{"id":"https://openalex.org/W2980477668","doi":null,"title":"MicroRNA-146b-3p regulates the development and progression of cerebral infarction with diabetes through RAF1/P38MAPK/COX-2 signaling pathway.","display_name":"MicroRNA-146b-3p regulates the development and progression of cerebral infarction with diabetes through RAF1/P38MAPK/COX-2 signaling pathway.","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2980477668","mag":"2980477668","pmid":"https://pubmed.ncbi.nlm.nih.gov/29511456","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5835827"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5835827","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5835827","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5835827","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Fan Cai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2801556517","display_name":"Ruijin Hospital","ror":"https://ror.org/01hv94n30","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801556517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fan Cai","raw_affiliation_strings":["Shanghai Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200030, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801556517"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102004719","display_name":"Fang Wu","orcid":"https://orcid.org/0000-0002-6242-1682","observed_orcids":["https://orcid.org/0000-0002-6242-1682"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2801556517","display_name":"Ruijin Hospital","ror":"https://ror.org/01hv94n30","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801556517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fang Wu","raw_affiliation_strings":["Shanghai Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200030, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801556517"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108736240","display_name":"Jiumei Cao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2801556517","display_name":"Ruijin Hospital","ror":"https://ror.org/01hv94n30","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801556517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiumei Cao","raw_affiliation_strings":["Shanghai Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200030, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801556517"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038669556","display_name":"Xiaonan Chen","orcid":"https://orcid.org/0000-0003-3714-6815","observed_orcids":["https://orcid.org/0000-0003-3714-6815","https://orcid.org/0009-0001-4202-9552"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2801556517","display_name":"Ruijin Hospital","ror":"https://ror.org/01hv94n30","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801556517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaonan Chen","raw_affiliation_strings":["Shanghai Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200030, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801556517"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5288,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.56237817,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"10","issue":"2","first_page":"618","last_page":"628"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cerebral-infarction","display_name":"cerebral infarction","score":0.8650000095367432},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.9330000281333923},{"id":"https://openalex.org/keywords/raf-1","display_name":"Raf-1","score":0.8349999785423279},{"id":"https://openalex.org/keywords/p38-mapk-signaling","display_name":"p38 MAPK signaling","score":0.859000027179718},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.9940000176429749},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9409999847412109},{"id":"https://openalex.org/keywords/peripheral-blood-mononuclear-cells","display_name":"peripheral blood mononuclear cells","score":0.902999997138977},{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":0.5899999737739563},{"id":"https://openalex.org/keywords/microrna-target-regulation","display_name":"microRNA target regulation","score":0.5809999704360962}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.7880955934524536},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.6884719133377075},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.6205813884735107},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5835260152816772},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.5659255385398865},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.48687830567359924},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48278653621673584},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.47896698117256165},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.42019689083099365},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.41105592250823975},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3937041461467743},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3872990012168884},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3726559281349182},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3425912857055664},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2089802324771881},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10054031014442444}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:5835827","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5835827","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},{"id":"pmid:29511456","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29511456","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of