{"id":"https://openalex.org/W2980488043","doi":"https://doi.org/10.11406/rinketsu.60.779","title":"[Aplastic anemia following drug-induced liver injury].","display_name":"[Aplastic anemia following drug-induced liver injury].","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W2980488043","doi":"https://doi.org/10.11406/rinketsu.60.779","mag":"2980488043","pmid":"https://pubmed.ncbi.nlm.nih.gov/31391366"},"language":"ja","primary_location":{"id":"pmid:31391366","doi":"https://doi.org/10.11406/rinketsu.60.779","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31391366","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"[Rinsho ketsueki] The Japanese journal of clinical hematology","raw_type":"Case Reports"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102900260","display_name":"Jun Nagai","orcid":"https://orcid.org/0000-0003-4720-5065","observed_orcids":["https://orcid.org/0000-0003-4720-5065"]},"institutions":[{"id":"https://openalex.org/I4210108351","display_name":"Kushiro Rosai Hospital","ror":"https://ror.org/01s9rzk09","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210108351"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jun Nagai","raw_affiliation_strings":["Department of Hematology, Kushiro Rosai Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Kushiro Rosai Hospital","institution_ids":["https://openalex.org/I4210108351"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018073323","display_name":"Toshihiro Matsukawa","orcid":"https://orcid.org/0000-0003-2371-3778","observed_orcids":["https://orcid.org/0000-0003-2371-3778"]},"institutions":[{"id":"https://openalex.org/I4210108351","display_name":"Kushiro Rosai Hospital","ror":"https://ror.org/01s9rzk09","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210108351"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshihiro Matsukawa","raw_affiliation_strings":["Department of Hematology, Kushiro Rosai Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Kushiro Rosai Hospital","institution_ids":["https://openalex.org/I4210108351"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029975826","display_name":"Keito Suto","orcid":"https://orcid.org/0000-0001-8212-5664","observed_orcids":["https://orcid.org/0000-0001-8212-5664"]},"institutions":[{"id":"https://openalex.org/I4210108351","display_name":"Kushiro Rosai Hospital","ror":"https://ror.org/01s9rzk09","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210108351"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keito Suto","raw_affiliation_strings":["Department of Hematology, Kushiro Rosai Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Kushiro Rosai Hospital","institution_ids":["https://openalex.org/I4210108351"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018814821","display_name":"Kazuo Oshimi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108351","display_name":"Kushiro Rosai Hospital","ror":"https://ror.org/01s9rzk09","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210108351"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuo Oshimi","raw_affiliation_strings":["Department of Hematology, Kushiro Rosai Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Kushiro Rosai Hospital","institution_ids":["https://openalex.org/I4210108351"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112256130","display_name":"Takuto Miyagishima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108351","display_name":"Kushiro Rosai Hospital","ror":"https://ror.org/01s9rzk09","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210108351"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takuto Miyagishima","raw_affiliation_strings":["Department of Hematology, Kushiro Rosai Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Kushiro Rosai Hospital","institution_ids":["https://openalex.org/I4210108351"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210108351"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.18966732,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"60","issue":"7","first_page":"779","last_page":"784"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13374","display_name":"Hematological disorders and diagnostics","score":0.6161999702453613,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13374","display_name":"Hematological disorders and diagnostics","score":0.6161999702453613,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":0.326200008392334,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.019700000062584877,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aplastic-anemia","display_name":"aplastic anemia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/drug-induced-liver-injury","display_name":"drug-induced liver injury","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pancytopenia","display_name":"pancytopenia","score":0.8479999899864197},{"id":"https://openalex.org/keywords/paroxysmal-nocturnal-hemoglobinuria","display_name":"paroxysmal nocturnal hemoglobinuria","score":0.7940000295639038},{"id":"https://openalex.org/keywords/antithymocyte-globulin","display_name":"antithymocyte globulin","score":0.8709999918937683},{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.9779999852180481},{"id":"https://openalex.org/keywords/immunosuppressive-therapy","display_name":"immunosuppressive therapy","score":0.9459999799728394},{"id":"https://openalex.org/keywords/over-the-counter-drugs","display_name":"over-the-counter