","display_name":"Umm al-Qura University","ror":"https://ror.org/01xjqrm90","country_code":"SA","type":"education","lineage":["https://openalex.org/I199693650"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Jawwad Ahmad","raw_affiliation_strings":["Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia","institution_ids":["https://openalex.org/I199693650"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031575784","display_name":"Shakir Idris","orcid":"https://orcid.org/0000-0002-2062-7893","observed_orcids":["https://orcid.org/0000-0002-2062-7893"]},"institutions":[{"id":"https://openalex.org/I199693650","display_name":"Umm al-Qura University","ror":"https://ror.org/01xjqrm90","country_code":"SA","type":"education","lineage":["https://openalex.org/I199693650"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Shakir Idris","raw_affiliation_strings":["Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia","institution_ids":["https://openalex.org/I199693650"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.5582,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.90058722,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"9","issue":"2","first_page":"774","last_page":"790"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12750","display_name":"Nigella sativa pharmacological applications","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12750","display_name":"Nigella sativa pharmacological applications","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12758","display_name":"Saffron Plant Research Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thymoquinone","display_name":"thymoquinone","score":1.0},{"id":"https://openalex.org/keywords/vitamin-d3","display_name":"vitamin D3","score":0.9990000128746033},{"id":"https://openalex.org/keywords/colon-cancer-chemoprevention","display_name":"colon cancer chemoprevention","score":0.9430000185966492},{"id":"https://openalex.org/keywords/synergistic-drug-combination","display_name":"synergistic drug combination","score":0.753000020980835},{"id":"https://openalex.org/keywords/aberrant-crypt-foci","display_name":"aberrant crypt foci","score":0.9879999756813049},{"id":"https://openalex.org/keywords/wnt-beta-catenin-signaling","display_name":"Wnt/\u03b2-catenin signaling","score":0.9210000038146973},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.9340000152587891},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.9599999785423279},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.875},{"id":"https://openalex.org/keywords/hsp90","display_name":"HSP90","score":0.9890000224113464},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.7429999709129333},{"id":"https://openalex.org/keywords/dkk1","display_name":"DKK1","score":0.7860000133514404},{"id":"https://openalex.org/keywords/smad4","display_name":"SMAD4","score":0.7300000190734863},{"id":"https://openalex.org/keywords/pre-neoplastic-lesions","display_name":"pre-neoplastic lesions","score":0.7670000195503235}],"concepts":[{"id":"https://openalex.org/C2778452354","wikidata":"https://www.wikidata.org/wiki/Q794084","display_name":"Azoxymethane","level":4,"score":0.9754641056060791},{"id":"https://openalex.org/C2779034068","wikidata":"https://www.wikidata.org/wiki/Q7799650","display_name":"Thymoquinone","level":3,"score":0.8650463819503784},{"id":"https://openalex.org/C2911092814","wikidata":"https://www.wikidata.org/wiki/Q5090611","display_name":"Chemoprotective","level":3,"score":0.8300740718841553},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7237047553062439},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.683289647102356},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5420201420783997},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5359426736831665},{"id":"https://openalex.org/C2776940978","wikidata":"https://www.wikidata.org/wiki/Q34956","display_name":"Vitamin","level":2,"score":0.5304630994796753},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.4770723581314087},{"id":"https://openalex.org/C2780022331","wikidata":"https://www.wikidata.org/wiki/Q199678","display_name":"Vitamin C","level":2,"score":0.4100201725959778},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39687004685401917},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39419347047805786},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.36353325843811035},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.16874375939369202},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.09960651397705078},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09169918298721313}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:4211847","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5340713","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:28337306","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28337306","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of translational