translational research","raw_type":"Journal Article"},{"id":"mag:2980477668","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29511456","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5835827","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5835827","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1418274437","https://openalex.org/W1992342871","https://openalex.org/W1998827333","https://openalex.org/W2009901264","https://openalex.org/W2011939283","https://openalex.org/W2012820125","https://openalex.org/W2019053153","https://openalex.org/W2020259322","https://openalex.org/W2030519974","https://openalex.org/W2071224053","https://openalex.org/W2083560029","https://openalex.org/W2089128978","https://openalex.org/W2104776720","https://openalex.org/W2108088896","https://openalex.org/W2115500682","https://openalex.org/W2115544910","https://openalex.org/W2122214237","https://openalex.org/W2122345275","https://openalex.org/W2129375084","https://openalex.org/W2150102205","https://openalex.org/W2162127267","https://openalex.org/W2167979173","https://openalex.org/W2168590981","https://openalex.org/W2169747922","https://openalex.org/W2173296354","https://openalex.org/W2184324737","https://openalex.org/W2199654459","https://openalex.org/W2228061813","https://openalex.org/W2291302433","https://openalex.org/W2293884966","https://openalex.org/W2314621992","https://openalex.org/W2342290396","https://openalex.org/W2394534432","https://openalex.org/W2499418010"],"related_works":["https://openalex.org/W2287751482","https://openalex.org/W2292188653","https://openalex.org/W2321880804","https://openalex.org/W2905271051","https://openalex.org/W2598135714","https://openalex.org/W2795849441","https://openalex.org/W2743439581","https://openalex.org/W4389486624","https://openalex.org/W7167265329","https://openalex.org/W3031818206"],"abstract_inverted_index":{"Diabetes":[0],"has":[1],"been":[2],"considered":[3],"as":[4],"an":[5],"independent":[6],"risk":[7],"factor":[8],"for":[9,99,104,111],"cerebral":[10,17],"infarction.":[11,211],"However,":[12],"the":[13,33,49,57,68,80,101,112,123,126,225,232],"pathological":[14],"mechanism":[15],"of":[16,59,83,125,136,146,197,205,219,229],"infarction":[18],"with":[19,150,171],"diabetes":[20],"(DMCI)":[21],"is":[22,221],"still":[23],"rarely":[24],"known.":[25],"In":[26,156],"this":[27],"study,":[28],"we":[29],"try":[30],"to":[31,121,183,203,224],"explore":[32],"relationship":[34],"between":[35],"microRNA-146b-3p":[36],"(miR-146b-3p)":[37],"and":[38,61,73,138,227],"DMCI":[39,147,169],"patients.":[40,190],"The":[41,191],"peripheral":[42,144],"blood":[43,145],"mononuclear":[44],"cells":[45],"were":[46,51,71,85,140],"separated":[47],"after":[48],"patients":[50,148],"selected":[52],"from":[53],"our":[54],"hospital.":[55],"Firstly,":[56],"content":[58],"IL-6":[60,137],"COX-2":[62,139],"was":[63,97,109,119,165,181],"detected":[64],"by":[65,75,87],"ELISA.":[66],"Then,":[67],"total":[69],"RNAs":[70],"extracted":[72],"analyzed":[74],"microRNA":[76],"(miRNA)":[77],"microarray.":[78],"Moreover,":[79,176],"target":[81,90,102],"genes":[82],"miR-146b-3p":[84,163,177,200,220],"predicted":[86],"online":[88],"miRNA":[89,113,158],"prediction":[91],"algorithms.":[92],"Meanwhile,":[93],"luciferase":[94],"reporter":[95],"system":[96],"used":[98,110],"assaying":[100],"gene":[103],"miRNA-146b-3p.":[105],"Simultaneously,":[106],"RT-PCR":[107],"assay":[108],"expression":[114,124,135,164,173,180,218],"detection.":[115],"Furthermore,":[116],"western":[117],"blot":[118],"applied":[120],"determine":[122],"signal":[127,234],"pathway":[128,208],"involved":[129],"proteins.":[130],"Our":[131,212],"results":[132],"demonstrated":[133],"that":[134,151,162,195,216],"remarkably":[141],"up-regulated":[142],"in":[143,152,168,188,209],"compared":[149],"normal":[153],"control":[154],"group.":[155],"addition,":[157],"microarray":[159],"data":[160,213],"suggested":[161],"significantly":[166],"down-regulated":[167],"patients,":[170],"v-raf-1":[172],"negatively":[174],"regulated.":[175],"regulated":[178],"RAF1":[179,198],"found":[182],"mediate":[184],"P38MAPK":[185],"signaling":[186,207],"activation":[187,196,204],"thrombosis":[189],"following":[192],"research":[193],"indicated":[194],"trough":[199],"down-regulation":[201],"contributed":[202],"RAF/P38MAPK/COX-2":[206,233],"vascular":[210],"have":[214],"implied":[215],"altered":[217],"closely":[222],"related":[223],"progression":[226],"development":[228],"DCMI":[230],"mediating":[231],"transduction":[235],"pathway.":[236]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2019-10-25T00:00:00"}