drugs","score":0.6449999809265137},{"id":"https://openalex.org/keywords/drug-induced-lymphocyte-stimulation-test","display_name":"drug-induced lymphocyte stimulation test","score":0.7689999938011169},{"id":"https://openalex.org/keywords/hepatitis-associated-aplastic-anemia","display_name":"hepatitis-associated aplastic anemia","score":0.7850000262260437}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.93756502866745},{"id":"https://openalex.org/C2779382419","wikidata":"https://www.wikidata.org/wiki/Q1757427","display_name":"Pancytopenia","level":3,"score":0.8868182897567749},{"id":"https://openalex.org/C2781440808","wikidata":"https://www.wikidata.org/wiki/Q846316","display_name":"Aplastic anemia","level":3,"score":0.6940872669219971},{"id":"https://openalex.org/C2776637226","wikidata":"https://www.wikidata.org/wiki/Q6658207","display_name":"Liver injury","level":2,"score":0.641822338104248},{"id":"https://openalex.org/C2777766500","wikidata":"https://www.wikidata.org/wiki/Q360841","display_name":"Liver biopsy","level":3,"score":0.616706371307373},{"id":"https://openalex.org/C2776029263","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Hepatitis","level":2,"score":0.5299585461616516},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.47658392786979675},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.46111205220222473},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.438669890165329},{"id":"https://openalex.org/C2777346216","wikidata":"https://www.wikidata.org/wiki/Q1479494","display_name":"Paroxysmal nocturnal hemoglobinuria","level":2,"score":0.4382782280445099},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4376709461212158},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.429703027009964},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4071239233016968},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.30740129947662354},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.14246299862861633}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000741","descriptor_name":"Anemia, Aplastic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000741","descriptor_name":"Anemia, Aplastic","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D000961","descriptor_name":"Antilymphocyte Serum","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006457","descriptor_name":"Hemoglobinuria, Paroxysmal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016572","descriptor_name":"Cyclosporine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D056486","descriptor_name":"Chemical and Drug Induced Liver Injury","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:31391366","doi":"https://doi.org/10.11406/rinketsu.60.779","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31391366","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"[Rinsho ketsueki] The Japanese journal of clinical hematology","raw_type":"Case Reports"},{"id":"mag:2980488043","doi":"https://doi.org/10.11406/rinketsu.60.779","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31391366","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7113897020","https://openalex.org/W2010581297","https://openalex.org/W4391767027","https://openalex.org/W2340476340","https://openalex.org/W3037140198","https://openalex.org/W3032778615","https://openalex.org/W2075402517","https://openalex.org/W7210281772","https://openalex.org/W2409894971","https://openalex.org/W2020422870"],"abstract_inverted_index":{"Aplastic":[0],"anemia":[1],"(AA),":[2],"a":[3,39,83,148],"hematopoietic":[4,15],"disorder":[5],"characterized":[6],"by":[7,13,117],"hypocellular":[8],"bone":[9],"marrow,":[10],"is":[11,21,33,140,158],"caused":[12],"immunologically-mediated":[14],"stem":[16],"cell":[17],"injury.":[18],"Viral":[19],"infection":[20],"hypothesized":[22],"as":[23],"the":[24,93,105,134,141,145,162],"underlying":[25],"cause":[26],"of":[27,41,85,101,107,136,150,164],"hepatitis-associated":[28,167],"AA,":[29],"although":[30],"its":[31],"mechanism":[32],"still":[34],"unclear.":[35],"This":[36],"report":[37,143],"describes":[38],"case":[40,149],"AA":[42,108,151],"following":[43,109,152],"suspected":[44,66],"drug-induced":[45,70,165],"liver":[46,54,75,79,90],"injury":[47],"(DILI).":[48],"An":[49],"18-year-old":[50],"man":[51,94],"developed":[52,96],"severe":[53],"dysfunction":[55,80],"after":[56,82],"taking":[57],"oral":[58],"over-the-counter":[59],"drugs.":[60],"The":[61],"patient":[62],"was":[63,128],"diagnosed":[64],"with":[65,123,130,147],"DILI":[67,102],"based":[68],"on":[69],"lymphocyte":[71],"stimulation":[72],"test":[73],"and":[74,89,126,154,166],"biopsy":[76],"results.":[77],"Although":[78],"improved":[81],"course":[84],"steroid":[86],"pulse":[87],"therapy":[88,122],"supporting":[91],"therapy,":[92],"gradually":[95],"pancytopenia":[97,131],"within":[98],"3":[99],"months":[100],"diagnosis,":[103],"prompting":[104],"diagnosis":[106],"DILI.":[110],"Paroxysmal":[111],"nocturnal":[112],"hemoglobinuria-type":[113],"cells":[114],"were":[115],"detected":[116],"high-sensitivity":[118],"flow":[119],"cytometry.":[120],"Immunosuppressive":[121],"antithymocyte":[124],"globulin":[125],"cyclosporin":[127],"administered,":[129],"improvement.":[132],"To":[133],"best":[135],"our":[137],"knowledge,":[138],"this":[139],"first":[142],"in":[144],"literature":[146],"DILI,":[153],"we":[155],"believe":[156],"it":[157],"important":[159],"for":[160],"evaluating":[161],"pathogenesis":[163],"AA.":[168]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2019-10-25T00:00:00"}