research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5340713","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5340713/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},{"id":"mag:2980588461","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28337306","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:4211847","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5340713","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":72,"referenced_works":["https://openalex.org/W607770413","https://openalex.org/W1539571840","https://openalex.org/W1540505497","https://openalex.org/W1540668106","https://openalex.org/W1548671031","https://openalex.org/W1757407923","https://openalex.org/W1853321321","https://openalex.org/W1871704727","https://openalex.org/W1915079118","https://openalex.org/W1936662132","https://openalex.org/W1964244253","https://openalex.org/W1965369905","https://openalex.org/W1974087595","https://openalex.org/W1976549710","https://openalex.org/W1977449716","https://openalex.org/W1978606574","https://openalex.org/W1982251648","https://openalex.org/W1984178014","https://openalex.org/W1984358846","https://openalex.org/W1986511854","https://openalex.org/W1987704691","https://openalex.org/W2004566532","https://openalex.org/W2007514658","https://openalex.org/W2011198737","https://openalex.org/W2013028549","https://openalex.org/W2015718862","https://openalex.org/W2020788984","https://openalex.org/W2032750086","https://openalex.org/W2037493927","https://openalex.org/W2044204464","https://openalex.org/W2044929965","https://openalex.org/W2048860195","https://openalex.org/W2052840896","https://openalex.org/W2056866215","https://openalex.org/W2057809866","https://openalex.org/W2065195395","https://openalex.org/W2071452498","https://openalex.org/W2077440316","https://openalex.org/W2079621764","https://openalex.org/W2080603887","https://openalex.org/W2080961798","https://openalex.org/W2084065462","https://openalex.org/W2089218510","https://openalex.org/W2091141094","https://openalex.org/W2093872436","https://openalex.org/W2099263399","https://openalex.org/W2103563428","https://openalex.org/W2106188989","https://openalex.org/W2106402853","https://openalex.org/W2112956266","https://openalex.org/W2113435266","https://openalex.org/W2115987868","https://openalex.org/W2118153923","https://openalex.org/W2119068203","https://openalex.org/W2120730389","https://openalex.org/W2121619780","https://openalex.org/W2125954809","https://openalex.org/W2139862399","https://openalex.org/W2140132504","https://openalex.org/W2141760501","https://openalex.org/W2141760646","https://openalex.org/W2157850262","https://openalex.org/W2161996879","https://openalex.org/W2165973588","https://openalex.org/W2168036403","https://openalex.org/W2168056522","https://openalex.org/W2172080383","https://openalex.org/W2185223750","https://openalex.org/W2187584967","https://openalex.org/W2333976439","https://openalex.org/W2461734496","https://openalex.org/W2914751349"],"related_works":["https://openalex.org/W2023695948","https://openalex.org/W2149267837","https://openalex.org/W321988904","https://openalex.org/W3112982285","https://openalex.org/W4362459244","https://openalex.org/W2742623510","https://openalex.org/W2998573848","https://openalex.org/W2461734496","https://openalex.org/W2084065462","https://openalex.org/W2955000922"],"abstract_inverted_index":{"Prevention":[0],"of":[1,20,29,39,47,74,80,111,141,144,174,198,223,229,241],"colon":[2,48,230,245],"cancer":[3,49,231],"among":[4],"high-risk":[5],"group":[6],"has":[7],"been":[8],"long":[9],"lasting":[10],"research":[11],"goal.":[12],"Emerging":[13],"data":[14],"have":[15],"evidenced":[16],"the":[17,30,36,45,78,81,142,220,226,236],"anticancer":[18],"activities":[19],"Vitamin":[21,42],"D3":[22,43],"(Vit.D)":[23],"and":[24,41,56,69,87,94,114,121,147,170,183,193,205],"Thymoquinone":[25,40],"(TQ).":[26],"The":[27],"aim":[28],"current":[31],"study":[32],"was":[33],"to":[34,67,209,238],"evaluate":[35],"synergistic":[37],"potential":[38,237],"in":[44,62,232,244],"control":[46],"progression":[50,240],"using":[51,117],"azoxymethane-induced":[52],"rat":[53,233],"model.":[54],"Vit.D":[55,224],"TQ":[57,218],"were":[58,85,91,102],"given":[59],"individually":[60,212],"or":[61,211],"combination":[63],"4":[64],"week":[65],"prior":[66],"induction":[68],"continued":[70],"for":[71,96,104],"a":[72],"total":[73],"20":[75],"week.":[76],"At":[77],"end":[79],"study,":[82],"all":[83],"animals":[84],"euthanized":[86],"their":[88,125],"resected":[89],"colons":[90],"examined":[92],"macroscopically":[93],"microscopically":[95],"tumor":[97],"growth.":[98],"Colonic":[99],"tissue":[100],"preparations":[101],"used":[103],"measuring":[105],"gene":[106,153],"expression":[107,154],"and/or":[108,155],"protein":[109,156],"levels":[110],"selected":[112],"pro":[113],"anti-tumor":[115,132],"biomarkers":[116,200],"quantitative":[118],"RT-PCR,":[119],"ELISA":[120],"immunohistochemistry.":[122],"Compared":[123],"with":[124,235],"individual":[126],"supplementation,":[127],"combined":[128,161],"Vit.D/TQ":[129,162],"showed":[130],"prominent":[131],"effect":[133,222],"manifested":[134],"by":[135],"significant":[136,165,188],"reduction":[137,166],"(P":[138,167,190],"<":[139,168,172,191,195],"0.05)":[140,173],"numbers":[143],"grown":[145],"tumors":[146],"large":[148],"aberrant":[149],"crypts":[150],"foci.":[151],"Mechanistically,":[152],"quantification":[157],"studies":[158],"revealed":[159],"that":[160],"supplementation":[163],"induced":[164],"0.01":[169,192],"P":[171,194],"pro-cancerous":[175],"molecules":[176],"(Wnt,":[177],"\u03b2-catenin,":[178],"NF-\u03baB,":[179],"COX-2,":[180],"iNOS,":[181],"VEGF":[182],"HSP-90)":[184],"as":[185,187,207],"well":[186],"increase":[189],"0.05,":[196],"respectively)":[197],"anti-tumorigenesis":[199],"(DKK-1,":[201],"CDNK-1A,":[202],"TGF-\u03b21,":[203],"TGF-\u03b2/RII":[204],"smad4)":[206],"compared":[208],"un-supplemented":[210],"supplemented":[213],"groups,":[214],"respectively.":[215],"In":[216],"conclusion,":[217],"augmented":[219],"chemopreventive":[221],"during":[225],"initiation":[227],"phase":[228],"model,":[234],"suppress":[239],"pre-neoplastic":[242],"lesions":[243],"carcinogenesis.":[246]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-10-25T00:00:00"}